M J Tisdale

Summary

Affiliation: Aston University
Country: UK

Publications

  1. ncbi request reprint Catabolic mediators of cancer cachexia
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Curr Opin Support Palliat Care 2:256-61. 2008
  2. ncbi request reprint Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1409-16. 2008
  3. ncbi request reprint Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham B4 7ET, UK
    Am J Physiol Endocrinol Metab 293:E923-31. 2007
  4. ncbi request reprint Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    J Biol Chem 282:7087-97. 2007
  5. ncbi request reprint Tumor-host interactions
    M J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, United Kingdom
    J Cell Biochem 93:871-7. 2004
  6. pmc Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase
    H L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University Biomedical Science, Birmingham B4 7ET, UK
    Br J Cancer 96:1216-22. 2007
  7. pmc The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate
    S T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Br J Cancer 102:833-6. 2010
  8. pmc Induction of protein catabolism in myotubes by 15(S)-hydroxyeicosatetraenoic acid through increased expression of the ubiquitin-proteasome pathway
    A S Whitehouse
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 89:737-45. 2003
  9. pmc Role of lipid-mobilising factor (LMF) in protecting tumour cells from oxidative damage
    P M Sanders
    Pharmaceutical Sciences Research Institute, Aston University Birmingham B4 7ET, UK
    Br J Cancer 90:1274-8. 2004
  10. pmc NF-kappaB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitin-proteasome system in skeletal muscle
    S M Wyke
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 92:711-21. 2005

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Catabolic mediators of cancer cachexia
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Curr Opin Support Palliat Care 2:256-61. 2008
    ..This review compares the catabolic actions of tumour necrosis factor-alpha (TNF-alpha) and proteolysis-inducing factor (PIF) and their involvement in human cancer cachexia...
  2. ncbi request reprint Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1409-16. 2008
    ..These results suggest that HMB may be effective in attenuating muscle atrophy in a range of catabolic conditions...
  3. ncbi request reprint Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham B4 7ET, UK
    Am J Physiol Endocrinol Metab 293:E923-31. 2007
    ..25 g/kg). These results suggest that HMB attenuates the depression of protein synthesis by PIF in myotubes through multiple mechanisms...
  4. ncbi request reprint Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    J Biol Chem 282:7087-97. 2007
    ..These results provide a link between the depression of protein synthesis in skeletal muscle and the increase in protein degradation...
  5. ncbi request reprint Tumor-host interactions
    M J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, United Kingdom
    J Cell Biochem 93:871-7. 2004
    ..Thus, by producing circulating factors certain malignant tumors are able to interfere with host metabolism even without metastasis to that particular site...
  6. pmc Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase
    H L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University Biomedical Science, Birmingham B4 7ET, UK
    Br J Cancer 96:1216-22. 2007
    ..These results suggest that inhibition of the autophosphorylation of PKR may represent an appropriate target for the attenuation of muscle atrophy in cancer cachexia...
  7. pmc The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate
    S T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Br J Cancer 102:833-6. 2010
    ..D-myo-inositol-1,2,6-triphosphate (alpha-trinositol, AT) is a polyanionic molecule capable of chelating divalent metal ions with anti-tumour and anti-cachectic activity in a murine model...
  8. pmc Induction of protein catabolism in myotubes by 15(S)-hydroxyeicosatetraenoic acid through increased expression of the ubiquitin-proteasome pathway
    A S Whitehouse
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 89:737-45. 2003
    ....
  9. pmc Role of lipid-mobilising factor (LMF) in protecting tumour cells from oxidative damage
    P M Sanders
    Pharmaceutical Sciences Research Institute, Aston University Birmingham B4 7ET, UK
    Br J Cancer 90:1274-8. 2004
    ..These results indicate that LMF antagonises the antiproliferative effect of agents working through a free radical mechanism, and may partly explain the unresponsiveness to the chemotherapy of cachexia-inducing tumours...
  10. pmc NF-kappaB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitin-proteasome system in skeletal muscle
    S M Wyke
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 92:711-21. 2005
    ..The ability of mutant I-kappaBalpha to inhibit PIF-induced protein degradation, as well as expression of the ubiquitin-proteasome pathway, confirms that both of these responses depend on initiation of transcription by NF-kappaB...
  11. pmc Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice
    H J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 91:408-12. 2004
    ..The results suggest that combination therapy of cancer cachexia involving both inhibition of the enhanced protein degradation and stimulation of the reduced protein synthesis may be more effective than either treatment alone...
  12. pmc Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia
    J Khal
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Br J Cancer 93:774-80. 2005
    ....
  13. pmc Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia
    P M Sanders
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Br J Cancer 93:425-34. 2005
    ....
  14. pmc Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation
    S M Wyke
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 91:1742-50. 2004
    ..The inactivity of curcumin was probably due to a low bioavailability. These results suggest that agents which inhibit nuclear translocation of NF-kappaB may prove useful for the treatment of muscle wasting in cancer cachexia...
  15. pmc The role of glucocorticoids in the induction of zinc-alpha2-glycoprotein expression in adipose tissue in cancer cachexia
    S T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 92:876-81. 2005
    ..This suggests that glucocorticoids stimulate lipolysis through an increase in ZAG expression, and that they are responsible for the increase in ZAG expression seen in adipose tissue of cachectic mice...
  16. pmc Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients
    H L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 98:443-9. 2008
    ..77, P=0.004). These results suggest that phosphorylation of PKR may be an important initiator of muscle wasting in cancer patients...
  17. pmc Role of protein kinase C and NF-kappaB in proteolysis-inducing factor-induced proteasome expression in C(2)C(12) myotubes
    H J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    Br J Cancer 90:1850-7. 2004
    ..This suggests that PKC may be involved in the phosphorylation and degradation of I-kappaBalpha, induced by PIF, necessary for the release of NF-kappaB from its inactive cytosolic complex...
  18. pmc Signal transduction pathways involved in proteolysis-inducing factor induced proteasome expression in murine myotubes
    H J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 89:1783-8. 2003
    ....
  19. pmc Attenuation of muscle atrophy by an N-terminal peptide of the receptor for proteolysis-inducing factor (PIF)
    K A Mirza
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 105:83-8. 2011
    ..This study investigates the ability of peptides derived from the 20 N-terminal amino acids of the receptor to neutralise PIF action both in vitro and in vivo...
  20. pmc Metabolic and morphological alterations induced by proteolysis-inducing factor from Walker tumour-bearing rats in C2C12 myotubes
    Claudia L Yano
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083 970, Campinas, Sao Paulo, Brazil
    BMC Cancer 8:24. 2008
    ....
  21. ncbi request reprint Cachexia in cancer patients
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Nat Rev Cancer 2:862-71. 2002
  22. ncbi request reprint Pathogenesis of cancer cachexia
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham, United Kingdom
    J Support Oncol 1:159-68. 2003
    ..Eicosapentaenoic acid, found in oily fish, effectively attenuates protein degradation in cachectic muscle by inhibiting the increased proteasome expression and can stabilize body weight in cachectic cancer patients...
  23. ncbi request reprint Biochemical mechanisms of cellular catabolism
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Curr Opin Clin Nutr Metab Care 5:401-5. 2002
    ..There have been a number of important developments in this area over the past 12 months, particularly with respect to protein catabolism...
  24. pmc Development of an in-vitro model system to investigate the mechanism of muscle protein catabolism induced by proteolysis-inducing factor
    M C C Gomes-Marcondes
    Department of Physiology and Biophysics, University of Campinas, UNICAMP, SP, Brazil 13083 970
    Br J Cancer 86:1628-33. 2002
    ..These results show that proteolysis-inducing factor co-ordinately upregulates both ubiquitin conjugation and proteasome activity in both myoblasts and myotubes and may play an important role in the muscle wasting seen in cancer cachexia...
  25. ncbi request reprint The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting
    Michael J Tisdale
    Cancer Biochemistry at the Pharmaceutical Sciences Research Institute, Aston University, Birmingham, United Kingdom
    J Support Oncol 3:209-17. 2005
    ..These results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to prevent muscle wasting...
  26. ncbi request reprint Cancer cachexia
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, B4 7ET, Birmingham, UK
    Langenbecks Arch Surg 389:299-305. 2004
    ..These results suggest that mechanistic studies into the causes of cancer cachexia will allow appropriate therapeutic intervention...
  27. ncbi request reprint The 'cancer cachectic factor'
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, United Kingdom
    Support Care Cancer 11:73-8. 2003
    ..EPA is able to down-regulate the increased expression of this pathway and prevents muscle wasting in cancer patients...
  28. ncbi request reprint Are tumoral factors responsible for host tissue wasting in cancer cachexia?
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Future Oncol 6:503-13. 2010
    ..Furthermore, only antagonists to proteolysis inducing factor prevent muscle loss in cancer patients, suggesting that tumor factors are the most important...
  29. ncbi request reprint Loss of skeletal muscle in cancer: biochemical mechanisms
    M J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Front Biosci 6:D164-74. 2001
    ..Further knowledge on the biochemical mechanisms of muscle protein catabolism will aid the development of effective therapy for cachexia...
  30. ncbi request reprint Molecular pathways leading to cancer cachexia
    Michael J Tisdale
    Cancer Biochemistry, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
    Physiology (Bethesda) 20:340-8. 2005
    ..Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue...
  31. doi request reprint Mechanisms of cancer cachexia
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Physiol Rev 89:381-410. 2009
    ..Knowledge of the mechanisms of tissue destruction in cachexia should improve methods of treatment...
  32. ncbi request reprint Zinc-alpha2-glycoprotein in cachexia and obesity
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Curr Opin Support Palliat Care 3:288-93. 2009
    ..This review focuses on a novel adipokine, zinc-alpha2-glycoprotein (ZAG), which plays an important role in the mobilization and utilization of stored lipids...
  33. doi request reprint Cancer cachexia
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Curr Opin Gastroenterol 26:146-51. 2010
    ..Although cachexia has a major effect on both the morbidity and mortality of cancer patients, information on the mechanisms responsible for this condition is limited. This review summarizes recent data in this area...
  34. ncbi request reprint Metabolic abnormalities in cachexia and anorexia
    M J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Nutrition 16:1013-4. 2000
    ..Further trials are required to confirm the efficacy of eicosapentaenoic acid and to determine the anticachectic activity in other types of cancer...
  35. ncbi request reprint Clinical anticachexia treatments
    Michael J Tisdale
    Molecular Biosciences, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Nutr Clin Pract 21:168-74. 2006
    ..In order to develop new agents, more fundamental research is required on the cellular mechanisms governing protein synthesis and degradation in skeletal muscle in cachexia...
  36. pmc Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-kappaB
    A S Whitehouse
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 89:1116-22. 2003
    ..The results further suggest that EPA may attenuate protein degradation induced by PIF, at least partly, by preventing NF-kappaB accumulation in the nucleus...
  37. doi request reprint Attenuation of skeletal muscle atrophy in cancer cachexia by D-myo-inositol 1,2,6-triphosphate
    S T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Cancer Chemother Pharmacol 64:517-27. 2009
    ..To determine the effectiveness of the polyanionic, metal binding agent D-myo-inositol-1,2,6-triphosphate (alpha trinositol, AT), and its hexanoyl ester (HAT), in tissue wasting in cancer cachexia...
  38. ncbi request reprint Effect of eicosapentaenoic acid (EPA) on expression of a lipid mobilizing factor in adipose tissue in cancer cachexia
    S T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Prostaglandins Leukot Essent Fatty Acids 72:409-14. 2005
    ..These results suggest that EPA may preserve adipose tissue in cachectic mice by downregulation of ZAG expression through interference with glucocorticoid signalling...
  39. pmc Mechanism of muscle protein degradation induced by a cancer cachectic factor
    M J Lorite
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 78:850-6. 1998
    ..A monoclonal antibody to PIF attenuated the enhanced protein degradation in soleus muscle from mice bearing the MAC16 tumour, confirming that PIF is responsible for the loss of skeletal muscle in cachectic mice...
  40. pmc Role of a proteolysis-inducing factor (PIF) in cachexia induced by a human melanoma (G361)
    P T Todorov
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 80:1734-7. 1999
    ..This result suggests that depletion of lean body mass in mice bearing G361 melanoma arises from the production of PIF...
  41. ncbi request reprint Induction of apoptosis by a cachectic-factor in murine myotubes and inhibition by eicosapentaenoic acid
    H J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Apoptosis 8:161-9. 2003
    ..Both of these processes would contribute to the loss of skeletal muscle in cancer cachexia...
  42. pmc Induction of cachexia in mice by a product isolated from the urine of cachectic cancer patients
    P Cariuk
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 76:606-13. 1997
    ..These results show that the material of M(r) 24,000 present in the urine of cachectic cancer patients is capable of producing a syndrome of cachexia in mice...
  43. pmc Effect of a fluorinated pyrimidine on cachexia and tumour growth in murine cachexia models: relationship with a proteolysis inducing factor
    H J Hussey
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Br J Cancer 83:56-62. 2000
    ..Thus in these experimental models cachexia appears to be correlated with the presence of PIF...
  44. pmc Induction of muscle protein degradation by a tumour factor
    M J Lorite
    CRC Nutritional Biochemistry Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 76:1035-40. 1997
    ....
  45. ncbi request reprint Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss
    J Khal
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Int J Biochem Cell Biol 37:2196-206. 2005
    ....
  46. doi request reprint Mechanism of activation of dsRNA-dependent protein kinase (PKR) in muscle atrophy
    H L Eley
    Aston University, Birmingham, United Kingdom
    Cell Signal 22:783-90. 2010
    ..These results suggest that Ca(2+) is involved in the increase in protein degradation and decrease in protein synthesis by PIF and Ang II through activation of PKR by caspases-3 and -8...
  47. doi request reprint Role of the dsRNA-dependent protein kinase (PKR) in the attenuation of protein loss from muscle by insulin and insulin-like growth factor-I (IGF-I)
    H L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Mol Cell Biochem 313:63-9. 2008
    ..These results suggest an alternative mechanism involving PKR to explain the effect of insulin and IGF-I on protein synthesis and degradation in skeletal muscle in the presence of catabolic factors...
  48. pmc Tumour-associated hypoglycaemia in a murine cachexia model
    T M McDevitt
    CRC Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 66:815-20. 1992
    ..The relationship between the induction of cachexia and alteration in blood glucose levels remains unknown...
  49. ncbi request reprint Effect of a cancer cachectic factor on protein synthesis/degradation in murine C2C12 myoblasts: modulation by eicosapentaenoic acid
    H J Smith
    Pharmaceutical Sciences Institute, Aston University, Birmingham, United Kingdom
    Cancer Res 59:5507-13. 1999
    ..These results suggest that PIF enhances protein degradation as a result of an increased production of 15-HETE...
  50. pmc Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour
    S M Mahony
    CRC Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 57:385-9. 1988
    ..It is concluded that weight loss produced by TNF-alpha arises from an anorexic effect and that this differs from the complex metabolic changes associated with cancer cachexia...
  51. pmc Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo
    H J Hussey
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 70:6-10. 1994
    ..These results suggest that PUFAs may play an important role in tumour growth and may offer a potential target for the development of chemotherapeutic agents...
  52. pmc Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice
    S A Beck
    CRC Experimental Chemotherapy Group, Aston University, Birmingham, UK
    Br J Cancer 62:420-4. 1990
    ....
  53. pmc Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo
    S T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 87:580-4. 2002
    ....
  54. pmc Inhibition of tumour growth by lipoxygenase inhibitors
    H J Hussey
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 74:683-7. 1996
    ..The inhibitory effect of these agents on cell growth may result from an imbalance of metabolism of arachidonic acid between the 5-, 12- and 15-lipoxygenase pathways...
  55. pmc Lipid mobilising factors specifically associated with cancer cachexia
    S A Beck
    CRC Experimental Chemotherapy Group, Aston University, Birmingham, UK
    Br J Cancer 63:846-50. 1991
    ..The lipid mobilising species may be responsible for catabolism of host adipose tissue in the cachectic state...
  56. pmc Lipid metabolism in cancer cachexia
    H D Mulligan
    CRC Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 66:57-61. 1992
    ..These results suggest that in cachectic tumour-bearing animals mobilisation of body lipids is accompanied by an increased utilisation...
  57. pmc Effect of a cachectic factor on carbohydrate metabolism and attenuation by eicosapentaenoic acid
    H J Hussey
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 80:1231-5. 1999
    ..This suggests a direct effect of PIF on glucose uptake by skeletal muscle. These results suggest that in addition to a direct catabolic effect on skeletal muscle PIF has a profound effect on glucose utilization during cachexia...
  58. pmc Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC)
    H J Hussey
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 73:1187-92. 1996
    ..Tumour sensitivity may be correlated with increased DT-diaphorase that are required to metabolise CV-6504 to the active hydroquinone, which inhibits 5-lipoxygenase activity...
  59. ncbi request reprint Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation
    A S Whitehouse
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, United Kingdom
    Biochem Biophys Res Commun 285:598-602. 2001
    ..These results suggest that protein catabolism in starvation and cancer cachexia is mediated through a common pathway, which is inhibited by EPA and is likely to involve a lipoxygenase metabolite as a signal transducer...
  60. pmc Modulation of adipocyte G-protein expression in cancer cachexia by a lipid-mobilizing factor (LMF)
    B Islam Ali
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    Br J Cancer 85:758-63. 2001
    ..This suggests that this tumour-derived lipolytic factor acts to sensitize adipose tissue to lipolytic stimuli, and that this effect is attenuated by EPA, which is known to preserve adipose tissue in cancer cachexia...
  61. pmc Effect of a tumour-produced lipid-mobilizing factor on protein synthesis and degradation
    B S Islam Ali
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 84:1648-55. 2001
    ..These results show that in addition to its lipid-mobilizing activity LMF also increases protein accumulation in skeletal muscle both by an increase in protein synthesis and a decrease in protein catabolism...
  62. ncbi request reprint Cancer anorexia and cachexia
    M J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, United Kingdom
    Nutrition 17:438-42. 2001
    ..Antagonists of tumor catabolic factors will provide important new agents in the treatment of cancer cachexia...
  63. pmc Mechanism of muscle protein degradation in cancer cachexia
    K L Smith
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 68:314-8. 1993
    ..These results suggest that muscle protein degradation in cancer cachexia is associated with a rise in PGE2 content...
  64. ncbi request reprint Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid
    A S Whitehouse
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, United Kingdom
    Cancer Res 61:3604-9. 2001
    ..Thus EPA antagonizes loss of skeletal muscle proteins in cancer cachexia by down-regulation of proteasome expression, and this may also be the mechanism for inhibition of tumor growth...
  65. pmc Alterations in serum lipolytic activity of cancer patients with response to therapy
    S A Beck
    Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham
    Br J Cancer 62:822-5. 1990
    ....
  66. doi request reprint Studies on the anti-obesity activity of zinc-α2-glycoprotein in the rat
    S T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Int J Obes (Lond) 35:658-65. 2011
    ..To investigate the anti-obesity effect of the adipokine zinc-α(2)-glycoprotein (ZAG) in rats and the mechanism of this effect...
  67. pmc Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504)
    H J Hussey
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 75:845-9. 1997
    ..These results suggest that some tumours are dependent on lipoxygenase metabolites of LA and AA for their continual growth, and interference with this pathway produces a specific growth inhibition...
  68. pmc Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia
    K L Smith
    Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 67:680-5. 1993
    ..These results suggest that the increased degradation of skeletal muscle seen in this model of cachexia may be due to a circulating proteolysis-inducing factor...
  69. pmc Alteration of serum and urinary lipolytic activity with weight loss in cachectic cancer patients
    P Groundwater
    Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 62:816-21. 1990
    ..79 and 0.70 respectively) when the total body weight loss did not exceed 20%. This suggests that weight loss in cancer patients may be attributed, at least in part, to an, as yet, unidentified lipolytic factor...
  70. ncbi request reprint Downregulation of muscle protein degradation in sepsis by eicosapentaenoic acid (EPA)
    Jwan Khal
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Biochem Biophys Res Commun 375:238-40. 2008
    ..These results suggest that muscle protein catabolism in sepsis is mediated by the same intracellular signalling pathways as found in other catabolic conditions...
  71. ncbi request reprint Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate
    Helen J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, United Kingdom
    Cancer Res 64:8731-5. 2004
    ..These results suggest that HMB attenuates PIF-induced activation and increased gene expression of the ubiquitin-proteasome proteolytic pathway, reducing protein degradation...
  72. ncbi request reprint Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss
    Helen J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, United Kingdom
    Cancer Res 65:277-83. 2005
    ....
  73. ncbi request reprint Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein
    Steven T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Biochim Biophys Acta 1636:59-68. 2004
    ..These results suggest that ZAG may be effective in the treatment of obesity...
  74. ncbi request reprint Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress
    Maria Cristina C Gomes-Marcondes
    Department of Physiology and Biophysics, University of Campinas, UNICAMP, SP Brazil
    Cancer Lett 180:69-74. 2002
    ..These results show that mild oxidative stress increases protein degradation in skeletal muscle by causing an increased expression of the major components of the ubiquitin-proteasome pathway...
  75. ncbi request reprint Effect of n-3 fatty acids on the antitumour effects of cytotoxic drugs
    Michael P Wynter
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    In Vivo 18:543-7. 2004
    ..n-3 fatty acids are increasingly being administered to cancer patients for the treatment of cachexia, and it is thus important to know of any potential interactions with ongoing cytotoxic drug therapy...
  76. ncbi request reprint Effect of zinc-alpha2-glycoprotein (ZAG) on expression of uncoupling proteins in skeletal muscle and adipose tissue
    Paul M Sanders
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Cancer Lett 212:71-81. 2004
    ..These results confirm the ability of ZAG to directly influence UCP expression, which may play an important role in lipid utilization during cancer cachexia...
  77. doi request reprint Mechanism of attenuation of protein loss in murine C2C12 myotubes by D-myo-inositol 1,2,6-triphosphate
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Exp Cell Res 316:286-95. 2010
    ..The ability of AT to attenuate muscle atrophy by a range of stimuli suggests that it may be effective in several catabolic conditions...
  78. doi request reprint Mechanism of induction of muscle protein loss by hyperglycaemia
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B47ET, UK
    Exp Cell Res 315:16-25. 2009
    ....
  79. pmc Effect of branched-chain amino acids on muscle atrophy in cancer cachexia
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem J 407:113-20. 2007
    ..These changes would be expected to increase protein synthesis, whereas a reduction in the activation of PKR would be expected to attenuate the increased protein degradation...
  80. ncbi request reprint Identification and characterization of a membrane receptor for proteolysis-inducing factor on skeletal muscle
    Penio T Todorov
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
    Cancer Res 67:11419-27. 2007
    ..These results confirm that the PIF binding protein has a functional role in muscle protein atrophy in cachexia and that it represents a potential new therapeutic target...
  81. ncbi request reprint Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1417-26. 2008
    ..Increased ROS formation is known to induce protein degradation through the ubiquitin-proteasome pathway...
  82. ncbi request reprint Synthesis and evaluation of 5-arylated 2(5H)-furanones and 2-arylated pyridazin-3(2H)-ones as anti-cancer agents
    Eric Lattmann
    The School of Pharmacy, Aston University, Aston Triangle, Birmingham, UK
    J Pharm Pharmacol 55:1259-65. 2003
    ..On the resistant MAC 16 cell line the pyridazone 9b displayed 52% tumour inhibition in mice at a dose of 50 mg kg(-1) compared with 27% for the 5-FU standard...
  83. ncbi request reprint Cytotoxicity of 3,4-dihalogenated 2(5H)-furanones
    Eric Lattmann
    School of Life and Health Sciences, Biomedical Division, Aston University, Birmingham B4 7ET, UK
    J Pharm Pharmacol 56:1163-70. 2004
    ..The ester 5g, the acetate 4b and the carbamate 2b displayed a cytotoxicity in the low micromolar range. Further, an IC50 (50% inhibitory concentration) of 50 nM and 30 nM was determined for the epoxide 7 and the aziridine 8...
  84. ncbi request reprint Effect of cancer cachexia on the activity of tripeptidyl-peptidase II in skeletal muscle
    Anita Chand
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Cancer Lett 218:215-22. 2005
    ....
  85. ncbi request reprint Downregulation of ubiquitin-dependent protein degradation in murine myotubes during hyperthermia by eicosapentaenoic acid
    Helen J Smith
    Molecular Biosciences, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem Biophys Res Commun 332:83-8. 2005
    ..These results suggest that protein catabolism in hyperthermia and cancer cachexia is mediated through a common pathway...
  86. ncbi request reprint Mechanism of induction of muscle protein degradation by angiotensin II
    Steven T Russell
    Biomolecular Sciences, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Cell Signal 18:1087-96. 2006
    ..These results suggest that induction of proteasome expression by angiotensin I/II involves a signalling pathway involving PKC and NF-kappaB...
  87. doi request reprint Antidiabetic properties of zinc-alpha2-glycoprotein in ob/ob mice
    Steven T Russell
    Department of Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 151:948-57. 2010
    ..There was an increase in skeletal muscle mass due to an increase in protein synthesis and a decrease in protein degradation. These results suggest that ZAG may potentially be effective in the treatment of type 2 diabetes...
  88. pmc Activation of ATP-ubiquitin-dependent proteolysis in skeletal muscle in vivo and murine myoblasts in vitro by a proteolysis-inducing factor (PIF)
    M J Lorite
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    Br J Cancer 85:297-302. 2001
    ..These results confirm that PIF acts directly to stimulate the proteasome pathway in muscle cells and may play a pivotal role in protein catabolism in cancer cachexia...
  89. ncbi request reprint Effect of cancer cachexia on triacylglycerol/fatty acid substrate cycling in white adipose tissue
    S A Beck
    Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
    Lipids 39:1187-9. 2004
    ..This suggests that the presence of the tumor alone is sufficient to cause an increase in cycling rate, and in the absence of an elevated energy intake (MAC16) this may contribute to the depletion of adipose tissue...
  90. ncbi request reprint Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II
    S T Russell
    Biomedical Science, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Cell Signal 19:1797-806. 2007
    ....
  91. ncbi request reprint Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway
    S M Wyke
    Biomedicinal Chemistry Research Group, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Life Sci 78:2898-910. 2006
    ..These results suggest that the induction of proteasome expression by TPA may involve the transcription factor NF-kappaB...
  92. ncbi request reprint Structural analysis of a tumor-produced sulfated glycoprotein capable of initiating muscle protein degradation
    P T Todorov
    CRC Nutritional Biochemistry Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, United Kingdom
    J Biol Chem 272:12279-88. 1997
    ..Neither chain was cleaved into disaccharides with chondroitinase ABC, suggesting that the material is a sulfated glycoprotein...
  93. ncbi request reprint Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor
    Steven T Russell
    Nutritional Biomedicine, Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem J 409:751-9. 2008
    ..These results suggest that transient activation of Akt results in an increased protein degradation through activation of NF-kappaB and that this also allows for a specific synthesis of proteasome subunits...
  94. ncbi request reprint Signalling pathways in the induction of proteasome expression by proteolysis-inducing factor in murine myotubes
    Stacey M Wyke
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Cell Signal 17:67-75. 2005
    ..These results suggest potential control points in proteasome activation that could be useful for therapeutic intervention...
  95. ncbi request reprint Angiotensin II directly inhibits protein synthesis in murine myotubes
    Steven T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Cancer Lett 231:290-4. 2006
    ..The effect was attenuated by insulin-like growth factor-1 (IGF-1) (25-100 ng/ml). Thus, Ang I/II have the ability to induce muscle atrophy through inhibition of protein synthesis...
  96. ncbi request reprint Effect of catechol derivatives on cell growth and lipoxygenase activity
    Julie Simpson
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Bioorg Med Chem Lett 13:2435-9. 2003
    ..The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM)...
  97. ncbi request reprint Changes in nucleic acid and protein levels in atrophying skeletal muscle in cancer cachexia
    Ameek S Bhogal
    Biomedical Science, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Anticancer Res 26:4149-54. 2006
    ..To investigate factors responsible for muscle loss in cachexia changes in nucleic acid and protein levels have been determined and compared with those induced by a tumour-produced cachectic factor, proteolysis-inducing factor (PIF)...
  98. ncbi request reprint Mechanism of attenuation of angiotensin-II-induced protein degradation by insulin-like growth factor-I (IGF-I)
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Cell Signal 19:1583-95. 2007
    ....
  99. doi request reprint Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 151:4696-704. 2010
    ..These results suggest that protein accretion in skeletal muscle in response to ZAG may be due to changes in intracellular cAMP and also that ZAG may have a therapeutic application in the treatment of muscle wasting conditions...
  100. pmc A comparison of long-chain triglycerides and medium-chain triglycerides on weight loss and tumour size in a cachexia model
    M J Tisdale
    Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    Br J Cancer 58:580-3. 1988
    ..These results suggest that diets containing MCT would provide the best ketogenic regime to reverse the weight loss in cancer cachexia with a concomitant reduction in tumour size...
  101. pmc Role of prostaglandins in tumour necrosis factor induced weight loss
    S M Mahony
    CRC Experimental Chemotherapy Group, Aston University, Birmingham, UK
    Br J Cancer 60:51-5. 1989
    ..These results suggest that prostaglandins are not involved in the anorectic effect of TNF-alpha...