Afig Berdeli

Summary

Affiliation: Ege University
Country: Turkey

Publications

  1. ncbi Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    J Rheumatol 33:2498-500. 2006
  2. ncbi Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients
    A Berdeli
    Department of Paediatrics, Ege University School of Medicine, Bornova, Izmir, Turkey
    Scand J Rheumatol 35:44-7. 2006
  3. ncbi Association of macrophage migration inhibitory factor gene -173 G/C polymorphism with prognosis in Turkish children with juvenile rheumatoid arthritis
    Afig Berdeli
    Department of Pediatrics, Laboratory of Molecular Medicine, Ege University School of Medicine, Bornova, 35100, SSK Tepecik Hospital, Izmir, Turkey
    Rheumatol Int 26:726-31. 2006
  4. ncbi Association of macrophage migration inhibitory factor -173C allele polymorphism with steroid resistance in children with nephrotic syndrome
    Afig Berdeli
    Department of Pediatric Nephrology and Molecular Medicine Laboratory, School of Medicine, Ege University, 35100 Bornova, Izmir, Turkey
    Pediatr Nephrol 20:1566-71. 2005
  5. ncbi Involvement of immunoglobulin FcgammaRIIA and FcgammaRIIIB gene polymorphisms in susceptibility to rheumatic fever
    Afig Berdeli
    Laboratory of Molecular Medicine, Department of Pediatrics, Ege University School of Medicine, Bornova, 35100 Izmir, Turkey
    Clin Biochem 37:925-9. 2004
  6. ncbi TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children
    Afig Berdeli
    Laboratory of Molecular Medicine, Department of Pediatrics, Ege University School of Medicine, Bornova, Izmir, 35100, Turkey
    J Mol Med (Berl) 83:535-41. 2005
  7. ncbi Renin-angiotensin system gene polymorphisms and premature coronary heart disease
    Cevad Sekuri
    Department of Cardiology, Kent Hospital, Izmir, Turkey
    J Renin Angiotensin Aldosterone Syst 6:38-42. 2005
  8. doi Renin-angiotensin gene polymorphisms in relation to severe chronic periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 36:204-11. 2009
  9. ncbi Toll-like receptor 2 and 4 gene polymorphisms in generalized aggressive periodontitis
    Gulnur Emingil
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Periodontol 78:1968-77. 2007
  10. doi Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Bornova 35100, Izmir, Turkey
    Arch Oral Biol 54:337-44. 2009

Collaborators

Detail Information

Publications72

  1. ncbi Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease
    Seza Ozen
    Department of Pediatrics, Hacettepe University, Ankara, Turkey
    J Rheumatol 33:2498-500. 2006
    ..Toll-like receptor (TLR-2) plays a critical role in linking the recognition of microbes to immune activation. We investigated whether the Arg753Gln TLR2 polymorphism affected the development of secondary amyloidosis in patients with FMF...
  2. ncbi Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients
    A Berdeli
    Department of Paediatrics, Ege University School of Medicine, Bornova, Izmir, Turkey
    Scand J Rheumatol 35:44-7. 2006
    ..Thus, TNFalpha polymorphisms at -308 in ARF patients might be useful in contributing to identification of the primary factors associated with pathogenesis of ARF...
  3. ncbi Association of macrophage migration inhibitory factor gene -173 G/C polymorphism with prognosis in Turkish children with juvenile rheumatoid arthritis
    Afig Berdeli
    Department of Pediatrics, Laboratory of Molecular Medicine, Ege University School of Medicine, Bornova, 35100, SSK Tepecik Hospital, Izmir, Turkey
    Rheumatol Int 26:726-31. 2006
    ..MIF -173 C allele did not confer increased susceptibility to JRA in our study group. Carriage of the MIF -173 C allele was found to be a strong predictor of poor outcome in all types of JRA...
  4. ncbi Association of macrophage migration inhibitory factor -173C allele polymorphism with steroid resistance in children with nephrotic syndrome
    Afig Berdeli
    Department of Pediatric Nephrology and Molecular Medicine Laboratory, School of Medicine, Ege University, 35100 Bornova, Izmir, Turkey
    Pediatr Nephrol 20:1566-71. 2005
    ..7+/-3.1 years) and GG-homozygous (3.6+/-2.9 years, p=0.88). In summary, our results indicate that the MIF -173 C allele confers an increased risk of susceptibility to INS and plays a crucial role in glucocorticoid responsiveness...
  5. ncbi Involvement of immunoglobulin FcgammaRIIA and FcgammaRIIIB gene polymorphisms in susceptibility to rheumatic fever
    Afig Berdeli
    Laboratory of Molecular Medicine, Department of Pediatrics, Ege University School of Medicine, Bornova, 35100 Izmir, Turkey
    Clin Biochem 37:925-9. 2004
    ..To assess the impact of the human FcgammaRIIA and FcgammaRIIIB gene polymorphisms on the risk of rheumatic fever (RF)...
  6. ncbi TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children
    Afig Berdeli
    Laboratory of Molecular Medicine, Department of Pediatrics, Ege University School of Medicine, Bornova, Izmir, 35100, Turkey
    J Mol Med (Berl) 83:535-41. 2005
    ..The common TLR-2 Arg to Gln polymorphism at position 753 significantly contributes to the pathogenesis of ARF. These results will allow the construction of a profile of individuals prone to ARF and may assist in developing new therapies...
  7. ncbi Renin-angiotensin system gene polymorphisms and premature coronary heart disease
    Cevad Sekuri
    Department of Cardiology, Kent Hospital, Izmir, Turkey
    J Renin Angiotensin Aldosterone Syst 6:38-42. 2005
    ..The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population...
  8. doi Renin-angiotensin gene polymorphisms in relation to severe chronic periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 36:204-11. 2009
    ....
  9. ncbi Toll-like receptor 2 and 4 gene polymorphisms in generalized aggressive periodontitis
    Gulnur Emingil
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Periodontol 78:1968-77. 2007
    ..The aim of the present study was to investigate whether TLR2 and TLR4 gene polymorphisms are related to susceptibility to generalized aggressive periodontitis (GAgP)...
  10. doi Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Bornova 35100, Izmir, Turkey
    Arch Oral Biol 54:337-44. 2009
    ....
  11. doi The relationship of the Fas 670 A/G gene polymorphism with cardiovascular risk factors in polycystic ovary syndrome (PCOS) patients
    Sevki Cetinkalp
    Department of Endocrinology and Metabolism Disease, Medical School, Ege University, Bornova, Izmir, Turkey
    Gynecol Endocrinol 26:167-72. 2010
    ..We aimed to evaluate the relation between Fas 670 A/G gene polymorphism in polycystic ovary syndrome (PCOS) patients carrying a potential risk for developing cardiovascular disease (CVD)...
  12. ncbi Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome
    Gokhan Tumgor
    Department of Pediatric Gastroenterology, Hepatology and Nutrition and Organ Transplantation and Research Center, Ege University School of Medicine, Izmir, Turkey
    Dig Dis Sci 53:1345-51. 2008
    ..The aim of this case-control study was to investigate both the distribution of MCP-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes...
  13. ncbi Matrix metalloproteinase-2, -9, and -12 gene polymorphisms in generalized aggressive periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Periodontol 78:2338-47. 2007
    ..The aim of the present study was to determine the association between the aforementioned MMP polymorphisms and generalized aggressive periodontitis (GAgP)...
  14. ncbi TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population
    Afig Berdeli
    Molecular Medicine Laboratory, Department of Pediatrics, School of Medicine, Ege University, Izmir, Turkey
    J Clin Periodontol 34:551-7. 2007
    ..Toll-like receptor (TLR) gene polymorphisms could affect the host's ability to respond to microbial pathogens. In this case-control study, the association of TLR2 and TLR4 gene polymorphisms with chronic periodontitis (CP) was investigated...
  15. ncbi Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    Arch Oral Biol 53:337-45. 2008
    ..MMP polymorphisms could alter transcription and function of these enzymes. The aim of this study was to investigate MMP-2, MMP-9 and MMP-12 gene polymorphisms in relation to susceptibility to severe chronic periodontitis (CP)...
  16. doi Macrophage migration inhibitory factor expression and MIF gene -173 G/C polymorphism in nonalcoholic fatty liver disease
    Murat Akyildiz
    Department of Gastroenterology, Ege University Medical School, Bornova, Izmir 35100, Turkey
    Eur J Gastroenterol Hepatol 22:192-8. 2010
    ..To investigate the macrophage migration inhibitory factor (MIF) expression and -173 G/C polymorphism of the MIF gene in nonalcoholic fatty liver disease (NAFLD)...
  17. ncbi Endothelial nitric oxide synthase Glu298Asp gene polymorphism in periodontal diseases
    Afig Berdeli
    Molecular Medicine Laboratory, Department of Pediatrics, School of Medicine, Ege University, Izmir, Turkey
    J Periodontol 77:1348-54. 2006
    ..The aim of the present study was to evaluate genotype distribution and genotype-phenotype association in periodontal disease regarding Glu298Asp polymorphism of the eNOS gene...
  18. doi Association between mannose-binding lectin levels and gene polymorphisms in chronic periodontitis and response to treatment
    Ozgün Ozçaka
    Department of Periodontology, School of Dentistry, University of Ege, Izmir, Turkey
    Arch Oral Biol 55:235-41. 2010
    ....
  19. doi Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis
    Demet Pirhan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 35:862-70. 2008
    ....
  20. ncbi Tissue plasminogen activator and plasminogen activator inhibitor-1 gene polymorphisms in patients with chronic periodontitis
    Ali Gürkan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Periodontol 78:1256-63. 2007
    ..This study was designed to investigate the association of t-PA and PAI-1 gene polymorphisms with chronic periodontitis (CP)...
  21. ncbi No association of interleukin-6 gene polymorphism (-174 G/C) with premature coronary artery disease in a Turkish cohort
    Cevad Sekuri
    Department of Cardiology, Kent Hospital, Izmir, Turkey
    Coron Artery Dis 18:333-7. 2007
    ..The aim of this study was to investigate further the association of the IL-6 -174 G/C allele status with premature CAD...
  22. ncbi Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis
    Gulnur Emingil
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 34:278-84. 2007
    ..The aim of this study was to investigate TPA and PAI-1 gene polymorphisms in relation to susceptibility to generalized aggressive periodontitis (G-AgP)...
  23. ncbi G protein beta3 subunit gene polymorphism in Turkish hypertensives
    Emin Alioglu
    Department of Cardiology, Central Hospital, Izmir, Turkey
    Anadolu Kardiyol Derg 8:331-5. 2008
    ..The aim of the present study was to investigate the association between the C825T polymorphism of the G protein b3 subunit and essential hypertension in Turkish population...
  24. pmc Association between RAS gene polymorphisms (ACE I/D, AGT M235T) and Henoch-Schönlein purpura in a Turkish population
    Sinem Nalbantoglu
    Molecular Medicine Laboratory, Children s Hospital, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey
    Dis Markers 34:23-32. 2013
    ..Our findings suggest that ACE I/D polymorphism is significantly associated with HSP susceptibility...
  25. doi FcgammaRIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitis
    Dost Zeyrek
    Department of Pediatric Allergy and Pulmonology, Aegean University, Izmir, Turkey
    Pediatr Allergy Immunol 19:20-4. 2008
    ..77, 95% CI: 1.32-2.35, p < 0.001) compared to healthy controls. Our study shows that the V158V genotype in FcgammaRIIIa gene polymorphism may be a genetic risk factor for the development of atopic diseases...
  26. doi TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome
    Sevgi Mir
    Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey
    Nephrol Dial Transplant 27:205-9. 2012
    ..The aim of this study is to screen for TRPC6 mutations in familial and sporadic SRNS patients...
  27. pmc 4G/5G polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome
    Muammer Karadeniz
    Endocrinology and Metabolism Disease, Ege University Hospital, 35100, Bornova, Izmir, Turkey
    J Assist Reprod Genet 24:412-8. 2007
    ..Polycystic ovary syndrome (PCOS) is one of the most encountered endocrine malfunctions. PCOS patients have enhanced activation of the blood coagulation system...
  28. doi Polymorphisms of the ICAM-1 gene are associated with biliary atresia
    Cigdem Arikan
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, 250 sok No 6 D 1, Bornova, Izmir 35040, Turkey
    Dig Dis Sci 53:2000-4. 2008
    ..The intercellular adhesion molecule-1 (ICAM-1) is of paramount importance for the initiation and propagation of various inflammatory conditions...
  29. doi MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy
    Demet Pirhan
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 36:474-81. 2009
    ....
  30. ncbi ACE gene insertion/deletion polymorphism in childhood idiopathic nephrotic syndrome
    Erkin Serdaroglu
    Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey
    Pediatr Nephrol 20:1738-43. 2005
    ..ACE gene I/D polymorphism was not important in laboratory and histological findings and progression of the disease in children with NS...
  31. ncbi Positive association of macrophage migration inhibitory factor gene-173G/C polymorphism with biliary atresia
    Cigdem Arikan
    Pediatric Gastroenterology, Ege University School of Medicine, Izmir, Turkey
    J Pediatr Gastroenterol Nutr 42:77-82. 2006
    ..Its expression was increased in several inflammatory diseases, and MIF gene polymorphisms have an effect on disease outcome and response to glucocorticoid treatment...
  32. ncbi TGF-beta1 gene polymorphisms in periodontal diseases
    Gul Atilla
    Department of Periodontology, School of Dentistry, Ege University, Bornova 35100, Izmir, Turkey
    Clin Biochem 39:929-34. 2006
    ..Transforming growth factor-beta1 (TGF-beta1) gene polymorphism is associated with risk of inflammatory diseases...
  33. doi Interleukin-10 (-1082G/A) gene polymorphism in patients with type 2 diabetes with and without nephropathy
    Mehmet Erdogan
    Department of Endocrinology and Metabolism Disease, Ege University Medical School, Izmir, Turkey
    Genet Test Mol Biomarkers 16:91-4. 2012
    ..We aimed at evaluating the relation between the genotypic and allelic frequencies of the IL-10 (-1082G/A) polymorphisms, and their association with the risk to develop DN in the Turkish population...
  34. ncbi The Fc gammaRIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitis
    Figen Gulen
    Aegean University School of Medicine, Department of Paediatrics, Division of Allergy and Pulmonology, TR 35100, Bornova Izmir, Turkey
    Clin Biochem 40:392-6. 2007
    ..The aim of the present study was to evaluate the Fc gammaRIIa polymorphism in Turkish children with atopic asthma and allergic rhinitis...
  35. ncbi Effects of genetic polymorphisms of the renin-angiotensin system in children with nephrotic syndrome
    Yilmaz Tabel
    Department of Pediatric Nephrology, Ege University School of Medicine, Ismir, Turkey
    J Renin Angiotensin Aldosterone Syst 6:138-44. 2005
    ..Genetic polymorphisms of the various components of the RAS have been associated with differences in the clinical course of several disease states in adults and children...
  36. doi Fas, Fas Ligand, and vitamin D Receptor FokI gene polymorphisms in patients with type 1 diabetes mellitus in the Aegean region of Turkey
    Serap Baydur Sahin
    Department of Endocrinology and Metabolism Disease, Ege University Medical School, Bornova, Izmir, Turkey
    Genet Test Mol Biomarkers 16:1179-83. 2012
    ....
  37. ncbi Gingival crevicular fluid transforming growth factor-beta1 in several forms of periodontal disease
    Ali Gürkan
    Ege University, School of Dentistry, Department of Periodontology, Bornova 35100, Izmir, Turkey
    Arch Oral Biol 51:906-12. 2006
    ..The aim of the present study was to evaluate the gingival crevicular fluid (GCF) TGF-beta(1) levels in patients with different forms of periodontal disease...
  38. ncbi Allelic frequency of the MCP-1 promoter -2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis
    A Ruhi Ozyurek
    Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey
    Clin Rheumatol 26:546-50. 2007
    ..Further studies are needed to elucidate the role of this polymorphism in the pathogenesis of JRA in various populations because this polymorphism has a functional significance and an ethnic difference...
  39. doi Prevalence of the angiotensin I converting enzyme gene insertion/deletion polymorphism in a healthy Turkish population
    Afig Berdeli
    Molecular Medicine Laboratory, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
    Biochem Genet 47:412-20. 2009
    ..9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations...
  40. ncbi NPHS2 (podicin) mutations in Turkish children with idiopathic nephrotic syndrome
    Afig Berdeli
    Department of Molecular Genetics, Ege University Faculty of Medicine, Izmir, Turkey
    Pediatr Nephrol 22:2031-40. 2007
    ..3%). In conclusion, podocin mutations are responsible for some of both familial and sporadic SRNS cases in Turkey. The mutations in this gene should be searched for in every child after presentation with the first episode of NS...
  41. ncbi Arg753Gln polymorphism of the human toll-like receptor-2 gene in children with recurrent febrile infections
    Necil Kutukculer
    Department of Pediatrics, Faculty of Medicine, Ege University, Bornova, Izmir 35100, Turkey
    Biochem Genet 45:507-14. 2007
    ..These results have indicated that there is a strong significant relationship between susceptibility to recurrent bacterial infections and Arg753Gln polymorphism of the TLR-2 gene...
  42. doi Comprehensive analysis of a large-scale screen for MEFV gene mutations: do they truly provide a "heterozygote advantage" in Turkey?
    Afig Berdeli
    Molecular Medicine Laboratory, Children s Hospital, School of Medicine, Ege University, Bornova, Izmir, Turkey
    Genet Test Mol Biomarkers 15:475-82. 2011
    ....
  43. doi The influence of α-adducin gene polymorphism on response of blood pressure to exercise in patients with hypertension
    Emin Alioglu
    Department of Cardiology, Central Hospital, Izmir, Turkey
    Anadolu Kardiyol Derg 10:400-4. 2010
    ..The aim of the present study was to examine the influence of α-adducin gene polymorphism on response of BP to exercise in patients with hypertension...
  44. doi Lack of association between macrophage migration inhibitory factor gene promoter (-173 G/C) polymorphism and childhood Henoch-Schönlein purpura in Turkish patients
    Sinem Nalbantoglu
    Ege University, School of Medicine, Children s Hospital, Molecular Medicine Laboratory, Bornova, Izmir, Turkey
    Cytokine 62:160-4. 2013
    ..06, OR: 0.5538, 95% CI: 0.2985-1.0274) and C allele (odds ratio: C vs. G: 1.799, 95% CI: 1.002-3.23, p = 0.05). Our findings suggest that MIF gene -173 G/C polymorphism is not associated with HSP in the present Turkish population...
  45. pmc The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome
    Muammer Karadeniz
    Division of Internal Disease, Department of Endocrinology and Metabolism, Ege University, Izmir, 35100, Turkey
    Cardiovasc Diabetol 6:29. 2007
    ..Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS...
  46. ncbi Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease
    Nevin Oruc
    Department of Gastroenterology, Ege University, Faculty of Medicine, Izmir, Turkey
    Ann Hepatol 8:116-9. 2009
    ..Some genetic factors including the genetic variations in SPINK-1 protein have been linked to chronic pancreatitis and diabetes. We therefore hypothesized that SPINK-1 mutations might be a risk factor for the development of NAFLD...
  47. doi A novel p.S34N mutation of CAMP gene in patients with periodontal disease
    Oya Turkoglu
    Department of Periodontology, School of Dentistry, Ege University, Bornova 35100, Izmir, Turkey
    Arch Oral Biol 56:573-9. 2011
    ..hCAP-18/LL-37 is a part of the innate immune response in the oral cavity. The aim of the present study was to investigate the mutation of CAMP gene encoding hCAP-18/LL-37 in the patients with different periodontal diseases...
  48. ncbi Association of the IL-1RN2 allele with periodontal diseases
    Afig Berdeli
    Molecular Medicine Laboratory, Department of Pediatrics, School of Medicine, Ege University, Izmir, Turkey
    Clin Biochem 39:357-62. 2006
    ..The aim of this study was to investigate IL-1RN genotype and its associations with different periodontal diseases in a group of Turkish subjects...
  49. doi Does NPHS1 polymorphism modulate P118l mutation in NPHS2?
    Nida Dincel
    Department of Pediatric Nephrology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey
    Saudi J Kidney Dis Transpl 24:1210-3. 2013
    ..Perhaps, this would be called a genetic modifier in future. ..
  50. ncbi Alterations of blood pressure in type 1 diabetic children and adolescents
    Sukran Darcan
    Ege University Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Izmir, Turkey
    Pediatr Nephrol 21:672-6. 2006
    ..High diastolic blood pressure burden in diabetic patients could represent a risk for nephropathy...
  51. doi Familial Mediterranean fever gene mutation frequencies and genotype-phenotype correlations in the Aegean region of Turkey
    Elif Ozalkaya
    Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey
    Rheumatol Int 31:779-84. 2011
    ..9%, respectively). To our knowledge that FMF should be suspected in the case of non-specific but recurrent attacks of serositis and high fever, and molecular analysis should be performed in order to make diagnosis of FMF...
  52. doi Three different classifications, B lymphocyte subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CTLA-4 and ICOS gene polymorphisms in Turkish patients with common variable immunodeficiency
    Necil Kutukculer
    Department of Pediatric Immunology, Ege University, Faculty of Medicine, 35100, Bornova, Izmir, Turkey
    J Clin Immunol 32:1165-79. 2012
    ..18 fold, respectively. 1564 T > C polymorphisms on 3'UTR region in exon 2 of ICOS gene was not found to be significantly different in CVID patients. CVID classifications were not helpful in determining the genetic etiology of CVID...
  53. pmc Novel mutatıons and diverse clinical phenotypes in recombinase-activating gene 1 deficiency
    Necil Kutukculer
    Department of Pediatrics, Faculty of Medicine, Ege University, 35100 Bornova, Izmir, Turkey
    Ital J Pediatr 38:8. 2012
    ..Mutations in recombinase-activating genes 1 or 2 (RAG1/2) represent approximately 10% of all SCID cases. RAG1/2 are essential for V(D)J rearrangement of the B- and T-cell receptors...
  54. ncbi Hypertension and ace gene insertion/deletion polymorphism in pediatric renal transplant patients
    Erkin Serdaroglu
    Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey
    Pediatr Transplant 9:612-7. 2005
    ..The ACE gene I/D polymorphism and serum ACE levels did not influence the blood pressure values or circadian variability of blood pressure among pediatric renal transplant patients...
  55. ncbi Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population
    Afig Berdeli
    Ege University, Faculty of Medicine, Department of Pediatri, Izmir, Turkey
    Clin Chim Acta 351:87-94. 2005
    ..Our objective was to investigate the association between the polymorphisms of eNOS (Glu298Asp) and the RAS genes and premature CAD in a Turkish population...
  56. ncbi Relationship between ace genotype and short duration aerobic performance development
    Mesut Cerit
    Institute of Health Sciences, Sport Sciences Division, Ege University, Izmir, Turkey
    Eur J Appl Physiol 98:461-5. 2006
    ..This threshold may be anywhere between 10 and 30 min with lasting maximal exercises...
  57. ncbi [Familial Mediterranean fever with pulmonary manifestations alone; early diagnosis with genetic analysis]
    Fidan Sever
    Department of Chest Diseases, Faculty of Medicine, Sifa University, Izmir, Turkey
    Tuberk Toraks 60:380-4. 2012
    ..This should help patients receive specific treatment without unnecessary delay. Thus, by making early diagnosis and timely delivery of treatment, disease progression is delayed and development of secondary amyloidosis avoided...
  58. ncbi Gene polymorphism of complement factor H in a Turkish patient with membranoproliferative glomerulonephritis type II
    Betul Sozeri
    Department of Pediatric Nephrology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey
    Iran J Kidney Dis 6:149-53. 2012
    ....
  59. doi Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey
    Ekin Ozgür Aktaş
    Ege University School of Medicine, Department of Forensic Medicine, Izmir, Turkey
    Sci Justice 52:58-61. 2012
    ....
  60. doi Association of interleukin-6 -174 g>c promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey
    Muammer Karadeniz
    1 Department of Endocrinology and Metabolism, Sifa University Medical School, Izmir, Turkey
    Genet Test Mol Biomarkers 18:62-5. 2014
    ..9% in those without nephropathy (p=0.039). Conclusion: We suggest that the -174 G>C polymorphism of the IL-6 gene is an independent risk factor for DN in Turkish type 2 diabetes mellitus patients. ..
  61. ncbi Insulin-like growth factor attenuates apoptosis and mucosal damage in hypoxia/reoxygenation-induced intestinal injury
    Samim Ozen
    Department of Pediatrics, Ege University Medical School, Bornova, TR 35100 Izmir, Turkey
    Biol Neonate 87:91-6. 2005
    ....
  62. doi A molecular case report of autosomal dominant retinitis pigmentosa: RP1/RHO sequence variants in a Turkish family
    Sinem M Nalbantoglu
    Ege University, School of Medicine, Children s Hospital, Molecular Medicine Laboratory, Bornova, Izmir, Turkey
    OMICS 16:18-23. 2012
    ....
  63. pmc Complement-4 deficiency in a child with systemic lupus erythematosus presenting with standard treatment-resistant severe skin lesion
    Betul Sozeri
    Department of Pediatric Rheumatology, Faculty of Medicine, Ege University, Bornova, 35040 Izmir, Turkey
    ISRN Rheumatol 2011:917673. 2011
    ..In this study, we present the clinical features and determine the molecular basis responsible for the complete C4A and C4B deficiencies in a lupus patient presented subacute cutaneous lupus erythematosus and resistance to treatment...
  64. ncbi Is ACE gene polymorphism a risk factor for renal scarring with low-grade reflux?
    Hakan Erdogan
    Department of Pediatric Nephrology, Ege University Medical School, 35100 Izmir, Turkey
    Pediatr Nephrol 19:734-7. 2004
    ..0, P=0.024). Although renal scarring is not common in low-grade reflux patients, there may be scarring in some patients. DD polymorphism of the ACE gene is a significant risk factor in low-grade reflux patients with renal scarring...
  65. ncbi Gingival crevicular fluid EMAP-II, MIP-1alpha and MIP-1beta levels of patients with periodontal disease
    Gulnur Emingil
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 32:880-5. 2005
    ....
  66. pmc X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis
    Nesrin Gulez
    Department of Pediatric Immunology, Ege University Medical School, 35100 Izmir, Turkey
    Case Report Med 2011:121258. 2011
    ..The patient will to be followed up as CVID until he presents new diagnostic signs or until the identification of a new gene...
  67. ncbi Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages
    Afig Berdeli
    Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir 35100, Turkey
    Prostaglandins Leukot Essent Fatty Acids 71:227-32. 2004
    ..Furthermore, the protective effect of glucocorticoids in MAS could be due, at least in part, to a suppression of PAF and TNF-alpha generation...
  68. doi A case of hypomagnesemia with secondary hypocalcemia caused by Trpm6 gene mutation
    Hursit Apa
    Department of Pediatric Emergency, Izmir, Turkey
    Indian J Pediatr 75:632-4. 2008
    ..7 mg/dl, Mg(+2): 0.4 mg/dl (1,3-2,1), PTH: 28.4 pg/ml (12-92), and P-: 4.5 mg/dl. The case was diagnosed as hypomagnesemia with secondary hypocalcemia (HSH) and TRPM6 gene mutation analysis revealed a homozygote mutation of E157X...
  69. ncbi Association between the ACE I/D gene polymorphism and physical performance in a homogeneous non-elite cohort
    F Sirri Cam
    Faculty of Medicine, Dept of Medical Biology and Genetics, Celal Bayar University, Manisa, Turkey
    Can J Appl Physiol 30:74-86. 2005
    ..The aim of this study was to investigate the association between ACE gene polymorphism and athletic performance in a homogeneous cohort...
  70. ncbi Infantile steroid-resistant nephrotic syndrome associated with double homozygous mutations of podocin
    Gianluca Caridi
    Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, Genoa, Italy
    Am J Kidney Dis 43:727-32. 2004
    ..This is the first description of double homozygous mutations in an autosomal recessive renal disease reported in the literature. The association with infantile NS widens the panel of clinical presentation related to NPHS2 mutations...
  71. ncbi The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population
    Sirri F Cam
    Celal Bayar University, Faculty of Medicine, Department of Medical Biology and Genetics, Manisa, Turkey
    Thromb Res 116:287-92. 2005
    ..The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene...
  72. ncbi Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients
    Cevad Sekuri
    Department of Cardiology Faculty of Medicine, Celal Bayar University, Manisa, Turkey
    Anadolu Kardiyol Derg 6:132-4. 2006
    ..Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (G994T). The aim of this study was to investigate association of this mutation with premature coronary artery disease (CAD)...