J R Turner

Summary

Publications

  1. ncbi request reprint PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol 277:C554-62. 1999
  2. ncbi request reprint Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 279:C1918-24. 2000
  3. ncbi request reprint NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 281:C1533-41. 2001
  4. ncbi request reprint Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransport
    J J Berglund
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1487-93. 2001
  5. ncbi request reprint Show me the pathway! Regulation of paracellular permeability by Na(+)-glucose cotransport
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Adv Drug Deliv Rev 41:265-81. 2000
  6. ncbi request reprint Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport
    J R Turner
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    Dig Dis Sci 45:2122-6. 2000
  7. pmc Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins
    A Nusrat
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Infect Immun 69:1329-36. 2001
  8. ncbi request reprint 'Putting the squeeze' on the tight junction: understanding cytoskeletal regulation
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, USA
    Semin Cell Dev Biol 11:301-8. 2000
  9. pmc Inflammatory bowel disease: is it really just another break in the wall?
    C R Weber
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Gut 56:6-8. 2007
  10. ncbi request reprint Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR
    Y Yu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 280:C1083-9. 2001

Collaborators

  • A K Rishi
  • D E Cohen
  • M Donowitz
  • D Liu
  • C R Weber
  • Y Yu
  • A Nusrat
  • J J Berglund
  • C A Parkos
  • E Wenzl
  • J A Moshier
  • A P Majumdar
  • Y Zolotarevsky
  • E D Black
  • P Verkade
  • J L Madara
  • C von Eichel-Streiber
  • M Riegler

Detail Information

Publications10

  1. ncbi request reprint PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol 277:C554-62. 1999
    ..These data suggest that PKC regulates TER via decreased phosphorylation of MLC, possibly due to inhibitory phosphorylation of MLCK. The decreased phosphorylation of MLC likely reduces PAMR tension, leading to decreased TJ permeability...
  2. ncbi request reprint Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 279:C1918-24. 2000
    ..These data demonstrate that inhibition of NHE3 results in decreased MLC phosphorylation and increased TER and suggest that NHE3 may participate in the signaling pathway of Na(+)-glucose cotransport-dependent tight junction regulation...
  3. ncbi request reprint NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 281:C1533-41. 2001
    ..This coordinated regulation of glucose (SGLT1) and Na(+) (NHE3) absorptive processes may represent a functional activation of absorptive enterocytes by luminal nutrients...
  4. ncbi request reprint Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransport
    J J Berglund
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1487-93. 2001
    ..These data support the proposed critical role of the perijunctional cytoskeleton in physiological regulation of human small intestinal paracellular permeability...
  5. ncbi request reprint Show me the pathway! Regulation of paracellular permeability by Na(+)-glucose cotransport
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Adv Drug Deliv Rev 41:265-81. 2000
    ....
  6. ncbi request reprint Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport
    J R Turner
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    Dig Dis Sci 45:2122-6. 2000
    ..001). Thus, intestinal paracellular absorption of creatinine is increased by the presence of luminal glucose. Our results are consistent with in vivo human regulation of mucosal permeability by Na+-glucose cotransport...
  7. pmc Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins
    A Nusrat
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Infect Immun 69:1329-36. 2001
    ..These toxin-mediated effects on actin and TJ structure provide a mechanism for early events in the pathophysiology of pseudomembranous colitis...
  8. ncbi request reprint 'Putting the squeeze' on the tight junction: understanding cytoskeletal regulation
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, USA
    Semin Cell Dev Biol 11:301-8. 2000
    ..With the identification of novel tight junction proteins and characterization of their protein:protein interactions comes the promise of detailed understanding of the molecular interactions that mediate tight junction regulation...
  9. pmc Inflammatory bowel disease: is it really just another break in the wall?
    C R Weber
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Gut 56:6-8. 2007
  10. ncbi request reprint Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR
    Y Yu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 280:C1083-9. 2001
    ..We conclude that the ERRP cDNA may represent a new member of the EGFR gene family and that ERRP plays a role in regulating cell proliferation by modulating the function of EGFR...