Sibel Suzen

Summary

Affiliation: Ankara University
Country: Turkey

Publications

  1. ncbi request reprint Melatonin and synthetic analogs as antioxidants
    Sibel Suzen
    Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey
    Curr Drug Deliv 10:71-5. 2013
  2. ncbi request reprint Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines
    S Suzen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy ECZACILIK, Ankara University, Turkey
    Farmaco 55:246-8. 2000
  3. ncbi request reprint Combination of electrochemical, spectrometric and other analytical techniques for high throughput screening of pharmaceutically active compounds
    Sibel Suzen
    Department of Pharmaceutical Chemistry, Ankara Univetsity, Tandogan, Turkey
    Comb Chem High Throughput Screen 13:658-64. 2010
  4. doi request reprint Synthesis and comparison of antioxidant properties of indole-based melatonin analogue indole amino Acid derivatives
    Sibel Suzen
    Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, 06100 Tandogan, Ankara, Turkey
    Chem Biol Drug Des 79:76-83. 2012
  5. ncbi request reprint Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: discussion on possible antioxidant mechanisms and comparison with melatonin
    Sibel Suzen
    Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, Tandogan, Ankara 06100, Turkey
    J Enzyme Inhib Med Chem 21:405-11. 2006
  6. ncbi request reprint Recent developments of melatonin related antioxidant compounds
    Sibel Suzen
    Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey
    Comb Chem High Throughput Screen 9:409-19. 2006
  7. ncbi request reprint Novel N-acyl dehydroalanine derivatives as antioxidants: studies on rat liver lipid peroxidation levels and DPPH free radical scavenging activity
    Sibel Suzen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University 06100 Tandogan, Ankara, Turkey
    J Enzyme Inhib Med Chem 21:179-85. 2006
  8. ncbi request reprint Recent studies of aldose reductase enzyme inhibition for diabetic complications
    Sibel Suzen
    Ankara University, Faculty of Pharmacy ECZACILIK, Department of Pharmaceutical Chemistry, Tandogan 06100, Ankara, Turkey
    Curr Med Chem 10:1329-52. 2003
  9. ncbi request reprint Synthesis and analytical evaluation by voltammetric studies of some new indole-3-propionamide derivatives
    S Suzen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy ECZACILIK, Ankara University, Tandogan, Turkey
    Farmaco 56:835-40. 2001
  10. ncbi request reprint Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: synthesis and structure-activity relationships
    Gokce Gurkok
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey
    J Enzyme Inhib Med Chem 24:506-15. 2009

Collaborators

  • Hilmi Orhan
  • Nesrin Gokhan
  • Sevim Rollas
  • Nihal Yucel
  • Sibel A Ozkan
  • Nilufer Yuksel
  • Erden Banoglu
  • Hanif Shirinzadeh
  • Tulay Coban
  • Gokce Gurkok
  • Hande Gurer-Orhan
  • M Orhan Puskullu
  • Cigdem Karaaslan
  • Ayse Didem Yılmaz
  • Seçkin Ozden
  • Nurten Altanlar
  • Burcu Caliskan-Ergün
  • Bedia Koçyiğit Kaymakçioğlu
  • Hachemi Kadri
  • Betul Tekiner
  • Andrew D Westwell
  • Burcu Eren
  • Murat Süküroğlu
  • M Orhan Püsküllü
  • Erdem Buyukbingol
  • Kevser Erol
  • Semra Koyunoğlu
  • Yasemin Aktan
  • Akgul Yesilada

Detail Information

Publications20

  1. ncbi request reprint Melatonin and synthetic analogs as antioxidants
    Sibel Suzen
    Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey
    Curr Drug Deliv 10:71-5. 2013
    ..Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities. This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants...
  2. ncbi request reprint Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines
    S Suzen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy ECZACILIK, Ankara University, Turkey
    Farmaco 55:246-8. 2000
    ..The compound showed inhibitory activity on several cancer cell lines. No information is available on anti-cancer potency of this compound with normal cell lines...
  3. ncbi request reprint Combination of electrochemical, spectrometric and other analytical techniques for high throughput screening of pharmaceutically active compounds
    Sibel Suzen
    Department of Pharmaceutical Chemistry, Ankara Univetsity, Tandogan, Turkey
    Comb Chem High Throughput Screen 13:658-64. 2010
    ..In this review, the latest developments related to the use of electrochemical techniques in drug research in order to evaluate possible combination spectrometric methods with electrochemical techniques...
  4. doi request reprint Synthesis and comparison of antioxidant properties of indole-based melatonin analogue indole amino Acid derivatives
    Sibel Suzen
    Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, 06100 Tandogan, Ankara, Turkey
    Chem Biol Drug Des 79:76-83. 2012
    ....
  5. ncbi request reprint Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: discussion on possible antioxidant mechanisms and comparison with melatonin
    Sibel Suzen
    Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, Tandogan, Ankara 06100, Turkey
    J Enzyme Inhib Med Chem 21:405-11. 2006
    ..The compounds significantly inhibited (72-98%) lipid peroxidation at 10(-3) M. These values were similar to that observed with BHT (88%). Possible structure-activity relationships of the compounds were discussed...
  6. ncbi request reprint Recent developments of melatonin related antioxidant compounds
    Sibel Suzen
    Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey
    Comb Chem High Throughput Screen 9:409-19. 2006
    ..This review addresses recent studies with melatonin and related compounds...
  7. ncbi request reprint Novel N-acyl dehydroalanine derivatives as antioxidants: studies on rat liver lipid peroxidation levels and DPPH free radical scavenging activity
    Sibel Suzen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University 06100 Tandogan, Ankara, Turkey
    J Enzyme Inhib Med Chem 21:179-85. 2006
    ..The possible antioxidant mechanism of the compounds was discussed...
  8. ncbi request reprint Recent studies of aldose reductase enzyme inhibition for diabetic complications
    Sibel Suzen
    Ankara University, Faculty of Pharmacy ECZACILIK, Department of Pharmaceutical Chemistry, Tandogan 06100, Ankara, Turkey
    Curr Med Chem 10:1329-52. 2003
    ..The search for specific inhibitors of AR enzyme has still become a major pharmaceutic challenge, though a number of AR inhibitors have so far been assessed for diabetic complications...
  9. ncbi request reprint Synthesis and analytical evaluation by voltammetric studies of some new indole-3-propionamide derivatives
    S Suzen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy ECZACILIK, Ankara University, Tandogan, Turkey
    Farmaco 56:835-40. 2001
    ..The oxidative behavior of the indole derivatives was studied as a function of pH at a glassy carbon electrode. The characteristics of the corresponding electrode reaction were discussed...
  10. ncbi request reprint Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: synthesis and structure-activity relationships
    Gokce Gurkok
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey
    J Enzyme Inhib Med Chem 24:506-15. 2009
    ..Sixteen MLT analogue indole hydrazide/hydrazone derivatives were synthesized and in vitro antioxidant activity was investigated. Most of the compounds showed significantly higher activity than MLT at 10(-3) M and 10(-4) M concentrations...
  11. doi request reprint Synthesis and antioxidant activity evaluations of melatonin-based analogue indole-hydrazide/hydrazone derivatives
    Ayse Didem Yılmaz
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University 06100 Tandogan, Ankara, Turkey
    J Enzyme Inhib Med Chem 27:428-36. 2012
    ..Lastly, compound 1j revealed stronger inhibitory activity against MLT in the LP inhibitory assay at 0.1mM concentration (51%) while the rest of the compounds showed moderate inhibition...
  12. ncbi request reprint Antimicrobial evaluation of indole-containing hydrazone derivatives
    Hanif Shirinzadeh
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey Fax 90 312 2131081
    Z Naturforsch C 66:340-4. 2011
    ..25-100 microg/ml against the tested microorganisms. Aromaticity and disubstitution of the phenyl ring with especially fluorine and chlorine atoms were found to be significant for the antimicrobial activity..
  13. ncbi request reprint Screening and evaluation of antioxidant activity of some pyridazine derivatives
    Burcu Caliskan-Ergün
    Department of Pharmaceutical Chemistry, Gazi University, Faculty of Pharmacy, Etiler, Ankara, Turkey
    J Enzyme Inhib Med Chem 23:225-9. 2008
    ..Most of the compounds have strong inhibitory effect on superoxide anion (between 84% - 99%) at 10(- 3) M concentration. In addition, these compounds showed similar activity to alpha-tocopherol at 10(- 3) M concentrations...
  14. doi request reprint Novel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studies
    Hanif Shirinzadeh
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
    Molecules 15:2187-202. 2010
    ..The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin...
  15. doi request reprint Investigation of antimicrobial activities of indole-3-aldehyde hydrazide/hydrazone derivatives
    Gokce Gurkok
    Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Tandogan, Ankara, Turkey
    Chemotherapy 55:15-9. 2009
    ..Indoles and hydrazone-type compounds constitute an important class of compounds for new drug development in order to discover an effective compound against multi-drug-resistant microbial infections...
  16. ncbi request reprint Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives
    Hande Gurer-Orhan
    Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye 06100, Ankara, Turkey
    J Enzyme Inhib Med Chem 21:241-7. 2006
    ..Furthermore their effects on various antioxidant enzymes are discussed and evaluated from the perspective of structure- activity relationships...
  17. ncbi request reprint Recent studies of antioxidant quinoline derivatives
    M Orhan Puskullu
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, 38039, Kayseri, Turkey
    Mini Rev Med Chem 13:365-72. 2013
    ..The present review provides recent antioxidant activities covering in vivo and in vitro studies of natural and synthetic analogues, as well as the proposed mechanisms of action and structure-activity relationships...
  18. doi request reprint Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles
    Cigdem Karaaslan
    Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, 06100 Tandogan, Ankara, Turkey School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB Wales, UK
    Bioorg Med Chem Lett 23:2671-4. 2013
    ....
  19. ncbi request reprint In vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone in rats
    Bedia Koçyiğit Kaymakçioğlu
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul, Turkey
    Eur J Drug Metab Pharmacokinet 30:255-60. 2005
    ..In addition, the composition of these metabolites and substrate was confirmed by LC-MS in plasma...
  20. doi request reprint Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: evaluation of interactions using FT-IR and NMR spectroscopies
    Nilufer Yuksel
    Department of Pharmaceutical Technology, Ankara University, School of Pharmacy, 06100 Ankara, Turkey
    Int J Pharm 404:102-9. 2011
    ..The release enhancement of IND from microspheres was attributed to the physical plasticization effect of triacetin on PMMA and, to some extent, the amorphous state of the drug...