P J Hutchinson

Summary

Affiliation: Addenbrooke's Hospital
Country: UK

Publications

  1. ncbi request reprint Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra
    Peter J Hutchinson
    Academic Unit of Neurosurgery, Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, and Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 24:1545-57. 2007
  2. pmc Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:99-105. 2002
  3. ncbi request reprint Hyperglycemia and brain tissue pH after traumatic brain injury
    David A Zygun
    Neuroscience Critical Care Unit and Department of Anaesthesia, University of Cambridge, Cambridge, England
    Neurosurgery 55:877-81; discussion 882. 2004
  4. pmc Acute head injury for the neurologist
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 73:i3-7. 2002
  5. ncbi request reprint Future perspectives in the acute management of head injury
    P J Hutchinson
    Academic Neurosurgery Unit, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Surg 90:769-71. 2003
  6. ncbi request reprint How can we measure substrate, metabolite and neurotransmitter concentrations in the human brain?
    P J Hutchinson
    Department of Neurosurgery and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, University of Cambridge, UK
    Physiol Meas 23:R75-109. 2002
  7. ncbi request reprint Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study
    Peter J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 22:735-45. 2002
  8. ncbi request reprint Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes
    Rupert Kett-White
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 50:1213-21; discussion 1221-2. 2002
  9. pmc Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent
    P J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Clin Pharmacol 53:275-83. 2002
  10. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra
    Peter J Hutchinson
    Academic Unit of Neurosurgery, Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, and Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 24:1545-57. 2007
    ..It remains to be seen whether exogenous IL-1ra or other agents can be used to manipulate cytokine levels in the brain, for potential therapeutic effect...
  2. pmc Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:99-105. 2002
    ....
  3. ncbi request reprint Hyperglycemia and brain tissue pH after traumatic brain injury
    David A Zygun
    Neuroscience Critical Care Unit and Department of Anaesthesia, University of Cambridge, Cambridge, England
    Neurosurgery 55:877-81; discussion 882. 2004
    ..We tested the hypothesis that blood glucose levels are associated with brain tissue pH (pH(b)) and that the correction of hyperglycemia would result in an improvement in pH(b)...
  4. pmc Acute head injury for the neurologist
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 73:i3-7. 2002
  5. ncbi request reprint Future perspectives in the acute management of head injury
    P J Hutchinson
    Academic Neurosurgery Unit, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Surg 90:769-71. 2003
  6. ncbi request reprint How can we measure substrate, metabolite and neurotransmitter concentrations in the human brain?
    P J Hutchinson
    Department of Neurosurgery and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, University of Cambridge, UK
    Physiol Meas 23:R75-109. 2002
    ..voltammetry and spectrophotometry) and functional imaging (e.g. positron emission tomography and magnetic resonance spectroscopy). This review describes these techniques in terms of their principles and clinical applications...
  7. ncbi request reprint Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study
    Peter J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 22:735-45. 2002
    ..9 kPa resulted in a significant elevation of the OEF, in association with a reduction in glucose, but no significant elevation in the L/P ratio or glutamate...
  8. ncbi request reprint Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes
    Rupert Kett-White
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 50:1213-21; discussion 1221-2. 2002
    ..A prospective observational study was conducted to investigate whether episodes of ischemia are detected by continuous cerebral monitoring and whether such episodes are related to clinical outcome...
  9. pmc Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent
    P J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Clin Pharmacol 53:275-83. 2002
    ....
  10. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  11. ncbi request reprint Ventriculostomy for control of raised ICP in acute traumatic brain injury
    I Timofeev
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Hills Road, Cambridge CB2 0QQ, UK
    Acta Neurochir Suppl 102:99-104. 2008
    ....
  12. ncbi request reprint Monitoring and interpretation of intracranial pressure after head injury
    M Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:114-8. 2006
    ..To investigate the relationships between long-term computer-assisted monitoring of intracranial pressure (ICP) and indices derived from its waveform versus outcome, age, and sex...
  13. ncbi request reprint Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:17-20. 2006
    ..We describe the concept of decompressive craniectomy in traumatic brain injury and the rationale and protocol of the RESCUEicp study...
  14. ncbi request reprint Multiparameter brain tissue monitoring--correlation between parameters and identification of CPP thresholds
    P G Al-Rawi
    University Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Zentralbl Neurochir 61:74-9. 2000
    ..The results must be interpreted whilst considering catheter position, autoregulation and systemic arterial changes for each individual...
  15. ncbi request reprint Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients
    K Guendling
    Academic Department of Clinical Neuroscience, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:108-13. 2006
    ..To summarize our experience from the first 2 years of use of the ICM+ software in our Neurocritical Care Unit (NCCU)...
  16. ncbi request reprint Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury
    A K Gupta
    Department of Anesthesia, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 88:549-53. 1999
    ..Thus, monitoring of PbO2 is a useful addition to multimodal monitoring of patients with traumatic head injury...
  17. ncbi request reprint Cerebrovascular reactivity during hypothermia and rewarming
    A Lavinio
    Department of Clinical Neurosciences, Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Anaesth 99:237-44. 2007
    ..The effects of hypothermia and subsequent rewarming on cerebral vasoreactivity in human TBI are unknown...
  18. ncbi request reprint Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism
    R Kett-White
    Academic Department of Neurosurgery, Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 81:327-9. 2002
    ....
  19. ncbi request reprint Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Physiol Meas 26:423-8. 2005
    ..CMA71 microdialysis catheters can, therefore, be used for routine clinical monitoring of extracellular substances, as well as for their intended research role of larger molecular weight protein sampling...
  20. ncbi request reprint Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy
    I Timofeev
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:11-6. 2006
    ..Formal prospective randomized studies of decompressive craniectomy are now indicated...
  21. doi request reprint Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study
    S J Price
    Academic Neurosurgery Unit, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Clin Radiol 64:52-63. 2009
    ..To compare regional variations in uptake of 3'-deoxy-3'- [(18)F]-fluorothymidine (FLT) images using positron-emission tomography (PET) with measures of cellular proliferation from biopsy specimens obtained by image-guided brain biopsies...
  22. ncbi request reprint Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study
    M T O'Connell
    Department of Anaesthesia, University of Cambridge, Cambridge CB2 2QQ, UK
    Acta Neurochir Suppl 95:165-8. 2005
    ..Further observations are required with regions of interest (microdialysis catheters positioned) adjacent to mass lesions notably contusions...
  23. ncbi request reprint Microdialysis in the management of hepatic encephalopathy
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 5:202-5. 2006
    ..Fulminant hepatic encephalopathy has a high mortality...
  24. ncbi request reprint Outcome from poor grade aneurysmal subarachnoid haemorrhage--which poor grade subarachnoid haemorrhage patients benefit from aneurysm clipping?
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbroke s Hospital, UK
    Br J Neurosurg 14:105-9. 2000
    ..However, following resuscitation and correction of any acute hydrocephalus, a patient subgroup identified on simple clinical criteria can be identified who can expect a better outcome...
  25. doi request reprint Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study
    S J Price
    Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, UK
    AJNR Am J Neuroradiol 32:501-6. 2011
    ..The aim of this study was to see how rCBV, a known marker of tumor vascularity, relates to cellular packing attenuation and cellular proliferation...
  26. ncbi request reprint Analysis of acute traumatic axonal injury using diffusion tensor imaging
    V F J Newcombe
    University Division of Anaesthesia, Cambridge University, Cambridge, UK
    Br J Neurosurg 21:340-8. 2007
    ..This technique holds promise for examining disease progression, and may help define therapeutic windows for the treatment of diffuse brain injury...
  27. pmc Standards for head injury management in acute hospitals: evidence from the six million population of the Eastern region
    H M Seeley
    Neurosciences Department, Addenbrooke s Hospital, Cambridge, UK
    Emerg Med J 23:128-32. 2006
    ..To develop standards of care for head injury and thereby identify and prioritize areas of the service needing development; to report the findings from a survey of compliance with such standards in the Eastern region of UK...
  28. ncbi request reprint A new cranial access device for cerebral monitoring
    P J Hutchinson
    Academic Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Neurosurg 14:46-8. 2000
    ..The bolt has been successfully applied to 100 patients with severe head injury and subarachnoid haemorrhage...
  29. ncbi request reprint Effect of hypothermia on brain tissue oxygenation in patients with severe head injury
    A K Gupta
    Department of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Anaesth 88:188-92. 2002
    ..In this study we have investigated the effects of hypothermia on brain tissue oxygenation in patients with severe head injury...
  30. pmc Late epilepsy following open surgery for aneurysmal subarachnoid haemorrhage
    S J Buczacki
    University of Cambridge, Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 75:1620-2. 2004
    ..To determine the risk for late epilepsy (>2 weeks postoperatively) following aneurysmal subarachnoid haemorrhage (SAH) treated by early aneurysm clipping...
  31. ncbi request reprint Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage
    J D Pickard
    Academic Neurosurgery Unit and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Blood Coagul Fibrinolysis 11:S117-20. 2000
    ..The last patient developed middle cerebral artery branch thrombosis contralateral to the aneurysm. The study is currently suspended pending further investigation...
  32. doi request reprint Critical thresholds for cerebrovascular reactivity after traumatic brain injury
    E Sorrentino
    Neurosurgery, University of Cambridge, Cambridge, UK
    Neurocrit Care 16:258-66. 2012
    ..We also investigated how these thresholds depend on clinical factors such as age, gender and initial GCS...
  33. ncbi request reprint Microdialysis in traumatic brain injury--methodology and pathophysiology
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, UK
    Acta Neurochir Suppl 95:441-5. 2005
    ..This manuscript describes the place of microdialysis in traumatic brain injury in terms of the fundamental principles, methodology, pathophysiology and clinical application...
  34. doi request reprint Low-dose and high-dose synacthen tests and the hemodynamic response to hydrocortisone in acute traumatic brain injury
    R S Wijesurendra
    University Division of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Box 93, Hills Road, Cambridge CB2 2QQ, UK
    Neurocrit Care 11:158-64. 2009
    ....
  35. ncbi request reprint Outcome after surgical decompression of severe traumatic brain injury
    I Timofeev
    University of Cambridge Academic Neurosurgery Unit, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Injury 37:1125-32. 2006
    ..This article reviews the existing evidence on the role of decompressive craniectomy in management of patients with traumatic brain injury and stresses the need for randomised controlled trials...
  36. ncbi request reprint Inappropriate acute neurosurgical bed occupancy and short falls in rehabilitation: implications for the National Service Framework
    L J Bradley
    Department of Rehabilitation Medicine, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:36-9. 2006
    ..Addressing this unmet need would increase the availability of acute neurosurgery beds, without needing to build and staff more neurosurgery wards...
  37. ncbi request reprint Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner
    J P Coles
    Department of Anaesthesia and Wolfson Brain Imaging Centre, Box 93, Addenbrookes Hospital, University of Cambridge, CB2 2QQ, UK
    Anaesthesia 58:143-8. 2003
    ..Although the system is MR compatible and produces generally acceptable imaging even at 3 Tesla, there is significant degradation of image quality during gradient echo sequences...
  38. ncbi request reprint Multi-modal monitoring of acute brain injury
    R Kett-White
    Academic Neurosurgical Unit and the Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Adv Tech Stand Neurosurg 27:87-134. 2002
    ..Thirdly, the respective roles of jugular venous oxygen and brain tissue oxygen monitoring are analysed. Fourthly, the use of cerebral microdialysis is described, together with an overview of its utility...
  39. ncbi request reprint Concept of "true ICP" in monitoring and prognostication in head trauma
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:341-4. 2005
    ..To propose a new coefficient, which contains information about both the absolute ICP and the position of the 'working point' on the pressure-volume curve...
  40. doi request reprint Community consultation in emergency neurotrauma research: results from a pre-protocol survey
    D J Clark
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital and University of Cambridge, Cambridge, UK
    Acta Neurochir (Wien) 155:1329-34; discussion 1334. 2013
    ..Clinical trials in the emergency setting face the problem that potential participants may be incapacitated and their next of kin initially unavailable. As a result, consent and enrolment of participants can often be difficult...
  41. ncbi request reprint Decompressive craniectomy in head injury
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Curr Opin Crit Care 10:101-4. 2004
    ..To examine the evidence for the role of decompressive craniectomy in the management of traumatic brain injury...
  42. doi request reprint The management of primary chronic subdural haematoma: a questionnaire survey of practice in the United Kingdom and the Republic of Ireland
    T Santarius
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Br J Neurosurg 22:529-34. 2008
    ..The current literature provides Class II and III evidence and there is a need for randomized studies to address the role of external drainage, steroids and postoperative bed rest...
  43. ncbi request reprint Is the recommended target of 4 hours from head injury to emergency craniotomy achievable?
    I G Sergides
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:301-5. 2006
    ..In order to investigate whether it is possible to reduce delays in transportation time, theoretical models were created to determine whether direct transfer to the RNU would be faster by land or air ambulance...
  44. doi request reprint Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: a prospective clinical study
    M Y Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Br J Neurosurg 22:257-68. 2008
    ..Intravenous fluid therapy using synthetic colloids or blood transfusions may be associated with increased unfavourable outcome following aSAH...
  45. doi request reprint Surgical management of acute subdural haematomas: current practice patterns in the United Kingdom and the Republic of Ireland
    A G Kolias
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital and University of Cambridge, Cambridge, UK
    Br J Neurosurg 27:330-3. 2013
    ..In this study, we used an online questionnaire to assess the current practice patterns in the management of ASDH in the UK and the Republic of Ireland, and to gauge neurosurgical opinion regarding the proposed RESCUE-ASDH trial...
  46. ncbi request reprint Head injury rehabilitation: the role of a neurotrauma clinic
    Helen M Seeley
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 23:530-7. 2009
    ..Early indications show that a specialist clinic can assist in providing continuity of patient care, in improving coordination of services, and act as a resource for further research on epidemiology, outcome and impact of rehabilitation...
  47. doi request reprint Neurotrauma - a multidisciplinary disease
    M H Wilson
    The Traumatic Brain Injury Centre, Department of Neurosurgery, St Mary s Hospital, Imperial College, London, UK London s Air Ambulance, The Helipad, The Royal London Hospital, Queen Mary University of London, London, UK The British Neurotrauma Group, The Society of British Neurosurgeons, Royal College of Surgeons, London, UK
    Int J Clin Pract 68:5-7. 2014
    ..Public health policy is key to reducing its incidence. Integrated multidisciplinary clinical care is vital to minimise its morbidity and mortality...
  48. ncbi request reprint Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study
    S J Price
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Department pf Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
    AJNR Am J Neuroradiol 27:1969-74. 2006
    ..In this study, results of histologic examination from samples obtained from image-guided brain biopsies were correlated with diffusion tensor images...
  49. pmc Mapping rehabilitation resources for head injury
    J D Pickard
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J R Soc Med 97:384-9. 2004
    ..The definitions and mapping system that emerged from this study should facilitate the design of care pathways for patients and identify gaps in the services...
  50. pmc Timing of surgery for supratentorial aneurysmal subarachnoid haemorrhage: report of a prospective study
    N Ross
    University Department of Neurosurgery, Box 167, Block A, Level 4, Addenbrookes Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:480-4. 2002
    ..By following a strict management protocol for SAH, the hypothesis has been tested that in the modern arena of treatment for aneurysmal SAH the timing of surgery to secure supratentorial aneurysms does not affect surgical outcome...
  51. ncbi request reprint The pharmacology of chlormethiazole: a potential neuroprotective agent?
    M J Wilby
    Academic Department of Neurosurgery, Box 167, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    CNS Drug Rev 10:281-94. 2004
    ..In addition, novel approaches involving human neurochemical analyses in vivo are described which may help bridge the gap between animal models and future phase III trials...
  52. ncbi request reprint Neurosurgical history: Comparing the management of penetrating head injury in 1969 with 2005
    N C H Keong
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:227-32. 2006
    ..Two unusual cases demonstrate the progress made in emergency medicine, radiology neurointensive care, and neurosurgical head injury management over 36 years...
  53. ncbi request reprint Prospective study of clinical and radiological outcome after anterior cervical discectomy
    R J Laing
    Academic Department of Neurosurgery, University of Cambridge, Cambridge, UK
    Br J Neurosurg 15:319-23. 2001
    ..Disturbance of cervical and segmental alignment is common in patients following cervical discectomy, but does not appear to compromise clinical outcome at 12 months...
  54. ncbi request reprint Post traumatic brain contusions and lacerations. An international focus meeting, September 19-20, 2003, Rimini, Italy
    P J Hutchinson
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 146:535-6. 2004
  55. ncbi request reprint Diffusion limited oxygen delivery following head injury
    David K Menon
    Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1384-90. 2004
    ..To use a range of techniques to explore diffusion limitation as a mechanism of cellular hypoxia in the setting of head injury...
  56. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
    ..To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury...
  57. ncbi request reprint Incidence and mechanisms of cerebral ischemia in early clinical head injury
    Jonathan P Coles
    The Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:202-11. 2004
    ..The ischemic burden represented by this "traumatic penumbra" is poorly detected by bedside clinical monitors and has significant associations with outcome...
  58. ncbi request reprint Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction
    Rupert Kett-White
    University Department of Neurosurgery and the Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:1013-9. 2002
    ....
  59. ncbi request reprint Specialist neurocritical care and outcome from head injury
    Hiren C Patel
    Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Intensive Care Med 28:547-53. 2002
    ..To document the effect of neurocritical care, delivered by specialist staff and based on protocol-driven therapy aimed at intracranial pressure (ICP) and cerebral perfusion pressure (CPP) targets, on outcome in acute head injury...
  60. ncbi request reprint Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method
    Arun K Gupta
    Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:263-8. 2002
    ..The goal of this study was to validate the use of a new multiparameter sensor that measures brain tissue oxygenation and metabolism (Neurotrend) by comparing it with positron emission tomography (PET) scanning...
  61. ncbi request reprint Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings
    Jurgens Nortje
    University Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 36:273-81. 2008
    ..To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury...
  62. ncbi request reprint Microdialysis in the human brain and its potential role in the development and clinical assessment of drugs
    Adel Helmy
    University of Cambridge, Academic Unit of Neurosurgery, Box 167, Level 4, Block A, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Curr Med Chem 14:1525-37. 2007
    ..It can therefore be used to determine the biochemical efficacy of therapeutic manoeuvres. In this review we address the practical application of this technology to the process of drug development...
  63. ncbi request reprint Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    J Neurosurg 107:274-82. 2007
    ..Whether the increment of change in CBF correlates with changes in autoregulation of CBF or outcome at discharge remains unknown...
  64. ncbi request reprint Age, intracranial pressure, autoregulation, and outcome after brain trauma
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 102:450-4. 2005
    ..The object of this study was to investigate whether a failure of cerebrovascular autoregulation contributes to the relationship between age and outcome in patients following head injury...
  65. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  66. pmc Deficiencies in rehabilitation after traumatic brain injury
    Peter J Hutchinson
    BMJ 332:118. 2006
  67. ncbi request reprint Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome
    Richard J Mannion
    Wolfson Brain Injury Unit, Addenbrooke s Hospital NHS Foundation Trust, Hills Road, Cambridge, United Kingdom
    J Neurotrauma 24:128-35. 2007
    ..Understanding the anatomy and extent of brainstem injury, as well as its relationship to supratentorial abnormalities, will facilitate a more accurate use of early MRI as a prognostic tool and assist in the counseling of families...
  68. ncbi request reprint Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Stroke 38:1545-50. 2007
    ..This study assesses the effects of pravastatin on the frequency and intensity for rescue therapy, length of inpatient stay, and long-term outcome at 6 months...
  69. ncbi request reprint Cost-effective outcome for treating poor-grade subarachnoid hemorrhage
    Martin J Wilby
    Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2508-11. 2003
    ..Outcome measures were clinical outcome at 6 months, number needed to treat (NNT) for favorable outcomes, and cost analysis...
  70. ncbi request reprint Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    J Neurosurg 107:1092-100. 2007
    ..The object of this study was to continue to examine potential mechanisms of these beneficial effects...
  71. doi request reprint Management of patients with head injury
    A David Mendelow
    The Society of British Neurological Surgeons, The Royal College of Surgeons of England, London, UK
    Lancet 372:685-7. 2008
  72. ncbi request reprint Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury
    Arun K Gupta
    Neuroscience Critical Care Unit, University of Cambridge Department of Anaesthesia, UK
    J Neurotrauma 21:678-84. 2004
    ..pH(b) differentiated between survivors and non-survivors. Measurement of pH(b) may be a useful indicator of outcome in patients with TBI...
  73. doi request reprint Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer
    Virginia F J Newcombe
    University Division of Anaesthesia, Cambridge University, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 109:159-64. 2008
    ..That is, in the authors' system, it can be safely used with the transmit-and-receive head coil, but when using the transmit body coil the transducer wire must be coiled into concentric loops outside of the receive-only head coil...
  74. ncbi request reprint Neuroimaging in trauma
    Clare N Gallagher
    University of Calgary, Alberta, Canada
    Curr Opin Neurol 20:403-9. 2007
    ..Some of these techniques are in clinical use while others are used primarily in research but have the potential to become clinically useful...