Joost B Beltman

Summary

Country: UK

Publications

  1. ncbi request reprint Spatial modelling of brief and long interactions between T cells and dendritic cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, CH 3584 Utrecht, The Netherlands
    Immunol Cell Biol 85:306-14. 2007
  2. doi request reprint Towards estimating the true duration of dendritic cell interactions with T cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Immunol Methods 347:54-69. 2009
  3. pmc Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens
    Renske M A Vroomans
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS Comput Biol 8:e1002763. 2012
  4. pmc Lymph node topology dictates T cell migration behavior
    Joost B Beltman
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, Netherlands
    J Exp Med 204:771-80. 2007
  5. doi request reprint Analysing immune cell migration
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Immunol 9:789-98. 2009
  6. pmc B cells within germinal centers migrate preferentially from dark to light zone
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 108:8755-60. 2011
  7. ncbi request reprint MHC polymorphism under host-pathogen coevolution
    Jose A M Borghans
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Immunogenetics 55:732-9. 2004

Detail Information

Publications7

  1. ncbi request reprint Spatial modelling of brief and long interactions between T cells and dendritic cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, CH 3584 Utrecht, The Netherlands
    Immunol Cell Biol 85:306-14. 2007
    ..Finally, by performing long simulations (after prior fitting to short time scale data) we are able to provide an estimate of the average contact duration between T cells and DCs...
  2. doi request reprint Towards estimating the true duration of dendritic cell interactions with T cells
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Immunol Methods 347:54-69. 2009
    ..We discuss in detail how future experiments can be optimized such that MPM contact data will be minimally affected by these factors...
  3. pmc Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens
    Renske M A Vroomans
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS Comput Biol 8:e1002763. 2012
    ..Moreover, the chemotaxis-driven migration still roughly appears as a random walk, hence fine-tuned analysis of cell tracks will be required to detect chemotaxis within microscopy data...
  4. pmc Lymph node topology dictates T cell migration behavior
    Joost B Beltman
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, Netherlands
    J Exp Med 204:771-80. 2007
    ..We present experimental evidence for the presence of such turbulent streams in LNs. Finally, the model allows us to estimate the scanning rates of DCs (2,000 different T cells per hour) and T cells (100 different DCs per hour)...
  5. doi request reprint Analysing immune cell migration
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Rev Immunol 9:789-98. 2009
    ..We propose how these errors can be recognized and corrected, and suggest ways to prevent the data analysis itself leading to biased results...
  6. pmc B cells within germinal centers migrate preferentially from dark to light zone
    Joost B Beltman
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 108:8755-60. 2011
    ..This is consistent with experimental observations, and we show that at the observed cellular motility such a time course cannot be explained without the small preferential migration from DZ to LZ...
  7. ncbi request reprint MHC polymorphism under host-pathogen coevolution
    Jose A M Borghans
    Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Immunogenetics 55:732-9. 2004
    ..Provided that the host population is sufficiently large, a large set of MHC alleles can persist over many host generations under host-pathogen coevolution, despite the fact that allele frequencies continuously change...