Genomes and Genes
J R Bradley
Affiliation: Addenbrooke's Hospital
- Tumor necrosis factor receptor-associated factors (TRAFs)J R Bradley
Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Oncogene 20:6482-91. 2001..TRAF proteins are expressed in normal and diseased tissue in a regulated fashion, suggesting that they play an important role in physiological and pathological processes...
- TNF receptors differentially signal and are differentially expressed and regulated in the human heartR S Al-Lamki
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Am J Transplant 9:2679-96. 2009..These observations demonstrate independent regulation and differential functions of TNFRs in myocardium, consistent with TNFR1-mediated cell death and TNFR2-mediated repair...
- Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplantsR S Al-Lamki
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Lab Invest 81:1503-15. 2001..These data reveal that there is both differential expression and regulation of the two TNF receptors in human kidney...
- TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1S J Jones
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
J Immunol 162:1042-8. 1999..These results suggest that although TNF-R1 is predominantly a Golgi-associated protein and TRADD also localizes to the Golgi region, exogenous TNF causes TRADD to bind to TNF-R1 only at the plasma membrane...
- TNF-mediated inflammatory diseaseJ R Bradley
NIHR Cambridge Biomedical Research Centre, Addenbrooke s Hospital, Cambridge, UK
J Pathol 214:149-60. 2008..The increased incidence of infection in patients receiving anti-TNF treatment has highlighted the physiological role of TNF in infectious diseases...
- Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptorsX Feng
Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
J Biol Chem 276:8341-9. 2001..These findings suggest that intracellular distribution of activated TNF receptors may be regulated by caveolin-1 via its interaction with TRAF2...
- Recent advances in the molecular basis of TNF signal transductionE C Ledgerwood
Department of Medicine, University of Cambridge, United Kingdom
Lab Invest 79:1041-50. 1999..The ability to specifically manipulate the involvement of these molecules in TNF signaling, without affecting other pathways, may provide new therapeutic approaches to the many diseases in which TNF has a crucial role...