Ozden Sanal

Summary

Affiliation: Hacettepe University
Country: Turkey

Publications

  1. ncbi request reprint A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis
    Ozden Sanal
    Divisions of Immunology, Hacettepe University Children s Hospital, Ankara, Turkey
    Pediatr Infect Dis J 26:366-8. 2007
  2. doi request reprint Thirty years of primary immunodeficiencies in Turkey
    Ozden Sanal
    Immunology Division, Hacettepe University Children s Hospital, Ankara, Turkey
    Ann N Y Acad Sci 1238:15-23. 2011
  3. pmc Additional diverse findings expand the clinical presentation of DOCK8 deficiency
    Ozden Sanal
    Department of Pediatric Immunology, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey
    J Clin Immunol 32:698-708. 2012
  4. ncbi request reprint Antibody response to a seven-valent pneumococcal conjugated vaccine in patients with ataxia-telangiectasia
    Ozden Sanal
    Immunology Division, Ihsan Dogramaci Children s Hospital, Hacettepe University, 06100 Ankara, Turkey
    J Clin Immunol 24:411-7. 2004
  5. ncbi request reprint Defective anti-polysaccharide antibody response in patients with ataxia-telangiectasia
    Ozden Sanal
    Department of Molecular Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 46:208-13. 2004
  6. ncbi request reprint Griscelli syndrome types 1 and 3: analysis of four new cases and long-term evaluation of previously diagnosed patients
    Deniz Cağdaş
    Division of Pediatric Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey
    Eur J Pediatr 171:1527-31. 2012
  7. ncbi request reprint Clinical features of chronic granulomatous disease: a series of 26 patients from a single center
    Tuba Turul-Ozgür
    Division of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:576-81. 2010
  8. ncbi request reprint Griscelli disease: genotype-phenotype correlation in an array of clinical heterogeneity
    Ozden Sanal
    Hacettepe University, Ihsan Dogramaci Children s Hospital, Immunology Division, Ankara, Turkey
    J Clin Immunol 22:237-43. 2002
  9. ncbi request reprint Presentation of interleukin-12/-23 receptor beta1 deficiency with various clinical symptoms of Salmonella infections
    Ozden Sanal
    Immunology Division, Hacettepe University Children s Hospital, Ankara, Turkey
    J Clin Immunol 26:1-6. 2006
  10. ncbi request reprint A novel mutation leading to a deletion in the SH3 domain of Bruton's tyrosine kinase
    Lütfiye Mesci
    Immunology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 48:362-4. 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis
    Ozden Sanal
    Divisions of Immunology, Hacettepe University Children s Hospital, Ankara, Turkey
    Pediatr Infect Dis J 26:366-8. 2007
    ..We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well...
  2. doi request reprint Thirty years of primary immunodeficiencies in Turkey
    Ozden Sanal
    Immunology Division, Hacettepe University Children s Hospital, Ankara, Turkey
    Ann N Y Acad Sci 1238:15-23. 2011
    ....
  3. pmc Additional diverse findings expand the clinical presentation of DOCK8 deficiency
    Ozden Sanal
    Department of Pediatric Immunology, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey
    J Clin Immunol 32:698-708. 2012
    ..Particularly for patients who feature unusual clinical manifestations, immunological testing, in conjunction with genetic testing, can prove invaluable in diagnosing DOCK8 deficiency and providing potentially curative treatment...
  4. ncbi request reprint Antibody response to a seven-valent pneumococcal conjugated vaccine in patients with ataxia-telangiectasia
    Ozden Sanal
    Immunology Division, Ihsan Dogramaci Children s Hospital, Hacettepe University, 06100 Ankara, Turkey
    J Clin Immunol 24:411-7. 2004
    ..In conclusion, A-T patients failed to respond to one dose of PCV7 vaccine. Two or more doses of conjugated vaccine may be required to recruit the help of T lymphocytes in A-T patients...
  5. ncbi request reprint Defective anti-polysaccharide antibody response in patients with ataxia-telangiectasia
    Ozden Sanal
    Department of Molecular Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 46:208-13. 2004
    ..Our results suggest that the extent and severity of the recurrent sinopulmonary infections may depend not only on the immunological defects but also on other ATM-dependent physiological responses...
  6. ncbi request reprint Griscelli syndrome types 1 and 3: analysis of four new cases and long-term evaluation of previously diagnosed patients
    Deniz Cağdaş
    Division of Pediatric Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey
    Eur J Pediatr 171:1527-31. 2012
    ..Since prognosis, treatment options, and genetic counseling markedly differ among different types, molecular characterization has utmost importance in GS...
  7. ncbi request reprint Clinical features of chronic granulomatous disease: a series of 26 patients from a single center
    Tuba Turul-Ozgür
    Division of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:576-81. 2010
    ..Overall mortality was 19.2%. These results showed that all features in our group (clinical, progression and outcome) were similar to the literature except for the predominance of autosomal recessive form...
  8. ncbi request reprint Griscelli disease: genotype-phenotype correlation in an array of clinical heterogeneity
    Ozden Sanal
    Hacettepe University, Ihsan Dogramaci Children s Hospital, Immunology Division, Ankara, Turkey
    J Clin Immunol 22:237-43. 2002
    ..This genotype-phenotype correlation suggests that the natural course of the disease and outcome is dictated by the site and type of the genetic mutation...
  9. ncbi request reprint Presentation of interleukin-12/-23 receptor beta1 deficiency with various clinical symptoms of Salmonella infections
    Ozden Sanal
    Immunology Division, Hacettepe University Children s Hospital, Ankara, Turkey
    J Clin Immunol 26:1-6. 2006
    ..IL-12/IL-23p40/IL-12R/IL-23Rbeta1 deficiency seem to be underdiagnosed in patients with salmonellosis, and since such patients need prolonged therapy, diagnosis is important...
  10. ncbi request reprint A novel mutation leading to a deletion in the SH3 domain of Bruton's tyrosine kinase
    Lütfiye Mesci
    Immunology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 48:362-4. 2006
    ..Here, we describe a novel four base pair mutation (838delGAGT) in intron 9 of the BTK gene leading to the skipping of exon 9 in a 2.5-year-old boy with this disorder...
  11. ncbi request reprint Long-term survival in severe combined immune deficiency: the role of persistent maternal engraftment
    Ilhan Tezcan
    Ihsan Dogramaci Children s Hospital, Sihhiye, Ankara, Turkey
    J Pediatr 146:137-40. 2005
    ..Both patients had the same JAK3 gene mutation, suggesting that maternal engraftment may result in immune competence leading to long-term survival in patients with severe combined immune deficiency...
  12. ncbi request reprint Hereditary C1q deficiency: a new family with C1qA deficiency
    Cağman Sun-Tan
    Division of Immunology, Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:184-6. 2010
    ..Molecular study disclosed a homozygous point mutation in the C1qA chain gene. Five members of the family, including the parents and three healthy siblings, were heterozygous for this mutation...
  13. ncbi request reprint The efficacy of immunoglobulin replacement therapy in the long-term follow-up of the B-cell deficiencies (XLA, HIM, CVID)
    Benan Bayrakci
    Division of Immunology, Department of Pediatrics Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 47:239-46. 2005
    ..Serum IgG levels between 300-500 mg/dl are sufficient for effective treatment of hypogammaglobulinemias. These concentrations can be maintained with 300-400 mg/kg/month doses. Higher doses and IgG levels are not needed...
  14. doi request reprint Parvovirus B19-induced persistent pure red cell aplasia in a child with T-cell immunodeficiency
    Betul Tavil
    Hacettepe University, Pediatric Hematology Unit, 06100 Sihhiye, Ankara, Turkey
    Pediatr Hematol Oncol 26:63-8. 2009
    ..Diagnosis may require demonstration of absence of late erythroid precursors in the bone marrow as well as serologic testing and detection of parvovirus B19 genome by PCR in the serum and/or bone marrow samples of the patient...
  15. ncbi request reprint Antioxidant enzymes in red blood cells and lymphocytes of ataxia-telangiectasia patients
    Yasemin Aksoy
    Department of Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 46:204-7. 2004
    ..Our results may be another indication for the presence of constant oxidative stress in A-T patients as suggested previously...
  16. doi request reprint Two SCID cases with Cernunnos-XLF deficiency successfully treated by hematopoietic stem cell transplantation
    Deniz Cağdaş
    Department of Pediatrics, Section of Pediatric Immunology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Transplant 16:E167-71. 2012
    ..Now, both of the patients are well and alive seven and one yr after transplantation, respectively. A remarkable observation was the severe diarrhea that occurred in both patients soon after transplantation...
  17. ncbi request reprint Acquired factor VIII deficiency associated with a novel primary immunodeficiency suggestive of autosomal recessive hyper IgE syndrome
    Tuba Turul Ozgur
    Division of Immunology, Hacettepe University Children s Hospital, Ankara, Turkey
    J Pediatr Hematol Oncol 29:327-9. 2007
    ..However, FVIII inhibitor reappeared 7 months later, and disappeared spontaneously 4 months ago. Long-term and close follow-up is needed to observe the long-term prognosis in this child...
  18. ncbi request reprint Multifocal leiomyosarcomatosis in a 6-year-old child with epidermodysplasia verruciformis and immune defect
    Ozlem Boybeyi
    Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
    J Pediatr Surg 44:e5-8. 2009
    ..A 6-year-old girl, who has had multifocal leiomyosarcomatosis after the previous diagnoses of epidermodysplasia verruciformis and immune defect, represents an interesting association of these features...
  19. ncbi request reprint The effect of mannose-binding protein gene polymorphisms in recurrent respiratory system infections in children and lung tuberculosis
    Filiz Ozbas-Gerçeker
    TUBITAK DNA Cell Bank and Gene Research Laboratory, Ankara, Turkey
    Turk J Pediatr 45:95-8. 2003
    ..It was found to be significantly lower in children with recurrent respiratory system infections than in controls (chi2: 4.68, d.f: 1, p: 0.030)...
  20. doi request reprint C1q deficiency: identification of a novel missense mutation and treatment with fresh frozen plasma
    Rezan Topaloglu
    Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Clin Rheumatol 31:1123-6. 2012
    ..Regular fresh frozen plasma infusions to the patient have been clinically and therapeutically successful...
  21. ncbi request reprint The relationship between periodontal status and peripheral levels of neutrophils in two consanguineous siblings with severe congenital neutropenia: case reports
    Tolga Fikret Tözüm
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    Quintessence Int 34:221-6. 2003
    ..This report demonstrates that periodontal therapy supported by adequate oral hygiene may result in restoration of neutrophil counts in siblings with congenital neutropenia...
  22. doi request reprint Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma
    Banu Bozkurt
    Department of Ophthalmology, Selcuk University, Meram Medical Faculty, Konya, Turkey
    Clin Experiment Ophthalmol 40:e156-62. 2012
    ..The aim of the study was to evaluate the association of TNF-α -308 G/A and -238 G/A polymorphisms with primary open-angle glaucoma (POAG)...
  23. ncbi request reprint Malignant solid tumors associated with congenital immunodeficiency disorders
    Ali Varan
    Department of Pediatric Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey
    Pediatr Hematol Oncol 21:441-51. 2004
    ..The survival rates of the malignant diseases were very poor in immunodeficiency. Overall survival in non-Hodgkin lymphoma patients was relatively worse than Hodgkin disease patients...
  24. doi request reprint Hyperimmunoglobulinemia D and periodic fever syndrome; treatment with etanercept and follow-up
    Rezan Topaloglu
    Pediatric Nephrology and Rheumatology Unit, Faculty of Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey
    Clin Rheumatol 27:1317-20. 2008
    ..We are reporting a case evaluated for the complaints of abdominal pain and febrile episodes with massive hepatomegaly, not common finding on physical examination, its treatment with etanercept, and long-term follow-up...
  25. ncbi request reprint Hodgkin's disease and ataxia telangiectasia with pulmonary cavities
    Bilgehan Yalcin
    Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey
    Pediatr Pulmonol 33:399-403. 2002
    ..The increased incidence of malignancies in AT patients may relate to immunodeficiency and to the chromosomal alterations identified...
  26. ncbi request reprint Comprehensive scanning of the ATM gene with DOVAM-S
    Carolyn H Buzin
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Hum Mutat 21:123-31. 2003
    ..DOVAM-S is a rapid, efficient method of performing A-T diagnosis and carrier testing on a clinical time scale...
  27. ncbi request reprint Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency
    Elgin G R Lichtenauer-Kaligis
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:59-69. 2003
    ..Collectively, our findings indicate that idiopathic, unusually severe infections due to M. bovis BCG can be caused by complete as well as partial IL-12Rbeta1 deficiency...
  28. ncbi request reprint Recurrent Salmonella bacteremia in interleukin-12 receptor beta1 deficiency
    Metehan Ozen
    Inonu University, Faculty of Medicine, Division of Pediatric Infectious Disease, Malatya, Turkey
    J Trop Pediatr 52:296-8. 2006
    ..We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp...
  29. ncbi request reprint Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae
    Tom H M Ottenhoff
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Genet 32:97-105. 2002
    ..Ten syndromes have thus far been identified. Recent insights in genetically controlled host defense and susceptibility to mycobacterial disease are discussed...
  30. ncbi request reprint Early diagnosis of ataxia-telangiectasia using radiosensitivity testing
    Xia Sun
    Department of Pathology, UCLA School of Medicine, Los Angeles, California 90095 1732, USA
    J Pediatr 140:724-31. 2002
    ..To utilize radiosensitivity testing to improve early diagnosis of patients with ataxia-telangiectasia (A-T)...
  31. ncbi request reprint Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans
    Calman MacLennan
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, Alabama, USA
    J Infect Dis 190:1755-7. 2004
    ..Investigation of the IL-12/IL-23-IFN- gamma axis should be considered in patients with invasive salmonella disease...