Egle Avizienyte

Summary

Country: UK

Publications

  1. pmc Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition
    Egle Avizienyte
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Biol Cell 15:2794-803. 2004
  2. ncbi The SRC-induced mesenchymal state in late-stage colon cancer cells
    Egle Avizienyte
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, UK
    Cells Tissues Organs 179:73-80. 2005
  3. ncbi Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition
    Egle Avizienyte
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, United Kingdom
    Curr Opin Cell Biol 17:542-7. 2005
  4. ncbi Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
    Egle Avizienyte
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, UK
    Nat Cell Biol 4:632-8. 2002
  5. ncbi An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells
    Egle Avizienyte
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, UK
    Exp Cell Res 313:3175-88. 2007
  6. ncbi Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
    Valerie G Brunton
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, United Kingdom
    Cancer Res 65:1335-42. 2005
  7. ncbi The role of focal-adhesion kinase in cancer - a new therapeutic opportunity
    Gordon W McLean
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Nat Rev Cancer 5:505-15. 2005
  8. doi Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly
    Sebastien Vitale
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
    Eur J Cell Biol 87:569-79. 2008

Detail Information

Publications8

  1. pmc Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition
    Egle Avizienyte
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Biol Cell 15:2794-803. 2004
    ..This further implicates spatially regulated contractile force as a determinant of epithelial cell plasticity, particularly in cancer cells that can switch between epithelial and mesenchymal-like states...
  2. ncbi The SRC-induced mesenchymal state in late-stage colon cancer cells
    Egle Avizienyte
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, UK
    Cells Tissues Organs 179:73-80. 2005
    ..Our recent data therefore imply an important, and perhaps general, role for spatially controlled contractility in suppressing normal cadherin localization and inducing a mesenchymal-like phenotype...
  3. ncbi Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition
    Egle Avizienyte
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, United Kingdom
    Curr Opin Cell Biol 17:542-7. 2005
    ....
  4. ncbi Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
    Egle Avizienyte
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, UK
    Nat Cell Biol 4:632-8. 2002
    ....
  5. ncbi An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells
    Egle Avizienyte
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, UK
    Exp Cell Res 313:3175-88. 2007
    ..Interestingly, there is no FRET between Src and beta-actin at cadherin-mediated cell-cell contacts, despite apparent co-localization there, demonstrating precise spatial specificity of Src/beta-actin complexes...
  6. ncbi Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
    Valerie G Brunton
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, United Kingdom
    Cancer Res 65:1335-42. 2005
    ..These studies have implications for tumor progression with respect to the use of Src kinase inhibitors...
  7. ncbi The role of focal-adhesion kinase in cancer - a new therapeutic opportunity
    Gordon W McLean
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Nat Rev Cancer 5:505-15. 2005
    ..Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target...
  8. doi Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly
    Sebastien Vitale
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
    Eur J Cell Biol 87:569-79. 2008
    ....