Turgay Isbir

Summary

Affiliation: Istanbul University
Country: Turkey

Publications

  1. ncbi request reprint The effects of Brassica oleraceae var capitata on epidermal glutathione and lipid peroxides in DMBA-initiated-TPA-promoted mice
    T Isbir
    University of Istanbul, Department of Molecular Medicine, Turkey
    Anticancer Res 20:219-24. 2000
  2. ncbi request reprint Association between angiotensin-converting enzyme gene polymorphism and coronary artery disease
    T Isbir
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    IUBMB Life 48:205-7. 1999
  3. ncbi request reprint Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease in the Turkish population
    T Isbir
    Department of Molecular Medicine, Istanbul Istanbul University, Turkey
    Clin Genet 64:228-34. 2003
  4. ncbi request reprint The influence of cyclin D1 A870G polymorphism on colorectal cancer risk and prognosis in a Turkish population
    Ilhan Yaylim-Eraltan
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Anticancer Res 30:2875-80. 2010
  5. ncbi request reprint Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking
    Bedia Agachan
    Department of Molecular Medicine, Institute for Experimental Medicine DETAE, Faculty of Pharmacy, Istanbul University, CAPA 34390 Istanbul, Turkey
    Anticancer Res 29:2417-20. 2009
  6. ncbi request reprint Fas-1377 A/G polymorphism in lung cancer
    Uzay Gormus
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Turkey
    In Vivo 21:663-6. 2007
  7. doi request reprint Investigation of polymorphic variants of PPARD and APOE genes in Turkish coronary heart disease patients
    Hulya Yilmaz-Aydogan
    Department of Molecular Medicine, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
    DNA Cell Biol 31:867-75. 2012
  8. ncbi request reprint Close correlation between restriction fragment length polymorphism of L-myc gene and susceptibility to gastric cancer
    Turgay Isbir
    Department of Molecular Medicine, Institute of Experimental Medical Research, University of Istanbul, DETAE 34390, P O Box 7 Capa, Istanbul, Turkey
    Cancer Detect Prev 26:454-7. 2002
  9. ncbi request reprint ARE-I polymorphism on PSA gene in prostate cancer patients of a Turkish population
    Ebru Kalay
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Istanbul, Turkey
    Anticancer Res 29:1395-8. 2009
  10. ncbi request reprint APE1 and XRCC3 polymorphisms and myocardial infarction
    Atike Tekeli
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Capa Istanbul, Turkey
    In Vivo 22:477-9. 2008

Collaborators

Detail Information

Publications79

  1. ncbi request reprint The effects of Brassica oleraceae var capitata on epidermal glutathione and lipid peroxides in DMBA-initiated-TPA-promoted mice
    T Isbir
    University of Istanbul, Department of Molecular Medicine, Turkey
    Anticancer Res 20:219-24. 2000
    ..The objective of the present study was to determine if modulation of GSH-dependent antioxidant protective system by Brassica oleraceae var capitata might inhibit the molecular mechanism of skin tumor promotion...
  2. ncbi request reprint Association between angiotensin-converting enzyme gene polymorphism and coronary artery disease
    T Isbir
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    IUBMB Life 48:205-7. 1999
    ..26% and 37.73 % and in the control subjects were 49.3% and 50.76%, respectively. The greater frequency of deletion allele (D) was in the CAD group than in the control subjects was significant (P < 0.01)...
  3. ncbi request reprint Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease in the Turkish population
    T Isbir
    Department of Molecular Medicine, Istanbul Istanbul University, Turkey
    Clin Genet 64:228-34. 2003
    ..The present study demonstrates that the CETP Msp1 and Apo E gene polymorphisms are associated with variations in lipids in patients with CAD and healthy controls in Turkish population...
  4. ncbi request reprint The influence of cyclin D1 A870G polymorphism on colorectal cancer risk and prognosis in a Turkish population
    Ilhan Yaylim-Eraltan
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Anticancer Res 30:2875-80. 2010
    ..The present study was performed to test the association between A870G polymorphisms in the CCND1 gene and colorectal cancer risk and progression...
  5. ncbi request reprint Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking
    Bedia Agachan
    Department of Molecular Medicine, Institute for Experimental Medicine DETAE, Faculty of Pharmacy, Istanbul University, CAPA 34390 Istanbul, Turkey
    Anticancer Res 29:2417-20. 2009
    ..Based on this hypothesis, the relationship between APE1 polymorphism, smoking and the risk of lung cancer was explored...
  6. ncbi request reprint Fas-1377 A/G polymorphism in lung cancer
    Uzay Gormus
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Turkey
    In Vivo 21:663-6. 2007
    ..Functional mutations in the Fas gene that impair apoptotic signal transduction are associated with susceptibility to various types of cancer. In this study, we focused on lung cancer...
  7. doi request reprint Investigation of polymorphic variants of PPARD and APOE genes in Turkish coronary heart disease patients
    Hulya Yilmaz-Aydogan
    Department of Molecular Medicine, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
    DNA Cell Biol 31:867-75. 2012
    ..Furthermore, gene-gene interaction between the PPARD +294T/C and the APOE polymorphisms was observed regarding LDL-C concentrations...
  8. ncbi request reprint Close correlation between restriction fragment length polymorphism of L-myc gene and susceptibility to gastric cancer
    Turgay Isbir
    Department of Molecular Medicine, Institute of Experimental Medical Research, University of Istanbul, DETAE 34390, P O Box 7 Capa, Istanbul, Turkey
    Cancer Detect Prev 26:454-7. 2002
    ..Our aim was to test the hypothesis that there was association between L-myc S allele in gastric cancer and predisposition to the disease...
  9. ncbi request reprint ARE-I polymorphism on PSA gene in prostate cancer patients of a Turkish population
    Ebru Kalay
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Istanbul, Turkey
    Anticancer Res 29:1395-8. 2009
    ..The polymorphism of the ARE-I locus on the PSA gene was studied in prostate cancer patients to determine a possible relationship of that locus to prostate cancer risk...
  10. ncbi request reprint APE1 and XRCC3 polymorphisms and myocardial infarction
    Atike Tekeli
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Capa Istanbul, Turkey
    In Vivo 22:477-9. 2008
    ..In the present study, APE1 and XRCC3 gene polymorphisms were investigated in patients with myocardial infarction...
  11. ncbi request reprint Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population
    Yasemin K Ozbek
    Department of Molecular Medicine, Institute of Experimental Medicine DETAE, Istanbul University, Vakif Gureba Cad Sehremini, Istanbul, Turkey
    Anticancer Res 30:2885-9. 2010
    ..CYP1B1*3 polymorphism and seven missense and four silent polymorphisms of NAT2 were investigated...
  12. ncbi request reprint Breast cancer and cyclin D1 gene polymorphism in Turkish women
    Ilhan Yaylim-Eraltan
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    In Vivo 23:767-72. 2009
    ..It has been suggested that G870A polymorphism at the exon4/intron4 splicing region of the CCND1 gene may play a role in tumorigenesis and invasiveness...
  13. ncbi request reprint Is LOX-1 K167N polymorphism protective for coronary artery disease?
    Ozlem Kurnaz
    Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    In Vivo 23:969-73. 2009
    ..Replacement of this Lys residue causes reduced binding and internalization of oxLDL. The purpose of this study was to investigate the effect of the LOX-1 K167N gene polymorphism in Turkish patients with coronary artery disease (CAD)...
  14. ncbi request reprint Associations of lipoprotein lipase S447X and apolipoprotein E genotypes with low-density lipoprotein subfractions in Turkish patients with coronary artery disease
    Hulya Yilmaz Aydogan
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    In Vivo 23:155-61. 2009
    ....
  15. ncbi request reprint CYP17 (T-34C) and CYP19 (Trp39Arg) polymorphisms and their cooperative effects on breast cancer susceptibility
    Bora M Tüzüner
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    In Vivo 24:71-4. 2010
    ..In this study, for the first time the T/C (A1/A2) polymorphism at the 5' untranslated region (UTR) of CYP17 and the Arg/Trp (T/C) polymorphism at codon 39 of CYP19 among genes regulating endogenous estrogen levels was studied...
  16. ncbi request reprint C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease
    Hulya Yilmaz
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    Cell Biochem Funct 24:87-90. 2006
    ..In spite of the clear effect of the MTHFR polymorphism on elevated homocysteine levels, we did not observe any associations among the MTHFR genotypes with a the risk of CAD in the Turkish population...
  17. ncbi request reprint Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer
    H Arzu Ergen
    Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Capa Istanbul, Turkey
    Anticancer Res 27:4107-10. 2007
    ..Oxidative stress may contribute to carcinogenesis as an important risk factor. This study aimed to investigate the relationship between prostate cancer and NQO1 C609T polymorphism in a Turkish population...
  18. ncbi request reprint Comparison of lipid profiles with APOA1 MspI polymorphism in obese children with hyperlipidemia
    Bahar Toptas
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Capa Istanbul, Turkey
    In Vivo 25:425-30. 2011
    ..The relationship between lipid levels in obese children and the APOA1 MspI polymorphisms, was examined...
  19. ncbi request reprint Effects of the MTHFR C677T polymorphism on prostate specific antigen and prostate cancer
    Ozlem Kucukhuseyin
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Asian Pac J Cancer Prev 12:2275-8. 2011
    ..We suggest that the heterozygote CT genotype and the 677T allele of the MTHFR polymorphism might be associated with an decreased prostate cancer risk...
  20. doi request reprint Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients
    Hulya Yilmaz Aydogan
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Genet Test Mol Biomarkers 16:134-7. 2012
    ....
  21. doi request reprint The LOX-1 3'UTR188CT polymorphism and coronary artery disease in Turkish patients
    Ozlem Kurnaz
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Capa, 34390, Istanbul, Turkey
    Mol Biol Rep 39:4351-8. 2012
    ..031) and increased levels of VLDL-C in the patient group (P = 0.009). The LOX-1 3'UTR188CT gene polymorphism may predispose to the development of LVH in CAD patients, dependent on blood pressure...
  22. doi request reprint Effects of myeloperoxidase -463 G/A gene polymorphism and plasma levels on coronary artery disease
    Arzu Ergen
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, 34280, Capa Istanbul, Turkey
    Mol Biol Rep 38:887-91. 2011
    ..We observed that MPO levels were increased in CAD but there were no effect of MPO -463 G/A polymorphism on MPO levels...
  23. ncbi request reprint Effects of cholesterol ester transfer protein Taq1B gene polymorphism on serum lipoprotein levels in Turkish coronary artery disease patients
    Hulya Yilmaz
    Department of Molecular Medicine, Institute of Experimental Medical Research, University of Istanbul, Istanbul, Turkey
    Cell Biochem Funct 23:23-8. 2005
    ..The present study demonstrates that CETP Taq1B gene polymorphism may be responsible for low HDL cholesterol levels in patients with CAD and in healthy controls in Turkey...
  24. ncbi request reprint Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer
    Umit Zeybek
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    Cell Biochem Funct 25:419-22. 2007
    ..MTHFR C677T polymorphism may not be important in an individual's susceptibility to gastric and colorectal cancer in Turkey and may not be a useful marker for identifying patients at high risk of developing gastric and colorectal cancer...
  25. ncbi request reprint 192R allele of paraoxanase 1 (PON1) gene as a new marker for susceptibility to bladder cancer
    Oguz Ozturk
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    Anticancer Res 29:4041-6. 2009
    ..The purpose of this study was to investigate the relationship between bladder cancer and the polymorphism of PON1 which results in Q/R substitution at codon 192. This is the first report of this polymorphism in bladder cancer...
  26. ncbi request reprint Investigation of the VDR gene polymorphisms association with susceptibility to colorectal cancer
    Ilhan Yaylim-Eraltan
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    Cell Biochem Funct 25:731-7. 2007
    ..112; 95%CI 0.030-0.419). These data suggest that VDR TtFf or TTFf genotypes may protect against colorectal carcinogenesis. However, further studies are necessary to confirm these findings...
  27. ncbi request reprint Investigation of PON1 192 and PON1 55 polymorphisms in ovarian cancer patients in Turkish population
    Aytaç Arpaci
    Department of Molecular Medicine, Istanbul University, Capa, Istanbul, Turkey
    In Vivo 23:421-4. 2009
    ..Paraoxonase (PON1) is an antioxidative enzyme, which eliminates lipid peroxides. PON1 has two common polymorphisms (M/L55 and A/B192) that influence PON1 concentration and activity...
  28. doi request reprint Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?
    Ozlem Kucukhuseyin
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Vakif Gureba Street, Capa Istanbul, Turkey
    Mol Biol Rep 39:4423-8. 2012
    ..In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics...
  29. doi request reprint Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes
    Hulya Yilmaz-Aydogan
    Department of Molecular Medicine, Institute for Experimental Medicine, Istanbul University, Capa, 34390 Istanbul, Turkey
    Mol Cell Biochem 358:355-63. 2011
    ..We observed that the C161T CT heterozygote genotype shows an unfavorable effect on serum lipid profile in CHD patients with diabetes and this effect was weaken with the presence of P12P homozygote genotype...
  30. ncbi request reprint GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas
    Oguz Ozturk
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    In Vivo 17:625-32. 2003
    ..It has been suggested that an increased phase I enzyme activity (CYP1A1) and a decreased phase II enzyme activity (GST M1) could each individually cause an increase in the risk of cancer...
  31. ncbi request reprint Methylene tetrahydrofolate reductase C677T mutation and left ventricular hypertrophy in Turkish patients with type II diabetes mellitus
    Hulya Yilmaz
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    J Biochem Mol Biol 37:234-8. 2004
    ..01). The MTHFR gene C677T mutation may be a possible risk factor for the development of LVH in the type II diabetic patients...
  32. ncbi request reprint Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients
    H Arzu Ergen
    Institue of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    Exp Mol Med 36:345-50. 2004
    ..05). There is no significant correlation between diabetic nephropathy and ACE gene polymorphism. But we found that ACE DD genotype increased significantly in type 2 diabetic patients compared to control subjects (P <.05)...
  33. ncbi request reprint Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis
    Zelal Erkisi
    Department of Medicine, Institute of Experimental Medical Research, University of Istanbul, Istanbul, Turkey
    Tumori 96:756-63. 2010
    ..mEH is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens...
  34. doi request reprint Manganese superoxide dismutase gene polymorphism, MnSOD plasma levels and risk of epithelial ovarian cancer
    Altay Burak Dalan
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Capa, Turkey
    J Obstet Gynaecol Res 34:878-84. 2008
    ....
  35. ncbi request reprint Associations of -374T/A polymorphism of receptor for advanced glycation end products (RAGE) gene in Turkish diabetic and non-diabetic patients with coronary artery disease
    Ozlem Kucukhuseyin
    The Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Capa, 34390 Istanbul, Turkey
    In Vivo 23:949-54. 2009
    ....
  36. ncbi request reprint Comparison of lipid profiles in relation to APOB EcoRI polymorphism in obese children with hyperlipidemia
    Ozlem Timirci
    Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Capa Istanbul, Turkey
    In Vivo 24:65-9. 2010
    ..We aimed to evaluate apolipoprotein B-100 (APOB) EcoRI polymorphism and plasma lipid parameters together in children and adolescents. This is the first such study in Turkey to determine possible relationships of these parameters...
  37. ncbi request reprint Taq1B polymorphism of CETP gene on lipid abnormalities in patients with type II diabetes mellitus
    Hulya Yilmaz
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    Int J Mol Med 13:889-93. 2004
    ..We also showed that CATE Taq1B gene polymorphism may be related to myocardial infarction in type II diabetic patients...
  38. doi request reprint Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma
    Arzu Ergen
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, 34390, Capa, Istanbul, Turkey
    Mol Biol Rep 38:4181-4. 2011
    ..PON1 192 QQ genotype was associated with osteosarcoma in multivariate logistic regression analysis. Our findings have suggested that PON1 192 wild type genotypes may be associated with a risk of developing osteosarcoma...
  39. pmc Increased frequency of the S-allele of the L-myc oncogene in breast cancer
    Turgay Isbir
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    Mol Med 8:521-4. 2002
    ..Our aim was to test the hypothesis that there was an association between L-myc S allele in breast cancer and a predisposition to the disease...
  40. ncbi request reprint Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus
    Bedia Agachan
    Department of Molecular Medicine, Institute of Experimental Medical Research, University of Istanbul, Istanbul, Turkey
    Cell Biochem Funct 22:163-8. 2004
    ..In conclusion, our results suggest that the paraoxonase activities are affected by PON1 genetic variability in Turkish NIDDM patients and controls...
  41. ncbi request reprint Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension?
    H Yilmaz
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    Cell Biochem Funct 19:191-5. 2001
    ..05)) as compared to those who were not carriers of apo epsilon4. These results showed a trend for the epsilon4 allele to be associated with a higher prevalence of target organ damage in patients with mild to moderate hypertension...
  42. pmc Is there any correlation between TNF-related apoptosis-inducing ligand (TRAIL) genetic variants and breast cancer?
    Yemliha Yildiz
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Arch Med Sci 6:932-6. 2010
    ..Here, we report the results of the first association study on genetic variation in the TRAIL gene and its effect on breast cancer susceptibility and prognosis...
  43. ncbi request reprint Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population
    Hulya Yilmaz
    Institute for Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    Aust N Z J Obstet Gynaecol 44:423-7. 2004
    ..One of the known causes of hyperhomocysteinaemia is polymorphism in the methylenetetrahydrofolate reductase gene that lowers the activity of the enzyme...
  44. doi request reprint Association of monocyte chemotactic protein-1 and CC chemokine receptor 2 gene variants with preeclampsia
    Bedia Agachan
    Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey
    J Interferon Cytokine Res 30:673-6. 2010
    ..We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia...
  45. ncbi request reprint Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients
    Bedia Agachan
    University of Istanbul, Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul, Turkey
    Exp Mol Med 35:545-9. 2003
    ..81%). Frequency of ATR1 C allele (AC+CC genotypes) was found higher hypertensives than controls (39.4% vs 25.9%; P = 0.054). Our results suggest that an interaction exists between the RAS genes and hypertension in Turkish population...
  46. ncbi request reprint MMP2 gene polymorphisms and MMP2 mRNA levels in patients with superficial varices of lower extremities
    Uzay Gormus
    Department of Biochemistry, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey
    In Vivo 25:387-91. 2011
    ..Matrix metalloproteinase enzyme-2 (MMP2) is one of the enzymes known to have functions in remodelling of the extracellular matrix mainly in vascular structures...
  47. ncbi request reprint Effects of cholesteryl ester transfer protein TAQ1B polymorphism in renal transplant patients
    U Zeybek
    University of Istanbul, Institute of Experimental Medicine, Research Department of Molecular Medicine, Istanbul, Turkey
    Transplant Proc 38:1382-4. 2006
    ..The aim of this study was to investigate CETP Taq1B gene polymorphism and lipid abnormalities in renal transplant patients...
  48. ncbi request reprint Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease
    T Isbir
    Department Head of Molecular Medicine, University of Istanbul, Institute for Experimental Medical Research Department of Molecular Medicine, Istanbul, Turkey
    Am J Alzheimers Dis Other Demen 16:205-10. 2001
    ..7 percent, respectively. In conclusion ACE D and apo epsilon 4 allele were found to be more frequent in patients with Alzheimer's disease than in the control group...
  49. ncbi request reprint L-myc gene polymorphism and risk of thyroid cancer
    I Yaylim-Eraltan
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul Research and Education Hospital, Surgery Clinic, Istanbul, Turkey
    Exp Oncol 30:117-20. 2008
    ..L-myc gene polymorphism is a representative genetic trait responsible for an individual's susceptibility to several cancers. However, there have been no reports concerning the association between thyroid cancer and L-myc gene polymorphism...
  50. ncbi request reprint Apolipoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease
    T Isbir
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    Am J Alzheimers Dis Other Demen 16:77-81. 2001
    ..05). This study confirms the association of apo E epsilon 4 allele with lipid profiles in AD patients...
  51. ncbi request reprint CK2 enzyme affinity against c-myc 424-434 substrate in human lung cancer tissue
    Ilhan Yaylim
    Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Asian Pac J Cancer Prev 13:5233-6. 2012
    ..Considering the metabolic position of c-myc 424-434, our results suggest that phosphorylation by CK2 may be important in dimerization and thus it might affect the regulation of c-myc in cancer tissues...
  52. ncbi request reprint Fas-1377A/G and FasL-844 T/C gene polymorphisms and epithelial ovarian cancer
    Uzay Gormus
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Istanbul, Turkey
    Anticancer Res 27:991-4. 2007
    ..Ovarian cells are known to exhibit marked FasL immunoreactivity throughout follicular development; there may also be a relationship between Fas and FasL polymorphisms and the immune privileges of the epithelial ovarian cells...
  53. ncbi request reprint Is paraoxonase 192 gene polymorphism a risk factor for membranoproliferative glomerulonephritis in children?
    Ilmay Bilge
    Istanbul University, Medical Faculty of Istanbul, Department of Pediatric Nephrology, Istanbul, Turkey
    Cell Biochem Funct 25:159-65. 2007
    ..In conclusion, we suggest that the PON1 activities are affected by PON1 genetic variability in Turkish patients with MPGN...
  54. ncbi request reprint Effect of paraoxonase 1 gene polymorphisms on clinical course of Henoch-Schönlein purpura
    Alev Yilmaz
    Pediatric Nephrology Department, Bakirkoy Maternity and Children Hospital, Istanbul, Turkey
    J Nephrol 22:726-32. 2009
    ..In the present study, we aimed to investigate the effect of PON1 gene polymorphisms on the course and renal involvement of HSP in Turkish children...
  55. ncbi request reprint The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat
    F Ildan
    Department of Neurosurgery, Cukurova University School of Medicine, Balcali Adana 01330, Turkey
    Neurol Res 23:96-104. 2001
    ....
  56. ncbi request reprint Association between Apo B signal peptide gene polymorphism and NIDDM
    Turgay Isbir
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    Cell Biochem Funct 21:189-90. 2003
  57. ncbi request reprint Effects of manganase superoxide dismutase Ala-9Val polymorphism on prostate cancer: a case-control study
    H Arzu Ergen
    Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Capa, Istanbul, Turkey
    Anticancer Res 27:1227-30. 2007
    ..Mitochondrial DNA damage may contribute to carcinogenesis as an important risk factor. The aim of this study was to investigate the relationship between prostate cancer and MnSOD Ala-9Val polymorphism in Turkish men with prostate cancer...
  58. ncbi request reprint Is there any correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human nonsmall cell lung cancer?
    Ilhan Yaylim
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    Cancer Genet Cytogenet 134:118-22. 2002
    ..Our results suggested that L-myc gene polymorphism was not a suitable prognostic marker of metastatic development in Turkish NSCLC patients...
  59. doi request reprint L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers
    Aydin Gozu
    Department of Plastic and Reconstructive Surgery, Vakif Gureba Research and Education Hospital, Istanbul, Turkey
    Arch Otolaryngol Head Neck Surg 134:725-8. 2008
    ..To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC)...
  60. ncbi request reprint Genetic variants of vascular endothelial growth factor and risk for the development of endometriosis
    Rukset Attar
    Department of Obstetrics and Gynecology, Teditepe University Hospital, Istanbul, Turkey
    In Vivo 24:297-301. 2010
    ..Whether vascular endothelial growth factor (VEGF) -460 C/T and +405 G/C polymorphisms are associated with susceptibility to endometriosis was investigated...
  61. ncbi request reprint Paraoxonase (PON1) 55 and 192 polymorphism and its effects to oxidant-antioxidant system in turkish patients with type 2 diabetes mellitus
    B Agachan
    University of Istanbul, Institute for Experimental Medical Research, Department of Molecular Medicine, Istanbul, Turkey
    Physiol Res 54:287-93. 2005
    ..We thus conclude that PON1 192 BB and PON1 55 LL alleles have protective effect against oxidative stress...
  62. ncbi request reprint Paraoxonase 192 polymorphism and its relationship to serum lipids in Turkish renal transplant recipients
    B Agachan
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    Transplant Proc 36:1385-6. 2004
    ..Cardiovascular disorders are the leading cause of death in patients with chronic renal insufficiency. Paraoxonase (PON1) gene variants have been identified as risk factors for cardiovascular disease (CVD)...
  63. ncbi request reprint Association of CCL2 and CCR2 gene variants with endometrial cancer in Turkish women
    Rukset Attar
    Department of Obstetrics and Gynecology, Yeditepe University Hospital, Istanbul, Turkey
    In Vivo 24:243-8. 2010
    ..019). In conclusion, we state that there appears to be an association between polymorphism of CCL2 and its receptor CCR2 and endometrial cancer. To the best of our knowledge, this is the first study to show such an association...
  64. doi request reprint Association of interleukin 1beta gene (+3953) polymorphism and severity of endometriosis in Turkish women
    Rukset Attar
    Department of Obstetrics and Gynecology, Yeditepe University Hospital, Istanbul, Turkey
    Mol Biol Rep 37:369-74. 2010
    ..7, 15.4 and 27.8%, respectively. We observed a statistically insignificant increase in TT genotype in stage IV endometriosis (P > 0.05). We suggest that IL-1beta (+3953) polymorphism is not associated with endometriosis in Turkish women...
  65. ncbi request reprint Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas
    Ali Metin Kafadar
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Capa, Istanbul, Turkey
    Cell Biochem Funct 24:455-60. 2006
    ..05). Our results suggest that serum PON1 as a part of the lipid peroxidation scavenging systems might be involved in the tumourigenesis of brain tumours...
  66. ncbi request reprint Association between CDKN1A Ser31Arg and C20T gene polymorphisms and colorectal cancer risk and prognosis
    Canan Cacina
    Institute of Experimental Medicine, Istanbul, Turkey
    In Vivo 24:179-83. 2010
    ..The purpose of this study was to investigate the effect of the CDKN1A Ser31Arg and C20T gene polymorphisms in Turkish patients with colorectal cancer...
  67. ncbi request reprint Is there additional effect of MTHFR C677T mutation on lipid abnormalities in renal allograft recipients?
    H Yilmaz
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    Transplant Proc 35:1390-2. 2003
    ..The aim of the present study was to eveluate the contribution of MTHFR C677T mutation to the risk of dyslipidemia in renal transplant recipients. We also studied the effect of the MTHFR-C677 T genotype on transplant survival...
  68. ncbi request reprint Analysis of L-myc gene polymorphism in patients with renal failure outcome to renal transplant
    B Yigit
    Haydarpasa Numune Research and Educational Hospital, Renal Transplantation Unit, Department of Molecular Medicine, Istanbul University, Turkey
    Transplant Proc 38:1267-9. 2006
    ..The aim of this study was to investigate the relationship between the distribution of L-myc genotypes and renal failure...
  69. ncbi request reprint The association between preeclampsia and angiotensin-converting enzyme insertion/deletion polymorphism
    Figen Gurdol
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey
    Clin Chim Acta 341:127-31. 2004
    ..In this study, we examined the insertion/deletion genotype distribution and the activity of ACE in preeclamptic pregnants...
  70. ncbi request reprint Effects of ACE I/D polymorphism on prostate cancer risk, tumor grade and metastatis
    Bulent Yigit
    Renal Transplantation Unit, Haydarpasa Numune Research and Educational Hospital, Istanbul, Turkey
    Anticancer Res 27:933-6. 2007
    ....
  71. ncbi request reprint Analysis of CC chemokine receptor 5 and 2 polymorphisms and renal transplant survival
    Bulent Yigit
    Haydarpasa Numune Research and Educational Hospital, Renal Transplantation Unit, Istanbul, Turkey
    Cell Biochem Funct 25:423-6. 2007
    ....
  72. ncbi request reprint C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas
    Ali Metin Kafadar
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Anticancer Res 26:2445-9. 2006
    ..MTHFR polymorphisms have been studied in various cancers but not in primary brain tumors. The purpose of this case-control study was to explore a possible association between MTHFR C677T polymorphism and primary brain tumors...
  73. ncbi request reprint Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1)
    Kamil Fehmi Narter
    Istanbul Universitesi Deneysel Tip Arastirma Enstitüsü, Molekuler Tip Anabilim Dali, Capa, Istanbul, Turkey
    Anticancer Res 29:1389-93. 2009
    ..The genotype distribution for the APE gene was determined to be significantly different between local and invasive cases; G allele carriers for this gene were significantly higher in invasive cancer types...
  74. ncbi request reprint Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer
    Emel Canbay
    General Surgery, Basaksehir State Hospital, Basaksehir, Istanbul, 34230, Turkey
    Anticancer Res 30:1359-64. 2010
    ..In this study, we examined the polymorphisms of six DNA repair genes: APE1, HOGG1, XRCC1, XRCC3, XPD, and XPG in patients with gastric cancer (GC)...
  75. ncbi request reprint No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer
    Nezih Hekim
    Dr Pakize I Tarzi Laboratories, Istanbul, Turkey
    Cell Biochem Funct 25:115-7. 2007
    ..Our data fail to support a relationship between MTHFR C677T and the risk for breast cancer. It may be that there are ethnic differences in terms of this relationship...
  76. ncbi request reprint Angiotensin-converting enzyme I/D gene polymorphisms and effects of left ventricular hypertrophy in Turkish myocardial infarction patients
    Zeynep Ermis Karaali
    Haseki Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey
    Acta Cardiol 59:493-7. 2004
    ..In view of the clinical importance of the ACE as a major marker of cardiovascular diseases, we investigated the I/D polymorphism of the ACE gene in Turkish patients with acute myocardial infarction in comparison with control subjects...
  77. ncbi request reprint Increased plasma levels of interleukin-6 and interleukin-8 in beta-thalassaemia major
    O Ozturk
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Turkey
    Haematologia (Budap) 31:237-44. 2001
    ..Before a clinical value can be ascribed to these changes in plasma cytokine levels in beta-thalassaemia, the follow-up samples of larger series of patients with 8-thalassaemia should be evaluated...
  78. pmc Albumin Naskapi variant in North American Indians and Eti Turks
    S G Franklin
    Proc Natl Acad Sci U S A 77:5480-2. 1980
    ....
  79. ncbi request reprint Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients
    H Ozger
    Department of Orthopaedics and Traumatology, Istanbul Faculty of Medicine, Turkey
    Folia Biol (Praha) 54:53-7. 2008
    ..The MTHFR C677T polymorphism may not be important in an individual's susceptibility to osteosarcoma and chondrosarcoma in Turkey and may not be a useful marker for identifying patients at high risk of developing sarcomas...