Affiliation: Selcuk University
- Mahomoodally M, Atalay A, Nancy Picot M, Bender O, Celebi E, Mollica A, et al. Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations. J Pharm Biomed Anal. 2018;161:425-435 pubmed publisher..This study supports the safe use of AM as a biomedicine for the management and/or treatment of common non-communicable diseases. ..
- Zengin G, Uysal A, Diuzheva A, Güneş E, Jeko J, Cziáky Z, et al. Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight. J Pharm Biomed Anal. 2018;160:374-382 pubmed publisher..The observed inhibitory effects of F. halophila against the studied enzyme suggest that this plant could be a promising source of bioactive phytochemicals for the management of clinical conditions. ..
- Mollica A, Stefanucci A, Zengin G, Locatelli M, Macedonio G, Orlando G, et al. Polyphenolic composition, enzyme inhibitory effects ex-vivo and in-vivo studies on two Brassicaceae of north-central Italy. Biomed Pharmacother. 2018;107:129-138 pubmed publisher..Overall, our results could provide new insights on the use of these Broccoli species not only as foods but also as functional and nutraceutical supplements. ..
- Zengin G, Degirmenci N, Alpsoy L, Aktumsek A. Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin). Hum Exp Toxicol. 2016;35:544-53 pubmed publisher..These AQs showed positive effects on L929 cell lines with high half-maximal inhibitory concentration values. Our results demonstrate that AQs may be used as antioxidative compounds in food and medicinal applications. ..
- Locatelli M, Yerlikaya Ş, Baloglu M, Zengin G, Altunoğlu Y, Cacciagrano F, et al. Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives. Food Chem Toxicol. 2018;120:172-182 pubmed publisher..liburnica. This study has provided insights on the potential usage of A. liburnica which could open new avenues for research and stimulate future interest for the development of safe novel biopharmaceuticals. ..
- Zengin G, Sarikurkcu C, Güneş E, Uysal A, Ceylan R, Uysal S, et al. Two Ganoderma species: profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders. Food Funct. 2015;6:2794-802 pubmed publisher..The results suggest that the Ganoderma species may be considered as a candidate for preparing new food supplements and can represent a good model for the development of new drug formulations. ..
- Mollica A, Zengin G, Locatelli M, Picot Allain C, Mahomoodally M. Multidirectional investigations on different parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn: Phenolic components, in vitro biological, and in silico propensities. Food Res Int. 2018;108:641-649 pubmed publisher..These results suggest that the different plant parts of A. scorodoprasum possessed different biological activities and might be used as a medicinal food plants for specific therapeutic applications. ..
- Locatelli M, Macchione N, Ferrante C, Chiavaroli A, Recinella L, Carradori S, et al. Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS. Molecules. 2018;23: pubmed publisher..According to our experimental evidence, Graminex pollen appears to be a promising natural product for the management of the inflammatory components in the prostate. ..
- Zengin G, Senkardes I, Mollica A, Picot Allain C, Bulut G, Dogan A, et al. New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L. Comput Biol Chem. 2018;75:111-119 pubmed publisher..Docking studies showed that quercetin binds to tyrosinase by two hydrogen and a pi-pi bonds. Salvia sclarea showed interesting biological activity against key enzymes involved in the pathogenesis of common ailments. ..
- Zengin G, Aumeeruddy Elalfi Z, Mollica A, Yılmaz M, Mahomoodally M. In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species-A source of innovative phytopharmaceuticals from nature. Phytomedicine. 2018;38:35-44 pubmed publisher..Docking studies revealed that the above compounds showed scores for the enzymes tested. The three halophytes studies could be considered as potential sources of biologically-active compounds for novel phytopharmaceuticals development. ..
- Uysal S, Aktumsek A, Picot Allain C, Unuvar H, Mollica A, Georgiev M, et al. Biological, chemical and in silico fingerprints of Dianthus calocephalus Boiss.: A novel source for rutin. Food Chem Toxicol. 2018;113:179-186 pubmed publisher..Methanol extracts showed highest antioxidant capacity. D. calocephalus showed interesting biological properties that could be further studied to manage diabetes, neurodegenerative diseases, Alzheimer's disease, and hyperpigmentation. ..
- Zengin G, Bulut G, Mollica A, Nancy Picot Allain C, Mahomoodally M. In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz-An endemic folk medicinal plant. Comput Biol Chem. 2018;73:120-126 pubmed publisher..saligna for the management of complications related to the target enzymes, such as diabetes type II, Alzheimer's disease, and epidermal hyperpigmentation. ..
- Melucci D, Locatelli M, Locatelli C, Zappi A, de Laurentiis F, Carradori S, et al. A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts. Molecules. 2018;23: pubmed publisher..The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance. ..
- Lazarova I, Simeonova R, Vitcheva V, Kondeva Burdina M, Gevrenova R, Zheleva Dimitrova D, et al. Hepatoprotective and antioxidant potential of Asphodeline lutea (L.) Rchb. roots extract in experimental models in vitro/in vivo. Biomed Pharmacother. 2016;83:70-78 pubmed publisher..ALE is rich in anthraquinones, naphthalenes and caffeic acid. The pro-oxidant effects of ALE could be due to naphthalene and anthraquinone bioactivation pathways involving toxic metabolites. ..
- Uysal A, Zengin G, Mollica A, Güneş E, Locatelli M, Yilmaz T, et al. Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications. Phytomedicine. 2016;23:979-88 pubmed publisher..Also, molecular docking was used to understand enzyme-epicatechin interactions. From these results, this plant has a great potential as a health promoter for developing novel functional food ingredients and pharmaceutical preparations. ..
- Zengin G, Abdallah H, Dogan A, Mollica A, Aumeeruddy Elalfi Z, Mahomoodally M. Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products. Food Chem Toxicol. 2018;111:423-431 pubmed publisher..In conclusion, the potential clinical applications observed during this study may provide new insights into the molecular aspect particularly for neuroprotective and anti-diabetic mechanisms involving oxidative stress. ..
- Zengin G, Zheleva Dimitrova D, Gevrenova R, Nedialkov P, Mocan A, Ciric A, et al. Identification of phenolic components via LC-MS analysis and biological activities of two Centaurea species: C. drabifolia subsp. drabifolia and C. lycopifolia. J Pharm Biomed Anal. 2018;149:436-441 pubmed publisher..It is anticipated that results amassed from this still will open new avenues for research and contribute towards establishing primary data on these species for designing novel phytopharmaceuticals. ..
- Llorent Martínez E, Ortega Barrales P, Zengin G, Mocan A, Simirgiotis M, Ceylan R, et al. Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus: Potential sources of bioactive compounds for the food industry. Food Chem Toxicol. 2017;107:609-619 pubmed publisher..The high number of phenolic compounds and the results of the antioxidant and enzyme assays suggest that these plants may be further used as sources of bioactive compounds, and for the preparation of new nutraceuticals. ..
- Zengin G, Uysal A, Aktumsek A, Mocan A, Mollica A, Locatelli M, et al. Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations. Biomed Pharmacother. 2017;87:27-36 pubmed publisher..56 to 6.25mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals. ..
- Zengin G, Bulut G, Mollica A, Haznedaroglu M, Dogan A, Aktumsek A. Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches. Food Chem Toxicol. 2017;107:597-608 pubmed publisher..Overall, these species could be suggested as valuable sources of natural-bioactive agents for developing new functional, pharmacological and health-promoting ingredients. ..