Jane Achan

Summary

Country: UK

Publications

  1. pmc Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
    Jane Achan
    Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
    BMJ 339:b2763. 2009
  2. pmc Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children
    Jane Achan
    Department of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    N Engl J Med 367:2110-8. 2012
  3. pmc Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance
    Anne F Gasasira
    School of Medicine, Makerere University Kampala, Uganda
    Malar J 9:177. 2010
  4. pmc Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda
    Patrick M Newman
    School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
    Malar J 8:254. 2009
  5. pmc Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
    Jane Achan
    Department of Pediatrics and Child Health, Makerere University College of Health Sciences, P O Box 7475, Kampala, Uganda
    Malar J 10:144. 2011
  6. pmc Case management of severe malaria--a forgotten practice: experiences from health facilities in Uganda
    Jane Achan
    Department of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 6:e17053. 2011
  7. pmc Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies
    Gloria Ikilezi
    Infectious Diseases Research Collaboration, Kampala, Uganda
    Am J Trop Med Hyg 88:744-6. 2013
  8. doi request reprint High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda
    Anne F Gasasira
    Department of Internal Medicine, Makerere University, Mulago Hospital, Kampala, Uganda
    Clin Infect Dis 46:985-91. 2008
  9. pmc Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy
    Theodore D Ruel
    Department of Pediatrics, University of California, San Francisco, CA Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, University of California, San Francisco, San Francisco, CA and Departments of Medicine Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    J Acquir Immune Defic Syndr 65:535-41. 2014
  10. doi request reprint Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial
    Moses R Kamya
    aDepartment of Medicine, Makerere University College of Health Sciences bInfectious Diseases Research Collaboration, Kampala, Uganda cDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA dDepartment of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda
    AIDS 28:2701-9. 2014

Collaborators

Detail Information

Publications22

  1. pmc Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
    Jane Achan
    Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
    BMJ 339:b2763. 2009
    ..To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children...
  2. pmc Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children
    Jane Achan
    Department of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    N Engl J Med 367:2110-8. 2012
    ....
  3. pmc Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance
    Anne F Gasasira
    School of Medicine, Makerere University Kampala, Uganda
    Malar J 9:177. 2010
    ..This study assessed the incidence of falciparum malaria and the prevalence of resistance-conferring Plasmodium falciparum mutations in HIV-infected children receiving daily TS and HIV-uninfected children not taking TS...
  4. pmc Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda
    Patrick M Newman
    School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
    Malar J 8:254. 2009
    ..TS decreases the risk of malaria in HIV-infected adults and children but has not been evaluated among pregnant women...
  5. pmc Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
    Jane Achan
    Department of Pediatrics and Child Health, Makerere University College of Health Sciences, P O Box 7475, Kampala, Uganda
    Malar J 10:144. 2011
    ..In HIV and TB infected populations, concerns about potential interactions between quinine and antiretroviral and anti-tuberculosis drugs exist, and these will need further research and pharmacovigilance...
  6. pmc Case management of severe malaria--a forgotten practice: experiences from health facilities in Uganda
    Jane Achan
    Department of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 6:e17053. 2011
    ..There is paucity of published information on current practices of severe malaria case management in sub-Saharan Africa; we evaluated the management practices for severe malaria in Ugandan health facilities..
  7. pmc Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies
    Gloria Ikilezi
    Infectious Diseases Research Collaboration, Kampala, Uganda
    Am J Trop Med Hyg 88:744-6. 2013
    ..4% versus 6.5%, P = 0.04). Thus, in addition to decreasing the incidence of malaria, the use of PI-based ART may lower transmission, as a result of a decrease in gametocytemia, in areas of high malaria transmission intensity...
  8. doi request reprint High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda
    Anne F Gasasira
    Department of Internal Medicine, Makerere University, Mulago Hospital, Kampala, Uganda
    Clin Infect Dis 46:985-91. 2008
    ..Artemisinin-based combination therapies are rapidly being adopted for the treatment of malaria in Africa; however, there are limited data on their safety and efficacy among human immunodeficiency virus (HIV)-infected populations...
  9. pmc Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy
    Theodore D Ruel
    Department of Pediatrics, University of California, San Francisco, CA Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, University of California, San Francisco, San Francisco, CA and Departments of Medicine Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    J Acquir Immune Defic Syndr 65:535-41. 2014
    ..Here we present the results of the noninferiority analysis of virologic efficacy and comparison of immunologic outcomes...
  10. doi request reprint Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial
    Moses R Kamya
    aDepartment of Medicine, Makerere University College of Health Sciences bInfectious Diseases Research Collaboration, Kampala, Uganda cDepartment of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA dDepartment of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda
    AIDS 28:2701-9. 2014
    ..Extending prophylaxis with a focus on preventing malaria may be beneficial in high transmission areas. We investigated three regimens for the prevention of malaria in young HIV-exposed children...
  11. pmc Parasite-based malaria diagnosis: are health systems in Uganda equipped enough to implement the policy?
    Daniel J Kyabayinze
    Malaria Consortium, Upper Naguru East Road, P, O, Box 8045, Kampala, Uganda
    BMC Public Health 12:695. 2012
    ..Effective coverage of parasite-based malaria diagnosis (PMD) remains limited in malaria endemic countries. This study assessed the health system's capacity to absorb PMD at primary health care facilities in Uganda...
  12. pmc Efficacy of quinine, artemether-lumefantrine and dihydroartemisinin-piperaquine as rescue treatment for uncomplicated malaria in Ugandan children
    Adoke Yeka
    Uganda Malaria Surveillance Project, Kampala, Uganda
    PLoS ONE 8:e53772. 2013
    ..Moreover, such practice goes against the World Health Organisation (WHO) recommendation to use combination therapy for uncomplicated malaria...
  13. pmc Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts
    Adoke Yeka
    Infectious Diseases Research Collaboration, Kampala, Uganda
    Acta Trop 121:184-95. 2012
    ..Despite these challenges, prospects for the control of malaria have improved, and with attention to underlying challenges, progress toward the control of malaria in Uganda can be expected...
  14. doi request reprint Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy?
    Adoke Yeka
    Uganda Malaria Surveillance Project, Kampala, Uganda
    Lancet Infect Dis 9:448-52. 2009
    ....
  15. doi request reprint Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women
    Deborah Cohan
    aDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA bMakerere University University of California, San Francisco Research Collaboration, Kampala, Uganda cHIV AIDS Division, San Francisco General Hospital dCenter for AIDS Prevention Studies, University of California, San Francisco, San Francisco, California eDepartment of Obstetrics and Gynecology, New York University, New York, USA fMedical Research Council Unit, The Gambia gDepartment of Pediatrics, University of California, San Francisco, San Francisco, California, USA hDepartment of Medicine, Makerere University College of Health Sciences, Kampala, Uganda
    AIDS 29:183-91. 2015
    ..We compared the efficacy and safety of an efavirenz versus lopinavir/ritonavir regimen for HIV-infected pregnant women initiating ART in rural Uganda...
  16. ncbi request reprint Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children
    Moses R Kamya
    Makerere University Medical School, Kampala, Uganda
    AIDS 21:2059-66. 2007
    ..The efficacy of TMP/SMX may be diminished where antifolate resistance to malaria is high. We evaluated the efficacy of these interventions for malaria prevention among Ugandan children...
  17. doi request reprint Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens
    James Kapisi
    Infectious Diseases Research Collaboration, Mulago Hospital Complex, PO Box 7475, Kampala, Uganda
    Malar J 14:53. 2015
    ..Chemoprevention has the potential of reducing the malaria burden; however, limited data exist on the efficacy and safety of anti-malarial therapy in the setting of chemoprevention...
  18. ncbi request reprint Profile of T cell immune responses in HIV-infected children from Uganda
    Isaac Ssewanyana
    Joint Clinical Research Centre, Kampala, Uganda
    J Infect Dis 196:1667-70. 2007
    ..Understanding the balance between immune activation and T cell immunity in HIV-infected children may provide further insights into the mechanisms leading to effective immune control...
  19. doi request reprint Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir- or efavirenz-based antiretroviral therapy
    Catherine A Koss
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA Makerere University University of California, San Francisco Research Collaboration, Kampala, Uganda Center for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, San Francisco, CA Department of Obstetrics and Gynecology, New York University, New York, NY Medical Research Council Unit, The Gambia Division of Infectious Diseases, Department of Pediatrics, University of California, San Francisco, San Francisco, CA Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda and Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA
    J Acquir Immune Defic Syndr 67:128-35. 2014
    ..Protease inhibitor-based antiretroviral therapy (ART) has been associated with preterm birth in some studies. We examined risk factors for preterm birth among women randomized to lopinavir/ritonavir (LPV/r)- or efavirenz (EFV)-based ART...
  20. ncbi request reprint Rectal versus intravenous quinine for the treatment of childhood cerebral malaria in Kampala, Uganda: a randomized, double-blind clinical trial
    Jane Achan
    Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda
    Clin Infect Dis 45:1446-52. 2007
    ..We compared the efficacy and safety of intrarectal quinine with those of intravenous quinine in the treatment of childhood cerebral malaria...
  21. pmc Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young ugandan children: a randomized controlled trial
    Victor Bigira
    Infectious Diseases Research Collaboration, Kampala, Uganda
    PLoS Med 11:e1001689. 2014
    ..To compare three available regimens, we conducted an open-label randomized controlled trial of chemoprevention in Ugandan children...
  22. doi request reprint The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda
    Imke H Bartelink
    From the Department of Clinical Pharmacy, Bioengineering and Therapeutic Sciences, Medicine, and Pediatrics, and Center for AIDS Prevention Studies of the University of California, San Francisco, CA Department of Pediatric Immunology and Infectious Diseases, Emma Children s Hospital AMC, The Netherlands University of California San Diego, La Jolla, CA Department of Pharmacology, Hopital Europeen Georges Pompidou, Paris Descartes, France Division of Nutritional Sciences, Cornell University, Ithaca, NY and Departments of Pediatrics and Child Health, and Medicine, Makerere University, Kampala, Uganda
    Pediatr Infect Dis J 34:e63-70. 2015
    ..The authors therefore evaluated the PK of nevirapine (NVP), efavirenz (EFV) and lopinavir (LPV) in associations with nutritional status in a cohort of HIV-infected Ugandan children...