J R Bradley

Summary

Affiliation: Addenbrooke's Hospital
Country: UK

Publications

  1. ncbi request reprint Tumor necrosis factor receptor-associated factors (TRAFs)
    J R Bradley
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Oncogene 20:6482-91. 2001
  2. pmc TNF receptors differentially signal and are differentially expressed and regulated in the human heart
    R S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Am J Transplant 9:2679-96. 2009
  3. ncbi request reprint Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplants
    R S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Lab Invest 81:1503-15. 2001
  4. ncbi request reprint TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1
    S J Jones
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    J Immunol 162:1042-8. 1999
  5. ncbi request reprint TNF-mediated inflammatory disease
    J R Bradley
    NIHR Cambridge Biomedical Research Centre, Addenbrooke s Hospital, Cambridge, UK
    J Pathol 214:149-60. 2008
  6. ncbi request reprint Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
    X Feng
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 276:8341-9. 2001
  7. ncbi request reprint Recent advances in the molecular basis of TNF signal transduction
    E C Ledgerwood
    Department of Medicine, University of Cambridge, United Kingdom
    Lab Invest 79:1041-50. 1999

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Tumor necrosis factor receptor-associated factors (TRAFs)
    J R Bradley
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Oncogene 20:6482-91. 2001
    ..TRAF proteins are expressed in normal and diseased tissue in a regulated fashion, suggesting that they play an important role in physiological and pathological processes...
  2. pmc TNF receptors differentially signal and are differentially expressed and regulated in the human heart
    R S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Am J Transplant 9:2679-96. 2009
    ..These observations demonstrate independent regulation and differential functions of TNFRs in myocardium, consistent with TNFR1-mediated cell death and TNFR2-mediated repair...
  3. ncbi request reprint Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplants
    R S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Lab Invest 81:1503-15. 2001
    ..These data reveal that there is both differential expression and regulation of the two TNF receptors in human kidney...
  4. ncbi request reprint TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1
    S J Jones
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    J Immunol 162:1042-8. 1999
    ..These results suggest that although TNF-R1 is predominantly a Golgi-associated protein and TRADD also localizes to the Golgi region, exogenous TNF causes TRADD to bind to TNF-R1 only at the plasma membrane...
  5. ncbi request reprint TNF-mediated inflammatory disease
    J R Bradley
    NIHR Cambridge Biomedical Research Centre, Addenbrooke s Hospital, Cambridge, UK
    J Pathol 214:149-60. 2008
    ..The increased incidence of infection in patients receiving anti-TNF treatment has highlighted the physiological role of TNF in infectious diseases...
  6. ncbi request reprint Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
    X Feng
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 276:8341-9. 2001
    ..These findings suggest that intracellular distribution of activated TNF receptors may be regulated by caveolin-1 via its interaction with TRAF2...
  7. ncbi request reprint Recent advances in the molecular basis of TNF signal transduction
    E C Ledgerwood
    Department of Medicine, University of Cambridge, United Kingdom
    Lab Invest 79:1041-50. 1999
    ..The ability to specifically manipulate the involvement of these molecules in TNF signaling, without affecting other pathways, may provide new therapeutic approaches to the many diseases in which TNF has a crucial role...