M Emre

Summary

Affiliation: Istanbul University
Country: Turkey

Publications

  1. ncbi request reprint Dementia in Parkinson's disease: cause and treatment
    Murat Emre
    Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey
    Curr Opin Neurol 17:399-404. 2004
  2. ncbi request reprint Rivastigmine in dementia associated with Parkinson's disease and Alzheimer's disease: similarities and differences
    Murat Emre
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey
    J Alzheimers Dis 11:509-19. 2007
  3. ncbi request reprint Evidence-based pharmacological treatment of dementia
    M Emre
    Department of Neurology, Istanbul Medical School, University of Istanbul, Turkey
    Eur J Neurol 7:247-53. 2000
  4. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
  5. doi request reprint Treatment of dementia associated with Parkinson's disease
    M Emre
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Parkinsonism Relat Disord 13:S457-61. 2007
  6. ncbi request reprint Pooled analyses on cognitive effects of memantine in patients with moderate to severe Alzheimer's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Alzheimers Dis 14:193-9. 2008
  7. ncbi request reprint Rivastigmine for dementia associated with Parkinson's disease
    Murat Emre
    Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    N Engl J Med 351:2509-18. 2004
  8. doi request reprint Classification and diagnosis of dementia: a mechanism-based approach
    M Emre
    Department of Neurology, Istanbul Faculty of Medicine, Capa Istanbul, Turkey
    Eur J Neurol 16:168-73. 2009
  9. doi request reprint Drug profile: transdermal rivastigmine patch in the treatment of Alzheimer disease
    Murat Emre
    Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    CNS Neurosci Ther 16:246-53. 2010
  10. ncbi request reprint What causes mental dysfunction in Parkinson's disease?
    Murat Emre
    Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University, Capa Istanbul, Turkey
    Mov Disord 18:S63-71. 2003

Detail Information

Publications50

  1. ncbi request reprint Dementia in Parkinson's disease: cause and treatment
    Murat Emre
    Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey
    Curr Opin Neurol 17:399-404. 2004
    ..The purpose of this article is to provide an overview of recent findings on dementia associated with Parkinson's disease, from February 2003 to the present...
  2. ncbi request reprint Rivastigmine in dementia associated with Parkinson's disease and Alzheimer's disease: similarities and differences
    Murat Emre
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey
    J Alzheimers Dis 11:509-19. 2007
    ..In both populations, hallucinations may identify patients who are likely to be more treatment-responsive...
  3. ncbi request reprint Evidence-based pharmacological treatment of dementia
    M Emre
    Department of Neurology, Istanbul Medical School, University of Istanbul, Turkey
    Eur J Neurol 7:247-53. 2000
    ..The evidence for efficacy, however, is not strong for the majority of these compounds...
  4. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  5. doi request reprint Treatment of dementia associated with Parkinson's disease
    M Emre
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Parkinsonism Relat Disord 13:S457-61. 2007
    ..Based on a large, randomized, placebo controlled trial, the ChE-I rivastigmine has been approved for the treatment of dementia associated with PD...
  6. ncbi request reprint Pooled analyses on cognitive effects of memantine in patients with moderate to severe Alzheimer's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Alzheimers Dis 14:193-9. 2008
    ..It is concluded that treatment with memantine provides benefits in all three cognitive functions...
  7. ncbi request reprint Rivastigmine for dementia associated with Parkinson's disease
    Murat Emre
    Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    N Engl J Med 351:2509-18. 2004
    ..Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such patients...
  8. doi request reprint Classification and diagnosis of dementia: a mechanism-based approach
    M Emre
    Department of Neurology, Istanbul Faculty of Medicine, Capa Istanbul, Turkey
    Eur J Neurol 16:168-73. 2009
    ..This article is an attempt to provide a comprehensive, yet simplified classification of dementias following a mechanism-based approach. A systematic approach to diagnostic work-up is also proposed based on this classification...
  9. doi request reprint Drug profile: transdermal rivastigmine patch in the treatment of Alzheimer disease
    Murat Emre
    Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    CNS Neurosci Ther 16:246-53. 2010
    ..Rivastigmine patch provides an efficient option for managing patients with AD, to be considered among the first line therapies for the disease...
  10. ncbi request reprint What causes mental dysfunction in Parkinson's disease?
    Murat Emre
    Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University, Capa Istanbul, Turkey
    Mov Disord 18:S63-71. 2003
    ....
  11. ncbi request reprint Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial
    Murat Emre
    Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
    Lancet Neurol 9:969-77. 2010
    ..Therefore, the efficacy and safety of memantine were investigated in patients with mild to moderate Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB)...
  12. ncbi request reprint Dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey
    Lancet Neurol 2:229-37. 2003
    ..Alzheimer's disease-type pathology is commonly associated with dementia but less predictive. Recent evidence from small studies suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD...
  13. ncbi request reprint Experimental approaches and drugs in development for the treatment of dementia
    M Emre
    Istanbul Medical School, Department of Neirology, Capa Istanbul, Turkey
    Expert Opin Investig Drugs 10:607-17. 2001
    ..Likewise, recent studies suggest that some statins may have a prophylactic effect...
  14. doi request reprint The combinations of TNFalpha-308 and IL-6 -174 or IL-10 -1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's disease
    P Vural
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093, Istanbul, Turkey
    Acta Neurol Scand 120:396-401. 2009
    ....
  15. doi request reprint The prevalence of dementia in an urban Turkish population
    H Gurvit
    Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    Am J Alzheimers Dis Other Demen 23:67-76. 2008
    ..0% (95% CI, 7.0% to 15.0%) and 20.0% (95% CI, 14.0% to 26.0%), respectively, in this population. Prevalence rates of dementia and AD in Istanbul, Turkey, are comparable with those seen in the Western world...
  16. ncbi request reprint Do unilateral ablative lesions of the subthalamic nucleu in parkinsonian patients lead to hemiballism?
    O Barlas
    Department of Neurosurgery, Istanbul Faculty of Medicine, University of Istanbul, Capa Istanbul, Turkey
    Mov Disord 16:306-10. 2001
    ..We conclude that hemiballism following unilateral ablation of STN in patients with PD is a rare phenomenon, and unilateral ablative lesions of STN can be performed safely...
  17. ncbi request reprint Treatment of behavioural symptoms and dementia in Parkinson's disease
    Hasmet A Hanagasi
    Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, 34390 Capa Istanbul, Turkey
    Fundam Clin Pharmacol 19:133-46. 2005
    ..Recent evidence from small double-blind and open-label trials suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD...
  18. ncbi request reprint Genetic bases and phenotypes of autosomal recessive Parkinson disease in a Turkish population
    E Lohmann
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Turkey
    Eur J Neurol 19:769-75. 2012
    ..To evaluate the phenotype and the frequencies of mutations in PRKN, DJ1 and PINK1 genes in patients with Parkinson disease (PD) in Turkey...
  19. ncbi request reprint Stiff leg syndrome: case report
    M E Gurol
    Department of Neurology, Istanbul School of Medicine, University of Istanbul, Istanbul, Turkey
    Mov Disord 16:1189-93. 2001
    ..She improved substantially with clonazepam 4 mg/day. She presented with electrophysiological findings not previously reported in stiff leg syndrome, which may suggest increased inhibition in the uninvolved upper extremities...
  20. ncbi request reprint Atypical neurological involvement associated with celiac disease
    H A Hanagasi
    Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Medical School, Istanbul University, Istanbul, Turkey
    Eur J Neurol 8:67-9. 2001
    ..We suggest that celiac disease can present with a variety of unusual neurological manifestations...
  21. ncbi request reprint The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease
    S Dogru-Abbasoglu
    Department of Biochemistry, Istanbul University, Capa 34093, Istanbul, Turkey
    Neurol Sci 28:31-4. 2007
    ..In addition, the 194Trp allele revealed a borderline significance (OR=2.05, 95% CI 0.96-4.37, p=0.056). According to our results, it may be speculated that the polymorphic variants of XRCC1 codon 194 have a role in the development of AD...
  22. ncbi request reprint Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials
    Hasmet A Hanagasi
    University of Istanbul, Istanbul Medical School, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Turkey
    Brain Res Cogn Brain Res 14:234-44. 2002
    ..These results indicate subclinical impairment of cognitive functions in patients with ALS. The pattern of cognitive impairment suggests the dysfunction of the frontal network...
  23. ncbi request reprint Therapeutic effects of an acetylcholinesterase inhibitor (donepezil) on memory in Wernicke-Korsakoff's disease
    Huseyin A Sahin
    University of Istanbul, Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Turkey
    Clin Neuropharmacol 25:16-20. 2002
    ..Subtle benefits, however, cannot be excluded because of the small sample size and the relatively short duration of the treatment...
  24. ncbi request reprint The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies
    Huseyin A Sahin
    Department of Neurology, Ondokuz Mayis University, Faculty of Medicine, Kurupelit, 55139, Samsun, Turkey
    Acta Neuropathol 111:115-25. 2006
    ....
  25. ncbi request reprint Parkin expression in muscle from three patients with autosomal recessive Parkinson's disease carrying parkin mutation
    P Serdaroglu
    Department of Neurology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Acta Myol 24:2-5. 2005
    ..Further investigation of parkin expression in skeletal muscle is warranted...
  26. doi request reprint Presenilin-1 gene intronic polymorphism and late-onset Alzheimer's disease
    Erdinç Dursun
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Geriatr Psychiatry Neurol 21:268-73. 2008
    ..52, P = .32, respectively), when the control and patients were compared. Consequently, our results showed that the 1/1 genotype does not increase the risk of developing late-onset Alzheimer's disease in the Turkish population...
  27. ncbi request reprint Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease
    Hande Parildar-Karpuzoglu
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa, Istanbul, Turkey
    Neurosci Lett 442:287-91. 2008
    ..08, 95% CI=0.70-1.68), XRCC1-Arg280His (OR=0.53, 95% CI=0.24-1.14) and XRCC1-Arg399Gln (OR=1.05, 95% CI=0.68-1.63) and AD. Our results suggest that the polymorphic variants of these BER genes are not independent risk factors for AD...
  28. ncbi request reprint Association between vitamin D receptor gene polymorphism and Alzheimer's disease
    Duygu Gezen-Ak
    Istanbul University, Cerrahpasa Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
    Tohoku J Exp Med 212:275-82. 2007
    ..On the other hand, the "AT" haplotype was significantly higher in controls (p = 0.006) indicating a protective role of the "AT" haplotype in AD. Consequently, this study provides evidence for a possible link between AD and vitamin D...
  29. doi request reprint Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease
    Erdinç Dursun
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Dement Geriatr Cogn Disord 27:82-7. 2009
    ..The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1alpha gene and late-onset AD in a cohort of Turkish patients...
  30. ncbi request reprint Unrecognized depression in community-dwelling elderly persons in Istanbul
    Isin Baral Kulaksizoglu
    Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Capa 34390
    Int Psychogeriatr 17:303-12. 2005
    ..Most studies of old age depression have been conducted in developed countries. The present study was conducted to determine the prevalence of depressive disorders among Turkish elderly in an urban community...
  31. ncbi request reprint Clinical and magnetic resonance imaging findings of HIV-negative patients with neurosyphilis
    Candan Gurses
    Department of Neurology, Faculty of Medicine, University of Istanbul, 34390, Capa, Istanbul, Turkey
    J Neurol 254:368-74. 2007
    ..This finding may be due to cytotoxic edema associated with status epilepticus and may mimic herpes simplex and other limbic encephalitides. Though not typical, certain MRI findings guides for the diagnosis of neurosyphilis...
  32. ncbi request reprint The attitude of elderly lay people towards the symptoms of dementia
    Huseyin A Sahin
    Ondokuz Mayis University, Faculty of Medicine, Department of Neurology, Kurupelit, Samsun, Turkey
    Int Psychogeriatr 18:251-8. 2006
    ..To assess the attitude of elderly lay people towards the concept and symptoms of dementia...
  33. ncbi request reprint Risk factors for Alzheimer disease: a population-based case-control study in Istanbul, Turkey
    Hande Harmanci
    Department of Public Health, Marmara University Medical Faculty, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    Alzheimer Dis Assoc Disord 17:139-45. 2003
    ..77, 95% CI = 1.12-6.85). Our results suggest that having a higher education is protective from AD and that electromagnetic field exposure at work or at home is a significant risk factor...
  34. ncbi request reprint Clozapine treatment in oromandibular dystonia
    Hasmet A Hanagasi
    Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Turkey
    Clin Neuropharmacol 27:84-6. 2004
    ..We suggest that clozapine should be considered in patients with OMD who fail to response to other treatments...
  35. ncbi request reprint Mitochondrial complex I, II/III, and IV activities in familial and sporadic Parkinson's disease
    Hasmet Ayhan Hanagasi
    Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Turkey
    Int J Neurosci 115:479-93. 2005
    ..In this study, the data indicate no significant differences in mitochondrial complex I-IV activities in PDF and PDS...
  36. ncbi request reprint Comparative analysis of event-related potentials during Go/NoGo and CPT: decomposition of electrophysiological markers of response inhibition and sustained attention
    Elif Kirmizi-Alsan
    Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul Tip Fakultesi, Fizyoloji Anabilim Dali, 34390 Capa Istanbul, Turkey
    Brain Res 1104:114-28. 2006
    ..The latency prolongation observed with the NoGo condition of the CPT paradigm was thought to be due to perseverance/inhibition conflict enhanced by the primer stimuli in CPT...
  37. ncbi request reprint Polymorphisms in the DNA repair genes XPD (ERCC2) and XPF (ERCC4) are not associated with sporadic late-onset Alzheimer's disease
    Semra Dogru-Abbasoglu
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa, Istanbul, Turkey
    Neurosci Lett 404:258-61. 2006
    ..94, 95% CI=0.63-1.41), XPD/exon 23 (OR=1.24, 95% CI=0.82-1.86) and XPF/exon 11 (OR=1.08, 95% CI=0.72-1.64) and AD. Our results suggest that the polymorphic variants of these NER genes do not contribute to the risk of developing AD...
  38. ncbi request reprint Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors
    Serge Gauthier
    McGill Centre for Studies in Aging, Verdun, Quebec, Canada
    Curr Med Res Opin 19:707-14. 2003
    ..The panel also aimed to reach consensus on 'whom to switch', 'when to switch' and 'how to switch'. The key findings from that meeting are reported in this review...
  39. ncbi request reprint Long-term benefits of rivastigmine in dementia associated with Parkinson's disease: an active treatment extension study
    Werner Poewe
    Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:456-61. 2006
    ..Long-term rivastigmine treatment appeared well tolerated and may provide sustained benefits in dementia associated with PD patients who remain on treatment for up to 48 weeks...
  40. pmc Profile of cognitive impairment in dementia associated with Parkinson's disease compared with Alzheimer's disease
    Kolbjorn Bronnick
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Helse Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:1064-8. 2007
    ..To compare the profile of cognitive impairment in Alzheimer's disease (AD) with dementia associated with Parkinson's disease (PDD)...
  41. ncbi request reprint Changes in motor subtype and risk for incident dementia in Parkinson's disease
    Guido Alves
    The Norwegian Center for Movement Disorders, Stavanger, Norway
    Mov Disord 21:1123-30. 2006
    ..These findings raise the question whether PIGD and dementia share common or parallel neuropathology...
  42. ncbi request reprint Subthreshold depression in patients with Parkinson's disease and dementia--clinical and demographic correlates
    Uwe Ehrt
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway
    Int J Geriatr Psychiatry 22:980-5. 2007
    ....
  43. ncbi request reprint Characterizing clinical phenotypes: the Lewys in their life or the life of their Lewys?
    Carol F Lippa
    Neurology 67:1910-1. 2006
  44. ncbi request reprint Effects of rivastigmine on tremor and other motor symptoms in patients with Parkinson's disease dementia: a retrospective analysis of a double-blind trial and an open-label extension
    Wolfgang Oertel
    Department of Neurology, Philipps University, Marburg, Germany
    Drug Saf 31:79-94. 2008
    ..The current analyses were performed to examine the potential of rivastigmine to affect tremor and other motor symptoms in patients with PDD...
  45. ncbi request reprint Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease
    David Burn
    Regional Neuroscience Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1899-907. 2006
    ..Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD...
  46. ncbi request reprint Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force
    Bruno Dubois
    INSERM UPMC UMRS 610, Federation of Neurology, AP HP, Salpêtrière Hospital Université Paris6, Paris, France
    Mov Disord 22:2314-24. 2007
    ..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...
  47. ncbi request reprint The 3rd International Symposium on Alzheimer's Disease and Related Disorders in the Middle East, Istanbul, Turkey, October 1 - 2, 2005
    Robert P Friedland
    Department of Neurology, Case School of Medicine, Cleveland, OH 44106, USA
    Amyloid 14:161-8. 2007
  48. ncbi request reprint The 2nd International Symposium on Alzheimer's disease and related disorders in the Middle East, May 1-3, 2003, Istanbul, Turkey
    Changiz Geula
    Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Amyloid 11:276-80. 2004
  49. ncbi request reprint Efficacy and safety of levodopa with entacapone in Parkinson's disease patients suboptimally controlled with levodopa alone, in daily clinical practice: an international, multicentre, open-label study
    Oscar Gershanik
    Hospital Frances La Rioja 951, Buenos Aires, Argentina
    Prog Neuropsychopharmacol Biol Psychiatry 27:963-71. 2003
    ....
  50. ncbi request reprint Efficacy and safety of donepezil in patients with Alzheimer's disease: results of a global, multinational, clinical experience study
    Mercè Boada-Rovira
    Fundacio ACE, Barcelona, Spain
    Drugs Aging 21:43-53. 2004
    ..However, in order to control for confounding factors, some clinical trials of donepezil have excluded patients with comorbid illness and concomitant medication use...