Seza Ozen

Summary

Affiliation: Hacettepe University
Country: Turkey

Publications

  1. ncbi Juvenile polyarteritis: results of a multicenter survey of 110 children
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    J Pediatr 145:517-22. 2004
  2. ncbi Renal amyloidosis in children
    Yelda Bilginer
    Hacettepe University Faculty of Medicine, Pediatric Nephrology and Rheumatology Unit, Ankara, Turkey
    Pediatr Nephrol 26:1215-27. 2011
  3. ncbi EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria
    Seza Ozen
    Hacettepe University Children s Hospital, Department of Pediatric Nephrology and Rheumatology, Sihhiye, Ankara 06100, Turkey
    Ann Rheum Dis 69:798-806. 2010
  4. ncbi EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides
    S Ozen
    Department of Paediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey, and Paediatric Nephrology, Institute of Child Health and Great Ormond Street Hospital for Sick Children, London, UK
    Ann Rheum Dis 65:936-41. 2006
  5. ncbi Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease
    S Ozen
    Department of Paediatrics, Hacettepe University, Faculty of Medicine, 06100 Ankara, Turkey
    Ann Rheum Dis 68:246-8. 2009
  6. ncbi Familial mediterranean fever: revisiting an ancient disease
    Seza Ozen
    Department of Paediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey
    Eur J Pediatr 162:449-54. 2003
  7. ncbi Problems in classifying vasculitis in children
    Seza Ozen
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pediatr Nephrol 20:1214-8. 2005
  8. ncbi Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation?
    Seza Ozen
    Department of Pediatrics, Hacettepe University, 06100 Ankara, Turkey
    J Rheumatol 30:2014-8. 2003
  9. ncbi The "other" vasculitis syndromes and kidney involvement
    Seza Ozen
    Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Pediatr Nephrol 25:1633-9. 2010
  10. ncbi Renal amyloidosis in familial Mediterranean fever
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    Kidney Int 65:1118-27. 2004

Detail Information

Publications124 found, 100 shown here

  1. ncbi Juvenile polyarteritis: results of a multicenter survey of 110 children
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    J Pediatr 145:517-22. 2004
    ..To characterize pediatric patients who had been diagnosed with polyarteritis nodosa (PAN) through necrotizing vasculitis of the small and mid-size arteries or those with characteristic findings on angiograms data were collected...
  2. ncbi Renal amyloidosis in children
    Yelda Bilginer
    Hacettepe University Faculty of Medicine, Pediatric Nephrology and Rheumatology Unit, Ankara, Turkey
    Pediatr Nephrol 26:1215-27. 2011
    ..The treatment of secondary amyloidosis mainly depends on the treatment of the disease. However, a number of new treatments for amyloid per se are in the pipeline...
  3. ncbi EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria
    Seza Ozen
    Hacettepe University Children s Hospital, Department of Pediatric Nephrology and Rheumatology, Sihhiye, Ankara 06100, Turkey
    Ann Rheum Dis 69:798-806. 2010
    ..To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA)...
  4. ncbi EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides
    S Ozen
    Department of Paediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey, and Paediatric Nephrology, Institute of Child Health and Great Ormond Street Hospital for Sick Children, London, UK
    Ann Rheum Dis 65:936-41. 2006
    ..There has been a lack of appropriate classification criteria for vasculitis in children...
  5. ncbi Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease
    S Ozen
    Department of Paediatrics, Hacettepe University, Faculty of Medicine, 06100 Ankara, Turkey
    Ann Rheum Dis 68:246-8. 2009
    ..Worldwide, familial Mediterranean fever (FMF) is the most common autoinflammatory disease. It has been suggested that environmental factors affect the phenotype as some patients do not develop the complication of secondary amyloidosis...
  6. ncbi Familial mediterranean fever: revisiting an ancient disease
    Seza Ozen
    Department of Paediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey
    Eur J Pediatr 162:449-54. 2003
    ..CONCLUSION: Familial mediterranean fever and other auto-inflammatory syndromes should be suspected in children with recurrent febrile attacks. Early diagnosis will save the child from unnecessary work-up and kidney involvement...
  7. ncbi Problems in classifying vasculitis in children
    Seza Ozen
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pediatr Nephrol 20:1214-8. 2005
    ..Paediatricians should revise the existing criteria based on registries and international consensus in the field...
  8. ncbi Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation?
    Seza Ozen
    Department of Pediatrics, Hacettepe University, 06100 Ankara, Turkey
    J Rheumatol 30:2014-8. 2003
    ..We also prospectively evaluated 72 patients with childhood rheumatic diseases for the presence of MEFV mutations...
  9. ncbi The "other" vasculitis syndromes and kidney involvement
    Seza Ozen
    Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Pediatr Nephrol 25:1633-9. 2010
    ..Here, we introduce the reader to the wide scope of these diseases; although rare, such diseases represent a challenge to the nephrologist...
  10. ncbi Renal amyloidosis in familial Mediterranean fever
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    Kidney Int 65:1118-27. 2004
  11. ncbi Behçet disease: treatment of vascular involvement in children
    Seza Ozen
    Department of Pediatrics, Nephrology and Rheumatology Unit, Hacettepe University School of Medicine, Ankara, Turkey
    Eur J Pediatr 169:427-30. 2010
    ..In conclusion, features of vascular involvement should be carefully sought for in patients with Behçet disease. Effective management has enabled disease-free survival in the presented patients...
  12. ncbi Update in paediatric vasculitis
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    Best Pract Res Clin Rheumatol 23:679-88. 2009
    ..Availability of improved classification criteria for children should prompt planning for multicentre-controlled studies for the treatment of these rare but important diseases...
  13. ncbi Childhood vasculitides in Turkey: a nationwide survey
    Seza Ozen
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
    Clin Rheumatol 26:196-200. 2007
    ..The aims of this study were to evaluate the characteristics of childhood vasculitides and to establish the first registry in Turkey, an eastern Mediterranean country with a white population...
  14. ncbi Mutations/polymorphisms in a monogenetic autoinflammatory disease may be susceptibility markers for certain rheumatic diseases: lessons from the bedside for the benchside
    S Ozen
    Pediatric Nephrology and Rheumatology, Hacettepe University, Ankara, Turkey
    Clin Exp Rheumatol 27:S29-31. 2009
    ..It may be suggested for the aforementioned clinical associations that mutations/polymorphisms in the MEFV gene may well be susceptibility factors for the disease or a more severe course of the disease for a number of rheumatic diseases...
  15. ncbi Anti-interleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine
    Seza Ozen
    Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Rheumatol 38:516-8. 2011
    ..We report the effect of anti-tumor necrosis factor therapy (etanercept) and anti-interleukin 1 (IL-1) treatment (anakinra) in 6 cases resistant to colchicine therapy...
  16. ncbi Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    J Rheumatol 33:2498-500. 2006
    ..Toll-like receptor (TLR-2) plays a critical role in linking the recognition of microbes to immune activation. We investigated whether the Arg753Gln TLR2 polymorphism affected the development of secondary amyloidosis in patients with FMF...
  17. ncbi The Eurofever Project: towards better care for autoinflammatory diseases
    Seza Ozen
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Eur J Pediatr 170:445-52. 2011
    ..We conclude that the pediatrician should be aware of the features and management of autoinflammatory diseases since all present with fever-the most common symptom of pediatric practice...
  18. ncbi Takayasu arteritis in children: preliminary experience with cyclophosphamide induction and corticosteroids followed by methotrexate
    Seza Ozen
    Department of Pediatrics, Pediatric Nephrology and Rheumatology Unit, Hacettepe University Faculty of Medicine, Ankara Turkey
    J Pediatr 150:72-6. 2007
    ..To review the results of our treatment protocol in the last 7 years...
  19. ncbi A view from the Eastern Mediterranean
    Seza Ozen
    Hacettepe University Faculty of Medicine, Ankara, Turkey
    Arthritis Rheum 58:S143-4. 2008
  20. ncbi Familial Mediterranean fever (FMF) and beyond: a new horizon. Fourth International Congress on the Systemic Autoinflammatory Diseases held in Bethesda, USA, 6-10 November 2005
    S Ozen
    Department of Paediatrics, Hacettepe University, Ankara 06100 Turkey
    Ann Rheum Dis 65:961-4. 2006
    ..Identification of the inflammatory pathways involved has opened up new areas of research which have implications for the treatment of these disorders and the pathogenesis of common inflammatory diseases...
  21. ncbi Pediatric onset Behçet disease
    Seza Ozen
    Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey
    Curr Opin Rheumatol 22:585-9. 2010
    ..We need to understand the scope of the disease, its pathogenesis and the available treatment strategies for better management of these patients...
  22. ncbi Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis
    Yelda Bilginer
    Department of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Rheumatol Int 28:1211-6. 2008
    ..Further studies will enlighten whether these patients will be predisposed more to coronary artery disease...
  23. ncbi Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population
    Aysin Bakkaloglu
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Rheumatol 31:1139-42. 2004
    ..To evaluate the effect of serum amyloid A (SAA) 1 and SAA2 gene polymorphisms on SAA levels and renal amyloidosis in Turkish patients with familial Mediterranean fever (FMF)...
  24. ncbi Treatment of severe Henoch-Schönlein nephritis: justifying more immunosuppression
    Fatma Semsa Altugan
    Unit of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 51:551-5. 2009
    ..Long-term, multicenter controlled studies are needed to verify our results...
  25. ncbi MEFV gene mutations in familial Mediterranean fever phenotype II patients with renal amyloidosis in childhood: a retrospective clinicopathological and molecular study
    Banu Balci
    Department of Medical Biology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey
    Nephrol Dial Transplant 17:1921-3. 2002
    ..In this study, the mutations of the MEFV gene were analysed in a group of patients clinically recognized as phenotype II...
  26. ncbi The association of inflammatory bowel disease and Mediterranean fever gene (MEFV) mutations in Turkish children
    Nuray Uslu
    Department of Pediatrics, Gastroenterology, Hepatology and Nutrition Unit, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
    Dig Dis Sci 55:3488-94. 2010
    ..We investigated MEFV mutations and prevalence of FMF disease in Turkish children with IBD and their relationship with the disease severity...
  27. ncbi Carotid intima-media thickness in children and young adults with renal transplant: Internal carotid artery vs. common carotid artery
    Yelda Bilginer
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Transplant 11:888-94. 2007
    ..These changes can be detected by measuring CCA/ICA-IMT ultrasonographically. We suggest that early renal transplantation can potentially avoid long-term cardiovascular events in children with end stage kidney disease...
  28. ncbi Prevalence of the MEFV gene mutations in childhood polyarteritis nodosa
    Fatos Yalcinkaya
    Ankara University School of Medicine, Division of Pediatric Nephrology, Ankara, Turkey
    J Pediatr 151:675-8. 2007
    ....
  29. ncbi Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis
    Nesrin Besbas
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Nephrol 18:696-9. 2003
    ..We describe here an unusual pediatric patient with MPO-ANCA-associated rapidly progressive glomerulonephritis (RPGN), emphasizing the management and outcome of the disease...
  30. ncbi Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients
    Engin Yilmaz
    Department of Medical Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 45:198-202. 2003
    ..Determination of genotypes at SAA1 locus can play a key role in conferring genetic susceptibility and patient's prognosis to renal amyloidosis...
  31. ncbi Preventing tuberculosis in children receiving anti-TNF treatment
    Nuray Aktay Ayaz
    Medical Faculty, Pediatric Rheumatology Unit, Acibadem University, Ankara, Turkey
    Clin Rheumatol 29:389-92. 2010
    ..An initial 1-2 months of INH treatment followed by chemoprophylaxis for 9 months is suggested for children with a TST of >10 mm...
  32. ncbi A new set of criteria for the diagnosis of familial Mediterranean fever in childhood
    Fatos Yalcinkaya
    Department of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey
    Rheumatology (Oxford) 48:395-8. 2009
    ..The aim of the present study is to validate the most widely used diagnostic 'Tel Hashomer' criteria in children and to establish a new set of criteria for use in childhood...
  33. ncbi The significance of IgA class of antineutrophil cytoplasmic antibodies (ANCA) in childhood Henoch-Schönlein purpura
    Fatih Ozaltin
    Department of Pediatrics, Unit of Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Sihhiye, 06100, Ankara, Turkey
    Clin Rheumatol 23:426-9. 2004
    ..Positive IgA rheumatoid factor was present in only two patients with HSP. In conclusion, our results suggest that IgA ANCA may be useful to confirm the diagnosis of HSP in children...
  34. ncbi Is the CD14 C159T polymorphism effective in the development of secondary amyloidosis in Familial Mediterranean fever?
    Ozlem Keskin
    Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Hacettepe, 06100 Ankara, Turkey
    Rheumatol Int 27:691-4. 2007
    ..The effect of the genetic variations in the endotoxin signaling pathway under different environmental conditions such as high and low endotoxin exposure remain to be determined...
  35. ncbi Beneficial role of intravenous calcitriol on bone mineral density in children with severe secondary hyperparathyroidism
    Esra Baskin
    Department of Pediatric Nephrology, Baskent University, Ankara, Turkey
    Int Urol Nephrol 36:113-8. 2004
    ..In this prospective study, the effect of calcitriol therapy on bone mineral density and osteopenia in patients with severe secondary hyperparathyroidism has been investigated...
  36. ncbi Expression of ASC in renal tissues of familial mediterranean fever patients with amyloidosis: postulating a role for ASC in AA type amyloid deposition
    Banu Balci-Peynircioglu
    Hacettepe University, Tip Fakultesi, Tibbi Biyoloji AD, Rektorluk Binasi, A Kapisi, 4 Kat, 06100 Sihhiye, Ankara, Turkey
    Exp Biol Med (Maywood) 233:1324-33. 2008
    ..The fact that speck formation requires an intact microtubule network as shown here could potentially account for the ability of prophylactic colchicine to prevent or reverse amyloidosis in patients with FMF...
  37. ncbi Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behçet's disease
    Yelda Bilginer
    Department of Pediatrics, Nephrology and Rheumatology Unit, Hacettepe University School of Medicine, Sihhiye, 06100, Ankara, Turkey
    Clin Rheumatol 29:209-10. 2010
    ..We suggest that anti-IL-1 treatment is beneficial for the suppression of inflammation; however, long-term studies are needed to understand whether progressive renal disease will be prevented...
  38. ncbi Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
    Elif Uz
    Bilkent University, Faculty of Science and Institute of Materials Science and Nanotechnology, Ankara, Turkey
    Arthritis Rheum 60:3410-2. 2009
    ..This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA...
  39. ncbi Decrease in the rate of secondary amyloidosis in Turkish children with FMF: are we doing better?
    Victoria Akse-Onal
    Department of Pediatrics, Hacettepe University, Ankara 06100, Turkey
    Eur J Pediatr 169:971-4. 2010
    ..However, we suggest that the improvement of infectious milieu may possibly have had a positive effect on the course of this monogenic disease, since inflammatory pathways related to innate immunity are deregulated...
  40. ncbi DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN
    Fatih Ozaltin
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Am Soc Nephrol 24:377-84. 2013
    ..Taken together, these results not only identify a genetic cause of a glomerular microangiopathy but also suggest that the phosphatidylinositol cycle, which requires DGKE, is critical to the normal function of podocytes...
  41. ncbi A child with Behçet's disease presenting with a spectrum of inflammatory manifestations including epididymoorchitis
    Ayhan Pektas
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 50:78-80. 2008
    ..Here we report an 11-year-old Behçet's disease patient presenting with attacks of myositis accompanied by epididymoorchitis and periodic fever attacks as well as a separate attack of thrombophlebitis...
  42. ncbi A very frequent mutation and remarkable association of R761H with M694V mutations in Turkish familial Mediterranean fever patients
    Erkan Demirkaya
    Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    Clin Rheumatol 27:729-32. 2008
    ..Larger serial studies need to be done to investigate the rate and coexistence of these mutations...
  43. ncbi Urinary glycosaminoglycans in the course of familial Mediterranean fever
    Esra Baskin
    Baskent University Hospital, Department of Paediatric Nephrology, 6 Cadde, 72 3 Bahcelievler, 06490, Ankara, Turkey
    Eur J Pediatr 162:305-8. 2003
    ..We also suggest that effective colchicine doses may be monitored by following urinary glycosaminoglycan excretion...
  44. ncbi Risk factors in community-acquired urinary tract infections caused by ESBL-producing bacteria in children
    Rezan Topaloglu
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Nephrol 25:919-25. 2010
    ..In conclusion, the recognition of risk factors for UTI, caused by ESBL(+) bacteria in children, may aid in the identification of high-risk cases and may enable proper management of these patients...
  45. ncbi Neuroendocrine immune system in familial Mediterranean fever
    Rezan Topaloglu
    Unit of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:588-93. 2010
    ....
  46. ncbi Apoptosis and proliferation in childhood acute proliferative glomerulonephritis
    Fatih Ozaltin
    Pediatric Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Pediatr Nephrol 20:1572-7. 2005
    ..Further studies, however, are still needed to clarify the importance of these histopathological parameters...
  47. ncbi Purpura fulminans as the presenting manifestation in a patient with juvenile SLE
    Erkan Demirkaya
    Units of Pediatric Rheumatology and Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 51:378-80. 2009
    ..This is the first pediatric case of purpura fulminans due to secondary antiphospholipid syndrome of systemic lupus erythematosus. We suggest that SLE patients with lupus anticoagulant should be followed closely for similar complications...
  48. ncbi Evaluation of the current disease severity scores in paediatric FMF: is it necessary to develop a new one?
    Gokhan Kalkan
    FMF Arthritis Vasculitis and Orphan Disease Research in Paediatric Rheumatology FAVOR, Department of Paediatrics, Pediatric Nephrology and Rheumatology Unit, Gulhane Military Medical Faculty, School of Medicine, 06018 Etlik, Ankara, Turkey
    Rheumatology (Oxford) 51:743-8. 2012
    ..We aim to test the clinical consistency of two common severity scoring systems and to evaluate the correlation of scores with the type of FMF mutations in paediatric FMF patients since certain mutations are prone to severe disease...
  49. ncbi Severe Henoch-Schönlein purpura in a thalassemic patient under deferiprone treatment
    Sule Unal
    Division of Pediatric Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Am J Hematol 83:165-6. 2008
    ..Various cellular and humoral immunological impairments have been described in thalassemia major patients and the severe course of HSP in our case may be related to these underlying immunological defects...
  50. ncbi Eye involvement in children with primary focal segmental glomerulosclerosis
    Fatih Ozaltin
    Unit of Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey
    Pediatr Nephrol 23:421-7. 2008
    ..Ophthalmologic evaluation at the time of diagnosis might be beneficial to characterize further the spectrum of this possible association...
  51. ncbi The distribution of juvenile idiopathic arthritis in the eastern Mediterranean: results from the registry of the Turkish Paediatric Rheumatology Association
    Erkan Demirkaya
    Gulhane Military Medical Acedemy, School of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 29:111-6. 2011
    ..To analyse the demographics, main clinical and laboratory features and subtype distribution of juvenile idiopathic arthritis (JIA) in an eastern Mediterranean country, based on a multicentre registry...
  52. ncbi Genotoxicity of anti-tumor necrosis factor therapy in patients with juvenile idiopathic arthritis
    Erkan Demirkaya
    Hacettepe University Medical School, Ankara, Turkey
    Arthritis Care Res (Hoboken) 62:73-7. 2010
    ..To assess the possible effects of both inflammation and the anti-tumor necrosis factor agents (anti-TNF) on DNA damage with a specific assay, and their effects on the repair capacity of DNA...
  53. ncbi Musculoskeletal sonography in juvenile systemic lupus erythematosus
    Erkan Demirkaya
    Hacettepe University Medical School, Ankara, Turkey
    Arthritis Rheum 61:58-60. 2009
    ..To demonstrate the role of sonography in depicting periarticular changes in juvenile systemic lupus erythematosus (SLE) and to find out whether certain tendons in juvenile SLE patients were different from those of healthy controls...
  54. ncbi A patient with hyper-IgD syndrome responding to anti-TNF treatment
    Erkan Demirkaya
    Pediatric Nephrology and Rheumatology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Clin Rheumatol 26:1757-9. 2007
    ..The patient responded well to anti-tumor necrosis factor treatment. Our findings support the use of this anti-cytokine treatment in HIDS...
  55. ncbi Questions. Microscopic polyarteritis nodosa (PAN)
    Mukaddes Kalyoncu
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
    Pediatr Nephrol 18:962-5. 2003
  56. ncbi A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis
    Salih Pay
    Division of Rheumatology, Gulhane Military School of Medicine, Ankara, Turkey
    Clin Rheumatol 25:639-44. 2006
    ..AOSD and sJIA may still be the same disease, and children may simply be reacting differently as the result of the first encounter of the putative antigens with the immune system...
  57. ncbi Effect of early corticosteroid therapy on development of Henoch-Schönlein nephritis
    Umut S Bayrakci
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Nephrol 20:406-9. 2007
    ..The aim of this study was to determine whether corticosteroid therapy was effective in preventing Henoch-Schönlein nephritis...
  58. ncbi Th1 polarization in familial Mediterranean fever
    Ebru Aypar
    Department of Pediatrics, Hacettepe University, 06100 Ankara, Turkey
    J Rheumatol 30:2011-3. 2003
    ..CONCLUSION: Inflammation in FMF shows a Th1 polarization. We suggest that in patients with FMF the IFN-g concentrations may remain higher because the defective pyrin is not able to inhibit this Th1 mediated inflammation...
  59. ncbi Low cortisol levels in active juvenile idiopathic arthritis
    Yelda Bilginer
    Pediatric Nephrology and Rheumatology Unit, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, 06100, Turkey
    Clin Rheumatol 29:309-14. 2010
    ..Further studies are needed to clarify the consequences of the impaired hormone secretion in JIA...
  60. ncbi Low serum apolipoprotein AI levels in amyloidosis related to familial Mediterranean fever
    Ismail Islek
    Department of Pediatrics, Ondokuz Mayis University, 55139 Samsun, Turkey
    Pediatr Nephrol 18:1005-8. 2003
    ..Apo AII/AI ratio results were essentially equal in all groups ( P>0.05). It is concluded that a decreased Apo AI serum level, but not Apo AII/AI ratio, is a useful, non-invasive test for the early diagnosis of FMF-A in children...
  61. ncbi An overlap syndrome involving autoimmune hepatitis and systemic lupus erythematosus in childhood
    Yusuf Usta
    Hacettepe University, Faculty of Medicine, Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Ankara 06100, Turkey
    World J Gastroenterol 13:2764-7. 2007
    ..The present case indicates that children with liver dysfunction and SLE should be investigated for AIH. There is much diagnostic and therapeutic dilemma in patients with AIH-SLE overlap syndrome...
  62. ncbi Focal segmental glomerulosclerosis associated with mitochondrial cytopathy: report of two cases with special emphasis on podocytes
    Safak Gucer
    Department of Pediatrics, Pathology Unit, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
    Pediatr Dev Pathol 8:710-7. 2005
    ....
  63. ncbi Ulcerative colitis associated with Takayasu's arteritis in a child
    Necati Balamtekin
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Hacettepe University, Medical Faculty, Ankara 0610, Turkey
    Acta Paediatr 98:1368-71. 2009
    ..CONCLUSION: Findings from our patients suggest that paediatricians must remain alert to the possibility of abdominal vasculitis in patients with UC and unresolved abdominal pain in spite of clinical remission...
  64. ncbi Takayasu arteritis in children
    Nilgun Cakar
    From the Department of Nephrology, Ministry of Health Diskapi Children s Hospital, Ankara, Turkey
    J Rheumatol 35:913-9. 2008
    ..To retrospectively evaluate the clinical features, angiographic findings, and outcomes of children with Takayasu arteritis (TA) in Turkey...
  65. ncbi Ceruloplasmin levels in antineutrophil cytoplasmic antibody-positive patients
    Esra Baskin
    Department of Pediatric Nephrology, Hacettepe University, Ankara, Turkey
    Pediatr Nephrol 17:917-9. 2002
    ..The correlation between ceruloplasmin and MPO levels supports their association. Further studies are necessary to elucidate whether genetic and/or functional alterations in ceruloplasmin are effective in the pathogenesis of vasculitis...
  66. ncbi Noonan syndrome and systemic lupus erythematosus: presentation in childhood
    Yasemin Alanay
    Hacettepe University, Ihsan Dogramaci Children s Hospital, Department of Paediatrics, Clinical Genetics Unit, Ankara, Turkey
    Clin Dysmorphol 13:161-3. 2004
    ..In this report we present an 11-year-old boy with Noonan syndrome and systemic lupus erythematosus, supporting the previous observations of an association between these two conditions...
  67. ncbi Stanozolol treatment for successful prevention of attacks of severe primary cryofibrinogenemia
    Sule Unal
    Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology, Hacettepe University, Ankara, Turkey
    Pediatr Blood Cancer 55:174-6. 2010
    ..Stanozolol (2 mg/day, orally) prophylaxis was initiated and no new skin lesions developed following starting this treatment. Some of the newly formed lesions at the onset of stanozolol healed...
  68. ncbi Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis
    Nesrin Besbas
    Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey
    Pediatr Nephrol 19:864-8. 2004
    ..Our results emphasize the important role of locally produced chemokines in immune-mediated glomerular injury...
  69. ncbi Peripheral gangrene associated with Kawasaki disease and successful management using prostacycline analogue: a case report
    Omer Faruk Dogan
    Department of Cardiovascular Surgery, Hacettepe University Medical Faculty, Ankara, Turkey
    Heart Surg Forum 10:E70-2. 2007
    ....
  70. ncbi Interferon-gamma assays for the diagnosis of tuberculosis infection before using tumour necrosis factor-alpha blockers
    N Cobanoglu
    Hacettepe University Faculty of Medicine, Pediatric Pulmonary Diseases Unit, Ankara, Turkey
    Int J Tuberc Lung Dis 11:1177-82. 2007
    ..A study was performed to investigate whether an interferon-gamma (IFN-gamma) assay could represent an alternative approach to the tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection (LTBI) in these patients...
  71. ncbi Bone mineral density in children with familial Mediterranean fever
    Ali Duzova
    Department of Pediatrics, Nephrology and Rheumatology Unit, Hacettepe University Faculty of Medicine, Sihhiye 06100 Ankara, Turkey
    Clin Rheumatol 23:230-4. 2004
    ..In conclusion, FMF patients had lower BMC, BMD and z-scores than a control group. We suggest that decreased BMD, BMC and z-score in FMF patients may be secondary to subclinical inflammation...
  72. ncbi The role of apoptosis in childhood Henoch-Schonlein purpura
    F Ozaltin
    Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Rheumatol 22:265-7. 2003
    ....
  73. ncbi Increased neutrophil apoptosis during attacks of familial Mediterranean fever
    S Ozen
    Department of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Sihhiye 06100 Ankara, Turkey
    Clin Exp Rheumatol 19:S68-71. 2001
    ..On the other hand the increased apoptosis maybe the explanation of the self-limited nature of the FMF attacks. Future studies will enlighten us on the significance of this increased apoptosis in the process of inflammation...
  74. ncbi E148Q is a disease-causing MEFV mutation: a phenotypic evaluation in patients with familial Mediterranean fever
    R Topaloglu
    Hacettepe University Faculty of Medicine, Department of Paediatric Nephrology and Rheumatology, 06100 Ankara, Turkey
    Ann Rheum Dis 64:750-2. 2005
    ..Several mutations in the MEFV gene, including E148Q, have been identified as causing this disease. It has been suggested that the E148Q mutation is the mildest mutation and some reports have questioned its disease association...
  75. ncbi Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever
    A Duzova
    Department of Pediatrics, Pediatric Nephrology and Rheumatology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 21:509-14. 2003
    ....
  76. ncbi Are carriers for MEFV mutations "healthy"?
    M Kalyoncu
    Hacettepe University Faculty of Medicine, Department of Pediatrics, Pediatric Nephrology and Rheumatology Unit, Ankara, Turkey
    Clin Exp Rheumatol 24:S120-2. 2006
    ..We aimed to compare whether carriers for the MEFV mutations display an increase or decrease in certain features. We compared the frequency of a number of inflammatory symptoms and diseases in carriers and a control population...
  77. ncbi Triple immunosuppression with tacrolimus in pediatric renal transplantation: single-center experience
    A Duzova
    Department of Pediatrics, Pediatric Nephrology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Transplant Proc 40:132-4. 2008
    ..In this single-center cohort, we retrospectively analyzed the efficacy and safety of tacrolimus in pediatric renal transplantation...
  78. ncbi Outcome of primary glomerular disease in pediatric renal transplantation: a single-center experience
    Y Bilginer
    Department of Pediatrics Nephrology Unit, Hacettepe University School of Medicine, Ankara, Turkey
    Transplant Proc 40:129-31. 2008
    ..The recurrence of primary disease in transplantation is a well-known problem. We report our single-center experience to assess the frequency of the recurrence of primary glomerulonephritis in children after renal transplantation...
  79. ncbi MEFV mutations in systemic onset juvenile idiopathic arthritis
    N A Ayaz
    Pediatric Nephrology and Rheumatology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Rheumatology (Oxford) 48:23-5. 2009
    ..The aim of the study is to search for MEFV mutations in our patients with SoJIA and see whether these mutations had an effect on disease course or complications...
  80. ncbi Etanercept in the treatment of arthritis in a patient with familial Mediterranean fever
    O Sakallioglu
    Pediatric Nephrology and Rheumatology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 24:435-7. 2006
    ..We suggest that anti-TNF drugs may be an alternative for resistant attacks. However the timing and dosage, as well as efficacy, need to be further studied...
  81. ncbi Mutation frequency of Familial Mediterranean Fever and evidence for a high carrier rate in the Turkish population
    E Yilmaz
    Hacettepe University, Faculty of Medicine, Department of Medical Biology, Ankara, Turkey
    Eur J Hum Genet 9:553-5. 2001
    ..005) from that found in patients (M694V 51.55%, M680I 9.22%, V726A 2.88%, M694I 0.44% and E148Q 3.55%)...
  82. ncbi Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis
    E Aganna
    Department of Diabetes and Metabolic Medicine, Barts and London, Queen Mary s School of Medicine and Dentistry, Whitechapel, London, UK
    Genes Immun 5:289-93. 2004
    ..Although allelic variants in HPFs genes are not major susceptibility factors for AA amyloidosis in chronic inflammatory disease, low-penetrance variants of MEFV and TNFRSF1A may have clinically significant proinflammatory effects...
  83. ncbi Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature
    Deniz N Cagdas
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Nephrol 20:1352-4. 2005
    ..Due to increased inflammatory response observed in FMF, immunologic glomerular injury, a common cause of glomerulonephritis, may occur more frequently in patients with FMF...
  84. ncbi Four-month-old infant with focal segmental glomerulosclerosis and mitochondrial DNA deletion
    Sule Unal
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Child Neurol 20:83-4. 2005
    ..Herein we report the case of a 4-month-old Turkish girl with a mitochondrial DNA deletion and focal segmental glomerulosclerosis...
  85. ncbi Systemic lupus erythematosus presenting with pseudotumor cerebri: a rare association
    Semanur Kuyucu
    Departments of Pediatrics, Mersin University, Faculty of Medicine, Mersin, Turkey
    Turk J Pediatr 49:98-101. 2007
    ..PTC may also be a neurological manifestation of childhood SLE and should be considered in the differential diagnosis. We suggest that pulse steroids and azathioprine is an effective treatment for this feature...
  86. ncbi Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schönlein purpura
    N Besbas
    Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Rheumatol 20:293-6. 2001
    ..Renal biopsy is helpful in the differential diagnosis of HSP-mimicking pulmonary vasculitic syndromes. Combining cyclophosphamide with glucocorticoids may improve the outcome in severe HSP cases with pulmonary haemorrhage...
  87. ncbi The spectrum of vasculitis in children
    S Ozen
    Department of Paediatrics, Hacettepe University Faculty of Medicine, Sihhiye 06100, Ankara, Turkey
    Best Pract Res Clin Rheumatol 16:411-25. 2002
    ..The definitions and classification criteria for the other major vasculitides encountered in children are also presented. Current treatment protocols for polyartertis nodosa, Wegener's granulomatosis and Behcet's disease are summarized...
  88. ncbi Tumour necrosis factor alpha G-->A -238 and G-->A -308 polymorphisms in juvenile idiopathic arthritis
    S Ozen
    Department of Paediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Rheumatology (Oxford) 41:223-7. 2002
    ..We analysed whether there were any associations between these polymorphisms and the type of JIA and/or the clinical course of the disease in two populations...
  89. ncbi Polyarteritis nodosa in patients with Familial Mediterranean Fever (FMF): a concomitant disease or a feature of FMF?
    S Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    Semin Arthritis Rheum 30:281-7. 2001
    ..Vasculitis has been increasingly reported in FMF. A study evaluating the prognosis in FMF and polyarteritis nodosa (PAN) patients has not been reported previously...
  90. ncbi Henoch-Schönlein nephritis: a nationwide study
    O Soylemezoglu
    Gazi University, Department of Pediatric Nephrology, Ankara, Turkey
    Nephron Clin Pract 112:c199-204. 2009
    ..The aim of this retrospective study was to evaluate the presentation, clinical and pathological manifestations and outcome of the Henoch-Schönlein purpura (HSP) nephritis in children...
  91. ncbi Biologic therapy in primary systemic vasculitis of the young
    Despina Eleftheriou
    Rheumatology Department, Institute of Child Health, London, UK
    Rheumatology (Oxford) 48:978-86. 2009
    ..To describe the biologic treatment regimens and report the efficacy and safety of biologic therapies in a multicentre series of children with primary systemic vasculitis (PSV)...
  92. ncbi Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy in dialyzed children
    Esra Baskin
    Department of Pediatric Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 46:28-31. 2004
    ..44 and r = 0.51 respectively, p < 0.05). It is concluded that bone alkaline phosphatase and osteoocalcin combined with iPTH level seem to be useful noninvasive markers of bone metabolism in dialysis patients...
  93. ncbi Reversible posterior leukoencephalopathy syndrome: report of three cases
    Hamit Ozyurek
    Department of Pediatrics, Section of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Child Neurol 20:990-3. 2005
    ..In light of these cases, we review the literature for the etiology, clinical and laboratory findings, and pathogenetic mechanisms of the disease...
  94. ncbi The prevalence of familial Mediterranean fever in the Turkish province of Denizli: a field study with a zero patient design
    V Cobankara
    Department of Rheumatology, Pamukkale University, Faculty of Medicine, Denizli, Turkey
    Clin Exp Rheumatol 22:S27-30. 2004
    ....
  95. ncbi Vasculopathy, Behçet's syndrome, and familial Mediterranean fever
    S Ozen
    Department of Pediatric Rheumatology and Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Curr Opin Rheumatol 11:393-8. 1999
    ..Some researchers have proposed that pyrin is an anti-inflammatory protein. Understanding its mode of action will help us understand more of the general inflammatory pathway...
  96. ncbi The analysis of interleukin-1 receptor antagonist and interleukin-1beta gene polymorphisms in Turkish FMF patients: do they predispose to secondary amyloidosis?
    B Balci-Peynircioglu
    Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Clin Exp Rheumatol 26:S99-102. 2008
    ..In view of the inflammatory nature of FMF disease we have investigated whether IL-1Beta and IL-1 receptor antagonist gene polymorphisms may be involved in amyloid development in FMF patients...
  97. ncbi New interest in an old disease: familial Mediterranean fever
    S Ozen
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 17:745-9. 1999
    ..Colchicine is the drug of choice. A trial of colchicine may also help in the differential diagnosis with other periodic fever syndromes...
  98. ncbi Behçet's disease with severe arterial involvement in a child
    N Besbas
    Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Clin Rheumatol 21:176-9. 2002
    ..He also received cyclosporin A and anticoagulant therapy. Severe vasculitis may become overt at any age in patients with Behçet's disease. Early diagnosis and management is important to prevent morbidity and mortality...
  99. ncbi Survey of factor V leiden and prothrombin gene mutations in systemic lupus erythematosus
    R Topaloglu
    Hacettepe University School of Medicine, Department of Pediatric Nephrology and Rheumatology, Ankara, Turkey
    Clin Rheumatol 20:259-61. 2001
    ..1; CI 2.99-133.6). Although factor V Leiden mutation seems to play a role in the development of venous thrombosis in SLE, the development of thrombosis in SLE is multifactorial...
  100. ncbi The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa
    A Bakkaloglu
    Department of Pediatric Nephrology and Rheumatology, Hacettepe University, Faculty of Medicine, , Ankara, Turkey
    Arch Dis Child 85:427-30. 2001
    ..In MPA, median MPO-ELISA level was 42.5 EU/ml (range 20-250). Treatment of childhood PAN was satisfactory with effective treatment; however relapses did occur. CONCLUSION: ANCA is useful in the diagnosis and follow up of MPA...
  101. ncbi Fatal cytophagic histiocytic panniculitis
    Gulten Secmeer
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Dermatol 21:246-9. 2004
    ..We report here a rare catastrophic form of systemic panniculitis in an adolescent girl. Despite compelling clinical evidence, the diagnosis was made only on postmortem biopsies...