Fatih Ozaltin

Summary

Affiliation: Hacettepe University
Country: Turkey

Publications

  1. doi request reprint Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis
    Fatih Ozaltin
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Ren Fail 35:380-5. 2013
  2. pmc Disruption of PTPRO causes childhood-onset nephrotic syndrome
    Fatih Ozaltin
    Pediatric Nephrology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey
    Am J Hum Genet 89:139-47. 2011
  3. ncbi request reprint Eye involvement in children with primary focal segmental glomerulosclerosis
    Fatih Ozaltin
    Unit of Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey
    Pediatr Nephrol 23:421-7. 2008
  4. ncbi request reprint Apoptosis and proliferation in childhood acute proliferative glomerulonephritis
    Fatih Ozaltin
    Pediatric Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Pediatr Nephrol 20:1572-7. 2005
  5. ncbi request reprint An unusual cause of acute renal failure: renal lymphoma
    Fatih Ozaltin
    Nephrology Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pediatr Nephrol 19:912-4. 2004
  6. ncbi request reprint The role of apoptosis in childhood Henoch-Schonlein purpura
    F Ozaltin
    Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Rheumatol 22:265-7. 2003
  7. doi request reprint Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis
    Yelda Bilginer
    Department of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Rheumatol Int 28:1211-6. 2008
  8. pmc Genetic basis of cystinosis in Turkish patients: a single-center experience
    Rezan Topaloglu
    Dept of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
    Pediatr Nephrol 27:115-21. 2012
  9. ncbi request reprint Carotid intima-media thickness in children and young adults with renal transplant: Internal carotid artery vs. common carotid artery
    Yelda Bilginer
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Transplant 11:888-94. 2007
  10. ncbi request reprint Treatment of severe Henoch-Schönlein nephritis: justifying more immunosuppression
    Fatma Semsa Altugan
    Unit of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 51:551-5. 2009

Detail Information

Publications40

  1. doi request reprint Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis
    Fatih Ozaltin
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Ren Fail 35:380-5. 2013
    ..CXCR1 may contribute to inflammation in experimental mesangioproliferative glomerulonephritis. CsA may be beneficial by inhibiting CXCR1 expression and corresponding inflammation...
  2. pmc Disruption of PTPRO causes childhood-onset nephrotic syndrome
    Fatih Ozaltin
    Pediatric Nephrology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey
    Am J Hum Genet 89:139-47. 2011
    ..The present study introduces mutations in PTPRO as another cause of autosomal-recessive nephrotic syndrome...
  3. ncbi request reprint Eye involvement in children with primary focal segmental glomerulosclerosis
    Fatih Ozaltin
    Unit of Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey
    Pediatr Nephrol 23:421-7. 2008
    ..Ophthalmologic evaluation at the time of diagnosis might be beneficial to characterize further the spectrum of this possible association...
  4. ncbi request reprint Apoptosis and proliferation in childhood acute proliferative glomerulonephritis
    Fatih Ozaltin
    Pediatric Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Pediatr Nephrol 20:1572-7. 2005
    ..Further studies, however, are still needed to clarify the importance of these histopathological parameters...
  5. ncbi request reprint An unusual cause of acute renal failure: renal lymphoma
    Fatih Ozaltin
    Nephrology Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pediatr Nephrol 19:912-4. 2004
    ....
  6. ncbi request reprint The role of apoptosis in childhood Henoch-Schonlein purpura
    F Ozaltin
    Hacettepe University Faculty of Medicine, Ankara, Turkey
    Clin Rheumatol 22:265-7. 2003
    ....
  7. doi request reprint Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis
    Yelda Bilginer
    Department of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Rheumatol Int 28:1211-6. 2008
    ..Further studies will enlighten whether these patients will be predisposed more to coronary artery disease...
  8. pmc Genetic basis of cystinosis in Turkish patients: a single-center experience
    Rezan Topaloglu
    Dept of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
    Pediatr Nephrol 27:115-21. 2012
    ..This study is the first molecular analysis of Turkish cystinosis patients and provides guidance for the molecular diagnosis of cystinosis in this population...
  9. ncbi request reprint Carotid intima-media thickness in children and young adults with renal transplant: Internal carotid artery vs. common carotid artery
    Yelda Bilginer
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Transplant 11:888-94. 2007
    ..These changes can be detected by measuring CCA/ICA-IMT ultrasonographically. We suggest that early renal transplantation can potentially avoid long-term cardiovascular events in children with end stage kidney disease...
  10. ncbi request reprint Treatment of severe Henoch-Schönlein nephritis: justifying more immunosuppression
    Fatma Semsa Altugan
    Unit of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 51:551-5. 2009
    ..Long-term, multicenter controlled studies are needed to verify our results...
  11. pmc DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN
    Fatih Ozaltin
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Am Soc Nephrol 24:377-84. 2013
    ..Taken together, these results not only identify a genetic cause of a glomerular microangiopathy but also suggest that the phosphatidylinositol cycle, which requires DGKE, is critical to the normal function of podocytes...
  12. ncbi request reprint Cyclosporine drug monitoring with C0 and C2 concentrations in children with stable renal allograft function
    Mukaddes Kalyoncu
    Department of Pediatrics, Pediatric Nephrology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Transplant 10:168-71. 2006
    ..However, no correlation was found between C0 levels and any of the above parameters. In conclusion, our data suggest that C2 levels are correlated better with dose and serum creatinine level...
  13. doi request reprint Right atrial thrombosis complicating renal transplantation in a child
    Yelda Bilginer
    Department of Pediatric Nephrology, Hacettepe Unviersity Faculty of Medicine, Ankara, Turkey
    Pediatr Transplant 12:251-5. 2008
    ..This report draws attention to the risks that could be associated with thrombosis in renal recipients with congenital or acquired thrombophilias and emphasizes the importance of identifying risk factors for thrombosis in these patients...
  14. pmc Respiratory-chain deficiency presenting as diffuse mesangial sclerosis with NPHS3 mutation
    Esra Baskin
    Department of Pediatric Nephrology, Baskent University, Ankara, Turkey
    Pediatr Nephrol 26:1157-61. 2011
    ..Another, more likely, possibility is that the mitochondriopathy phenotype is caused by another mutation homozygous by descent in a yet unidentified recessive gene...
  15. ncbi request reprint Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population
    Aysin Bakkaloglu
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Rheumatol 31:1139-42. 2004
    ..To evaluate the effect of serum amyloid A (SAA) 1 and SAA2 gene polymorphisms on SAA levels and renal amyloidosis in Turkish patients with familial Mediterranean fever (FMF)...
  16. ncbi request reprint Clinical course of primary focal segmental glomerulosclerosis (FSGS) in Turkish children: a report from the Turkish Pediatric Nephrology FSGS Study Group
    Nesrin Besbas
    Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Turk J Pediatr 52:255-61. 2010
    ..Failure to achieve remission is a predictor of renal failure in children with primary FSGS. The use of immunosuppressive treatment in conjunction with prolonged steroid seems beneficial in primary FSGS in children...
  17. ncbi request reprint Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis
    Nesrin Besbas
    Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey
    Pediatr Nephrol 19:864-8. 2004
    ..Our results emphasize the important role of locally produced chemokines in immune-mediated glomerular injury...
  18. ncbi request reprint Neuroendocrine immune system in familial Mediterranean fever
    Rezan Topaloglu
    Unit of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:588-93. 2010
    ....
  19. ncbi request reprint The significance of IgA class of antineutrophil cytoplasmic antibodies (ANCA) in childhood Henoch-Schönlein purpura
    Fatih Ozaltin
    Department of Pediatrics, Unit of Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Sihhiye, 06100, Ankara, Turkey
    Clin Rheumatol 23:426-9. 2004
    ..Positive IgA rheumatoid factor was present in only two patients with HSP. In conclusion, our results suggest that IgA ANCA may be useful to confirm the diagnosis of HSP in children...
  20. doi request reprint Risk factors in community-acquired urinary tract infections caused by ESBL-producing bacteria in children
    Rezan Topaloglu
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Nephrol 25:919-25. 2010
    ..In conclusion, the recognition of risk factors for UTI, caused by ESBL(+) bacteria in children, may aid in the identification of high-risk cases and may enable proper management of these patients...
  21. doi request reprint A novel CLCN7 mutation resulting in a most severe form of autosomal recessive osteopetrosis
    Nesrin Besbas
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey
    Eur J Pediatr 168:1449-54. 2009
    ..This is the first report of ARO associated with a novel recessive R561Q variant in CLCN7 gene, in which prenatal diagnosis was made...
  22. ncbi request reprint Toll-like receptors 2 and 4 cell surface expression reflects endotoxin tolerance in Henoch-Schönlein purpura
    Hande Canpinar
    Department of Basic Oncology, Institute of Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:22-7. 2010
    ..Further studies will clarify whether tolerance to microbial antigens may have a role in the pathogenesis and course of Henoch-Schönlein purpura...
  23. doi request reprint C1q deficiency: identification of a novel missense mutation and treatment with fresh frozen plasma
    Rezan Topaloglu
    Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Clin Rheumatol 31:1123-6. 2012
    ..Regular fresh frozen plasma infusions to the patient have been clinically and therapeutically successful...
  24. ncbi request reprint Bone mineral density in children with familial Mediterranean fever
    Ali Duzova
    Department of Pediatrics, Nephrology and Rheumatology Unit, Hacettepe University Faculty of Medicine, Sihhiye 06100 Ankara, Turkey
    Clin Rheumatol 23:230-4. 2004
    ..In conclusion, FMF patients had lower BMC, BMD and z-scores than a control group. We suggest that decreased BMD, BMC and z-score in FMF patients may be secondary to subclinical inflammation...
  25. ncbi request reprint Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis
    Nesrin Besbas
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Nephrol 18:696-9. 2003
    ..We describe here an unusual pediatric patient with MPO-ANCA-associated rapidly progressive glomerulonephritis (RPGN), emphasizing the management and outcome of the disease...
  26. ncbi request reprint Relationship of leptin and insulin-like growth factor I to nutritional status in hemodialyzed children
    Nesrin Besbas
    Unit of Pediatric Nephrology, Hacettepe University, Ankara, Turkey
    Pediatr Nephrol 18:1255-9. 2003
    ..In conclusion, the results of this study confirm the presence of high circulating plasma leptin levels, which may be one of the many factors involved in the pathogenesis of the malnutrition in children on hemodialysis...
  27. ncbi request reprint Childhood vasculitides in Turkey: a nationwide survey
    Seza Ozen
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
    Clin Rheumatol 26:196-200. 2007
    ..The aims of this study were to evaluate the characteristics of childhood vasculitides and to establish the first registry in Turkey, an eastern Mediterranean country with a white population...
  28. doi request reprint Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical
    Onur Cil
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Ren Fail 34:211-20. 2012
    ..These findings suggest that decreased endothelium-dependent vasodilation and augmented renal sympathetic tonus contribute to the development of renal vasoconstriction during rhabdomyolysis-induced ARF...
  29. doi request reprint Neonatal onset atypical hemolytic uremic syndrome successfully treated with eculizumab
    Nesrin Besbas
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey
    Pediatr Nephrol 28:155-8. 2013
    ..Plasma therapy is the first choice therapy in patients with aHUS based on the belief of an underlying complement dysregulation. Alternatively, eculizumab, which targets complement 5, is used to block complement activation...
  30. ncbi request reprint The distribution of juvenile idiopathic arthritis in the eastern Mediterranean: results from the registry of the Turkish Paediatric Rheumatology Association
    Erkan Demirkaya
    Gulhane Military Medical Acedemy, School of Medicine, Ankara, Turkey
    Clin Exp Rheumatol 29:111-6. 2011
    ..To analyse the demographics, main clinical and laboratory features and subtype distribution of juvenile idiopathic arthritis (JIA) in an eastern Mediterranean country, based on a multicentre registry...
  31. ncbi request reprint CLCN5 mutation (R347X) associated with hypokalaemic metabolic alkalosis in a Turkish child: an unusual presentation of Dent's disease
    Nesrin Besbas
    Hacettepe University Faculty of Medicine, Department of Pediatric, Ankara, Turkey
    Nephrol Dial Transplant 20:1476-9. 2005
  32. ncbi request reprint Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2)
    Bernward G Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Pediatrics 119:e907-19. 2007
    ..Therefore, we analyzed all 4 of the genes jointly in a large European cohort of 89 children from 80 families with nephrotic syndrome manifesting in the first year of life and characterized genotype/phenotype correlations...
  33. ncbi request reprint Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome
    Rainer G Ruf
    Departments of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Kidney Int 66:564-70. 2004
    ..Sporadic mutations in the Wilms' tumor suppressor gene WT1 have been found to be present in patients with SRNS in association with Wilms' tumor (WT) and urinary or genital malformations, as well as in patients with isolated SRNS...
  34. ncbi request reprint Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9
    Bettina Mucha
    Department of Pediatrics, University of Michigan, Ann Arbor, 48109, USA
    Pediatr Res 59:325-31. 2006
    ..Kidney Int 66: 564-570, 2004) indicate that screening of WT1 exons 8 and 9 in patients with sporadic SRNS is sufficient to detect pathogenic WT1 mutations and may open inroads into differential therapy of SRNS...
  35. ncbi request reprint Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS)
    Rasheed Gbadegesin
    Departments of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Nephrol Dial Transplant 23:1291-7. 2008
    ..Mutations in two other genes WT1 and LAMB2 may also cause IDMS. We therefore determine in this study the relative frequency of mutations in PLCE1, WT1 or LAMB2 as the cause of IDMS in a worldwide cohort...
  36. pmc Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Am Soc Nephrol 19:365-71. 2008
    ..Because the age of onset can vary by several years among those with identical mutations, additional factors may modify the phenotype...
  37. ncbi request reprint Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 38:1397-405. 2006
    ..These findings, together with the zebrafish model of human nephrotic syndrome generated by plce1 knockdown, open new inroads into pathophysiology and treatment mechanisms of nephrotic syndrome...
  38. ncbi request reprint Cerebral sinovenous thrombosis in a child with steroid sensitive nephrotic syndrome
    Yasemin Isik Balci
    Eur J Pediatr 166:757-8; author reply 759. 2007
  39. ncbi request reprint Helicobacter pylori infection in Turkish children with familial Mediterranean fever: is it a cause of persistent inflammation?
    Fatih Ozaltin
    Clin Rheumatol 23:186-7. 2004
  40. ncbi request reprint Novel OCRL1 mutations in patients with the phenotype of Dent disease
    Boris Utsch
    Klinik mit Poliklinik für Kinder und Jugendliche, Universitat Erlangen Nurnberg, Erlangen, Germany
    Am J Kidney Dis 48:942.e1-14. 2006
    ..A recent study showed that defects in OCRL1, encoding a phosphatidylinositol 4,5-bisphosphate 5-phosphatase (Ocrl) and usually found mutated in patients with Lowe syndrome, also can provoke a Dent-like phenotype (Dent 2 disease)...