- Running on empty: does mitochondrial DNA mutation limit replicative lifespan in yeast?: Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiaeCory D Dunn
Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey
Bioessays 33:742-8. 2011..These exciting, parallel findings imply a potential causal relationship between mtDNA mutation and replicative senescence. Furthermore, these results suggest more efficient methods for discovering genes that determine lifespan...
- Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiaeGörkem Garipler
Department of Molecular Biology and Genetics and School of Medicine, Koc University, Sariyer, Istanbul, 34450 Turkey
Proc Natl Acad Sci U S A 111:1473-8. 2014..Our work highlights the important role that nutrient-responsive signaling pathways can play in determining the response to mitochondrial dysfunction. ..
- Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiaeGörkem Garipler
Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, 34450, Turkey
Genetics 194:285-90. 2013..Furthermore, elevating vacuolar pH increases proliferation after mtDNA deletion and reverses the protein import defect of mitochondria lacking DNA...