E J Hill
Affiliation: Aston University
- Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural developmentEric J Hill
Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom
PLoS ONE 8:e58822. 2013..This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals...
- Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testingE J Hill
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
Toxicology 249:243-50. 2008..Acrylamide reduced neurosphere viability but did not affect neuronal protein marker expression. Overall, this NT2/D1-based neurosphere model of neurogenesis, may provide the basis for a model of developmental neurotoxicity in vitro...
- Evaluation of the importance of astrocytes when screening for acute toxicity in neuronal cell systemsE K Woehrling
School of Life and Health Sciences, Aston University, Birmingham, UK
Neurotox Res 17:103-13. 2010..In conclusion, the suitability of NT2 neurons and astrocytes as cell systems for acute toxicity screening deserves further investigation...
- Single-cell ELISA and flow cytometry as methods for highlighting potential neuronal and astrocytic toxicant specificityE K Woehrling
School of Life and Health Sciences, Aston University, Aston Street, Birmingham, UK
Neurotox Res 19:472-83. 2011..Further work using the NT2.N/A model and a broader array of toxicants is appropriate in order to confirm the applicability of these methods...
- Development of a neurotoxicity test-system, using human post-mitotic, astrocytic and neuronal cell lines in co-cultureE K Woehrling
School of Life and Health Sciences, Aston University, Aston Street, Birmingham, B4 7ET, UK
Toxicol In Vitro 21:1241-6. 2007..Thus, it appears the use of astrocytes in an in vitro predictive neurotoxicity test-system may be more relevant to human CNS structure and function than neuronal cells alone...