Tayfun Ozcelik

Summary

Affiliation: Bilkent University
Country: Turkey

Publications

  1. ncbi request reprint Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Bilkent University, Faculty of Science, Ankara, Turkey
    Eur J Hum Genet 14:791-7. 2006
  2. pmc Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Faculty of Science and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara 06800, Turkey
    Proc Natl Acad Sci U S A 105:4232-6. 2008
  3. ncbi request reprint X chromosome inactivation and female predisposition to autoimmunity
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, Ankara 06800, Turkey
    Clin Rev Allergy Immunol 34:348-51. 2008
  4. pmc Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion
    Onur Emre Onat
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey
    Eur J Hum Genet 21:281-5. 2013
  5. doi request reprint Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
    Elif Uz
    Bilkent University, Faculty of Science and Institute of Materials Science and Nanotechnology, Ankara, Turkey
    Arthritis Rheum 60:3410-2. 2009
  6. ncbi request reprint Skewed X chromosome inactivation in blood cells of women with scleroderma
    Zeynep Ozbalkan
    Hacettepe University Medical School, Ankara, Turkey
    Arthritis Rheum 52:1564-70. 2005
  7. ncbi request reprint Collaborative genomics for human health and cooperation in the Mediterranean region
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    Nat Genet 42:641-5. 2010
  8. ncbi request reprint Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias
    Cemaliye Boylu Akyerli
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, 06800, Ankara, Turkey
    J Cancer Res Clin Oncol 129:604-5. 2003
  9. doi request reprint Neuro-ophthalmologic findings in humans with quadrupedal locomotion
    Ozge Sarac
    Department of 2nd Ophthalmology, Ankara Ataturk Training and Research Hospital, Bilkent, Ankara, Turkey
    Ophthalmic Genet 33:249-52. 2012
  10. pmc Skewed X-chromosome inactivation in scleroderma
    Elif Uz
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, Ankara, 06800, Turkey
    Clin Rev Allergy Immunol 34:352-5. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Bilkent University, Faculty of Science, Ankara, Turkey
    Eur J Hum Genet 14:791-7. 2006
    ..Analysis of two familial cases showed that only the affected individuals demonstrate skewed XCI patterns. Based on these results, skewed XCI mosaicism may play a significant role in the pathogenesis of AITDs...
  2. pmc Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Faculty of Science and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara 06800, Turkey
    Proc Natl Acad Sci U S A 105:4232-6. 2008
    ....
  3. ncbi request reprint X chromosome inactivation and female predisposition to autoimmunity
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, Ankara 06800, Turkey
    Clin Rev Allergy Immunol 34:348-51. 2008
  4. pmc Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion
    Onur Emre Onat
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey
    Eur J Hum Genet 21:281-5. 2013
    ..These findings suggest that ATP8A2 is involved in the development of the cerebro-cerebellar structures required for posture and gait in humans...
  5. doi request reprint Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
    Elif Uz
    Bilkent University, Faculty of Science and Institute of Materials Science and Nanotechnology, Ankara, Turkey
    Arthritis Rheum 60:3410-2. 2009
    ..This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA...
  6. ncbi request reprint Skewed X chromosome inactivation in blood cells of women with scleroderma
    Zeynep Ozbalkan
    Hacettepe University Medical School, Ankara, Turkey
    Arthritis Rheum 52:1564-70. 2005
    ..Until now this has not been illustrated experimentally. This study was undertaken to test the hypothesis that disturbances in XCI mosaicism may be involved in the pathogenesis of the disease in female patients with SSc...
  7. ncbi request reprint Collaborative genomics for human health and cooperation in the Mediterranean region
    Tayfun Ozcelik
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    Nat Genet 42:641-5. 2010
    ..Such discoveries will enable genetic knowledge to be translated into medical knowledge that will benefit local populations and contribute substantially to the understanding of the genetic bases of human diseases worldwide...
  8. ncbi request reprint Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias
    Cemaliye Boylu Akyerli
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, 06800, Ankara, Turkey
    J Cancer Res Clin Oncol 129:604-5. 2003
  9. doi request reprint Neuro-ophthalmologic findings in humans with quadrupedal locomotion
    Ozge Sarac
    Department of 2nd Ophthalmology, Ankara Ataturk Training and Research Hospital, Bilkent, Ankara, Turkey
    Ophthalmic Genet 33:249-52. 2012
    ..To report the neuro-ophthalmologic findings in four patients from the same family with cerebellar ataxia, mental retardation, and dysequilibrium syndrome (CAMRQ)2 associated with quadrupedal locomotion...
  10. pmc Skewed X-chromosome inactivation in scleroderma
    Elif Uz
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, Ankara, 06800, Turkey
    Clin Rev Allergy Immunol 34:352-5. 2008
    ..Skewed XCI mosaicism could be considered as an important risk factor in scleroderma...
  11. ncbi request reprint DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population
    Bensu Karahalil
    Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
    Anticancer Res 26:4955-8. 2006
    ..Base excision repair (BER) genes (X-ray repair cross complementing 1, XRCC1 and human 8-oxoguanine DNA glycosylase 1, OGG1) may play a key role in maintaining genome integrity and preventing cancer development...
  12. ncbi request reprint Extremely skewed X-chromosome inactivation is increased in pre-eclampsia
    Elif Uz
    Department of Molecular Biology and Genetics, Bilkent University, Bilkent, Ankara 06800, Turkey
    Hum Genet 121:101-5. 2007
    ..74%), and in 2 of 86 informative controls (2.33%, P = 0.0005; chi(2) test). Our findings support a role for the X-chromosome in the pathogenesis of pre-eclampsia in a subgroup of patients...
  13. ncbi request reprint Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair
    Gülşah M Dal
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey
    J Med Genet 51:455-9. 2014
    ..Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82-1.70×10(-8) mutations per base per generation. However, contribution of early postzygotic mutations to the overall human de novo SNV rate is unknown...
  14. pmc Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred
    Suleyman Gulsuner
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara 06800, Turkey
    Genome Res 21:1995-2003. 2011
    ..It is highly expressed in the cerebellum and corpus callosum, in particular in the Purkinje cell layer of the cerebellum. WDR81 represents the third gene, after VLDLR and CA8, implicated in quadrupedal locomotion in humans...
  15. ncbi request reprint MDM2 T309G polymorphism is associated with bladder cancer
    Onur Emre Onat
    Department of Molecular Biology and Genetics, Bilkent University, Bilkent, Ankara 06800, Turkey
    Anticancer Res 26:3473-5. 2006
    ..To the best of our knowledge, this is the first study reporting that MDM2 T309G polymorphism may be a potential genetic susceptibility factor for bladder cancer...
  16. ncbi request reprint Extremely skewed X-chromosome inactivation patterns in women with recurrent spontaneous abortion
    Sevgi Bagislar
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey
    Aust N Z J Obstet Gynaecol 46:384-7. 2006
    ..The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of recurrent spontaneous abortion (RSA) but the results obtained were conflicting...
  17. pmc Reply to Herz et al. and Humphrey et al.: Genetic heterogeneity of cerebellar hypoplasia with quadrupedal locomotion
    Tayfun Ozcelik
    Proc Natl Acad Sci U S A 105:E32-3. 2008
  18. ncbi request reprint X-linked clonality testing and autoimmune diseases
    Tayfun Ozcelik
    Blood 110:2769; author reply 2770. 2007