Halis Suleyman

Summary

Country: Turkey

Publications

  1. ncbi Acute and chronic antiinflammatory profile of the ivy plant, Hedera helix, in rats
    H Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Phytomedicine 10:370-4. 2003
  2. ncbi Anti-inflammatory effects of selective COX-2 inhibitors
    Halis Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Pol J Pharmacol 56:775-80. 2004
  3. ncbi Role of adrenal gland hormones in the mechanism of antiulcer action of nimesulide and ranitidine
    Halis Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 56:799-804. 2004
  4. ncbi Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm
    H Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey
    Phytomedicine 10:552-7. 2003
  5. ncbi Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers
    Halis Suleyman
    Faculty of Medicine, Department of Pharmacology, Ataturk University, Erzurum, Turkey
    Inflammation 33:224-34. 2010
  6. ncbi Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Naunyn Schmiedebergs Arch Pharmacol 375:189-98. 2007
  7. ncbi Anti-inflammatory and side effects of cyclooxygenase inhibitors
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, TR 25240, Erzurum, Turkey
    Pharmacol Rep 59:247-58. 2007
  8. ncbi Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue
    Halis Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Pol J Pharmacol 54:255-9. 2002
  9. ncbi Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey
    Pharmacol Rep 61:514-9. 2009
  10. doi Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats
    Halis Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240 Erzurum, Turkey
    Chem Biol Interact 180:318-24. 2009

Collaborators

Detail Information

Publications87

  1. ncbi Acute and chronic antiinflammatory profile of the ivy plant, Hedera helix, in rats
    H Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Phytomedicine 10:370-4. 2003
    ..Indomethacin was found to be the most potent drug in the chronic phase of inflammation, with 66% effect. The SPE of Hedera helix was more potent than the CSE in its chronic antiinflammatory effect (60% and 49%, respectively)...
  2. ncbi Anti-inflammatory effects of selective COX-2 inhibitors
    Halis Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Pol J Pharmacol 56:775-80. 2004
    ..We could not clarify this observation. Further studies are required to enlighten this effect of rofecoxib...
  3. ncbi Role of adrenal gland hormones in the mechanism of antiulcer action of nimesulide and ranitidine
    Halis Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 56:799-804. 2004
    ..4 mm2 in control group given indomethacin, only nimesulide or indomethacin + ranitidine, respectively. The obtained results indicated that adrenal cortex hormones played a role in antiulcer effect of nimesulide, but not ranitidine...
  4. ncbi Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm
    H Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey
    Phytomedicine 10:552-7. 2003
    ..The carrageenan-induced paw edema, cotton pellet granuloma and indomethacin-induced gastric damage models were used to determine these effects. The extract exhibited moderate anti-inflammatory and strong antiulcerogenic activities...
  5. ncbi Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers
    Halis Suleyman
    Faculty of Medicine, Department of Pharmacology, Ataturk University, Erzurum, Turkey
    Inflammation 33:224-34. 2010
    ....
  6. ncbi Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Naunyn Schmiedebergs Arch Pharmacol 375:189-98. 2007
    ....
  7. ncbi Anti-inflammatory and side effects of cyclooxygenase inhibitors
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, TR 25240, Erzurum, Turkey
    Pharmacol Rep 59:247-58. 2007
    ..These drugs or their derivatives, which belong to the same group, have distinct pharmacological effects, side effects and potencies which implies that there may be more than two, five or even tens of COX isoforms...
  8. ncbi Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue
    Halis Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Pol J Pharmacol 54:255-9. 2002
    ..3 +/- 1.58 mm2 and 9.5 +/- 1.43 mm2, respectively. There were no chemical reactions between nimesulide and indomethacin or ranitidine and indomethacin in vitro. Nimesulide and ranitidine did not neutralize the gastric acid in vitro...
  9. ncbi Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey
    Pharmacol Rep 61:514-9. 2009
    ..The anti-inflammatory effects of the tested drugs was eliminated on rainy days due to the low level of corticosterone...
  10. doi Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats
    Halis Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240 Erzurum, Turkey
    Chem Biol Interact 180:318-24. 2009
    ..Our results indicate that activating enzymatic and non-enzymatic antioxidant mechanisms and inhibiting some toxic oxidant mechanisms play a role in tianeptine's antiulcer effect mechanism...
  11. ncbi Prevention of ischemia-reperfusion injury in rat ovarian tissue with the on-off method
    M Ingec
    Ataturk University, Medical Faculty, Department of Obstetrics and Gynecology, Erzurum, Turkiye
    J Physiol Pharmacol 62:575-82. 2011
    ..These results indicate that controlled reperfusion can be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia for various reasons (ovarian torsion, tumor, etc.)...
  12. ncbi The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats
    Halis Suleyman
    Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey
    Pharmacol Res 45:155-8. 2002
    ..3 +/- 10.3 mm(2) in the ethanol-given group and it was 4.5 +/- 4.8, 20.1 +/- 1.66, 15.16 +/- 4.05 mm(2) for nimesulide (at doses of 100, 300 and 500 mg kg(-1)), respectively, and 64.16 +/- 3.97 mm(2) for ranitidine...
  13. ncbi An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM
    Halis Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey
    Biol Pharm Bull 25:10-3. 2002
    ..3% (p<0.005) and 52.1% (p<0.005), respectively. It was seen that C-1 was more effective on chronic inflammation than on acute inflammation...
  14. ncbi Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDS
    H Suleyman
    Department of Pharmacology, Erzurum, Ataturk University, Faculty of Medicine, Turkey
    J Physiol Pharmacol 59:661-72. 2008
    ..It was also determined for the first time that adrenalin (totally) and prednisolone (partially) triggered anti-inflammatory effects via the beta(2)-receptors but not via the alpha(1), alpha(2) and beta(1)-receptors...
  15. ncbi Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug
    H Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240 Erzurum, Turkey
    Curr Med Chem 15:278-83. 2008
    ....
  16. ncbi Role of adrenal gland hormones in antiinflammatory effect of calcium channel blockers
    Halis Suleyman
    Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240 Erzurum, Turkey
    Pharmacol Rep 58:692-9. 2006
    ....
  17. ncbi Vitamin E and Hippophea rhamnoides L. extract reduce nicotine-induced oxidative stress in rat heart
    Kenan Gumustekin
    Department of Physiology, Ataturk University, Erzurum, Turkey
    Cell Biochem Funct 28:329-33. 2010
    ..rhamnoides L. extracts may be responsible for the antioxidant effects of this plant extract...
  18. doi The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats
    Fatih Albayrak
    Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    J Pharm Pharmacol 62:85-90. 2010
    ..Erythropoietin has anti-oxidative and anti-inflammatory activity. We wanted to evaluate its activity in preventing damage to the gastric mucosa...
  19. doi Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models
    Sevil Tanas
    Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Nat Med 64:42-9. 2010
    ..The anti-inflammatory effect of MEPR could be attributed to its reducing effect on the neutrophil-derived free radicals and its ameliorating effect on the antioxidant defense systems...
  20. ncbi Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats
    Elif Cadirci
    Ataturk University, Faculty of Pharmacy, Department of Pharmacology, 25240, Erzurum, Turkey
    Chem Biol Interact 170:40-8. 2007
    ..Our results indicate that the protection of some antioxidant mechanisms and the inhibition of some oxidant mechanisms have a role in AR-1's antiulcer effect mechanism...
  21. doi The effects of methanol extract of Lobaria pulmonaria, a lichen species, on indometacin-induced gastric mucosal damage, oxidative stress and neutrophil infiltration
    Basak Karakus
    Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Phytother Res 23:635-9. 2009
    ..The present results suggested that Lobaria pulmonaria has a gastroprotective effect, probably due to reducing oxidative stress and neutrophil infiltration...
  22. ncbi Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver
    Seyithan Taysi
    Department of Biochemistry and Clinical Biochemistry, University of Gaziantep, Faculty of Medicine, Gaziantep, Turkey
    Pharm Biol 48:488-93. 2010
    ..Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress...
  23. doi The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats
    Ayse Albayrak
    Department of Infection Disease, Education and Research Hospital, Erzurum, Turkey
    J Surg Res 169:67-75. 2011
    ..The rat sepsis model in the present study was used to understand the role of sustained hyperglycemia and ovariectomy, either separately or together, on the response of pro-inflammatory mediators and oxidative response...
  24. doi α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations
    Fehmi Odabasoglu
    Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey
    Br J Nutr 105:31-43. 2011
    ..In conclusion, these results suggest that the anti-inflammatory properties of ALA, which has a strong anti-oxidative potency, could be related to its positive effects on the antioxidant system in a variety of tissues in rats...
  25. ncbi Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats
    Gunnur Ozbakis Dengiz
    Department of Pharmacology, Faculty of Medicine, Karaelmas University, Turkey
    J Pharmacol Sci 105:94-102. 2007
    ..These results suggest that the gastroprotective effects of montelukast on indomethacin-induced ulcerations can be attributed to its ameliorating effect on oxidative damage and MPO activity...
  26. ncbi Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats
    Abdulmecit Albayrak
    Department of Pharmacology, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey
    Pharmacol Rep 62:113-9. 2010
    ..We also found that adrenalin levels are reduced upon metyrosine treatment, which may be the cause of the observed gastro-protective effects of this compound...
  27. ncbi Vitamin E but not Hippophea rhamnoides L. prevented nicotine-induced oxidative stress in rat brain
    Kenan Gumustekin
    Department of Physiology, Faculty of Medicine, Ataturk University 25240, Erzurum, Turkey
    Hum Exp Toxicol 22:425-31. 2003
    ..Vitamin E might have easily diffused to rat brain as a lipid soluble antioxidant, however, the plant extract, HRe-1, would not have sufficiently diffused to the brain to exert its antioxidant effect...
  28. doi Effects of female sex hormones on caffeine-induced epileptiform activity in rats
    Bunyamin Borekci
    Faculty of Medicine, Department of Obstetrics and Gynecology, Ataturk University, Erzurum, Turkey
    Gynecol Endocrinol 26:366-71. 2010
    ..In conclusion, we suggest that the occurrence or aggravation of epilepsy, despite estrogen deficiency in the menopausal or post-menopausal period, is related to excessive accumulation of FSH and LH...
  29. ncbi Adaptation of rat gastric tissue against indomethacin toxicity
    Beyzagul Polat
    Ataturk University, Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey
    Chem Biol Interact 186:82-9. 2010
    ..There is no relation between COX enzymes and adaptation mechanism. This circumstance shows that not COX-1 and COX-2 enzymes, oxidant and antioxidant parameters may play a role in the adaptation mechanism...
  30. doi Mirtazapine protects against cisplatin-induced oxidative stress and DNA damage in the rat brain
    Mustafa Gulec
    Department of Psychiatry, Ataturk University Medical Faculty, Erzurum, Turkey
    Psychiatry Clin Neurosci 67:50-8. 2013
    ..Mirtazapine may be a preventative agent via its less-known antioxidant properties. The aim of this study was to examine the potential chemoprotective effects of mirtazapine against cisplatin-induced oxidative stress and DNA damage...
  31. doi Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation
    Zekai Halici
    Department of Pharmacology, Ataturk University School of Medicine, Erzurum, Turkey
    Fertil Steril 90:2408-15. 2008
    ..To evaluate the effects of amlodipine as an antioxidant and analyze the histopathologic changes in experimental ischemic and ischemic-reperfusion (I/R) injury in rat ovaries...
  32. pmc Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue
    Hakan Dursun
    Department of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey
    BMC Gastroenterol 9:36. 2009
    ..This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants...
  33. ncbi Effects of progesterone on FSH-stimulated indomethacin ulcers in rats
    Bunyamin Borekci
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Fertil Steril 90:1899-903. 2008
    ..To investigate whether the balance between progesterone and FSH levels has a role in ulcer formation/inhibition...
  34. ncbi Effect of nimesulide, rofecoxib and celecoxib on gastric tissue glutathione level in rats with indomethacin-induced gastric ulcerations
    Konca Altinkaynak
    Department of Biochemistry, Ataturk University, Medical Faculty, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 55:645-8. 2003
    ..In conclusion, we propose that nimesulide exerts a prophylactic effect on the indomethacin-induced gastric ulcers by enhancing gastric GSH level...
  35. ncbi Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine
    Mustafa Talip Sener
    Department of Forensic Medicine, Faculty of Medicine, Ataturk University, Campus, 25240, Erzurum, Turkey
    Pharmacol Rep 64:594-602. 2012
    ..This biochemical and histologic study investigated a possible protective effect of mirtazapine with regard to cisplatin-induced nephrotoxicity in the rat...
  36. doi Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats
    Yavuz Albayrak
    Department of General Surgery, Regional Education and Research Hospital, 25240 Erzurum, Turkey
    Arch Pharm Res 34:1519-25. 2011
    ..The findings of this study may be useful in severe pain cases in which the available analgesics are unable to relieve the individual's pain...
  37. doi Effect of acute and chronic administration of progesterone, estrogen, FSH and LH on oxidant and antioxidant parameters in rat gastric tissue
    Yakup Kumtepe
    Ataturk University, Faculty of Medicine, Department of Obstetrics and Gynecology, Erzurum, Turkey
    Chem Biol Interact 182:1-6. 2009
    ..It is concluded that low doses of progesterone may inhibit FSH, whereas high doses of estrogen may stimulate alpha-2 receptors, suggesting that LH could have protective and antioxidant hormone effects...
  38. ncbi Effects of hypertension and ovariectomy on rat hepatocytes. Are amlodipine and lacidipine protective? (A stereological and histological study)
    Hakan Dursun
    Department of Gastroenterology, Ataturk University, School of Medicine, Erzurum
    Turk J Gastroenterol 21:387-95. 2010
    ..The aim of this study was to determine the effects of amlodipine and lacidipine in an ovariectomy-induced postmenopausal period model and a deoxycorticosterone acetate-salt-induced hypertensive model in rats...
  39. doi Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation
    Elif Cadirci
    Department of Pharmacology, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey
    Naunyn Schmiedebergs Arch Pharmacol 381:455-66. 2010
    ..Administration of atorvastatin is effective in reversing tissue damage induced by ischemia and/or I/R in ovaries...
  40. ncbi Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats
    Fehmi Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry, Erzurum, Turkey
    J Ethnopharmacol 103:59-65. 2006
    ..These results suggest that the gastroprotective effect of UA can be attributed to its reducing effect on the oxidative damage and neutrophil infiltration in tissues...
  41. ncbi Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 30:63-7. 2007
    ..Further detailed studies are needed to clarify the mechanism(s) of action responsible for the anti-inflammatory activity of B1...
  42. doi The effects of polymicrobial sepsis with diabetes mellitus on kidney tissues in ovariectomized rats
    Abdullah Uyanik
    Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Ren Fail 32:592-602. 2010
    ..The rats were divided into five groups: sham control (group 1), ovariectomy (group 2), ovariectomy + sepsis (group 3), ovariectomy + diabetes (group 4), and ovariectomy + diabetic + sepsis (group 5)...
  43. doi Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats
    Elif Cadirci
    Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey
    Shock 33:479-84. 2010
    ..We can suggest that ALA showed beneficial effects by decreasing nuclear factor kappaB activation in lung tissues, resulting in decreased serum levels of TNF-alpha and IL-6, and also increasing the antioxidant capacity of the lungs...
  44. ncbi Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats
    Beyzagul Polat
    Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey
    Pharmacol Rep 63:518-26. 2011
    ..Conversely, aside from myeloperoxidase (MPO), all oxidant parameters decreased. Therefore, oxidant/antioxidant parameters play a role in the antiulcer mechanism of dexmedetomidine...
  45. pmc Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney
    Durdu Altuner
    Department of Pharmacology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey
    Indian J Pharmacol 45:339-43. 2013
    ..The biochemical effects of thiamine pyrophosphate on ischemia-reperfusion (IR) induced oxidative damage and DNA mutation in rat kidney tissue were investigated, and compared to thiamine...
  46. doi Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats
    Fehmi Odabasoglu
    Department of Biochemistry, Ataturk University, 25240, Erzurum, Turkey
    Eur J Pharmacol 591:300-6. 2008
    ..These results suggest that indomethacin as well as other NSAIDs do not have any adverse effect on the gastrointestinal tract when they are used together with vegetable oils and vitamin E or as the preparations of the oils...
  47. doi Influence of adrenal hormones in the occurrence and prevention of stress ulcers
    Murat Yigiter
    Ataturk University, Faculty of Medicine, Department of Pediatric Surgery, 25240, Erzurum, Turkey
    J Pediatr Surg 45:2154-9. 2010
    ..The aim of the study was to examine whether endogenous cortisol and adrenalin have a role in the formation of stress ulcers in intact and adrenalectomized rats...
  48. ncbi Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema
    Zekai Halici
    Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240, Erzurum, Turkey
    Eur J Pharmacol 566:215-21. 2007
    ..These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage...
  49. ncbi Effect of mirtazapine on MNNG-induced gastric adenocarcinoma in rats
    Mehmet Bilici
    Ataturk University, Faculty of Medicine, Erzurum, Turkey
    Asian Pac J Cancer Prev 13:4897-900. 2012
    ..In this study, anticancer effects of mirtazapine on rats were investigated in an adenocarcinoma model induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and compared with those of cisplatin...
  50. doi Effect of chronic treatment of haloperidol on the rat liver: a stereological and histopathological study
    Zekai Halici
    Department of Pharmacology, Ataturk University School of Medicine, 25240, Erzurum, Turkey
    Naunyn Schmiedebergs Arch Pharmacol 379:253-61. 2009
    ..Results suggest a relationship between haloperidol dose and toxic effects on the liver, and they indicate that a high dose of haloperidol may result in irreversible liver damage...
  51. doi Preventive effect of amiodarone during acute period in isoproterenol-induced myocardial injury in Wistar rats
    Fatih Albayrak
    Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Ataturk University, Erzurum, Turkey
    Cardiovasc Toxicol 9:161-8. 2009
    ..Biochemical and histopathologic results in the ISO-induced model of myocardial injury emphasize the beneficial action of amiodarone as a cardioprotective agent...
  52. ncbi Does haloperidol have side effects on histological and stereological structure of the rat kidneys?
    Abdullah Uyanik
    Ataturk University, School of Medicine, Departments of Internal Medicine Division of Nephrology, Erzurum, Turkey
    Ren Fail 31:573-81. 2009
    ..It was shown that haloperidol may lead to undesirable changes in the kidney after chronic treatment with especially high doses...
  53. ncbi Acute and chronic antiinflammatory effects of Hedera colchica in rats
    Akcahan Gepdiremen
    Department of Pharmacology, Ataturk University, Medical Faculty, TR 25240 Erzurum, Turkey
    J Ethnopharmacol 94:191-5. 2004
    ..SPE was found as the most potent drug in chronic phase of inflammation with an effect of 64.32%. Indomethacin was found more potent than the CSE of Hedera colchica, and potency was found as 61.2 and 58%, respectively...
  54. doi Occurrence of anticancer activity of prednisolone via adrenalectomy and inhibition of adrenaline in rats
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Int J Cancer 126:1740-8. 2010
    ....
  55. ncbi Effects of calcium channel blockers on hyaluronidase-induced capillary vascular permeability
    Zekai Halici
    Faculty of Medicine, Department of Pharmacology, Ataturk University, Erzurum, Turkey
    Arch Pharm Res 31:891-9. 2008
    ..These results suggest that CCBs can be efficient anti-inflammatories, and can also significantly decrease capillary permeability...
  56. doi Role of alpha-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats
    Bunyamin Borekci
    Faculty of Medicine, Department of Obstetrics and Gynecology, Ataturk University, Erzurum, Turkey
    Gynecol Endocrinol 25:264-8. 2009
    ..To evaluate anti-ulcer effect of estrogen and luteinising hormone (LH) on indomethacin-induced ulcer model in female rats...
  57. doi The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats
    Murat Yigiter
    Department of Pediatric Surgery, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Surg Today 42:1051-60. 2012
    ....
  58. ncbi Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey
    Pharmacol Res 47:471-5. 2003
    ..1 and 43.1%, respectively, in cotton pellet test. C1 and indomethacin both significantly inhibited the hyaluronidase-induced increase in capillary permeability...
  59. doi Indirect role of beta2-adrenergic receptors in the mechanism of analgesic action of nonsteroidal antiinflammatory drugs
    Elif Cadirci
    Department of Pharmacology, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Crit Care Med 38:1860-7. 2010
    ..This study investigates whether the analgesic effects of indomethacin, diclofenac sodium, aspirin, and nimesulide (IDAN; upper case letters of the four drugs we used) are also related to adrenal gland hormones...
  60. ncbi Estimating the postmortem interval by the difference between oxidant/antioxidant parameters in liver tissue
    Mustafa T Sener
    Department of Forensic Medicine, Ataturk University, Erzurum, Turkey
    Adv Clin Exp Med 21:727-33. 2012
    ..So far the authors could not find any published paper that shows the presence of a possibly significant relationship between oxidant/antioxidant parameters and time of death...
  61. doi Biochemical and histopathological investigation of the protective effect of disulfiram in ischemia-induced ovary damage
    Unal Isaoglu
    Nenehatun Obstetrics and Gynecology Hospital, Erzurum, Turkey
    Gynecol Endocrinol 28:143-7. 2012
    ..Additionally, all doses of disulfiram significantly prevent DNA damage when compared to control group. Fewer histopathological findings were observed in tissues with higher antioxidant levels and lower oxidant and DNA damage levels...
  62. ncbi Effects of nicotine and vitamin E on carbonic anhydrase activity in some rat tissues in vivo and in vitro
    Mehmet Ciftci
    Ataturk University, Arts and Science Faculty, Department of Chemistry, 25240 Erzurum, Turkey
    J Enzyme Inhib Med Chem 20:103-8. 2005
    ..In vitro CA inhibition results for similar experiments correlated well with the in vivo experimental results in lungs, testicles, kidney, stomach, brain and liver tissues...
  63. ncbi The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage
    Bulent Aydinli
    Department of General Surgery, Medicine Faculty of Atatürk University, Erzurum, Turkey
    Ulus Travma Acil Cerrahi Derg 13:268-73. 2007
    ..To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model...
  64. ncbi Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats
    M Halici
    Department of Biochemistry, Faculty of Pharmacy Eczacilik Fakultesi, 25240 Campus, Ataturk University, Erzurum, Turkey
    Phytomedicine 12:656-62. 2005
    ..longissima and ranitidine. The present results indicate that the water extract of U. longissima has a protective effect in indomethacin-induced ulcers, which can be attributed to its antioxidant potential...
  65. doi Effect of mirtazapine on oxidative stress created in rat kidneys by ischemia-reperfusion
    Adem Tok
    Department of Urology, Erzurum Region Education and Research Hospital, Erzurum, Turkey
    Ren Fail 34:103-10. 2012
    ..In MRIR group, only mild tubular epithelial swelling and mild hyaline cast accumulation were observed in kidney tissue. Consequently, it can be said that mirtazapine has a protective effect on IR-induced kidney damage...
  66. ncbi Comparison of antioxidant activity and phenolic content of three lichen species
    Fehmi Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry 25240 Campus, Erzurum, Turkey
    Phytother Res 18:938-41. 2004
    ..On the other hand, there was a strong correlation between the reducing powers and the total phenolic contents of the extracts. The highest reducing power was determined for the methanol extract of L. pulmonaria...
  67. ncbi Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema
    A Gepdiremen
    Department of Pharmacology, Medical Faculty, Ondokuz Mayis University, TR 55050 Kurupelit, Samsun Turkey
    Phytomedicine 12:440-4. 2005
    ..Regarding the structure activity relationship, it is likely that sugars at C3 position and Rha7-Glcl-6Glc moiety at C28 position are essential for the acute anti-inflammatory effect...
  68. ncbi Contribution of the histaminergic receptor subtypes to histamine-induced cerebellar granular neurotoxicity
    Akcahan Gepdiremen
    Ataturk University, Faculty of Medicine, Department of Pharmacology, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 55:383-8. 2003
    ....
  69. ncbi Hippophae rhamnoides L. and dexpanthenol-bepanthene on blood flow after experimental skin burns in rats using 133Xe clearance technique
    Bedri Seven
    Department of Nuclear Medicine, Ataturk University, Medical School, 25240 Erzurum, Turkey
    Hell J Nucl Med 12:55-8. 2009
    ..The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique...
  70. ncbi The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid
    Y Bayir
    Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240, Campus, Erzurum, Turkey
    Phytomedicine 13:584-90. 2006
    ..These results suggest that the gastroprotective effect of DA can be attributed to its enhancing effects on antioxidant defense systems as well as reducing effects of neutrophil infiltration...
  71. ncbi Investigation of effects of Lacidipine, Ramipril and Valsartan on DNA damage and oxidative stress occurred in acute and chronic periods following isoproterenol-induced myocardial infarct in rats
    Mevlut Sait Keles
    Department of Biochemistry, Ataturk University, Erzurum, Turkey
    Mol Cell Biochem 328:109-17. 2009
    ..LAC, RAM and VAL may decrease the severity of MI and prevent DNA damage by reducing oxidative stress...
  72. doi Does telmisartan prevent hepatic fibrosis in rats with alloxan-induced diabetes?
    Zekai Halici
    Department of Pharmacology, Ataturk University School of Medicine, Erzurum, Turkey
    Eur J Pharmacol 614:146-52. 2009
    ....
  73. ncbi Protective effects of amlodipine and lacidipine on ovariectomy-induced bone loss in rats
    Zekai Halici
    Department of Pharmacology, Ataturk University School of Medicine, TR 25240 Erzurum, Turkey
    Eur J Pharmacol 579:241-5. 2008
    ..Our findings suggest that potent calcium channel blockers such as amlodipine and lacidipine have a beneficial effect on bone metabolism, and an antihypertensive effect...
  74. ncbi Intraperitoneal administration of salicylate dose-dependently prevents stress-induced ulcer formation in rats
    Akcahan Gepdiremen
    Ataturk University, Medical Faculty, Department of Pharmacology, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 55:209-12. 2003
    ..As expected, peroral (by gavage) administration of salicylate at 50 mg/kg exacerbated the ulcer score, in comparison with the control...
  75. doi Evaluation of pain levels after Nd: YAG laser and scalpel incisions: an experimental study in rats
    Cankat Kara
    Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
    Photomed Laser Surg 28:635-8. 2010
    ..The aim of the present study was to evaluate the pain levels following scalpel- and laser-incision of rat hind paws...
  76. doi Chronically administered risperidone did not change the number of hepatocytes in rats: a stereological and histopathological study
    Zekai Halici
    Department of Pharmacology, Ataturk University School of Medicine, Erzurum, Turkey
    Basic Clin Pharmacol Toxicol 102:426-32. 2008
    ..In conclusion, we did not find any evidence for hepatotoxicity of risperidone rats. Larger-scale, prospective studies are needed in order to confirm these findings...
  77. ncbi Beneficial effects of Hippophae rhamnoides L. on nicotine induced oxidative stress in rat blood compared with vitamin E
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 25:1133-6. 2002
    ..The results suggest that HRe-1 extract can be used as a dietary supplement, especially by people who smoke, in order to prevent nicotine-induced oxidative stress...
  78. ncbi Nitric oxide donor sodium nitroprusside induces neurotoxicity in cerebellar granular cell culture in rats by an independent mechanism from L-type or dantrolene-sensitive calcium channels
    Akcahan Gepdiremen
    Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey
    Biol Pharm Bull 25:1295-7. 2002
    ..According to our results, SNP-induced cerebellar toxicity appears to be an independent reaction from L-type or endoplasmic reticulum calcium currents...
  79. ncbi The effects of dantrolene alone or in combination with nimodipine in glutamate-induced neurotoxicity in cerebellar granular cell cultures of rat pups
    A Gepdiremen
    Department of Pharmacology, Medical Faculty, Ataturk University, Erzurum, Turkey
    Pharmacol Res 43:241-4. 2001
    ..The most effective dose of dantrolene was found to be 10(-4)M in combination with nimodipine. As a result, both extracellular and internal calcium stores play important roles in the genesis of neuronal cell death induced by glutamate...
  80. ncbi Relation of adrenergic receptors, which have roles in gastroprotective and anti-inflammatory effect of adrenal gland hormones, with cyclooxygenase enzyme levels in rats
    H Suleyman
    Faculty of Medicine, Department of Pharmacology, Ataturk University, Erzurum, Turkey
    J Physiol Pharmacol 60:129-34. 2009
    ..We investigated the relationship between COX levels and those adrenergic receptors known to play a role in gastroprotection and anti-inflammatory activity...
  81. ncbi The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats
    A Yildirim
    Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey
    J Physiol Pharmacol 58:105-16. 2007
    ..Thus, the present study provides a physiological regulatory role of adrenal gland in the maintenance of oxidant/antioxidant balance in gastric tissue and erythrocyte...
  82. ncbi The effects of melatonin in glutamate-induced neurotoxicity of rat cerebellar granular cell culture
    A Gepdiremen
    Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey
    Jpn J Pharmacol 84:467-9. 2000
    ..Glutamate may exert a neuroprotective effect by blocking one or more steps of the oxidation cascade in neurons and this effect may be blocked by melatonin...
  83. ncbi The effects of newly synthesized pyrazole derivatives on formaldehyde-, carrageenan-, and dextran-induced acute paw edema in rats
    H Suleyman
    Ataturk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey
    Biol Pharm Bull 24:1133-6. 2001
    ..002) inhibition, respectively. In the carrageenan-induced paw edema test, K-3 100 mg/kg decreased the inflammatory response by 52.0% after 4 h. Acute toxicity studies revealed that K-3 was nontoxic up to an oral dose of 2500 mg/kg...
  84. ncbi Antioxidant activity, reducing power and total phenolic content of some lichen species
    F Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry, 25240 Erzurum, Turkey
    Fitoterapia 76:216-9. 2005
    ..In contrast, there was a strong correlation between reducing power and total antioxidant activity of the extracts. The highest reducing power was determined for the methanol extract of P. rufescens...
  85. ncbi Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats
    G Ozbakis Dengiz
    Faculty of Medicine, Department of Pharmacology, Karaelmas University, Zonguldak, Turkey
    Arch Pharm Res 30:1426-34. 2007
    ..The results indicate that the gastroprotective activity of amiodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity...
  86. ncbi Sedative effect of Centranthus longiflorus ssp. longiflorus in rats and the influence of adrenalectomy on its effect
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Yakugaku Zasshi 127:1263-5. 2007
    ..It is clear, however, that these hormones are not glucocorticoids. Glucocorticoids were not responsible for shortening the sleep period...
  87. ncbi The effect of adrenalectomy on leptin levels and some metabolic parameters in rats with diet-induced obesity
    Adnan Yilmaz
    Department of Biochemistry, Faculty of Medicine, University of Ataturk, Erzurum, Turkey
    Biol Pharm Bull 25:580-3. 2002
    ..It was concluded that adrenalectomy might prevent obesity by affecting leptin and intermediate metabolism...