Moses Kamya

Summary

Affiliation: Ministry of Health
Country: Uganda

Publications

  1. pmc Anti-malarial prescription practices among outpatients with laboratory-confirmed malaria in the setting of a health facility-based sentinel site surveillance system in Uganda
    David Sears
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94143, USA
    Malar J 12:252. 2013
  2. pmc Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
    Prasanna Jagannathan
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Malar J 11:435. 2012
  3. pmc Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey
    Beth Osterbauer
    Department of Medicine, University of California, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, Room 3420, San Francisco, CA 94110, USA
    Malar J 11:432. 2012
  4. pmc Health facility-based malaria surveillance: the effects of age, area of residence and diagnostics on test positivity rates
    Damon Francis
    Department of Medicine, University of California, San Francisco General Hospital, 1001 Potrero Ave, Bldg, 30, RM, 408, San Francisco, CA 94110, USA
    Malar J 11:229. 2012
  5. pmc Fertility and contraceptive decision-making and support for HIV infected individuals: client and provider experiences and perceptions at two HIV clinics in Uganda
    Rhoda K Wanyenze
    Makerere University School of Public Health, Kampala, Uganda
    BMC Public Health 13:98. 2013
  6. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
  7. pmc Impaired T-cell proliferation among HAART-treated adults with suboptimal CD4 recovery in an African cohort
    Damalie Nakanjako
    Makerere University College of Health Sciences, Kampala, Uganda
    BMC Immunol 14:26. 2013
  8. pmc The association between malnutrition and the incidence of malaria among young HIV-infected and -uninfected Ugandan children: a prospective study
    Emmanuel Arinaitwe
    Makerere University University of California, San Francisco Research Collaboration, Mulago Hospital Complex, PO Box 7475, Kampala, Uganda
    Malar J 11:90. 2012
  9. pmc Prevalence and factors associated with cryptococcal antigenemia among severely immunosuppressed HIV-infected adults in Uganda: a cross-sectional study
    Jacinta Oyella
    Makerere University College of Health Sciences New Mulago Hospital Complex, Mulago Hill Road, Kampala, Uganda
    J Int AIDS Soc 15:15. 2012
  10. pmc Potential for false positive HIV test results with the serial rapid HIV testing algorithm
    Steven Baveewo
    Department of Medicine, Makerere University School of Medicine, Kampala, Uganda
    BMC Res Notes 5:154. 2012

Research Grants

  1. Uganda Malaria COHRE Training Program
    Moses Kamya; Fiscal Year: 2009

Detail Information

Publications84

  1. pmc Anti-malarial prescription practices among outpatients with laboratory-confirmed malaria in the setting of a health facility-based sentinel site surveillance system in Uganda
    David Sears
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94143, USA
    Malar J 12:252. 2013
    ..The World Health Organization now recommends limiting anti-malarial treatment to those with a positive malaria test result. Limited data exist on how these policies have affected ACT prescription practices...
  2. pmc Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
    Prasanna Jagannathan
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Malar J 11:435. 2012
    ..The burden of malaria has decreased in parts of Africa following the scaling up of control interventions. However, similar data are limited from high transmission settings...
  3. pmc Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey
    Beth Osterbauer
    Department of Medicine, University of California, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, Room 3420, San Francisco, CA 94110, USA
    Malar J 11:432. 2012
    ..The interplay between these conditions is complex and limited data exist on factors associated with these conditions among infants born to HIV-uninfected and infected women...
  4. pmc Health facility-based malaria surveillance: the effects of age, area of residence and diagnostics on test positivity rates
    Damon Francis
    Department of Medicine, University of California, San Francisco General Hospital, 1001 Potrero Ave, Bldg, 30, RM, 408, San Francisco, CA 94110, USA
    Malar J 11:229. 2012
    ..This study examines the effects of age, area of residence and diagnostic test on TPR at two health facilities in regions of Uganda with differing malaria endemicity...
  5. pmc Fertility and contraceptive decision-making and support for HIV infected individuals: client and provider experiences and perceptions at two HIV clinics in Uganda
    Rhoda K Wanyenze
    Makerere University School of Public Health, Kampala, Uganda
    BMC Public Health 13:98. 2013
    ..This study explored decisions to have or not to have children and contraceptive preferences among PLHIV at two clinics in Uganda...
  6. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
    ..We compared the genotypic resistance patterns between clients with VLM versus immunological monitoring (IM)...
  7. pmc Impaired T-cell proliferation among HAART-treated adults with suboptimal CD4 recovery in an African cohort
    Damalie Nakanjako
    Makerere University College of Health Sciences, Kampala, Uganda
    BMC Immunol 14:26. 2013
    ..However, a subset of individuals exhibit very poor CD4 T-cell recovery despite effective control of HIV-RNA viraemia. We evaluated CD4 T-cell proliferation among suboptimal responders and its correlation with CD4 T-cell activation...
  8. pmc The association between malnutrition and the incidence of malaria among young HIV-infected and -uninfected Ugandan children: a prospective study
    Emmanuel Arinaitwe
    Makerere University University of California, San Francisco Research Collaboration, Mulago Hospital Complex, PO Box 7475, Kampala, Uganda
    Malar J 11:90. 2012
    ..In addition, data are limited on the potential interaction between HIV infection and the association between malnutrition and the risk of malaria...
  9. pmc Prevalence and factors associated with cryptococcal antigenemia among severely immunosuppressed HIV-infected adults in Uganda: a cross-sectional study
    Jacinta Oyella
    Makerere University College of Health Sciences New Mulago Hospital Complex, Mulago Hill Road, Kampala, Uganda
    J Int AIDS Soc 15:15. 2012
    ..Factors associated with cryptococcal antigenemia may be used subsequently in resource-limited settings in screening for cryptococcal infection, and this data may also inform policy for HIV care...
  10. pmc Potential for false positive HIV test results with the serial rapid HIV testing algorithm
    Steven Baveewo
    Department of Medicine, Makerere University School of Medicine, Kampala, Uganda
    BMC Res Notes 5:154. 2012
    ..We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation...
  11. pmc Low prevalence of Plasmodium falciparum antigenaemia among asymptomatic HAART-treated adults in an urban cohort in Uganda
    Damalie Nakanjako
    Department of Medicine, Makerere University School of Medicine, Kampala, Uganda
    Malar J 10:66. 2011
    ..There is need to evaluate the use of RDTs among highly active anti-retroviral therapy (HAART)-treated people living with HIV (PLHIV)...
  12. pmc Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children
    Shereen Katrak
    Oregon Health and Science University, Portland, USA
    Malar J 8:272. 2009
    ..However, there is limited data on the safety and tolerability of these drugs, especially in young children and patients co-infected with HIV...
  13. pmc Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance
    Anne F Gasasira
    School of Medicine, Makerere University Kampala, Uganda
    Malar J 9:177. 2010
    ..This study assessed the incidence of falciparum malaria and the prevalence of resistance-conferring Plasmodium falciparum mutations in HIV-infected children receiving daily TS and HIV-uninfected children not taking TS...
  14. pmc Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children
    Catherine Maiteki-Sebuguzi
    Department of Medicine, Makerere University, Kampala, Uganda
    Malar J 7:106. 2008
    ..This study compared the safety and tolerability of three combination antimalarial regimens in a cohort of Ugandan children...
  15. pmc Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children
    Trevor P Jensen
    Department of Medicine, University of California, San Francisco, USA
    Malar J 8:213. 2009
    ..Yet measurement of incidence is challenging. The slide positivity rate (SPR) has been used as a surrogate measure of malaria incidence, but limited data exist on the relationship between SPR and the incidence of malaria...
  16. pmc Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children
    Denise Njama-Meya
    Makerere University Medical School, Kampala, Uganda
    Malar J 6:7. 2007
    ..However, with the introduction of new artemisinin-based combination therapy (ACT), presumptive treatment becomes economically and clinically less acceptable...
  17. pmc Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda
    Sarah G Staedke
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:107. 2008
    ..Here the reporting system is described, and difficulties faced in analysing and interpreting the safety results are illustrated, using data from the trials...
  18. pmc Mentorship needs at academic institutions in resource-limited settings: a survey at Makerere University College of Health Sciences
    Damalie Nakanjako
    Department of Medicine, Makerere University College of Health Sciences, P, O, Box 7072, Kampala, Uganda
    BMC Med Educ 11:53. 2011
    ..However, mentoring efforts are challenged by the high clinical, research and administrative demands. We evaluated the status and nature of mentoring practices at Makerere University College of Health Sciences (MAKCHS)...
  19. pmc High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort
    Damalie Nakanjako
    Department of Medicine, Makerere University School of Medicine, Kampala, Uganda
    BMC Infect Dis 11:43. 2011
    ..The levels of T-cell immune activation and exhaustion after long-term, suppressive ART and their correlation with CD4 T-cell count reconstitution among ART-treated patients in African cohorts have not been extensively evaluated...
  20. ncbi request reprint Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study
    Moses R Kamya
    Department of Medicine, Makerere University Medical School, Kampala, Uganda
    J Infect Dis 193:9-15. 2006
    ..We investigated the seroprevalence rate of HIV-1 infection and its effect on antimalarial treatment outcomes in adults and children with uncomplicated falciparum malaria in Uganda...
  21. ncbi request reprint Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children
    Moses R Kamya
    Makerere University Medical School, Kampala, Uganda
    AIDS 21:2059-66. 2007
    ..The efficacy of TMP/SMX may be diminished where antifolate resistance to malaria is high. We evaluated the efficacy of these interventions for malaria prevention among Ugandan children...
  22. ncbi request reprint Predictors of long-term viral failure among ugandan children and adults treated with antiretroviral therapy
    Moses R Kamya
    Department of Medicine, Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 46:187-93. 2007
    ..We identified predictors of viral failure and documented genotypic mutations in a subset of patients with viral failure after 12 months on antiretroviral therapy (ART)...
  23. pmc Total lymphocyte count of 1200 is not a sensitive predictor of CD4 lymphocyte count among patients with HIV disease in Kampala, Uganda
    Moses R Kamya
    Makerere University Medical School, Kampala, Uganda
    Afr Health Sci 4:94-101. 2004
    ..Access to HAART is expanding in Kampala, Uganda, yet there are no published data evaluating the utility of TLC as inexpensive surrogate marker of CD4 cell count to help guide therapeutic decisions...
  24. pmc Evaluation of the efficiency of patient flow at three HIV clinics in Uganda
    Rhoda K Wanyenze
    Makerere University School of Public Health, Kampala, Uganda
    AIDS Patient Care STDS 24:441-6. 2010
    ..Task-shifting may not be efficient in terms of time. More-effective triage and longer visit intervals could improve patient flow and capacity for cost-effective scale-up...
  25. pmc Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy
    Theodore D Ruel
    Department of Pediatrics, University of California, San Francisco, CA Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, University of California, San Francisco, San Francisco, CA and Departments of Medicine Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
    J Acquir Immune Defic Syndr 65:535-41. 2014
    ..Here we present the results of the noninferiority analysis of virologic efficacy and comparison of immunologic outcomes...
  26. pmc The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda
    Isaac Ssewanyana
    Joint Clinical Research Centre, Kampala, Uganda
    AIDS Res Hum Retroviruses 25:65-71. 2009
    ..The mechanisms of immunopathogenesis in pediatric HIV infection likely involve distinct contributions from individual naive and memory T cells subsets...
  27. pmc Electronic medical records and same day patient tracing improves clinic efficiency and adherence to appointments in a community based HIV/AIDS care program, in Uganda
    Stella T Alamo
    Medical Department, Reach Out Mbuya HIV AIDS Initiative, Kampala, Uganda
    AIDS Behav 16:368-74. 2012
    ..8% The total median waiting time to see providers significantly decreased from 291 to 94 min. Our findings suggest that EMR and same day patient tracing can significantly reduce missed appointments, and LTFU and improve clinic efficiency...
  28. ncbi request reprint Can response of a pruritic papular eruption to antiretroviral therapy be used as a clinical parameter to monitor virological outcome?
    Barbara Castelnuovo
    Infectious Diseases Institute, Kampala, Uganda
    AIDS 22:269-73. 2008
    ..A pruritic papular eruption (PPE) is a common skin manifestation observed in 12-46% of persons with HIV infection living in tropical countries...
  29. ncbi request reprint HIV counseling and testing practices at an urban hospital in Kampala, Uganda
    Rhoda Wanyenze
    Makerere University Institute of Public Health, Kampala, Uganda
    AIDS Behav 10:361-7. 2006
    ..The findings indicate that hospitals are important venues for HIV counseling and testing...
  30. doi request reprint Cause-specific mortality and the contribution of immune reconstitution inflammatory syndrome in the first 3 years after antiretroviral therapy initiation in an urban African cohort
    Barbara Castelnuovo
    Infectious Diseases Institute, Kampala, Uganda
    Clin Infect Dis 49:965-72. 2009
    ....
  31. doi request reprint Three-year outcome data of second-line antiretroviral therapy in Ugandan adults: good virological response but high rate of toxicity
    Barbara Castelnuovo
    Infectious Diseases Institute, Kampala, Uganda
    J Int Assoc Physicians AIDS Care (Chic) 8:52-9. 2009
    ..To evaluate the safety and virological response to lopinavir/ritonavir containing second-line therapy after failing a first line nonnucleoside reverse transcriptase inhibitor (NNRTI) based regimen...
  32. doi request reprint High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda
    Anne F Gasasira
    Department of Internal Medicine, Makerere University, Mulago Hospital, Kampala, Uganda
    Clin Infect Dis 46:985-91. 2008
    ..Artemisinin-based combination therapies are rapidly being adopted for the treatment of malaria in Africa; however, there are limited data on their safety and efficacy among human immunodeficiency virus (HIV)-infected populations...
  33. pmc Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?
    Barbara Castelnuovo
    Infectious Diseases Institute, Kampala, Uganda
    Afr Health Sci 8:133-4. 2008
    ..In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative...
  34. ncbi request reprint Profile of T cell immune responses in HIV-infected children from Uganda
    Isaac Ssewanyana
    Joint Clinical Research Centre, Kampala, Uganda
    J Infect Dis 196:1667-70. 2007
    ..Understanding the balance between immune activation and T cell immunity in HIV-infected children may provide further insights into the mechanisms leading to effective immune control...
  35. ncbi request reprint Are the best antiretrovirals being used in Africa?
    Laurence John
    Infectious Disease Institute, Mulago Hospital Complex, Kampala, Uganda
    J HIV Ther 11:11-5. 2006
  36. ncbi request reprint Assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda
    Hasifa Bukirwa
    Uganda Malaria Surveillance Project, Kampala, Uganda
    Am J Trop Med Hyg 81:611-4. 2009
    ..001) years of age, but this effect waned over the subsequent 12 months. IRS was effective in reducing malaria morbidity, but this was not sustained beyond 1 year for the proportion of blood smears read as positive...
  37. pmc Long-lasting insecticide-treated bed net ownership and use among children under five years of age following a targeted distribution in central Uganda
    Humphrey Wanzira
    Infectious Diseases Research Collaboration, Kampala, Uganda
    Malar J 13:185. 2014
    ..This survey was conducted after the targeted distribution in central Uganda to assess progress in LLIN ownership and usage among children <five years...
  38. pmc Effect of HIV-1 infection on malaria treatment outcome in Ugandan patients
    Pauline Byakika-Kibwika
    Makerere University Medical School, Department of Medicine, Kampala, Uganda
    Afr Health Sci 7:86-92. 2007
    ..HIV-1 increases risk for malaria with the risk increasing as immunity declines. The effect of HIV-1 infection on antimalarial treatment outcome is still inconclusive...
  39. pmc Free antiretrovirals must not be restricted only to treatment-naive patients. Experience in Uganda suggests that restricting access is not the way forward
    Robert Colebunders
    Infectious Diseases Institute, Faculty of Medicine, Makerere University, Kampala, Uganda
    PLoS Med 2:e276. 2005
  40. ncbi request reprint First-line antiretroviral therapy in Africa--how evidence-base are our recommendations?
    Robert Colebunders
    The Infectious Disease Institute, Faculty of Medicine, Makerere University, Kampala, Uganda
    AIDS Rev 7:148-54. 2005
    ..Most importantly, more HIV clinical trials need to be conducted in Africa, and African cohorts of patients on antiretroviral therapy need to be established in order to develop recommendations that are evidence based...
  41. ncbi request reprint Acceptance of routine testing for HIV among adult patients at the medical emergency unit at a national referral hospital in Kampala, Uganda
    Damalie Nakanjako
    Department of Medicine, Makerere University Kampala, P O Box 25308, Kampala, Uganda
    AIDS Behav 11:753-8. 2007
    ..We recommend adoption of RTC as standard of care in the medical emergency unit in order to scale HIV diagnosis and linkage to HIV/AIDS care...
  42. pmc Health-seeking behavior for malaria among child and adult headed households in Rakai district, Uganda
    Beatrice Amuge
    Makerere University, Faculty of Medicine, Ministry of Health, Uganda
    Afr Health Sci 4:119-24. 2004
    ..These children are likely to be faced with several health problems and have to take crucial life decisions without parental/adult guidance...
  43. pmc Client and provider perspectives of the efficiency and quality of care in the context of rapid scale-up of antiretroviral therapy
    Gideon Amanyire
    Makerere University Faculty of Medicine, Kampala, Uganda
    AIDS Patient Care STDS 24:719-27. 2010
    ..These findings highlight the need to address clinic efficiency as well as support for providers in the context of rapid scale-up...
  44. pmc Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda
    Adoke Yeka
    Ministry of Health, Kampala, Uganda
    PLoS Med 2:e190. 2005
    ..We compared artemisinin-based and other combination therapies in four districts in Uganda with varying transmission intensity...
  45. pmc Worsening and unmasking of tuberculosis in HIV-1 infected patients after initiating highly active anti-retroviral therapy in Uganda
    Joshua Baalwa
    Makerere University, Infectious Diseases Institute, Kampala, Uganda
    Afr Health Sci 8:190-5. 2008
    ..To determine the proportion of patients developing active tuberculosis (TB) versus that of patients who experience worsening of TB, after initiating highly active anti retroviral therapy (HAART)...
  46. ncbi request reprint Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda
    Anne F Gasasira
    Makerere University Medical School, Kampala, Uganda
    Am J Trop Med Hyg 68:127-32. 2003
    ..SP/AQ was the most efficacious. This low-cost combination regimen may provide an optimal alternative to CQ for the treatment of uncomplicated malaria in Uganda...
  47. ncbi request reprint Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda
    Nathan Bakyaita
    Ministry of Health, Kampala, Uganda
    Am J Trop Med Hyg 72:573-80. 2005
    ..Amodiaquine plus sulfadoxine-pyrimethamine was significantly more efficacious; however, existing levels of resistance raises concern about the useful therapeutic life-span of this regimen...
  48. pmc Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
    Adoke Yeka
    Uganda Malaria Surveillance Project, Kampala, Uganda
    PLoS ONE 3:e2390. 2008
    ..We compared the efficacy and safety of AL with DP in Kanungu, an area of moderate malaria transmission...
  49. ncbi request reprint Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda
    Jane Wanyama
    Infectious Disease Institute, Kampala, Uganda
    AIDS 21:1486-7. 2007
    ....
  50. pmc The effect of indoor residual spraying on malaria and anemia in a high-transmission area of northern Uganda
    Laura C Steinhardt
    Malaria Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Trop Med Hyg 88:855-61. 2013
    ..001). Carefully managed IRS can significantly reduce malaria burden in high-transmission settings...
  51. ncbi request reprint Strategies to optimize HIV treatment outcomes in resource-limited settings
    Damalie Nakanjako
    Faculty of Medicine, Department of Internal Medicine, Makerere University, Kampala, Uganda
    AIDS Rev 11:179-89. 2009
    ....
  52. ncbi request reprint Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria
    Daniel Kyabayinze
    Department of Biochemistry, Makerere University Medical School, Kampala, Uganda
    Am J Trop Med Hyg 69:247-52. 2003
    ..7, P = 0.009). These results support a previously proposed method of predicting clinical outcomes based on the prevalence of these two mutations...
  53. pmc Evaluation of Dynabeads and Cytospheres compared with flow cytometry to enumerate CD4+ T cells in HIV-infected Ugandans on antiretroviral therapy
    Fred Lutwama
    Academic Alliance for AIDS Care and Prevention and the Infectious Diseases Institute, Kampala, Uganda
    J Acquir Immune Defic Syndr 48:297-303. 2008
    ..The World Health Organization 2006 guidelines support the use of CD4 lymphocyte count (CD4) to define treatment failure in resource-limited settings...
  54. pmc Cost-effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ cell count < or = 100 cells/microL who start HIV therapy in resource-limited settings
    David B Meya
    Infectious Disease Institute, Makerere University, Mulago Hospital Complex, Kampala, Uganda
    Clin Infect Dis 51:448-55. 2010
    ..We sought to define the cost-effectiveness of serum cryptococcal antigen (CRAG) screening to identify persons with subclinical cryptococcosis and the efficacy of preemptive fluconazole therapy...
  55. ncbi request reprint Urban malaria: primary caregivers' knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children
    Denise Njama
    Makerere University Medical School, Kampala, Uganda
    Trop Med Int Health 8:685-92. 2003
    ....
  56. pmc False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria
    Anne F Gasasira
    Department of Medicine, Makerere University Medical School, Kampala, Uganda
    J Clin Microbiol 44:3021-4. 2006
    ..We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory...
  57. ncbi request reprint Asymptomatic parasitaemia as a risk factor for symptomatic malaria in a cohort of Ugandan children
    Denise Njama-Meya
    Department of Medicine, Makerere University Medical School, Kampala, Uganda
    Trop Med Int Health 9:862-8. 2004
    ..To assess the prevalence of asymptomatic parasitaemia, determine its association with symptomatic malaria, and identify independent predictors of asymptomatic parasitaemia in a cohort of children from Kampala, Uganda...
  58. pmc Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
    Jane Achan
    Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
    BMJ 339:b2763. 2009
    ..To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children...
  59. doi request reprint Provider-initiated HIV testing for paediatric inpatients and their caretakers is feasible and acceptable
    Rhoda K Wanyenze
    Makerere University School of Public Health, Kampala, Uganda
    Trop Med Int Health 15:113-9. 2010
    ..We introduced HIV Counselling and Testing (HCT) for hospitalised children and their caretakers in Mulago teaching hospital in Uganda to assess its feasibility...
  60. ncbi request reprint Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children
    Sammuel L Nsobya
    Makerere University Medical School, Kampala, Uganda
    J Infect Dis 189:2220-6. 2004
    ..Asymptomatic parasitemia detected by microscopy, but not by PCR, strongly predicted subsequent clinical malaria, often due to persistent infection...
  61. ncbi request reprint Increasing condom use without reducing HIV risk: results of a controlled community trial in Uganda
    Phoebe Kajubi
    Child Health and Development Centre, Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 40:77-82. 2005
    ..We assess the change in condom uptake and number of sex partners after a condom promotion trial in Kampala, Uganda...
  62. pmc Burden of tuberculosis in Kampala, Uganda
    David Guwatudde
    Institute of Public Health, Makerere University, Kampala, Uganda
    Bull World Health Organ 81:799-805. 2003
    ..To determine the prevalence and incidence of tuberculosis in one of Uganda's poor peri-urban areas...
  63. pmc Acceptability of routine HIV counselling and testing, and HIV seroprevalence in Ugandan hospitals
    Rhoda K Wanyenze
    Mulago Mbarara Teaching Hospitals Joint AIDS Program, Kampala, Uganda
    Bull World Health Organ 86:302-9. 2008
    ..All patients in participating units who had not previously tested HIV-positive were offered HIV testing. Family members of patients seen at the hospitals were also offered testing...
  64. ncbi request reprint Traditional healers for HIV/AIDS prevention and family planning, Kiboga District, Uganda: evaluation of a program to improve practices
    Agnes Ssali
    Traditional and Modern Health Practitioners Together against AIDS THETA, Kampala, Uganda
    AIDS Behav 9:485-93. 2005
    ..Findings provide evidence that traditional healers in a rural area of Uganda can successfully adapt HIV prevention messages and family planning information into their clinical practices...
  65. ncbi request reprint Measuring the outcomes of a comprehensive HIV care course: pilot test at the Infectious Diseases Institute, Kampala, Uganda
    Marcia R Weaver
    Department of Health Services and International Training and Education Center on HIV, I TECH, University of Washington, Seattle, 98104, USA
    J Acquir Immune Defic Syndr 43:293-303. 2006
    ..Institute's 4-week course for African doctors on comprehensive management of HIV including antiretroviral therapy on four outcomes: (1) clinical skills, (2) clinical activities, (3) monitoring of HIV patients, and (4) training activities..
  66. ncbi request reprint Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children
    Sarah G Staedke
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
    Am J Trop Med Hyg 69:244-6. 2003
    ..6-6.9, P < 0.001) between residence within a swamp and >100 meters from a swamp. In this urban setting, incidence of clinical episodes of malaria was strongly associated with proximity of residence to potential mosquito breeding sites...
  67. ncbi request reprint Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria
    Grant Dorsey
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94143, USA
    J Infect Dis 188:1231-8. 2003
    ..Our results suggest that the use of combination antimalarial therapy in Africa may slow the spread of drug-resistant malaria and prolong the therapeutic life span of available treatment regimens...
  68. ncbi request reprint Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda
    Alissa Myrick
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    Am J Trop Med Hyg 74:758-61. 2006
    ..These results highlight the complexity of malaria in Africa and have implications for efficacy trials, because missing late reappearances of strains could lead to misclassification of outcomes...
  69. ncbi request reprint Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial
    Sarah G Staedke
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
    Lancet 364:1950-7. 2004
    ..We compared chloroquine+sulfadoxine-pyrimethamine, amodiaquine+sulfadoxine-pyrimethamine, and amodiaquine+artesunate for treatment of uncomplicated malaria in Kampala, Uganda...
  70. ncbi request reprint Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial
    Grant Dorsey
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
    JAMA 297:2210-9. 2007
    ..Combination therapy is now widely advocated as first-line treatment for uncomplicated malaria in Africa. However, it is not clear which treatment regimens are optimal or how to best assess comparative efficacies in highly endemic areas...
  71. ncbi request reprint Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda
    Grant Dorsey
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
    Am J Trop Med Hyg 71:758-63. 2004
    ..The dhps Glu-540 mutation played a principal role and the dhfr Arg-59 mutation a secondary role in mediating resistance to SP alone and in combination...
  72. doi request reprint Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda
    Tamara D Clark
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Infect Dis 198:393-400. 2008
    ..Malaria risk may be heterogeneous in urban areas of Africa. Identifying those at highest risk for malaria may lead to more targeted approaches to malaria control...
  73. ncbi request reprint Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial
    Grant Dorsey
    Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
    Lancet 360:2031-8. 2002
    ..We aimed to compare the short-term and long-term effectiveness of three antimalarial regimens in children from Kampala, Uganda...
  74. ncbi request reprint Response to antiretroviral therapy in HIV-infected patients attending a public, urban clinic in Kampala, Uganda
    Lisa A Spacek
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Infect Dis 42:252-9. 2006
    ..We evaluated clinical, behavioral, and demographic risk factors associated with virologic suppression in a public, urban clinic in Kampala, Uganda...
  75. ncbi request reprint HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda
    Lisa M Bebell
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Acquir Immune Defic Syndr 46:624-30. 2007
    ..In children, the relationship between HIV and malaria is less clear. We investigated the relationship between malaria and HIV-1 infection among adults and children referred for malaria blood smears at government health clinics in Uganda...
  76. ncbi request reprint Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance
    Damon Francis
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
    J Infect Dis 193:978-86. 2006
    ..We tested the hypothesis that geographic differences in the response to therapy could be explained by differences in the prevalence of known molecular markers of drug resistance...
  77. ncbi request reprint Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy
    Madeline Slater
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
    Am J Trop Med Hyg 73:256-62. 2005
    ..The method used to classify treatment outcomes can have a major impact on estimates of drug efficacy, especially in areas of high transmission intensity...
  78. ncbi request reprint Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda
    Heidi Hopkins
    University of California, San Francisco, San Francisco, California 94143, USA
    Am J Trop Med Hyg 76:1092-7. 2007
    ..RDTs may provide an effective strategy for improving rational delivery of antimalarial therapy; in Kampala, either test could dramatically decrease inappropriate presumptive treatments...
  79. pmc Effectiveness of nevirapine and zidovudine in a pilot program for the prevention of mother-to-child transmission of HIV-1 in Uganda
    Francis Bajunirwe
    Department of Community Health, Mbarara University of Science and Technology, P O Box 1410, Mbarara, Uganda
    Afr Health Sci 4:146-54. 2004
    ..The effectiveness of these antiretroviral (ARV) regimens has been shown in the clinical trials but has not been demonstrated outside the clinical trials setting in this country...
  80. ncbi request reprint The impact of age, temperature, and parasite density on treatment outcomes from antimalarial clinical trials in Kampala, Uganda
    Grant Dorsey
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, Parnassus Avenue Box 0811, San Francisco, CA 94143, USA
    Am J Trop Med Hyg 71:531-6. 2004
    ..Caution should be taken when comparing results from drug efficacy studies with different subject selection criteria...
  81. ncbi request reprint Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda
    Sarah G Staedke
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
    Trop Med Int Health 9:624-9. 2004
    ..The use of molecular markers of SP resistance to predict treatment failure rates should take age into account...
  82. ncbi request reprint Gay and bisexual men in Kampala, Uganda
    Phoebe Kajubi
    Institute for Global Health, University of California, San Francisco, CA, USA
    AIDS Behav 12:492-504. 2008
    ..Recognition of gay and bisexual men in local HIV prevention programs and education messages are urgently needed. Our study demonstrates that gay and bisexual men in Uganda are willing to identify themselves and participate in research...
  83. pmc Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
    Andrew Kambugu
    Infectious Disease Institute, Makerere University, Kampala Uganda
    Clin Infect Dis 46:1694-701. 2008
    ..Cryptococcal meningitis (CM) is the proximate cause of death in 20%-30% of persons with acquired immunodeficiency syndrome in Africa...
  84. pmc HIV RNA suppression among HIV-infected Ugandan children with measles
    Theodore D Ruel
    J Acquir Immune Defic Syndr 48:225-7. 2008

Research Grants1

  1. Uganda Malaria COHRE Training Program
    Moses Kamya; Fiscal Year: 2009
    ..Improved in-country expertise in operational and health services research will assist the Ministry of Health in establishing policies for the control of malaria. ..