Adetola B Adesida
- Khan H, Mafi P, Mafi R, Khan W. The effects of ageing on differentiation and characterisation of human mesenchymal stem cells. Curr Stem Cell Res Ther. 2016;: pubmed..There is indication that ageing affects hMSC characterisation and differentiation, however it is not conclusive. There are not enough high quality controlled clinical trials to make reliable conclusions. ..
- Wheelton A, Mace J, Khan W, Anand S. Biomaterials and Fabrication to Optimise Scaffold Properties for Musculoskeletal Tissue Engineering. Curr Stem Cell Res Ther. 2016;: pubmed..We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development. ..
- Khan W, Malik A, Hardingham T. Stem cell applications and tissue engineering approaches in surgical practice. J Perioper Pract. 2009;19:130-5 pubmed..Significant hurdles however remain to be overcome before tissue engineering becomes more routinely used in surgical practice. ..
- Khan W, Al Rashid M, Marsh D. Non-steroidal anti-inflammatory drugs in orthopaedic and perioperative practice. J Perioper Pract. 2009;19:287-90 pubmed..There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. ..
- Khan W, Oragui E, Akagha E. Common fractures and injuries of the ankle and foot: functional anatomy, imaging, classification and management. J Perioper Pract. 2010;20:249-58 pubmed....
- Khan W, Tew S, Adesida A, Hardingham T. Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. Arthritis Res Ther. 2008;10:R74 pubmed publisher..These results suggest that the expansion of these cells with FGF-2 has important consequences for facilitating their chondrogenic differentiation. ..
- Khan W, Adesida A, Tew S, Andrew J, Hardingham T. The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life. Injury. 2009;40:150-7 pubmed publisher..This has many potential therapeutic tissue engineering applications for the repair of bone defects in an increasingly ageing population. ..
- Khan W, Adesida A, Tew S, Lowe E, Hardingham T. Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions. J Orthop Res. 2010;28:834-40 pubmed publisher..The response to chondrogenic culture in these cells was enhanced by lowered oxygen tension. This has important implications for tissue engineering applications of bone marrow-derived stem cells. ..
- Adesida A, Grady L, Khan W, Millward Sadler S, Salter D, Hardingham T. Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture. Arthritis Res Ther. 2007;9:R69 pubmed..These results suggest that the vasculature and greater oxygen tension in the outer meniscus may help to suppress cartilage-like matrix formation...
- Adesida A, Grady L, Khan W, Hardingham T. The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia. Arthritis Res Ther. 2006;8:R61 pubmed..Meniscus cells after expansion in monolayer can therefore respond to chondrogenic signals, and this is enhanced by FGF2 during expansion and low oxygen tension during aggregate cultures...