O Demirhan

Summary

Affiliation: Cukurova University
Country: Turkey

Publications

  1. pmc Diagnosis of chromosomal abnormalities in a patient with thanatophoric dysplasia (TD) type I: The first report describing an important association between cytogenetic findings and TD
    Mehmet Turgut
    Department of Pediatrics, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey
    Am J Case Rep 13:109-13. 2012
  2. pmc Phenotypic correlations in a patient with ring chromosome 22
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Cukurova, Adana, Turkey
    Indian J Hum Genet 16:97-9. 2010
  3. pmc The first report described as an important study: The association of mannose-binding lectin gene 2 polymorphisms in children with Down syndrome
    Osman Demirhan
    Department of Medical Biology and Genetics, Cukurova University, Adana, Turkey
    Indian J Hum Genet 17:59-64. 2011
  4. ncbi request reprint Chromosome imbalances and alterations of AURKA and MYCN genes in children with neuroblastoma
    Nihal Inandıklıoğlu
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Asian Pac J Cancer Prev 13:5391-7. 2012
  5. ncbi request reprint Chromosome imbalances and alterations in the p53 gene in uterine myomas from the same family members: familial leiomyomatosis in Turkey
    Sibel Hakverdi
    Department of Pathologi, Tayfur Ata Sokmen Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
    Asian Pac J Cancer Prev 14:651-8. 2013
  6. doi request reprint Identification of chromosome abnormalities in screening of a family with manic depression and psoriasis: predisposition to aneuploidy
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Asian J Psychiatr 5:169-74. 2012
  7. pmc The expression of folate sensitive fragile sites in patients with bipolar disorder
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Balcali Adana, Turkey
    Yonsei Med J 50:137-41. 2009
  8. doi request reprint The genotoxic effect of nicotine on chromosomes of human fetal cells: the first report described as an important study
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, 01330 Balcali, Adana, Turkey
    Inhal Toxicol 23:829-34. 2011
  9. doi request reprint Cytogenetic effects of ethanol on chronic alcohol users
    Osman Demirhan
    Department of Medical Biology and Genetics, Medical Faculty, Cukurova University, 01330, Balcali, Adana, Turkey
    Alcohol Alcohol 43:127-36. 2008
  10. ncbi request reprint Inheritance of pericentric inversion in chromosome 7 through the three progenies and a newborn with congenital hydronephrosis diagnosed prenatally by fetal urine sampling
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Fertil Steril 89:228.e1-6. 2008

Collaborators

Detail Information

Publications28

  1. pmc Diagnosis of chromosomal abnormalities in a patient with thanatophoric dysplasia (TD) type I: The first report describing an important association between cytogenetic findings and TD
    Mehmet Turgut
    Department of Pediatrics, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey
    Am J Case Rep 13:109-13. 2012
    ..It has been reported to be caused by mutations in the FGFR3 gene, but exactly how cytogenetic abnormalities might lead to TD is unclear...
  2. pmc Phenotypic correlations in a patient with ring chromosome 22
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Cukurova, Adana, Turkey
    Indian J Hum Genet 16:97-9. 2010
    ..The wide range of manifestations observed in patients with this cytogenetic alteration is probably due to size differences in the deleted region...
  3. pmc The first report described as an important study: The association of mannose-binding lectin gene 2 polymorphisms in children with Down syndrome
    Osman Demirhan
    Department of Medical Biology and Genetics, Cukurova University, Adana, Turkey
    Indian J Hum Genet 17:59-64. 2011
    ..This is the first report describing an important association between MBL2 gene polymorphisms and infections in children with DS...
  4. ncbi request reprint Chromosome imbalances and alterations of AURKA and MYCN genes in children with neuroblastoma
    Nihal Inandıklıoğlu
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Asian Pac J Cancer Prev 13:5391-7. 2012
    ..We aimed to investigate AURKA and MYCN gene rearrangements and the chromosomal aberrations (CAs) to determine the prognosis of neuroblastoma...
  5. ncbi request reprint Chromosome imbalances and alterations in the p53 gene in uterine myomas from the same family members: familial leiomyomatosis in Turkey
    Sibel Hakverdi
    Department of Pathologi, Tayfur Ata Sokmen Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
    Asian Pac J Cancer Prev 14:651-8. 2013
    ..The increased incidence of autosomal deletions, translocations, chromatid breaks and aneuploidy, could contribute to the progression of the disease along with other chromosomal alterations...
  6. doi request reprint Identification of chromosome abnormalities in screening of a family with manic depression and psoriasis: predisposition to aneuploidy
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Asian J Psychiatr 5:169-74. 2012
    ..The CD4/CD8 ratio of the father and the son was found to be significantly high. These results may suggest that MD and psoriasis have a significant impact on both genetic and immunological parameters...
  7. pmc The expression of folate sensitive fragile sites in patients with bipolar disorder
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Balcali Adana, Turkey
    Yonsei Med J 50:137-41. 2009
    ..The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile sites and bipolar disorder...
  8. doi request reprint The genotoxic effect of nicotine on chromosomes of human fetal cells: the first report described as an important study
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, 01330 Balcali, Adana, Turkey
    Inhal Toxicol 23:829-34. 2011
    ..Also, it has deleterious effects on the fetus. The sperm of smoking fathers and newborns of smoking mothers have elevated frequencies of chromosome translocations and DNA strand breaks...
  9. doi request reprint Cytogenetic effects of ethanol on chronic alcohol users
    Osman Demirhan
    Department of Medical Biology and Genetics, Medical Faculty, Cukurova University, 01330, Balcali, Adana, Turkey
    Alcohol Alcohol 43:127-36. 2008
    ..We aimed to find chromosomal damages in chronic alcohol users for the purpose of finding the correlation between alcohol and chromosomal anomalies...
  10. ncbi request reprint Inheritance of pericentric inversion in chromosome 7 through the three progenies and a newborn with congenital hydronephrosis diagnosed prenatally by fetal urine sampling
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Fertil Steril 89:228.e1-6. 2008
    ..To report the inheritance of a pericentric inversion in chromosome 7 through the three progenies, congenital hydronephrosis, and recurrent miscarriages in an extended family...
  11. doi request reprint Alterations in p16 and p53 genes and chromosomal findings in patients with lung cancer: fluorescence in situ hybridization and cytogenetic studies
    Osman Demirhan
    Department of Medical Biology and Genetics, Cukurova University, 01330 Balcali Adana, Turkey
    Cancer Epidemiol 34:472-7. 2010
    ..We carried out cytogenetic analysis by Giemsa-banding in 18 cases. FISH probes for the p16 and p53 genes were also used on interphase nuclei to screen the alterations in these genes in lung cancer (LC)...
  12. ncbi request reprint Chromosomal fragile sites in schizophrenic patients
    O Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Balcali Adana, Turkey
    Genetika 42:985-92. 2006
    ..Males exhibited twice as many FS as females, but no age effects were observed. The potential relationship between increased FS frequency and the occurrence of schizophrenia in these patients is discussed...
  13. ncbi request reprint Partial trisomy 1p due to paternal t(1;9) translocation in a family with recurrent miscarriages
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Cukurova, Balcali Adana, Turkey
    Fertil Steril 86:219.e15-9. 2006
    ..To report a new case with partial trisomy 1p due to paternal t(1;9) translocation in a family with recurrent miscarriages...
  14. ncbi request reprint Inheritance of a translocation between chromosomes 12 and 16 in a family with recurrent miscarriages and a newborn with Down syndrome carrying the same translocation
    A Pazarbasi
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Cukurova, Turkey
    Genet Couns 19:301-8. 2008
    ..These findings can be used in clinical genetics and may be used as an effective tool for reproductive guidance and genetic counseling...
  15. ncbi request reprint Cytogenetic study of recurrent miscarriages and their parents
    E Tunc
    Department of Medical Biology and Genetics, University of Cukurova, Adana, Turkey
    Genetika 43:545-52. 2007
    ..Mosaicism should be taken into account for cytogenetic analyses of pregnancy losses. Thus, cytogenetic analyses should be recommended in couples with recurrent miscarriages, when clinical data fail to clarify the cause...
  16. ncbi request reprint Chromosomal fragile site expression in Turkish psychiatric patients
    Deniz Tastemir
    Department of Medical Biology and Genetics, The Medical Faculty of Cukurova University, Balcali, Adana, Turkey
    Psychiatry Res 144:197-203. 2006
    ..These interesting regions, which may harbor important genes for psychosis, have produced strong support for linkage in the majority of genome scan projects...
  17. doi request reprint Detection of parental origin and cell stage errors of a double nondisjunction in a fetus by QF-PCR
    Ali Irfan Guzel
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey
    Genet Test Mol Biomarkers 13:73-7. 2009
    ..To investigate parental origins and cell stage errors of a double nondisjunction in a fetus...
  18. ncbi request reprint A cytogenetic study in 120 Turkish children with intellectual disability and characteristics of fragile X syndrome
    Osman Demirhan
    Department of Medical Biology and Genetics, Cukurova University Faculty of Medicine, 01330, Balcali, Adana, Turkey
    Yonsei Med J 44:583-92. 2003
    ..05). The tests for the fra X chromosome are likely to be of diagnostic benefit in young children with autism or developmental delay, particularly in speech, and who have large and prominent ears...
  19. ncbi request reprint Correlation of clinical phenotype with a pericentric inversion of chromosome 9 and genetic counseling
    Osman Demirhan
    Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Balcali, Adana, Turkey
    Saudi Med J 29:946-51. 2008
    ..To describe the history of 157 carriers of pericentric inversions on chromosome 9 [inv9] with karyotype analyses and evaluate the significance of these findings...
  20. ncbi request reprint Chromosome aberrations in a schizophrenia population
    Osman Demirhan
    Faculty of Medicine, Department of Medical Biology and Genetics, Cukurova University, 01330, Balcali, Adana, Turkey
    Schizophr Res 65:1-7. 2003
    ..The reason for this might be that these anomalies increase risk for schizophrenia in a relatively nonspecific way, such as contributing to disruption of normal embryogenesis of the nervous system...
  21. ncbi request reprint The clinical effects of isochromosome Xq in Klinefelter syndrome: report of a case and review of literature
    O Demirhan
    Department of Medical Biology, University of Cukurova, Adana, Turkey
    Genet Couns 20:235-42. 2009
    ..In conclusion, review of literature on 20 adult patients supports the view that the presence of an isochromosome Xq in KS has a favorable prognosis in terms of normal mental development and normal stature...
  22. doi request reprint Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome
    S Cetiner
    Central Laboratory of Balcali Hospital, Faculty of Medicine, University of Cukurova, Adana, Turkey
    Int J Immunogenet 37:233-7. 2010
    ..Our findings may demonstrate that the cell-mediated and humoral immune system parameters in children with DS were altered according to healthy children...
  23. ncbi request reprint Association of the Nramp1 gene polymorphisms and clinical forms in patients with tuberculosis
    I Hanta
    Department of Chest Diseases, Faculty of Medicine, Cukurova University, Adana, Turkey
    Bratisl Lek Listy 113:657-60. 2012
    ..In this study, we aimed to determine Nramp1 polymorphisms in our patients with tuberculosis population...
  24. doi request reprint Connexin 26 and 30 mutations in paediatric patients with congenital, non-syndromic hearing loss treated with cochlear implantation in Mediterranean Turkey
    O Tarkan
    Department of Otolaryngology Head and Neck Surgery, Cukurova University, Adana, Turkey
    J Laryngol Otol 127:33-7. 2013
    ....
  25. pmc A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies
    O Demirhan
    Department of Medical Biology and Genetics, Cukurova University, Adana, Turkey
    J Med Genet 42:314-7. 2005
    ..However, the phenotype described here differs from GDF5 associated chondrodysplasias because of the additional presence of genital anomalies and the distinct limb phenotype...
  26. doi request reprint Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey
    M B Yilmaz
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Cukurova, Adana, Turkey
    Genet Mol Res 10:1999-2008. 2011
    ..Femoral neck BMD and lumbar T-score were also diminished with GA transition. In conclusion, CYP17 and CYP19 gene polymorphisms were found to be associated with osteoporosis in postmenopausal women in Turkey...
  27. doi request reprint Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene
    S Turkmen
    Institut fur Medizinische Genetik, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Eur J Hum Genet 16:1070-4. 2008
    ..However, quadrupedal locomotion was never observed indicating that environmental factors play a major role in the pathogenesis of this form of locomotion...
  28. ncbi request reprint Clinical findings and phenotype in a toddler with 48,XXYY syndrome
    Osman Demirhan
    Am J Med Genet A 119:393-4. 2003