Affiliation: Barts and The London NHS Trust
- Clinical outcomes in children with sickle cell disease living in England: a neonatal cohort in East LondonPaul Telfer
Department of Paediatric Haematology and Oncology, Royal London Hospital, Whitechapel Road, London E1 1BB
Haematologica 92:905-12. 2007..We investigated outcomes in a UK neonatal cohort as a benchmark for care of children with sickle cell disease (SCD)...
- Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004Paul Telfer
Department of Paediatric Haematology and Oncology, St Bartholomew s and The Royal London Hospitals NHS Trust, UK
Haematologica 91:1187-92. 2006..In 1999, a combination chelation regime with desferrioxamine and deferiprone was introduced. We analyzed survival trends in Cypriots and tried to identify factors associated with prolonged survival...
- Update on survival in thalassemia majorPaul Telfer
Barts and the London School of Medicine and Dentistry, London, UK
Hemoglobin 33:S76-80. 2009..The life expectancy for those in low-income countries is similar to the situation 50 years ago in Europe and the United States. The global thalassemia and public health community should consider how to respond to this disparity...
- Cervical carotid artery disease in sickle cell anemia: clinical and radiological featuresPaul T Telfer
Department of Pediatric Hematology, Barts and The London Hospital National Health Service Trust NHST, London, United Kingdom
Blood 118:6192-9. 2011..Routine screening of children with SCD should also include evaluation of neck vessels by carotid Doppler followed by cMRA if a cervical vascular lesion is suspected...
- Intranasal diamorphine for acute sickle cell painP Telfer
Department of Paediatric Haematology and Oncology, Children s Hospital, Barts and The London NHS Trust, London, UK
Arch Dis Child 94:979-80. 2009..There were no serious side effects and questionnaire scores indicated that children found IND effective and acceptable. IND can be recommended for acute control of sickle pain in children presenting to hospital...
- Quality of life in thalassemiaP Telfer
Department of Haematology, St Bartholomew s Hospital, London, UK
Ann N Y Acad Sci 1054:273-82. 2005..Practical measures could be taken to address these issues...
- Deferasirox for iron chelation in multitransfused children with sickle cell disease; long-term experience in the East London clinical haemoglobinopathy networkEva Tsouana
Department of Paediatric Haematology, Royal London Hospital, London, UK
Eur J Haematol 94:336-42. 2015..We recommend further studies to confirm these findings and to optimise iron chelation in this population. ..
- Detecting white matter injury in sickle cell disease using voxel-based morphometryTorsten Baldeweg
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College, London, United Kingdom
Ann Neurol 59:662-72. 2006..This study aimed to detect the presence and extent of white matter abnormalities in individuals with SCD using voxel-based morphometry (VBM)...
- An exploratory study of physiological correlates of neurodevelopmental delay in infants with sickle cell anaemiaAlexandra M Hogan
Institute of Child Health, University College London, London, UK
Br J Haematol 132:99-107. 2006..This exploratory study suggests that SCA infants may be at greater risk of neurodevelopmental delay than previously considered, and may provide the impetus for further research into the very early precursors of cognitive impairment...
- Understanding the causes of problematic pain management in sickle cell disease: evidence that pseudoaddiction plays a more important role than genuine analgesic dependenceJames Elander
Department of Psychology, London Metropolitan University, London, United Kingdom
J Pain Symptom Manage 27:156-69. 2004..The results show how pseudoaddiction can adversely influence hospital pain management, and suggest that more emphasis should be placed on patients' pain and analgesic needs when responding to concern-raising behaviors in hospital...
- White Matter Damage Relates to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral InfarctsJamie M Kawadler
From the Developmental Imaging and Biophysics Section J M K, J D C, C A C, Clinical Neurosciences Section F J K, and Cognitive Neuroscience and Neuropsychiatry Section E L S, R E, UCL Institute of Child Health, London, United Kingdom Department of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom M J H Department of Paediatric Haematology, Barts and The London Hospital NHS Trust, London, United Kingdom P T Department of Paediatrics, Whittington Hospital NHS Trust, London, United Kingdom A R Department of Paediatrics, North Middlesex University Hospital NHS Trust, London, United Kingdom O W Wessex Neurological Centre S B, and Department of Child Health F J K, Southampton University Hospitals NHS Trust, Southampton, United Kingdom S B and Department of Radiology, Great Ormond Street Hospital, London, United Kingdom T C S C
Stroke 46:1793-9. 2015..However, in children with no evidence of cerebral infarction, there are changes in brain morphometry relative to healthy controls, which may be related to chronic anemia and oxygen desaturation...
- Nasopharyngeal carriage rate of Streptococcus pneumoniae in children with sickle cell disease before and after the introduction of heptavalent pneumococcal conjugate vaccineEllie Alexander
Academic Unit of Child Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, The Blizard Building, London, UK
J Infect Public Health 1:40-4. 2008..The introduction of PCV-7 appears to be associated with a shift in distribution of serotypes carried by children with SCD. This may have implications for vaccine effectiveness...
- Guidelines for the management of the acute painful crisis in sickle cell diseaseDavid C Rees
Department of Haematology, King s College Hospital, Denmark Hill, London, UK
Br J Haematol 120:744-52. 2003
- Analgesic addiction and pseudoaddiction in painful chronic illnessJoanne Lusher
London Metropolitan University, UK
Clin J Pain 22:316-24. 2006..This study tested predictions that certain drug-use behaviors and pain-coping strategies were associated with analgesic addiction, and that certain were associated with risk of pseudoaddiction...
- Pain management and symptoms of substance dependence among patients with sickle cell diseaseJames Elander
Department of Psychology, London Metropolitan University, Calcutta House, Old Castle Street, E1 7NT London, UK
Soc Sci Med 57:1683-96. 2003..Further research could examine ways that pain-related and non-pain-related symptoms of dependence may be associated with other pain coping strategies and with the outcomes of treatment for painful episodes in hospital...