Ahmet Ulugol

Summary

Affiliation: Trakya University
Country: Turkey

Publications

  1. ncbi request reprint Reduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibiotic
    Ahmet Ulugol
    Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Med Hypotheses 80:247-8. 2013
  2. doi request reprint 5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice
    Ahmet Ulugol
    Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Pharmacol Biochem Behav 102:344-8. 2012
  3. ncbi request reprint Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Brain Res 943:101-4. 2002
  4. ncbi request reprint Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey
    Neurosci Lett 328:129-32. 2002
  5. ncbi request reprint The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Neurosci Lett 371:167-70. 2004
  6. ncbi request reprint Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Life Sci 78:1592-7. 2006
  7. doi request reprint Modulatory role of asymmetric dimethylarginine (ADMA) in cannabinoid tolerance and dependence
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Med Hypotheses 73:213-4. 2009
  8. doi request reprint Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats
    Ozgur Gunduz
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Neurol Sci 32:1135-42. 2011
  9. ncbi request reprint The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac
    Ahmet Ulugol
    Department of Pharmacology, Trakya University, Edirne, Turkey
    Anesth Analg 102:443-7. 2006
  10. ncbi request reprint Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats
    Hakan C Karadag
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey
    Neurosci Lett 339:88-90. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Reduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibiotic
    Ahmet Ulugol
    Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Med Hypotheses 80:247-8. 2013
    ..Opioids and cannabinoids share many pharmacological properties. All together, it can be hypothesized that beta-lactam antibiotics may reduce the development of dependence to cannabinoids through activating GLT-1...
  2. doi request reprint 5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice
    Ahmet Ulugol
    Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Pharmacol Biochem Behav 102:344-8. 2012
    ..Our results indicate that systemic administration of 5-HT₇ receptor agonists may have clinical utility in treating diabetic neuropathic pain...
  3. ncbi request reprint Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Brain Res 943:101-4. 2002
    ..These results suggest that combining low doses of magnesium sulfate with opiates might be an alternative in treating neuropathic pain, with reduced risk of side effects...
  4. ncbi request reprint Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey
    Neurosci Lett 328:129-32. 2002
    ..These data also suggest that topical application of tricyclic antidepressants may be useful in treating neuropathic pain in diabetics...
  5. ncbi request reprint The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Neurosci Lett 371:167-70. 2004
    ..injections of WIN 55,212-2 reduced mechanical allodynia. These results suggest that WIN 55,212-2 has an antiallodynic effect in streptozocin-induced diabetic rats and may be a promising approach in the treatment of diabetic neuropathy...
  6. ncbi request reprint Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Life Sci 78:1592-7. 2006
    ..It is also concluded that l-arginine-NO pathway and opioidergic system are involved in the antihyperalgesic effect of melatonin in nerve-injured mice...
  7. doi request reprint Modulatory role of asymmetric dimethylarginine (ADMA) in cannabinoid tolerance and dependence
    Ahmet Ulugol
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Med Hypotheses 73:213-4. 2009
    ..Taken together, we hypothesized that ADMA and/or L-arginine/ADMA ratio may play a modulatory role in tolerance and dependence to cannabinoids...
  8. doi request reprint Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats
    Ozgur Gunduz
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Neurol Sci 32:1135-42. 2011
    ..Our data establish a rat model of saphenous CCI with significant allodynia and hyperalgesia, which is sensitive to a number of analgesic compounds...
  9. ncbi request reprint The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac
    Ahmet Ulugol
    Department of Pharmacology, Trakya University, Edirne, Turkey
    Anesth Analg 102:443-7. 2006
    ..This study demonstrated an additive antinociceptive interaction between WIN 55,212-2 and ketorolac in an inflammatory visceral pain model. The combination of cannabinoids and NSAIDs may have utility in the pharmacotherapy of pain...
  10. ncbi request reprint Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats
    Hakan C Karadag
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey
    Neurosci Lett 339:88-90. 2003
    ..These results suggest that agmatine has an antiallodynic effect in both spinal nerve ligation and diabetic models and may be a promising drug in the treatment of neuropathic pain...
  11. ncbi request reprint Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice
    Ozgur Gunduz
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Pharmacol Biochem Behav 99:540-4. 2011
    ..In conclusion, co-administration of a cannabinoid with a nociceptin/orphanin FQ receptor antagonist resulted in a synergistic interaction, which may have utility in the pharmacological treatment of neuropathic pain...
  12. ncbi request reprint Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone
    Pinar Elmas
    Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey
    J Neural Transm 120:1533-8. 2013
    ..Our findings suggest that, unlike paracetamol, cannabinoid CB1 receptors do not participate in the antinociceptive action of dipyrone when acute pain tests used...
  13. doi request reprint Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the β-lactam antibiotic, ceftriaxone, in mice
    Ozgur Gunduz
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Pharmacol Biochem Behav 99:100-3. 2011
    ....
  14. doi request reprint Modulatory role of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), in morphine tolerance and dependence in mice
    Ozgur Gunduz
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    J Neural Transm 117:1027-32. 2010
    ..Our results suggest that endogenous plasma ADMA, SDMA, L: -homoarginine and L: -arginine levels remain unchanged during the development of morphine tolerance and dependence, and are not associated with these phenomena...
  15. doi request reprint Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats
    Ozgur Gunduz
    Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Neurosci Lett 491:23-5. 2011
    ..Our results indicate that ceftriaxone exerts an antinociceptive effect in streptozocin-induced diabetic rats and GLT-1 activation by beta lactam antibiotics may be a promising option in the treatment of diabetic neuropathy...
  16. doi request reprint The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice
    Ibrahim Yilmaz
    Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Int J Neurosci 119:755-64. 2009
    ....
  17. doi request reprint Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
    Ahmet Dogrul
    Department of Medical Pharmacology, Gulhane Military Academy of Medicine, Ankara, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 38:97-105. 2012
    ....
  18. doi request reprint Lack of effect of ceftriaxone, a GLT-1 transporter activator, on spatial memory in mice
    Ipek Karaman
    Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
    Pharmacol Biochem Behav 108:61-5. 2013
    ....