P D Arkwright

Summary

Country: UK

Publications

  1. ncbi request reprint Factors determining the ability of parents to effectively administer intramuscular adrenaline to food allergic children
    Peter D Arkwright
    Department of Immunology, University of Manchester, UK
    Pediatr Allergy Immunol 17:227-9. 2006
  2. ncbi request reprint Mycobacterium vaccae reduces scratching behavior but not the rash in NC mice with eczema: a randomized, blinded, placebo-controlled trial
    Peter D Arkwright
    University of Manchester, Manchester, UK
    J Invest Dermatol 124:140-3. 2005
  3. ncbi request reprint End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms
    Peter D Arkwright
    Academic Unit of Child Health, Booth Hall Children s Hospital, and School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 167:384-9. 2003
  4. pmc Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept
    P D Arkwright
    Academic Unit of Child Health, St Mary s Hospital, Manchester, UK
    Clin Exp Immunol 130:484-8. 2002
  5. ncbi request reprint Age-related prevalence and antibiotic resistance of pathogenic staphylococci and streptococci in children with infected atopic dermatitis at a single-specialty center
    Peter D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Ward 3, Charlestown Road, Blackley, Manchester M9 7AA, England
    Arch Dermatol 138:939-41. 2002
  6. ncbi request reprint Autoimmunity in human primary immunodeficiency diseases
    Peter D Arkwright
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Blood 99:2694-702. 2002
  7. ncbi request reprint Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Charlestown Road, Manchester, UK
    Clin Exp Dermatol 32:145-7. 2007
  8. pmc Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD5- B lymphocytes without an increase in disease severity
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Manchester, UK
    Clin Exp Immunol 125:184-9. 2001
  9. doi request reprint Recently identified factors predisposing children to infectious diseases
    Peter D Arkwright
    Paediatric Immunology, University of Manchester, UK
    Curr Opin Infect Dis 21:217-22. 2008
  10. pmc Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine
    P D Arkwright
    University Department of Child Health, Booth Hall Children s Hospital, and Immunology Department, Hope Hospital, Manchester, UK
    Clin Exp Immunol 122:16-9. 2000

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Factors determining the ability of parents to effectively administer intramuscular adrenaline to food allergic children
    Peter D Arkwright
    Department of Immunology, University of Manchester, UK
    Pediatr Allergy Immunol 17:227-9. 2006
    ..005). The study clearly shows that for EpiPens to be used safely and effectively it is essential to educate the carer at the time the device is prescribed...
  2. ncbi request reprint Mycobacterium vaccae reduces scratching behavior but not the rash in NC mice with eczema: a randomized, blinded, placebo-controlled trial
    Peter D Arkwright
    University of Manchester, Manchester, UK
    J Invest Dermatol 124:140-3. 2005
    ..2; 95% confidence interval 0.1-0.7; p=0.01). We conclude that in this NC/Nga mouse model, SRP299 did have a beneficial effect in reducing pruritus, a major clinical symptom of eczema, although it does not prevent the rash from developing...
  3. ncbi request reprint End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms
    Peter D Arkwright
    Academic Unit of Child Health, Booth Hall Children s Hospital, and School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 167:384-9. 2003
    ....
  4. pmc Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept
    P D Arkwright
    Academic Unit of Child Health, St Mary s Hospital, Manchester, UK
    Clin Exp Immunol 130:484-8. 2002
    ..The proband therefore appears to have a novel clinical entity combining Hyper IgD syndrome with defective TNFRSF1A homeostasis, which is partially responsive to etanercept...
  5. ncbi request reprint Age-related prevalence and antibiotic resistance of pathogenic staphylococci and streptococci in children with infected atopic dermatitis at a single-specialty center
    Peter D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Ward 3, Charlestown Road, Blackley, Manchester M9 7AA, England
    Arch Dermatol 138:939-41. 2002
    ..This study examined the age-related prevalence and antibiotic resistance of these pathogenic bacteria in children with atopic dermatitis and suspected skin infections...
  6. ncbi request reprint Autoimmunity in human primary immunodeficiency diseases
    Peter D Arkwright
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Blood 99:2694-702. 2002
    ..Reviewing recent advances in our understanding of the small subgroup of patients with defined causes for their autoimmunity may lead to the development of more effective treatment strategies for idiopathic human autoimmune diseases...
  7. ncbi request reprint Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Charlestown Road, Manchester, UK
    Clin Exp Dermatol 32:145-7. 2007
    ..13; 95% ci 0.02-0.74)...
  8. pmc Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD5- B lymphocytes without an increase in disease severity
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Manchester, UK
    Clin Exp Immunol 125:184-9. 2001
    ..002). However, in this cohort of children with atopic dermatitis, despite th in vivo expansion of B cells in children harbouring T + S. aureus, there was no associated increase in IgE levels or in clinical disease severity scores...
  9. doi request reprint Recently identified factors predisposing children to infectious diseases
    Peter D Arkwright
    Paediatric Immunology, University of Manchester, UK
    Curr Opin Infect Dis 21:217-22. 2008
    ..To identify articles published between January 2006 and January 2008 that have significantly enhanced our understanding of why some children are prone to severe or recurrent infectious diseases...
  10. pmc Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine
    P D Arkwright
    University Department of Child Health, Booth Hall Children s Hospital, and Immunology Department, Hope Hospital, Manchester, UK
    Clin Exp Immunol 122:16-9. 2000
    ..Delay in maturation of the total IgG and IgG2 antibody response to Pneumococcus is a feature in this group of children with moderately severe atopic eczema...
  11. ncbi request reprint Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children's Hospital, Manchester, UK
    J Allergy Clin Immunol 107:531-4. 2001
    ..CONCLUSION: SRL 172 was associated with an improvement in the severity of the dermatitis in children with moderate-to-severe disease...
  12. ncbi request reprint Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss
    S J Babbage
    Immunology Research Group, School of Biological Sciences, University of Manchester, Stopford Building, M13 9PT, Manchester, UK
    J Reprod Immunol 51:21-7. 2001
    ....
  13. pmc Effect of Mycobacterium vaccae on cytokine responses in children with atopic dermatitis
    E A Hadley
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, UK
    Clin Exp Immunol 140:101-8. 2005
    ..vaccae reduces Th2-type or increases TGF-beta(1) activity of PBMC isolated from children with atopic dermatitis. The transient surge in IFN-gamma at 1 month is unlikely to explain any improvement in eczema score at 3 months...
  14. pmc TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester M13 0JH, UK
    Thorax 55:459-62. 2000
    ..This study was undertaken to examine the association between TGF-beta(1) gene polymorphisms and the development of pulmonary dysfunction in patients with cystic fibrosis...
  15. ncbi request reprint Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Charlestown Road, Manchester M9 7AA, UK
    Br J Dermatol 149:1029-34. 2003
    ..We have previously shown that administration of a Mycobacterium vaccae suspension significantly reduced the severity of atopic dermatitis (AD) in children aged 5-18 years...
  16. ncbi request reprint Effect of childhood eczema and asthma on parental sleep and well-being: a prospective comparative study
    K Moore
    Academic Unit of Child Health, University of Manchester, UK
    Br J Dermatol 154:514-8. 2006
    ..The psychological impact of childhood atopic eczema on parents and carers is poorly quantified. Objectives To compare the impact of caring for a child with atopic eczema vs. asthma on parents' sleep and well-being...
  17. doi request reprint Association between hypoparathyroidism and defective T cell immunity in 22q11.2 deletion syndrome
    A Herwadkar
    Department of Immunology, Salford Royal Hospital NHS Trust, Manchester, UK
    J Clin Pathol 63:151-5. 2010
    ..The aim of this study was to investigate which clinical and laboratory parameters best predict the likelihood of serious or recurrent infections in patients with this syndrome...
  18. ncbi request reprint Atopic dermatitis is associated with a low-producer transforming growth factor beta(1) cytokine genotype
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Manchester, United Kingdom
    J Allergy Clin Immunol 108:281-4. 2001
    ..IL-10 and transforming growth factor beta(1) (TGF-beta(1)) are immunosuppressive cytokines that inhibit the activity of both T(H) cell types in human subjects...
  19. pmc Past mortality from infectious diseases and current burden of allergic diseases in England and Wales
    P D Arkwright
    Academic Unit of Child Health, University of Manchester, Manchester, UK
    Epidemiol Infect 133:979-84. 2005
    ..However, the relationship between changes in rates of infection and allergy is complex and not fully understood...
  20. pmc Transient lymphopenia in acutely unwell young infants
    J K Adamski
    Academic Unit of Child Health, University of Manchester, Booth Hall Children s Hospital, Charlestown Rd, Manchester M9 7AA, UK
    Arch Dis Child 86:200-1. 2002
    ..Lymphopenic infants were significantly more likely to require active resuscitation and intensive care, independent of total leucocyte count, gender, degree of prematurity, and diagnosis...
  21. ncbi request reprint Clinical variability and characteristic autoantibody profile in primary C1q complement deficiency
    G Vassallo
    Department of Paediatric Neurology, Booth Hall Children s Hospital, Manchester, M9 7AA, UK
    Rheumatology (Oxford) 46:1612-4. 2007
    ..C1q deficiency is a rare inherited defect in the early part of the complement cascade. In this report, we describe the varied clinical features of patients with this condition as well as the characteristic autoantibody profile...
  22. ncbi request reprint Childhood linear IgA disease in association with autoimmune lymphoproliferative syndrome
    C S M Wong
    Dermatology Centre, University of Manchester Medical School, Hope Hospital, Stott Lane, Salford, Manchester, UK
    Br J Dermatol 150:578-80. 2004
    ..A child is described who had the signs of autoimmune lymphoproliferative syndrome from an early age and later developed a blistering dermatosis that was shown to be childhood linear IgA disease...
  23. doi request reprint Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center
    Colin W Summers
    Department of Immunology, University of Manchester, Manchester Royal Infirmary, Manchester, United Kingdom
    J Allergy Clin Immunol 121:632-638.e2. 2008
    ..Other than patients with coexisting asthma, it is currently not possible to predict which patients are most likely to develop severe reactions...
  24. ncbi request reprint Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis
    Andrew Gray
    School of Biological Sciences, University of Manchester, Manchester, UK
    Pediatr Allergy Immunol 17:578-82. 2006
    ..2)], as well as bfl-1-1182:+141:+202:+303 G:A:G:A/G:A:G:A diplotype frequencies [3.5 (1.0-12.2)] in AD (p < 0.05). The study thus provides evidence for an association between bfl-1 polymorphisms and the genetic predisposition to AD...
  25. doi request reprint Prevalence, outcome and pre-hospital management of anaphylaxis by first aiders and paramedical ambulance staff in Manchester, UK
    Jennifer A Capps
    University of Manchester, UK
    Resuscitation 81:653-7. 2010
    ..The aim of this study was to investigate the frequency, severity and outcome of calls, as well as whether intramuscular adrenaline was required for successful management of allergic reactions by paramedics and first aiders...
  26. ncbi request reprint Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis
    Houshang Rafatpanah
    Immunology Research Group School of Biological Sciences, University of Manchester, Manchester, UK
    J Allergy Clin Immunol 112:593-8. 2003
    ..Genetic factors are known to be important in determining an individual's predisposition to atopic dermatitis. The specific genes that are clinically important in this process are still largely unknown...
  27. doi request reprint Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses
    Niamat Khan
    Department of Immunology, University of Manchester, Manchester, UK
    Hum Immunol 71:372-6. 2010
    ..Furthermore, an understanding the effects of immunosuppressive agents on TLR-pathway activity should allow more focused therapy for autoimmune disorders...
  28. ncbi request reprint Total and serotype-specific pneumococcal antibody titres in children with normal and abnormal humoral immunity
    Sharif Uddin
    University of Manchester, Booth Hall Children s Hospital, Charlestown Rd, Manchester, M9 7AA, United Kingdom
    Vaccine 24:5637-44. 2006
    ..Serotype-specific IgG were useful in determining the protection against specific pneumococcal strains, and showed that the PPV-23 did not broaden protection against non-PCV-7 serotypes...
  29. ncbi request reprint Autoimmune lymphoproliferative syndrome with somatic Fas mutations
    Eliska Holzelova
    INSERM Unité 429, Hopital Necker Enfants Malades, Paris
    N Engl J Med 351:1409-18. 2004
    ..We studied six children with ALPS whose lymphocytes had normal sensitivity to Fas-induced apoptosis in vitro...
  30. ncbi request reprint SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease
    Reza Sharifi
    Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom
    Blood 103:3821-7. 2004
    ..These studies demonstrate that in XLP the lack of SAP affects specific signaling pathways resulting in severe disruption of CTL function...
  31. ncbi request reprint Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo
    Ariane Chapgier
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche R550, Faculte de Medecine Necker Enfants Malades, Paris, France
    J Immunol 176:5078-83. 2006
    ..Stat-1 deficiency should be suspected in children with severe infections, notably but not exclusively patients with mycobacterial or viral diseases...
  32. doi request reprint Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome
    Belinda Nedjai
    Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Arthritis Rheum 58:273-83. 2008
    ....
  33. ncbi request reprint Mevalonic aciduria cured by bone marrow transplantation
    Peter D Arkwright
    N Engl J Med 357:1350. 2007
  34. ncbi request reprint The 23-valent pneumococcal polysaccharide vaccine does not provide additional serotype antibody protection in children who have been primed with two doses of heptavalent pneumococcal conjugate vaccine
    Paul Balmer
    Health Protection Agency, Clinical Sciences Building II, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    Vaccine 25:6321-5. 2007
    ..In this cohort of children, PPV-23 vaccine did not broaden the protection in vitro against potentially pathogenic strains of Streptococcus pneumoniae. We call into question the recommendation to use the PPV-23 in children...
  35. pmc Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease
    Ariane Chapgier
    Laboratory of Human Genetics of Infectious Diseases, University of Paris Rene Descartes, INSERM U550, Necker Medical School, Paris, France
    PLoS Genet 2:e131. 2006
    ..These STAT1 alleles define two forms of dominant STAT1 deficiency, depending on whether the mutations impair STAT1 phosphorylation or DNA binding...