Research Topics
| J ToddSummaryAffiliation: MRC/UVRI Uganda Research Unit on AIDS Country: Uganda Publications
| Collaborators
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Detail Information
Publications
Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, UgandaAndrew M Abaasa
Clinical Epidemiology Unit, Makerere University, Kampala, Uganda
BMC Health Serv Res 8:241. 2008..We therefore conducted a study to assess the effect of adherence to HAART on survival in The AIDS Support Organization (TASO) community HAART programme in Kampala, Uganda...- Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 countPaul Kelly
Tropical Gastroenterology and Nutrition Group, Department of Medicine, University of Zambia School of Medicine, Lusaka, Zambia
BMC Gastroenterol 9:7. 2009..We measured the incidence and seasonality of intestinal infection and diarrhoea, aggregation of disease in susceptible individuals, clustering by co-habitation and genetic relatedness, and the disease-to-infection ratio... - Reported number of sexual partners: comparison of data from four African longitudinal studiesJ Todd
Medical Research Council Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda
Sex Transm Infect 85:i72-80. 2009..To compare reported numbers of sexual partners in Eastern and Southern Africa... 
Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapyJim Todd
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
AIDS 21:S55-63. 2007..To estimate survival patterns after HIV infection in adults in low and middle-income countries...- Evolution of drug resistance during 48 weeks of zidovudine/lamivudine/tenofovir in the absence of real-time viral load monitoringFred Lyagoba
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
J Acquir Immune Defic Syndr 55:277-83. 2010..To describe the resistance mutations selected by a first-line regimen of zidovudine/lamivudine/tenofovir in the absence of real-time viral load monitoring... - Nevirapine/zidovudine/lamivudine has superior immunological and virological responses not reflected in clinical outcomes in a 48-week randomized comparison with abacavir/zidovudine/lamivudine in HIV-infected Ugandan adults with low CD4 cell countsP Munderi
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
HIV Med 11:334-44. 2010..Concerns exist about virological potency; efficacy has not been assessed in Africa... - Distribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DARTPaula Munderi
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
Trop Med Int Health 16:200-4. 2011..To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy of the DART trial and to compare HLA-B allele frequencies in those with and without clinically diagnosed hypersensitivity reaction (HSR)... - Septicaemia in a population-based HIV clinical cohort in rural Uganda, 1996-2007: incidence, aetiology, antimicrobial drug resistance and impact of antiretroviral therapyB N Mayanja
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
Trop Med Int Health 15:697-705. 2010..To describe the incidence and aetiology of septicaemia, and antimicrobial drug resistance in HIV-infected and uninfected individuals, and the impact of antiretroviral therapy (ART) on septicaemia... - Viral rebound and emergence of drug resistance in the absence of viral load testing: a randomized comparison between zidovudine-lamivudine plus Nevirapine and zidovudine-lamivudine plus AbacavirNicaise Ndembi
Uganda Research Unit on AIDS, Medical Research Council MRC Uganda Virus Research Institute, Entebbe, Kampala, Uganda
J Infect Dis 201:106-13. 2010..We investigated virological response and the emergence of resistance in the Nevirapine or Abacavir (NORA) substudy of the Development of Antiretroviral Treatment in Africa (DART) trial... - Patterns of individual and population-level adherence to antiretroviral therapy and risk factors for poor adherence in the first year of the DART trial in Uganda and ZimbabweSylvia K Muyingo
MRC Uganda Research Unit on AIDS, Entebbe, Uganda
J Acquir Immune Defic Syndr 48:468-75. 2008..Good adherence is essential for successful antiretroviral therapy (ART) provision, but simple measures have rarely been validated in Africa... - Translating global health research aims into action: the example of the ALPHA networkD Maher
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
Trop Med Int Health 15:321-8. 2010.... 
HIV-1 disease progression and mortality before the introduction of highly active antiretroviral therapy in rural UgandaLieve Van der Paal
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
AIDS 21:S21-9. 2007..To provide estimates of survival and progression to different HIV disease endpoints after HIV infection among adults in a rural Ugandan setting...- Reduced morbidity and mortality in the first year after initiating highly active anti-retroviral therapy (HAART) among Ugandan adultsGeorge Miiro
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
Trop Med Int Health 14:556-63. 2009..To evaluate the effect of highly active anti-retroviral therapy (HAART) and cotrimoxazole prophylaxis on morbidity after HAART eligibility... - Nutritional status of children living in a community with high HIV prevalence in rural Uganda: a cross-sectional population-based surveyAgnes Nalwoga
MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
Trop Med Int Health 15:414-22. 2010..Children with a Z score of <-2 were defined as undernourished, with a Z score <-2 for weight for age defining underweight, for height for age defining stunting and for weight for height defining wasting... - Feasibility and effectiveness of cotrimoxazole prophylaxis for HIV-1-infected adults attending an HIV/AIDS clinic in UgandaChristine Watera
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
J Acquir Immune Defic Syndr 42:373-8. 2006..These results reinforce the need for large-scale provision of cotrimoxazole prophylaxis for all HIV-positive patients in developing countries... - Duration from seroconversion to eligibility for antiretroviral therapy and from ART eligibility to death in adult HIV-infected patients from low and middle-income countries: collaborative analysis of prospective studiesSimon Wandel
Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, CH 3012 Bern, Switzerland
Sex Transm Infect 84:i31-i36. 2008..Estimation of the number of people in need of antiretroviral therapy (ART) in resource-limited settings requires information on the time from seroconversion to ART eligibility and from ART eligibility to death... - Herpes simplex virus type 2 infection increases HIV incidence: a prospective study in rural TanzaniaMaría del Mar Pujades Rodríguez
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
AIDS 16:451-62. 2002..To quantify the association between prevalent or incident Herpes simplex virus type-2 (HSV2) infection and the incidence of HIV seroconversion among adults in the general population in rural Tanzania... - Effects of cotrimoxazole on hematologic parameters in HIV-infected adults in a community-based clinic in Entebbe, UgandaChristine Watera
J Acquir Immune Defic Syndr 46:369-71. 2007 - Age-specific mortality patterns in HIV-infected individuals: a comparative analysis of African community study dataBasia Zaba
London School of Hygiene and Tropical Medicine, London, UK
AIDS 21:S87-96. 2007..Describe age-specific mortality patterns of HIV-infected adults in African communities before introduction of HAART... - The effects of alternative study designs on the power of community randomized trials: evidence from three studies of human immunodeficiency virus prevention in East AfricaJim Todd
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Int J Epidemiol 32:755-62. 2003..In the design of community randomized trials (CRT), the power of the study is likely to be affected by two issues: the matching or stratification of communities, and the number and size of the communities to be randomized... - No differences in cellular immune responses between asymptomatic HIV type 1- and type 2-infected Gambian patientsAssan Jaye
Medical Research Council Laboratories, Banjul, The Gambia
J Infect Dis 189:498-505. 2004..Contrary to widely held views, our results suggest that nonprogression in HIV-2 infection may not be due to more vigorous immune responses... - Asking semi-literate adolescents about sexual behaviour: the validity of assisted self-completion questionnaire (ASCQ) data in rural TanzaniaMary L Plummer
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 9:737-54. 2004..To develop and test a sexual behaviour survey method for semi-literate populations, combining the privacy of a self-completion questionnaire (SCQ) with the clarity of a face-to-face questionnaire (FFQ)... - Active trachoma in children aged three to nine years in rural communities in Ethiopia: prevalence, indicators and risk factorsPhillippa Cumberland
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trans R Soc Trop Med Hyg 99:120-7. 2005..This study demonstrates the need for broad target interventions and a flexible approach to the prevention of trachoma in high prevalence endemic rural populations... - The MEMA kwa Vijana project: design of a community randomised trial of an innovative adolescent sexual health intervention in rural TanzaniaRichard J Hayes
London School of Hygiene and Tropical Medicine, London, UK
Contemp Clin Trials 26:430-42. 2005..This paper describes the rationale and design of a randomised trial of the impact of an innovative sexual health intervention among adolescents in rural Mwanza Region, Tanzania... - Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilisGabriele Riedner
London School of Hygiene and Tropical Medicine, London
N Engl J Med 353:1236-44. 2005..4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country... - Decline in sexually transmitted infection prevalence and HIV incidence in female barworkers attending prevention and care services in Mbeya Region, TanzaniaGabriele Riedner
London School of Hygiene and Tropical Medicine, London, UK
AIDS 20:609-15. 2006..To assess trends in sexually transmitted infection (STI) prevalence and HIV incidence and associated factors in a cohort of female barworkers exposed to behavioural interventions and STI screening and treatment... - From trial intervention to scale-up: costs of an adolescent sexual health program in Mwanza, TanzaniaFern Terris-Prestholt
London School of Hygiene and Tropical Medicine, London, UK
Sex Transm Dis 33:S133-9. 2006.... - Biological and behavioural impact of an adolescent sexual health intervention in Tanzania: a community-randomized trialDavid A Ross
London School of Hygiene and Tropical Medicine, London, UK
AIDS 21:1943-55. 2007..The impact of a multicomponent intervention programme on the sexual health of adolescents was assessed in rural Tanzania... - Estimating 'net' HIV-related mortality and the importance of background mortality ratesMilly Marston
London School of Hygiene and Tropical Medicine, London, UK
AIDS 21:S65-71. 2007..To estimate mortality directly attributable to HIV in HIV-infected adults in low and middle income countries and discuss appropriate methodology... - Micronutrient supplementation has limited effects on intestinal infectious disease and mortality in a Zambian population of mixed HIV status: a cluster randomized trialPaul Kelly
Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia
Am J Clin Nutr 88:1010-7. 2008..Diarrheal disease remains a major contributor to morbidity and mortality in Africa, but host defense against intestinal infection is poorly understood and may depend on nutritional status... - Elevated iron status strongly predicts mortality in West African adults with HIV infectionJoann M McDermid
Medical Research Council International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, England, WC1E 7HT
J Acquir Immune Defic Syndr 46:498-507. 2007..To comprehensively assess iron status and determine whether elevated iron status, like anemia, predicts mortality... - Estimating incidence from prevalence in generalised HIV epidemics: methods and validationTimothy B Hallett
Imperial College London, London, United Kingdom
PLoS Med 5:e80. 2008..Repeated cross-sectional measures of HIV prevalence are now becoming available for general populations in many countries, and we aim to develop and validate methods that use these data to estimate HIV incidence... - Circumcision among adolescent boys in rural northwestern TanzaniaHelen A Weiss
Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 13:1054-61. 2008..Modelling the impact of circumcision on HIV transmission, and planning service expansion, relies on self-reported circumcision status. We investigated the validity of self-reported status... - The impact of community level treatment and preventative interventions on trachoma prevalence in rural EthiopiaPhillippa Cumberland
Centre of Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London WC1N 1EH, UK
Int J Epidemiol 37:549-58. 2008..In 2005, eye swabs were taken for Polymerase Chain Reaction (PCR) detection of ocular C. trachomatis DNA. Adult knowledge and behaviour related to trachoma were assessed... - Risk factors for active trachoma and Chlamydia trachomatis infection in rural Ethiopia after mass treatment with azithromycinTansy Edwards
London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 13:556-65. 2008..To investigate risk factors for ocular Chlamydia trachomatis infection and active trachoma, comparing communities receiving or not receiving an intervention programme of community-wide azithromycin treatment and health education...