Bahar Tunctan

Summary

Publications

  1. pmc Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Basic Clin Pharmacol Toxicol 107:877-82. 2010
  2. pmc A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Shock 30:329-35. 2008
  3. ncbi Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats
    B Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, Mersin 33169, Turkey
    Pharmacol Res 56:56-64. 2007
  4. pmc Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Arch Pharm Res 31:856-65. 2008
  5. ncbi Nitric oxide reverses endotoxin-induced inflammatory hyperalgesia via inhibition of prostacyclin production in mice
    B Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, Mersin 33169, Turkey
    Pharmacol Res 53:177-92. 2006
  6. pmc NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Prostaglandins Other Lipid Mediat 104:93-108. 2013
  7. pmc Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide
    C Kemal Buharalioglu
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Turkey
    Basic Clin Pharmacol Toxicol 109:186-94. 2011
  8. pmc 5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Prostaglandins Other Lipid Mediat 102:31-41. 2013
  9. pmc A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats
    Tuba Cuez
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Basic Clin Pharmacol Toxicol 106:378-88. 2010
  10. pmc Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, 33169 Mersin, Turkey
    Nitric Oxide 33:18-41. 2013

Collaborators

  • Lokman Ayaz
  • Nehir Sucu
  • Lulufer Tamer
  • Abdullah T Demiryurek
  • Richard J Roman
  • Belma Korkmaz
  • C Kemal Buharalioglu
  • Seyhan Sahan-Firat
  • A Nihal Sari
  • Tuba Cuez
  • Necmiye Canacankatan
  • Demet Unsal
  • Meltem Kacan
  • Kafait U Malik
  • Orhan Uludag
  • Sedat Altug
  • Seyhan Sahan Firat
  • Ozden Vezir
  • Aysegul Gorur
  • Hakan Zengil
  • Nurettin Abacioglu
  • E Ozveren
  • Lülüfer Tamer Gümüş
  • Vijay L Manthati
  • John R Falck
  • Mehmet Sami Serin
  • Efsun S Antmen
  • Barlas Aytacoglu
  • Arzu Kanik
  • Oguz E Gul
  • Hatice Yildirim
  • Ayse Nihal Sari
  • Kemal Buharalioglu
  • A Tuncay Demiryurek
  • John Falck
  • Cuneyt Kemal Buharalioglu
  • Iclal Cakici
  • B Korkmaz
  • C K Buharalioglu
  • Elif Ozveren

Detail Information

Publications24

  1. pmc Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Basic Clin Pharmacol Toxicol 107:877-82. 2010
    ....
  2. pmc A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Shock 30:329-35. 2008
    ..These data are consistent with the view that a fall in the production of 20-HETE contributes to the fall in MAP and vascular reactivity in rats treated with endotoxin, and that 5,14-HEDGE has a beneficial effect...
  3. ncbi Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats
    B Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, Mersin 33169, Turkey
    Pharmacol Res 56:56-64. 2007
    ..Moreover, ERK1/2 seems to be involved in the endotoxin-induced increase in total antioxidant capacity in mesenteric artery...
  4. pmc Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Arch Pharm Res 31:856-65. 2008
    ....
  5. ncbi Nitric oxide reverses endotoxin-induced inflammatory hyperalgesia via inhibition of prostacyclin production in mice
    B Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, Mersin 33169, Turkey
    Pharmacol Res 53:177-92. 2006
    ..In conclusion, NO reverses endotoxin-induced inflammatory hyperalgesia via inhibition of prostacyclin production, and also contributes to the analgesic effect of NF-kappaB, COX or PARS inhibitors...
  6. pmc NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Prostaglandins Other Lipid Mediat 104:93-108. 2013
    ..Taken together, we concluded that an increase in 20-HETE levels associated with a decrease in the production of vasodilator prostanoids and NO participates in the effect of NS-398 to prevent hypotension in the rat model of septic shock...
  7. pmc Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide
    C Kemal Buharalioglu
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Turkey
    Basic Clin Pharmacol Toxicol 109:186-94. 2011
    ....
  8. pmc 5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Prostaglandins Other Lipid Mediat 102:31-41. 2013
    ....
  9. pmc A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats
    Tuba Cuez
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Basic Clin Pharmacol Toxicol 106:378-88. 2010
    ....
  10. pmc Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, 33169 Mersin, Turkey
    Nitric Oxide 33:18-41. 2013
    ....
  11. ncbi Contribution of MEK1/ERK1/2/iNOS pathway to oxidative stress and decreased caspase-3 activity in endotoxemic rats
    Belma Korkmaz
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, Mersin, 33169, Turkey
    Antiinflamm Antiallergy Agents Med Chem 11:243-52. 2012
    ..Our results suggest that decreased activity of MEK1/ERK1/2/iNOS pathway prevents oxidative stress by increasing systemic antioxidant enzyme activities and restores decreased caspase-3 activity in thoracic aorta in endotoxemic rat...
  12. doi Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats
    Belma Korkmaz
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Nitric Oxide 24:160-72. 2011
    ..However, further study is needed to confirm the involvement of PKG to the fall in vascular reactivity in the rat model of endotoxemia...
  13. ncbi Increased production of nitric oxide mediates selective organ-specific effects of endotoxin on oxidative stress
    Seyhan Sahan-Firat
    Department of Pharmacology, Yenisehir Campus, Mersin University, Mersin, Turkey
    Antiinflamm Antiallergy Agents Med Chem 11:161-72. 2012
    ..These effects of endotoxin were prevented by a selective iNOS inhibitor, phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide. These data suggest that iNOS-derived NO mediates selective organ-specific effects of endotoxin on OS...
  14. ncbi Twenty-four-hour variation of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway demonstrated by the mouse visceral pain model
    Orhan Uludag
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Chronobiol Int 24:413-24. 2007
    ..These results suggest that components of L-arginine/NO/cGMP pathway exhibit biological time-dependent effects on visceral nociceptive process...
  15. ncbi A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid
    Bahar Tunctan
    Department of Pharmacology, Yenisehir Campus, Mersin University, Mersin, Turkey
    Antiinflamm Antiallergy Agents Med Chem 11:121-50. 2012
    ....
  16. ncbi Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    Pharmacol Res 48:37-48. 2003
    ..The results suggest that the COX inhibitors may have different effects on the survival and NO production depending on tissue and dose...
  17. pmc Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock
    A Nihal Sari
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169, Mersin, Turkey
    Inflamm Res 63:741-56. 2014
    ....
  18. ncbi Extracellular signal-regulated kinase (ERK1/2) contributes to endotoxin-induced hyporeactivity via nitric oxide and prostacyclin production in rat aorta
    Belma Korkmaz
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Pharmacology 78:123-8. 2006
    ..These data suggest that events related to the activation of ERK1/2 contribute to the endotoxin-induced hyporeactivity by increasing NO and PGI(2) production...
  19. doi Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats
    A Nihal Sari
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169 Mersin, Turkey
    Eur J Pharmacol 723:234-45. 2014
    ..It also seems that hindlimb I/R induces target organ injury via upregulation of RhoA/MEK1/ERK1/2/iNOS pathway associated with decreased Rho-kinase activity. ..
  20. ncbi Biological time-dependent difference in effect of peroxynitrite demonstrated by the mouse hot plate pain model
    Sedat Altug
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Chronobiol Int 23:583-91. 2006
    ....
  21. ncbi Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, Turkey
    Nitric Oxide 14:51-7. 2006
    ....
  22. ncbi Circadian variation of nitric oxide synthase activity in mouse tissue
    Bahar Tunctan
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Chronobiol Int 19:393-404. 2002
    ..The findings suggest that NOS activity in mouse brain, aorta, lung, and testis are regulated by an endogenous clock, while in kidney the rhythm in NOS activity is synchronized by the exogenous signals...
  23. ncbi Involvement of calcium/calmodulin-dependent protein kinase II to endotoxin-induced vascular hyporeactivity in rat superior mesenteric artery
    E Ozveren
    Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169 Mersin, Turkey
    Pharmacol Res 54:208-18. 2006
    ....
  24. doi Affirmative effects of iloprost on apoptosis during ischemia-reperfusion injury in kidney as a distant organ
    Necmiye Canacankatan
    Department of Biochemistry, Faculty of Pharmacy, Mersin University, Mersin, Turkey
    Ren Fail 34:111-8. 2012
    ..In this context, we investigated the antiapoptotic and cytoprotective effects of iloprost, a prostacyclin analog, in kidney as a distant organ...