Mohamed Ridha Barbouche
Affiliation: Institut Pasteur de Tunis
Ben Ali M, Ben Khemis L, Mekki N, Yaakoubi R, Ouni R, Benabdessalem C, et al
. Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients. J Allergy Clin Immunol. 2018;: pubmed publisher
..PGM3 deficient patients have impaired STAT3 signaling downstream of the highly glycosylated protein gp130, thereby constituting the mechanistic basis for the clinical features shared by STAT3-, gp130- and PGM3-deficient patients. ..
Belghith M, Bahrini K, Kchaou M, Maghrebi O, Belal S, Barbouche M. Cerebrospinal fluid IL-10 as an early stage discriminative marker between multiple sclerosis and neuro-Behçet disease. Cytokine. 2018;108:160-167 pubmed publisher
..The most striking finding was the significant increase of CSF IL-10 that we did observe in NBD patients only. Thus, we propose CSF IL-10 as a predictive marker to help clinicians discriminating between these two neurological disorders. ..
Ouadani H, Ben Mustapha I, Ben Ali M, Ben Khemis L, LarguÃ¨che B, Boussoffara R, et al
. Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients. Immunogenetics. 2016;68:19-28 pubmed publisher
..This finding and the presence of specific recurrent mutations are probably due to the critical role played by inbreeding in North African populations. ..
Ouadani H, Ben Mustapha I, Ben Ali M, Larguèche B, Jovanic T, Garcia S, et al
. Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate. Mol Immunol. 2016;79:77-82 pubmed publisher
..Indeed, the His130 residue is located in a putative specific CSR region in the APOBEC-like domain, known to involve CSR specific cofactors that probably play a major role in AID physiological activities. ..