On the use of tranquillisers in epilepsyMichael R Trimble
Institute of Neurology, National Hospital for Neurology, London, UK
Epilepsia 43:25-7. 2002
..It is useful in patients that have catamenial seizures, clusters of seizures, and also in the prevention of postictal syndromes. It is used in childhood epilepsy, and is also helpful in the management of febrile seizures...
- The amygdala and psychopathology studies in epilepsy
Michael R Trimble
Institute of Neurology, Queen Square, London WC1N3BG, England
Ann N Y Acad Sci 985:461-8. 2003
..The main data relate to the increased size of the amygdala in patients with epilepsy and psychosis. The associations between the amygdala and affective disorders, notably dysthymia and euphoria, are also discussed...
- The role of hippocampal sclerosis in antiepileptic drug-related depression in patients with epilepsy: a study on levetiracetam
Marco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
Seizure 15:405-8. 2006
..The aim of our study was to clarify whether patients with temporal lobe epilepsy (TLE) and HS were also at risk during therapy with levetiracetam (LEV)...
- The importance of being seizure free: topiramate and psychopathology in epilepsy
Marco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Epilepsy Behav 4:430-4. 2003
..We observed that psychopathology was related to seizure control in a subgroup of patients. The role of forced normalization, interlinked with interactions with other antiepileptic drugs, could be relevant...
- Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam
Marco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
Seizure 13:55-7. 2004
..To investigate the prevalence and psychopathological features of psychiatric adverse events (PAEs) in patients with learning disabilities (LD) in therapy with levetiracetam (LEV)...
- The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy
Marco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, England, UK
Epilepsia 44:1573-7. 2003
..To clarify the role of hippocampal sclerosis (HS) in developing psychiatric and cognitive adverse events during therapy with topiramate (TPM) in patients with temporal lobe epilepsy (TLE)...
- Topiramate and psychiatric adverse events in patients with epilepsy
Marco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Epilepsia 44:659-63. 2003
..CONCLUSIONS: We found that PAEs associated with TPM were related to the titration schedule of the drug and that a unique patient profile is suggested by the clinical history...
- Absence of cortical gray matter abnormalities in psychosis of epilepsy: a voxel-based MRI study in patients with temporal lobe epilepsy
NICOLAS RUSCH
Raymond Way Research Group, Institute of Neurology, University College London, London, UK
J Neuropsychiatry Clin Neurosci 16:148-55. 2004
..There were no significant cortical gray matter differences between the POE and the TLE group. Since cortical pathology is prominent in schizophrenia, POE may be a clinical entity separate from schizophrenia...
- Evaluation of health status in epilepsy using the EQ-5D questionnaire: a prospective, observational, 6-month study of adjunctive therapy with anti-epileptic drugs
Caroline E Selai
University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
Curr Med Res Opin 21:733-9. 2005
..The aims of this project were to evaluate the impact of adjunctive treatment with an anti-epileptic drug (AED) on the health status of people with epilepsy and to investigate how seizure frequency affects their health status...
- A comparative study of mismatch negativity (MMN) in epilepsy and non-epileptic seizures
Nuri Gene-Cos
Traumatic Stress Service, Clinical Treatment Center, Maudsley Hospital, London, UK
Epileptic Disord 7:363-72. 2005
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- Mesial temporal structures and comorbid anxiety in refractory partial epilepsy
Parthasarathy Satishchandra
Raymond Way Neuropsychiatry Research Group, Institute of Neurology, London, United Kingdom
J Neuropsychiatry Clin Neurosci 15:450-2. 2003
..The findings indicate a role for this brain region in the genesis of anxiety...
- Clinical efficacy of galvanic skin response biofeedback training in reducing seizures in adult epilepsy: a preliminary randomized controlled study
Yoko Nagai
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Epilepsy Behav 5:216-23. 2004
..Our findings highlight the potential therapeutic value of GSR biofeedback in reducing seizure frequency in patients with drug-resistant epilepsy...
- Topiramate and word-finding difficulties in patients with epilepsy
Marco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
Neurology 60:1104-7. 2003
..CONCLUSIONS: The presence of word-finding difficulties seems to be a titration schedule independent phenomenon that occurs in a subgroup of patients with a specific biologic vulnerability...
- The insular lobe of Reil--its anatamico-functional, behavioural and neuropsychiatric attributes in humans--a review
Bhaskara P Shelley
Raymond Way Neuropsychiatry Research Group, Institute of Neurology, Queen Square, London, United Kingdom
World J Biol Psychiatry 5:176-200. 2004
..The functional role of the insula in these disorders with particular reference to the current functional neuroimaging data has been also reviewed in this article...
- The precuneus: a review of its functional anatomy and behavioural correlates
Andrea E Cavanna
Institute of Neurology, Queen Square, London WC1N3BG, UK
Brain 129:564-83. 2006
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Vagus nerve stimulation for treatment-resistant depression: behavioral and neural effects on encoding negative materialHugo D Critchley
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London, UK
Psychosom Med 69:17-22. 2007
..We hypothesized that the antidepressant action of VNS may emerge through corrective influences on 'negativity bias' in memory. We therefore examined the impact of VNS on emotional memory and its underlying brain activity...
- Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorder
Richard J Brown
Department of Clinical Neurology, Institute of Neurology, London, UK
Am J Psychiatry 162:899-905. 2005
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- Pharmacokinetic Interactions between Antiepileptic and Antidepressant Drugs
Marco Mula
Raymond Way Neuropsychiatry Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, United Kingdom
World J Biol Psychiatry 4:21-4. 2003
..In this paper, the available data about the mechanisms of metabolic kinetic interactions between antidepressant and antiepileptic drugs, as well as their clinical significance, has been reviewed...
- Clinical presentations in neuropsychiatry
Michael R Trimble
National Hospital for Neurology and Neurosurgery, London, UK
Semin Clin Neuropsychiatry 7:11-7. 2002
..A plea is made that any future diagnostic schedules contain references to neuropsychiatric disorders and presentations...
- Long-term follow-up of topiramate and lamotrigine: a perspective on quality of life
Stefan Kaiser
Raymond Way Neuropsychiatry Research Unit, Institute of Neurology, London
Seizure 11:356-60. 2002
..These data suggest that about one third of the patients on lamotrigine or topiramate as add-on therapy stay on the drug in the long term. These patients are likely to benefit with respect to objective and subjective outcome measures...
- Neuropsychiatric disorders in epilepsy: some transcultural issues
Michael R Trimble
Department of Behavioural Neurology, Institute of Neurology, London, United Kingdom
Epilepsia 44:21-4. 2003
..To review transcultural perspectives in the neuropsychiatry of epilepsy...
- A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials
Joyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, Room 7 127, West Haven, CT 06516 2770, USA
Epilepsy Behav 4:124-32. 2003
..These data support the hypothesis that some feature related to epilepsy is the cause of many behavioral events rather than the addition of a specific antiepileptic drug...
- Use of psychotropic drugs in patients with epilepsy: interactions and seizure risk
Marco Mula
Department of Neurology, Amedeo Avogadro University, C so Mazzini, 18 28100 Novara, Italy
Expert Rev Neurother 4:953-64. 2004
..On the other hand, the main factors that may affect choice of therapy, patients' response and compliance, when prescribing antidepressants or antipsychotic drugs, drug interactions and the potential proconvulsive risk are reviewed...
- Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetam
Marco Mula
Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsia 48:2322-6. 2007
..To investigate the hypothesis that some patients with epilepsy are generally prone to develop psychiatric adverse events (PAEs) during antiepileptic drug (AED) therapy irrespective of the mechanism of action of the drugs...
- Neuropharmacological aspects of cognitive neurorehabilitation in epilepsy
Marco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Behav Neurol 17:69-75. 2006
..This paper reviews different pharmacological aspects of cognitive neurorehabilitation in epilepsy...
- Re: Drug-induced psychosis with levetiracetam
Marco Mula
Can J Psychiatry 50:948; author reply 948. 2005
- The end of the seizure can be the beginning of the problem: Epilepsy is more than just the ictus
Michael R Trimble
Neurology 62:683. 2004
- Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy
Ludger Tebartz van Elst
Neurology 63:942-3; author reply 942-3. 2004
Electroencephalographic cerebral dysrhythmic abnormalities in the trinity of nonepileptic general population, neuropsychiatric, and neurobehavioral disordersBhaskara P Shelley
Raymond Way Neuropsychiatry Research Group, Institute of Neurology at Queen Sq, London
J Neuropsychiatry Clin Neurosci 20:7-22. 2008
..These EEG aberrations may be reflective of underlying morpho-functional brain abnormalities that underpin various neurobehavioral disturbances...
