Adetola B Adesida

Summary

Country: UK

Publications

  1. Khan H, Mafi P, Mafi R, Khan W. The effects of ageing on differentiation and characterisation of human mesenchymal stem cells. Curr Stem Cell Res Ther. 2016;: pubmed
    ..There is indication that ageing affects hMSC characterisation and differentiation, however it is not conclusive. There are not enough high quality controlled clinical trials to make reliable conclusions. ..
  2. Wheelton A, Mace J, Khan W, Anand S. Biomaterials and Fabrication to Optimise Scaffold Properties for Musculoskeletal Tissue Engineering. Curr Stem Cell Res Ther. 2016;: pubmed
    ..We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development. ..
  3. Khan W, Malik A, Hardingham T. Stem cell applications and tissue engineering approaches in surgical practice. J Perioper Pract. 2009;19:130-5 pubmed
    ..Significant hurdles however remain to be overcome before tissue engineering becomes more routinely used in surgical practice. ..
  4. Khan W, Al Rashid M, Marsh D. Non-steroidal anti-inflammatory drugs in orthopaedic and perioperative practice. J Perioper Pract. 2009;19:287-90 pubmed
    ..There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. ..
  5. Khan W, Oragui E, Akagha E. Common fractures and injuries of the ankle and foot: functional anatomy, imaging, classification and management. J Perioper Pract. 2010;20:249-58 pubmed
    ....
  6. Khan W, Tew S, Adesida A, Hardingham T. Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. Arthritis Res Ther. 2008;10:R74 pubmed publisher
    ..These results suggest that the expansion of these cells with FGF-2 has important consequences for facilitating their chondrogenic differentiation. ..
  7. Khan W, Adesida A, Tew S, Andrew J, Hardingham T. The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life. Injury. 2009;40:150-7 pubmed publisher
    ..This has many potential therapeutic tissue engineering applications for the repair of bone defects in an increasingly ageing population. ..
  8. Khan W, Adesida A, Tew S, Lowe E, Hardingham T. Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions. J Orthop Res. 2010;28:834-40 pubmed publisher
    ..The response to chondrogenic culture in these cells was enhanced by lowered oxygen tension. This has important implications for tissue engineering applications of bone marrow-derived stem cells. ..
  9. Adesida A, Grady L, Khan W, Millward Sadler S, Salter D, Hardingham T. Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture. Arthritis Res Ther. 2007;9:R69 pubmed
    ..These results suggest that the vasculature and greater oxygen tension in the outer meniscus may help to suppress cartilage-like matrix formation...
  10. Adesida A, Grady L, Khan W, Hardingham T. The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia. Arthritis Res Ther. 2006;8:R61 pubmed
    ..Meniscus cells after expansion in monolayer can therefore respond to chondrogenic signals, and this is enhanced by FGF2 during expansion and low oxygen tension during aggregate cultures...

Detail Information

Publications10

  1. Khan H, Mafi P, Mafi R, Khan W. The effects of ageing on differentiation and characterisation of human mesenchymal stem cells. Curr Stem Cell Res Ther. 2016;: pubmed
    ..There is indication that ageing affects hMSC characterisation and differentiation, however it is not conclusive. There are not enough high quality controlled clinical trials to make reliable conclusions. ..
  2. Wheelton A, Mace J, Khan W, Anand S. Biomaterials and Fabrication to Optimise Scaffold Properties for Musculoskeletal Tissue Engineering. Curr Stem Cell Res Ther. 2016;: pubmed
    ..We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development. ..
  3. Khan W, Malik A, Hardingham T. Stem cell applications and tissue engineering approaches in surgical practice. J Perioper Pract. 2009;19:130-5 pubmed
    ..Significant hurdles however remain to be overcome before tissue engineering becomes more routinely used in surgical practice. ..
  4. Khan W, Al Rashid M, Marsh D. Non-steroidal anti-inflammatory drugs in orthopaedic and perioperative practice. J Perioper Pract. 2009;19:287-90 pubmed
    ..There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. ..
  5. Khan W, Oragui E, Akagha E. Common fractures and injuries of the ankle and foot: functional anatomy, imaging, classification and management. J Perioper Pract. 2010;20:249-58 pubmed
    ....
  6. Khan W, Tew S, Adesida A, Hardingham T. Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. Arthritis Res Ther. 2008;10:R74 pubmed publisher
    ..These results suggest that the expansion of these cells with FGF-2 has important consequences for facilitating their chondrogenic differentiation. ..
  7. Khan W, Adesida A, Tew S, Andrew J, Hardingham T. The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life. Injury. 2009;40:150-7 pubmed publisher
    ..This has many potential therapeutic tissue engineering applications for the repair of bone defects in an increasingly ageing population. ..
  8. Khan W, Adesida A, Tew S, Lowe E, Hardingham T. Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions. J Orthop Res. 2010;28:834-40 pubmed publisher
    ..The response to chondrogenic culture in these cells was enhanced by lowered oxygen tension. This has important implications for tissue engineering applications of bone marrow-derived stem cells. ..
  9. Adesida A, Grady L, Khan W, Millward Sadler S, Salter D, Hardingham T. Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture. Arthritis Res Ther. 2007;9:R69 pubmed
    ..These results suggest that the vasculature and greater oxygen tension in the outer meniscus may help to suppress cartilage-like matrix formation...
  10. Adesida A, Grady L, Khan W, Hardingham T. The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia. Arthritis Res Ther. 2006;8:R61 pubmed
    ..Meniscus cells after expansion in monolayer can therefore respond to chondrogenic signals, and this is enhanced by FGF2 during expansion and low oxygen tension during aggregate cultures...