Trevor Baglin

Summary

Affiliation: Addenbrooke's Hospital
Country: UK

Publications

  1. ncbi request reprint The measurement and application of thrombin generation
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 130:653-61. 2005
  2. doi request reprint The biphasic transmittance waveform: an early marker of sepsis in patients with neutropenia
    Nazia Hussain
    Addenbrookes Hospital Haematology, Box 234, Cambridge, Cambs CB2 0QQ, United Kingdom
    Thromb Haemost 100:146-8. 2008
  3. doi request reprint The role of the laboratory in treatment with new oral anticoagulants
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    J Thromb Haemost 11:122-8. 2013
  4. doi request reprint Inherited and acquired risk factors for venous thromboembolism
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom
    Semin Respir Crit Care Med 33:127-37. 2012
  5. ncbi request reprint Value of D-dimer testing to decide duration of anticoagulation after deep vein thrombosis: not yet
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    J Thromb Haemost 4:2530-2. 2006
  6. ncbi request reprint Acquired bleeding disorders
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge
    Clin Med 5:326-8. 2005
  7. doi request reprint Unprovoked recurrent venous thrombosis: prediction by D-dimer and clinical risk factors
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 6:577-82. 2008
  8. doi request reprint Venous thromboembolism in hospitalised patients: a public health crisis?
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Br J Haematol 141:764-70. 2008
  9. ncbi request reprint Communicating benefit and risk
    Trevor Baglin
    Department of Haematology, Cambridge University Hospitals NHS Trust, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 146:31-3. 2009
  10. ncbi request reprint Unprovoked deep vein thrombosis should be treated with long-term anticoagulation--no
    T Baglin
    Department of Haematology, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 5:2336-9. 2007

Collaborators

Detail Information

Publications38

  1. ncbi request reprint The measurement and application of thrombin generation
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 130:653-61. 2005
    ..Ultimately management studies will be required if the clinical utility of measurement of thrombin generation is to be proven...
  2. doi request reprint The biphasic transmittance waveform: an early marker of sepsis in patients with neutropenia
    Nazia Hussain
    Addenbrookes Hospital Haematology, Box 234, Cambridge, Cambs CB2 0QQ, United Kingdom
    Thromb Haemost 100:146-8. 2008
    ..It may also provide a useful marker to monitor the effects of treatment...
  3. doi request reprint The role of the laboratory in treatment with new oral anticoagulants
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    J Thromb Haemost 11:122-8. 2013
    ..Laboratories should be aware of the sensitivity of their own assays to each drug. This may be achieved by using appropriate calibrated plasma samples...
  4. doi request reprint Inherited and acquired risk factors for venous thromboembolism
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom
    Semin Respir Crit Care Med 33:127-37. 2012
    ..The results of testing for heritable thrombophilia rarely influence duration of treatment...
  5. ncbi request reprint Value of D-dimer testing to decide duration of anticoagulation after deep vein thrombosis: not yet
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    J Thromb Haemost 4:2530-2. 2006
  6. ncbi request reprint Acquired bleeding disorders
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge
    Clin Med 5:326-8. 2005
  7. doi request reprint Unprovoked recurrent venous thrombosis: prediction by D-dimer and clinical risk factors
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 6:577-82. 2008
    ..The aim of the study was to determine the predictive value of D-dimer measurement for unprovoked recurrent venous thrombosis and the influence of sex, age and type of first event (unprovoked or provoked)...
  8. doi request reprint Venous thromboembolism in hospitalised patients: a public health crisis?
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Br J Haematol 141:764-70. 2008
    ..It is anticipated that, by 2009, risk assessment will be mandatory for all hospitalised patients in England; the same strategy is likely for the whole UK...
  9. ncbi request reprint Communicating benefit and risk
    Trevor Baglin
    Department of Haematology, Cambridge University Hospitals NHS Trust, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 146:31-3. 2009
    ..Conveying uncertainty in relation to estimates of likelihood is particularly difficult when discussing outcomes with patients and often the clinician is still left with phrases such as 'best guess'...
  10. ncbi request reprint Unprovoked deep vein thrombosis should be treated with long-term anticoagulation--no
    T Baglin
    Department of Haematology, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 5:2336-9. 2007
  11. ncbi request reprint What happens after venous thromboembolism?
    T Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    J Thromb Haemost 7:287-90. 2009
    ..This suggests that the kinetics of thrombin generation and the resulting fibrinolytic response may influence clot structure and likelihood of embolization...
  12. doi request reprint Unraveling the thrombophilia paradox: from hypercoagulability to the prothrombotic state
    T Baglin
    Department of Haematology, Cambridge University Hospitals NHS Trust, Addenbrooke s Hospital, Cambridge, UK
    J Thromb Haemost 8:228-33. 2010
    ....
  13. doi request reprint Defining the population in need of thromboprophylaxis - making hospitals safer
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Br J Haematol 149:805-12. 2010
    ..Strategies for refining and validating risk assessment models and evaluating the effect of risk assessment and thromboprophylaxis are suggested...
  14. doi request reprint Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    J Thromb Haemost 8:2436-42. 2010
    ..To determine if the mode of presentation of venous thromboembolism (VTE), as deep vein thrombosis (DVT) or pulmonary embolism (PE), predicts the likelihood and type of recurrence...
  15. doi request reprint Using the laboratory to predict recurrent venous thrombosis
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Int J Lab Hematol 33:333-42. 2011
    ....
  16. ncbi request reprint Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Lancet 362:523-6. 2003
    ..We aimed to determine the incidence of recurrence of VTE in relation to clinical risk factors and standard laboratory testing for heritable thrombophilic defects...
  17. ncbi request reprint Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study
    Yesim Dargaud
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 139:303-9. 2007
    ..Standardization and normalization should be considered in future clinical studies which apply TG testing to clinical decision making...
  18. ncbi request reprint Oral anticoagulant therapy in subjects with congenital or acquired thrombophilia
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    Semin Vasc Med 3:315-22. 2003
    ....
  19. ncbi request reprint Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls
    Peter W Collins
    Department of Haematology, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK
    Br J Haematol 135:220-7. 2006
    ..005). In conclusion, global tests of haemostasis suggest that in this patient group, activation of haemostasis is delayed but once initiated thrombin generation and clot formation are normal or enhanced...
  20. doi request reprint Clinical use of new oral anticoagulant drugs: dabigatran and rivaroxaban
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Br J Haematol 163:160-7. 2013
    ..Dabigatran and rivaroxaban have been chosen for this review as examples of a thrombin inhibitor and an inhibitor of factor Xa respectively. The clinical application of these drugs is the focus of the review. ..
  21. ncbi request reprint Platelet-dependent thrombography: a method for diagnostic laboratories
    Yesim Dargaud
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 134:323-5. 2006
    ..This method has potential application to the measurement of platelet-dependent thrombin generation in clinical diagnostic laboratories and hence the investigation of patients with apparent hypo- or hypercoagulable phenotypes...
  22. ncbi request reprint Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition
    R Luddington
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    J Thromb Haemost 2:1954-9. 2004
    ....
  23. doi request reprint High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study
    M Besser
    Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK
    J Thromb Haemost 6:1720-5. 2008
    ..To determine the predictive value of measurement of parameters of thrombin generation for unprovoked recurrent venous thrombosis...
  24. ncbi request reprint Guidelines on the use and monitoring of heparin
    T Baglin
    Department of Haematology, Addenbrookes NHS Trust, Cambridge, UK
    Br J Haematol 133:19-34. 2006
  25. ncbi request reprint Severe factor X deficiency due to a homozygous mutation (Cys364Arg) that disrupts a disulphide bond in the catalytic domain
    T Todd
    Department of Haematology, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Haemophilia 12:621-4. 2006
    ..Our experience and a review of the literature suggest that optimal frequency of dosing is likely to be two or three times weekly and that the risk of thrombosis is very small...
  26. ncbi request reprint Lupus anticoagulant testing with optical end point automation
    R Luddington
    Department of Haematology, Addenbrookes NHS Trust, Cambridge, United Kingdom
    Thromb Res 96:197-203. 1999
    ..The factor V ratio is a useful second-line screen for both anticoagulated patients and anticardiolipin antibody-positive samples...
  27. ncbi request reprint Beriplex P/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding
    G Evans
    Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Cambridge CB2 2QQ, UK
    Br J Haematol 115:998-1001. 2001
    ..The median INR before treatment was greater than 20 and, after treatment, 1.1. All patients had a satisfactory clinical response with immediate cessation of bleeding, and no thromboembolic complications occurred...
  28. ncbi request reprint High risk of recurrent venous thromboembolism in men
    T Baglin
    Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Thromb Haemost 2:2152-5. 2004
    ..We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE)...
  29. ncbi request reprint Management of warfarin (coumarin) overdose
    T Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Blood Rev 12:91-8. 1998
    ..Further studies are required to determine the most effective use of products and the dose required for safe reversal of overanticoagulation...
  30. ncbi request reprint Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism
    A Jackson
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 111:562-4. 2000
    ..The possibility that the I/D polymorphism is a risk factor for venous thromboembolism specifically after hip replacement cannot be excluded...
  31. ncbi request reprint Management of thrombophilia: who to screen?
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Pathophysiol Haemost Thromb 33:401-4. 2003
    ..If thrombophilia testing is performed there is a strong case for selecting patients for testing as in most cases decisions regarding intensity and duration of anticoagulant therapy can be made purely in relation to clinical criteria...
  32. doi request reprint Human immunodeficiency virus associated thrombotic thrombocytopenic purpura--favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapy
    Daniel Hart
    Department of Haematology, St Bartholomew s and the London Hospital, London, UK
    Br J Haematol 153:515-9. 2011
    ..More PEX is required in cases with higher viral loads. Continued HAART maintains remission. In a small proportion of cases, further immunomodulatory therapy may be required...
  33. ncbi request reprint Avoiding overanticoagulation: knowing your antibiotics
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals Trust, Cambridge CB2 2QQ, United Kingdom
    Thromb Haemost 88:703-4. 2002
  34. ncbi request reprint Narrative review: aspirin resistance and its clinical implications
    Simon Sanderson
    University of Cambridge, Addenbrooke s Hospital, and Institute of Public Health, Cambridge, United Kingdom
    Ann Intern Med 142:370-80. 2005
    ..These challenges must be met before researchers conduct studies to assess the clinical utility of testing on patient outcomes and cost-effective prescribing...
  35. ncbi request reprint Factor V Cambridge: a new mutation (Arg306-->Thr) associated with resistance to activated protein C
    D Williamson
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Blood 91:1140-4. 1998
    ..It also supports the concept that APC resistance and venous thrombosis can result from a variety of genetic mutations affecting critical sites in the factor V cofactor...
  36. ncbi request reprint A comparison of the efficacy and rate of response to oral and intravenous Vitamin K in reversal of over-anticoagulation with warfarin
    H G Watson
    Department of Haematology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Br J Haematol 115:145-9. 2001
    ..Satisfactory, but slower, reversal of anticoagulation can be effected using oral Vitamin K, but there may be differences in efficacy between the products tested in our study...
  37. ncbi request reprint Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism
    Madeleine Verhovsek
    McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 149:481-90, W94. 2008
    ..Methods for predicting risk for recurrence may identify low-risk patients who are less likely to benefit from prolonged anticoagulation...
  38. ncbi request reprint Is smoking a risk factor for venous thromboembolism?
    Trevor Baglin
    Thromb Haemost 88:881-2. 2002