H R Griffiths

Summary

Affiliation: Aston University
Country: UK

Publications

  1. pmc Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study
    Tracey E Toms
    Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
    Arthritis Res Ther 10:R145. 2008
  2. ncbi request reprint Antioxidants and protein oxidation
    H R Griffiths
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Free Radic Res 33:S47-58. 2000
  3. doi request reprint Free radicals and redox signalling in T-cells during chronic inflammation and ageing
    Helen R Griffiths
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Biochem Soc Trans 39:1273-8. 2011
  4. doi request reprint In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals
    Helen R Griffiths
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Br J Nutr 101:1432-9. 2009
  5. doi request reprint Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?
    Helen R Griffiths
    Life and Health Sciences, Aston University, Birmingham B4 7ET, West Midlands, UK
    Autoimmun Rev 7:544-9. 2008
  6. ncbi request reprint Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake
    Helen R Griffiths
    Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Free Radic Biol Med 40:488-500. 2006
  7. ncbi request reprint ROS as signalling molecules in T cells--evidence for abnormal redox signalling in the autoimmune disease, rheumatoid arthritis
    Helen R Griffiths
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Redox Rep 10:273-80. 2005
  8. ncbi request reprint Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH
    Thomas R Zilz
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Toxicology 231:210-4. 2007
  9. ncbi request reprint The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival
    Melissa M Grant
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Proteomics 5:534-40. 2005
  10. pmc The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species
    Darren C Phillips
    Molecular Biosciences Group, Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET
    Br J Pharmacol 138:501-11. 2003

Detail Information

Publications35

  1. pmc Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study
    Tracey E Toms
    Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
    Arthritis Res Ther 10:R145. 2008
    ..We examined whether GC exposure associates with the presence of metabolic syndrome in patients with RA...
  2. ncbi request reprint Antioxidants and protein oxidation
    H R Griffiths
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK
    Free Radic Res 33:S47-58. 2000
    ..Two studies on humans have been reported last year. The further application of these methods to human studies is indicated, where the quality of the determinations will be enhanced through inter-laboratory validation...
  3. doi request reprint Free radicals and redox signalling in T-cells during chronic inflammation and ageing
    Helen R Griffiths
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Biochem Soc Trans 39:1273-8. 2011
    ..Together, these data suggest that a complex relationship exists between intra- and extra-cellular redox compartments which contribute to the T-cell phenotype...
  4. doi request reprint In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals
    Helen R Griffiths
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Br J Nutr 101:1432-9. 2009
    ..These data provide one of the first demonstrations that proteomics may be valuable in developing predictive markers of nutrient effects in vivo and may identify novel pathways for studying mechanisms of action in vivo...
  5. doi request reprint Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?
    Helen R Griffiths
    Life and Health Sciences, Aston University, Birmingham B4 7ET, West Midlands, UK
    Autoimmun Rev 7:544-9. 2008
    ....
  6. ncbi request reprint Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake
    Helen R Griffiths
    Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Free Radic Biol Med 40:488-500. 2006
    ..The present studies suggest that elevated plasma tHcy may promote LDL nitration and increased scavenger receptor uptake, providing a molecular mechanism that may contribute to the clinical link between CVD and elevated plasma tHcy...
  7. ncbi request reprint ROS as signalling molecules in T cells--evidence for abnormal redox signalling in the autoimmune disease, rheumatoid arthritis
    Helen R Griffiths
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Redox Rep 10:273-80. 2005
    ..To address this hypothesis, this review considers the putative sources of ROS involved in normal intracellular signalling in T cells and the evidence in support of abnormal ROS fluxes contributing to T-cell hyporesponsiveness...
  8. ncbi request reprint Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH
    Thomas R Zilz
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Toxicology 231:210-4. 2007
    ....
  9. ncbi request reprint The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival
    Melissa M Grant
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Proteomics 5:534-40. 2005
    ..g. acyl CoA oxidase 3) and induced brain derived neurotrophic factor (BDNF) expression. Enhanced expression of BDNF may contribute to the protective effects of ascorbate against oxidative stress in neuronal cells...
  10. pmc The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species
    Darren C Phillips
    Molecular Biosciences Group, Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET
    Br J Pharmacol 138:501-11. 2003
    ..Furthermore, MTX caused a reduction in monocyte adhesion to endothelial cells, where the mechanism of MTX action requires the production of ROS. Therefore its clinical efficacy can be attributed to multiple targets...
  11. ncbi request reprint A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y
    Michael D Coleman
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Basic Clin Pharmacol Toxicol 102:25-9. 2008
    ..These alpha-diketones also display a degree of toxic selectivity towards neuroblastoma cells, which may have therapeutic implications...
  12. ncbi request reprint Alpha-tocopherol supplementation does not affect monocyte endothelial adhesion or C-reactive protein levels but reduces soluble vascular adhesion molecule-1 in the plasma of healthy subjects
    Kevin J Woollard
    Life and Health Sciences, Aston University, Birmingham, UK
    Redox Rep 11:214-22. 2006
    ..In conclusion, alpha-tocopherol supplementation had little effect on cardiovascular disease risk factors in healthy subjects and the effects of tocopherol were not consistently affected by plasma vitamin C concentration...
  13. doi request reprint Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance
    L Li
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Free Radic Res 44:241-8. 2010
    ..The association between folate deficiency, LDL modification and dysfunction in VaD but not in AD may provide a novel biomarker assessment to discriminate between the diseases...
  14. doi request reprint Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention
    Darren C Phillips
    Life and Health Sciences, Aston University, Birmingham B4 7ET, West Midlands, United Kingdom
    Antioxid Redox Signal 12:743-85. 2010
    ..We postulate that ROS generation is required for effective therapeutic intervention...
  15. ncbi request reprint Biomarkers
    Helen R Griffiths
    Pharmaceutical Sciences, Aston University, Birmingham, UK
    Mol Aspects Med 23:101-208. 2002
  16. ncbi request reprint Dose-dependent modulation of the T cell proteome by ascorbic acid
    Melissa M Grant
    Aston University, Birmingham, UK
    Br J Nutr 97:19-26. 2007
    ..Together, these observations suggest that ascorbic acid modulates the T cell proteome in a time- and dose-dependent manner and identify molecular targets for study following antioxidant supplementation in vivo...
  17. ncbi request reprint C-reactive protein mediates CD11b expression in monocytes through the non-receptor tyrosine kinase, Syk, and calcium mobilization but not through cytosolic peroxides
    K J Woollard
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
    Inflamm Res 54:485-92. 2005
    ..C-Reactive protein (CRP) can modulate integrin surface expression on monocytes following Fcgamma receptor engagement. We have investigated the signal transduction events causing this phenotypic alteration...
  18. pmc Contributions to our understanding of T cell physiology through unveiling the T cell proteome
    M M Grant
    School of Dentistry, The University of Birmingham, St Chads Queensway, Birmingham, UK
    Clin Exp Immunol 149:9-15. 2007
    ..These include post-translational modifications, which are not encoded by the genome...
  19. ncbi request reprint Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity?
    Vicki S Barber
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Biofactors 17:215-28. 2003
  20. ncbi request reprint Effects of oral vitamin C on monocyte: endothelial cell adhesion in healthy subjects
    Kevin J Woollard
    Pharmacology Research Group, PSRI, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Biochem Biophys Res Commun 294:1161-8. 2002
    ..In conclusion, vitamin C supplementation normalises monocyte adhesion in subjects with low plasma vitamin C (LOC). This process may be related to a direct effect on monocytes, independent of lipid peroxidation...
  21. pmc Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells
    E E Torr
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Cell Death Differ 19:671-9. 2012
    ..The defined function of ICAM-3 in these processes and profound defect in chemotaxis noted to ICAM-3-deficient microparticles suggest that ICAM-3 may be an important adhesion molecule involved in chemotaxis to apoptotic human leukocytes...
  22. pmc The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens
    C R Dunston
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Clin Exp Immunol 161:407-16. 2010
    ....
  23. ncbi request reprint Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression
    Sarah J Rayment
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Biochem Biophys Res Commun 308:339-45. 2003
    ..05). For the first time, these results show that dietary vitamin C can modulate monocyte ICAM-1 gene expression in vivo, where regulation of gene expression represents a novel mechanism for benefit from dietary antioxidants...
  24. ncbi request reprint Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects
    Sarah Aldred
    Life and Health Sciences, Aston University, Birmingham, UK
    Proteomics 6:1695-703. 2006
    ..01 after 28 days supplementation with 268 mg AT/day). These data demonstrate the time and dose sensitivity of the plasma proteome to AT supplementation...
  25. ncbi request reprint Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status
    Darren Charles Phillips
    Pharmacology Research Group, Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Arch Biochem Biophys 407:15-24. 2002
    ..However, in U937 monocytes, glutathione loss is transient. Differences in the magnitude and kinetics of this alteration in cellular redox state associate with discrete outcomes, namely growth arrest or apoptosis...
  26. pmc Ceramide induces a loss in cytosolic peroxide levels in mononuclear cells
    Darren C Phillips
    Molecular Biosciences Group, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Biochem J 375:567-79. 2003
    ..Therefore the primary redox effect of cellular ceramide accumulation is to lower the [peroxide](cyt) of both primary and immortalized cells, the magnitude of which dictates the cellular response...
  27. ncbi request reprint Gravity spun polycaprolactone fibers for applications in vascular tissue engineering: proliferation and function of human vascular endothelial cells
    Matthew R Williamson
    Aston Pharmacy School, Aston University, Aston Triangle, Birmingham, United Kingdom
    Tissue Eng 12:45-51. 2006
    ....
  28. ncbi request reprint Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages
    Yingjun Luan
    Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Arch Biochem Biophys 450:89-99. 2006
    ..Taken together, it is suggested that ceramide blocks the transport of CD36 to the membrane of monocytes/macrophages, thereby preventing uptake of oxidised LDL...
  29. doi request reprint Oleate protects against palmitate-induced insulin resistance in L6 myotubes
    Dan Gao
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Br J Nutr 102:1557-63. 2009
    ..Thus, the prevention of palmitate-induced insulin resistance by oleate in L6 muscle cells is associated with the ability of oleate to maintain insulin signalling through PI3-kinase...
  30. ncbi request reprint Validation of a novel ELISA for measurement of MDA-LDL in human plasma
    Ruth J Bevan
    Department of Clinical Biochemistry, University of Leicester, Leicester, UK
    Free Radic Biol Med 35:517-27. 2003
    ..Further, the ELISA was used to show significantly increased plasma MDA-LDL levels in subjects with confirmed ischemic heart disease, and could therefore possibly be of benefit as a diagnostic tool for assessing CHD risk...
  31. ncbi request reprint Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects
    Timur Anlasik
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Br J Nutr 94:639-42. 2005
    ..Modification of nutritional habits among other lifestyle changes should be encouraged to lower prevalence of disease risk factors in later life...
  32. ncbi request reprint Deoxycytidine glyoxal: lesion induction and evidence of repair following vitamin C supplementation in vivo
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
    Free Radic Biol Med 34:218-25. 2003
    ..These results are also consistent with our hypothesis for a role of vitamin C in an adaptive/repair response and indicate that nucleotide excision repair specifically may be affected...
  33. ncbi request reprint Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function
    Malcolm J Jackson
    Department of Medicine, University of Liverpool, UK
    Mol Aspects Med 23:209-85. 2002
  34. ncbi request reprint Urinary 8-oxo-2'-deoxyguanosine: redox regulation of DNA repair in vivo?
    Joseph Lunec
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, UK
    Free Radic Biol Med 33:875-85. 2002
    ..We also propose that redox-active components of the diet, such as vitamin C, may promote such repair, affecting NER specifically...
  35. ncbi request reprint Immunochemical detection of UV-induced DNA damage and repair
    Marcus S Cooke
    Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, UK
    J Immunol Methods 280:125-33. 2003
    ..Moreover, the subsequent removal of this damage, as evidenced by a reduction in antiserum staining, was noted in sections of biopsies taken in the hours following irradiation...