Pamela W Ewan
Affiliation: Addenbrooke's Hospital
- IgE mediated food allergy: when is food challenge needed?P W Ewan
Allergy Dept, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, and University of Cambridge Clinical School, Cambridge, UK
Arch Dis Child 90:555-6. 2005
- New insight into immunological mechanisms of venom immunotherapyP W Ewan
Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, University of Cambridge Clinical School, Cambridge, UK
Curr Opin Allergy Clin Immunol 1:367-74. 2001..Immunostimulatory DNA sequences have an adjuvant effect and induce T helper type 1 cytokines, independent of antigen. They may be co-administered with allergen and used to redirect allergen-specific T helper type 2 responses...
- NHS allergy services in the UK: proposals to improve allergy carePamela W Ewan
Immunology Clinic, Addenbrooke s Hospital, Cambridge
Clin Med 2:122-7. 2002..As a first step, we propose the setting up of appropriately staffed regional allergy centres. This could be achieved with a central directive and (relatively minor) pump-priming of funding...
- Interleukin-10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapyS M Nasser
Departments of Allergy and Clinical Immunology, University of Cambridge Clinical School, Cambridge, UK
Eur J Immunol 31:3704-13. 2001..These results suggest that induction of IL-10 may be important in VIT and occur independently of the switch to a Th1 phenotype. IL-10 generation may down-regulate IL-4 expression and eosinophil recruitment...
- The development and progression of allergy to multiple nuts at different agesAndrew T Clark
Department of Allergy, Addenbrookes NHS Trust, Cambridge, UK
Pediatr Allergy Immunol 16:507-11. 2005..This is related to increased duration of allergy and exposure to multiple nut types with age. Children with nut allergy should avoid all nut types from the onset...
- Successful oral tolerance induction in severe peanut allergyA T Clark
Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Box 40, Addenbrooke s Hospital, Hills Roads, Cambridge CB2 2QQ, UK
Allergy 64:1218-20. 2009..Peanut allergy is common, potentially severe and rarely resolves causing impaired quality of life. No disease-modifying treatment exists and there is therefore a need to develop a therapeutic intervention...
- Patterns of immunoglobulin G responses to egg and peanut allergens are distinct: ovalbumin-specific immunoglobulin responses are ubiquitous, but peanut-specific immunoglobulin responses are up-regulated in peanut allergyS S Tay
Department of Medicine, Cambridge University, Cambridge, UK
Clin Exp Allergy 37:1512-8. 2007..The clinical significance of food-specific IgG subclasses in food allergy and tolerance remains unclear. Specific IgG titres are often reported in non-standardized units, which do not allow comparisons between studies or allergens...
- Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapyS M McHugh
Molecular Immunopathology Unit, Medical Research Centre, Cambridge, UK
Clin Exp Allergy 25:828-38. 1995..The mechanism of immunotherapy is unclear. Allergic disease is known to involve enhanced TH-2 cytokine responses to allergen...
- Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or toleranceA T Clark
Department of Allergy and Clinical Immunology, Addenbrooke's Hospital, University of Cambridge Clinical School, Cambridge, UK
Clin Exp Allergy 33:1041-5. 2003..Understanding this is essential for accurate diagnosis. Patients with SPT > or = 8 mm and CAP > or = 15 kU/L were rarely tolerant so these levels are almost always (in > or = 95%) diagnostic...
- Opiate-sensitivity: clinical characteristics and the role of skin prick testingS M Nasser
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK
Clin Exp Allergy 31:1014-20. 2001..CONCLUSION: Skin prick testing is not useful in the diagnosis of opiate sensitivity and placebo-controlled challenge should be considered...
- Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cellsT L Rowland
Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, England, UK
Immunopharmacology 40:11-20. 1998..Due to their markedly different effects on cytokine production, and the fact that both drugs act at the level of transcription, we believe they influence separate pathways involved in cytokine gene regulation...
- Food allergy in childhoodA T Clark
Addenbrooke's Hospital, Cambridge, UK
Arch Dis Child 88:79-81. 2003
- Facial thermography is a sensitive and specific method for assessing food challenge outcomeA T Clark
Department of Allergy, Cambridge University Hospitals NHS Trust, Addenbrookes Hospital, Cambridge, UK
Allergy 62:744-9. 2007..Oral challenge is widely used for diagnosing food allergy but variable interpretation of subjective symptoms may cause error. Facial thermography was evaluated as a novel, objective and sensitive indicator of challenge outcome...
- Long-term prospective observational study of patients with peanut and nut allergy after participation in a management planP W Ewan
Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, Cambridge, UK
Lancet 357:111-5. 2001..We devised and assessed a management programme providing advice on nut avoidance and emergency medication...
- T cell proliferation and cytokine responses to ovalbumin and ovomucoid detected in children with and without egg allergyS S Tay
Department of Medicine, Addenbrookes Hospital, Cambridge University, Cambridge, UK
Clin Exp Allergy 37:1519-27. 2007..The specific T cell responses in egg allergy and resolution have not been fully elucidated...
- BSACI guidelines for the management of drug allergyR Mirakian
Cambridge University, NHS Foundation Trust, Allergy Clinic, Cambridge, UK
Clin Exp Allergy 39:43-61. 2009..After the diagnosis of drug allergy has been established, communication of results and patient education are vital components of overall patient management...
- Anaphylaxis to patent blue V: a case series and proposed diagnostic protocolR A Haque
Department of Allergy, Addenbrooke s Hospital, Cambridge, UK
Allergy 65:396-400. 2010..On the basis of our experience of patent blue V allergy, we propose a diagnostic protocol that can be safely and reliably utilised in centres equipped for allergy testing...
- BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesiaP W Ewan
Allergy Clinic, Cambridge University NHS Foundation Trust, Cambridge, UK
Clin Exp Allergy 40:15-31. 2010..We suggest this focus since there is a distinct lack of validated data for testing, thus requiring experience in interpreting tests and because of the serious consequences of diagnostic error...