Anita Balakrishnan

Summary

Country: UK

Publications

  1. doi Upregulation of proapoptotic microRNA mir-125a after massive small bowel resection in rats
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Surg 255:747-53. 2012
  2. pmc Circadian clock genes and implications for intestinal nutrient uptake
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Nutr Biochem 23:417-22. 2012
  3. pmc PER1 modulates SGLT1 transcription in vitro independent of E-box status
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Dig Dis Sci 57:1525-36. 2012
  4. pmc MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Exp Cell Res 316:3512-21. 2010
  5. pmc Restricted feeding phase shifts clock gene and sodium glucose cotransporter 1 (SGLT1) expression in rats
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 140:908-14. 2010
  6. pmc Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 297:G950-7. 2009
  7. pmc Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1)
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Surgery 143:813-8. 2008
  8. pmc Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Surgery 145:294-302. 2009
  9. doi Circadian variation in intestinal dihydropyrimidine dehydrogenase (DPD) expression: a potential mechanism for benefits of 5FU chrono-chemotherapy
    Kamran Abolmaali
    Department of Surgery, Brigham and Women s Hospital, Boston, MA Harvard Medical School, Boston, MA 02115, USA
    Surgery 146:269-73. 2009
  10. ncbi Diurnal rhythmicity in the transcription of jejunal drug transporters
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Pharmacol Sci 108:144-8. 2008

Collaborators

Detail Information

Publications15

  1. doi Upregulation of proapoptotic microRNA mir-125a after massive small bowel resection in rats
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Surg 255:747-53. 2012
    ..To identify new treatments we focused on postresection changes in microRNAs--short noncoding RNAs, which suppress target genes--and suggest a previously undiscovered role for microRNA-125a (mir-125a) in intestinal adaptation...
  2. pmc Circadian clock genes and implications for intestinal nutrient uptake
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Nutr Biochem 23:417-22. 2012
    ..Clock genes have since been shown via a combination of in vitro and in vivo techniques to play a role in the transcriptional regulation of key absorptive proteins...
  3. pmc PER1 modulates SGLT1 transcription in vitro independent of E-box status
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Dig Dis Sci 57:1525-36. 2012
    ..We investigated the effects of one clock gene, PER1, on SGLT1 transcription in vitro...
  4. pmc MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Exp Cell Res 316:3512-21. 2010
    ..The regulatory mechanisms behind these rhythms remain largely unknown. We hypothesized that microRNAs are involved in mediating these rhythms, and studied the role of microRNAs specifically in modulating intestinal proliferation...
  5. pmc Restricted feeding phase shifts clock gene and sodium glucose cotransporter 1 (SGLT1) expression in rats
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 140:908-14. 2010
    ..Understanding the regulatory cues governing rhythms in intestinal function may allow new therapeutic options for conditions of dysregulated absorption such as diabetes and obesity...
  6. pmc Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 297:G950-7. 2009
    ..This provides a novel mechanistic explanation for some of the antidiabetic effects of RYGB...
  7. pmc Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1)
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Surgery 143:813-8. 2008
    ..To address this gap, we assessed temporal changes in glucose transport mediated by the Na(+)/glucose cotransporter SGLT1...
  8. pmc Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Surgery 145:294-302. 2009
    ..SGLT1 expression varies with a profound diurnal rhythm, matching expression to nutrient intake. The mechanisms entraining this rhythm remain unknown. We investigated the role of local nutrient signals in diurnal SGLT1 entrainment...
  9. doi Circadian variation in intestinal dihydropyrimidine dehydrogenase (DPD) expression: a potential mechanism for benefits of 5FU chrono-chemotherapy
    Kamran Abolmaali
    Department of Surgery, Brigham and Women s Hospital, Boston, MA Harvard Medical School, Boston, MA 02115, USA
    Surgery 146:269-73. 2009
    ..Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in 5FU breakdown. We hypothesized that DPD has a circadian expression pattern, accounting for the reduced GI side effects of chrono-modulated 5FU therapy...
  10. ncbi Diurnal rhythmicity in the transcription of jejunal drug transporters
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Pharmacol Sci 108:144-8. 2008
    ..6 - 5.4-fold-changes). Acrophases occurred during fasting hours. We conclude that many drug transporters display profound diurnal rhythms in transcription, which may underlie diurnal rhythms in drug pharmacokinetics...
  11. doi Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation
    Adam T Stearns
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Surg 251:865-71. 2010
    ..We set out to examine the short-term regulation of the intestinal sodium/glucose cotransporter SGLT1 by its substrate glucose and sweet taste analogs...
  12. pmc Defining the transcriptional regulation of the intestinal sodium-glucose cotransporter using RNA-interference mediated gene silencing
    Anita Balakrishnan
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Surgery 144:168-73. 2008
    ..We investigated SGLT1 regulation by these transcription factors using promoter studies and RNA interference...
  13. doi Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na+/glucose cotransporter SGLT1
    Adam T Stearns
    Dept of Surgery, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1078-83. 2008
    ..The vagus nerve has been implicated in the entrainment of some transporters. We aimed to clarify the influence of the vagus nerve on the diurnal entrainment pathway for SGLT1 and examine the role of vagal afferent fibers...
  14. ncbi Is there a role for serum endothelin in predicting the severity of acute pancreatitis?
    John Bennett
    Department of Surgery, Norfolk, England
    Hepatobiliary Pancreat Dis Int 5:290-3. 2006
    ....
  15. doi A historic perspective on the contributions of surgeons to the understanding of acute pancreatitis
    Flavio G Rocha
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg 196:442-9. 2008
    ..However, critical aspects of therapy have remained the responsibility of the general surgeon. The purpose of this review is to examine the many contributions of surgeons in acute pancreatitis...