Jill Trewhella

Summary

Publications

  1. doi request reprint Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB
    Jill Trewhella
    School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia
    Structure 21:875-81. 2013
  2. pmc Reliable structural interpretation of small-angle scattering data from bio-molecules in solution--the importance of quality control and a standard reporting framework
    David A Jacques
    School of Molecular Bioscience Building, University of Sydney, G08 Butlin Avenue, Sydney, NSW 2006, Australia
    BMC Struct Biol 12:9. 2012
  3. pmc The motif of human cardiac myosin-binding protein C is required for its Ca2+-dependent interaction with calmodulin
    Yanling Lu
    School of Molecular Bioscience, Building G08, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 287:31596-607. 2012
  4. pmc Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions
    Mugdha Bhati
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e40719. 2012
  5. doi request reprint Human cardiac myosin binding protein C: structural flexibility within an extended modular architecture
    Cy M Jeffries
    School of Molecular Bioscience, University of Sydney, New South Wales 2006, Australia
    J Mol Biol 414:735-48. 2011
  6. doi request reprint The C0C1 fragment of human cardiac myosin binding protein C has common binding determinants for both actin and myosin
    Yanling Lu
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    J Mol Biol 413:908-13. 2011
  7. doi request reprint The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase
    David A Jacques
    School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
    Acta Crystallogr D Biol Crystallogr 67:105-11. 2011
  8. pmc Solution structure studies of monomeric human TIP47/perilipin-3 reveal a highly extended conformation
    Robert M G Hynson
    School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia
    Proteins 80:2046-55. 2012
  9. doi request reprint 1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis
    Robert M G Hynson
    School of Molecular Biosciences, The University of Sydney, New South Wales, 2006, Australia
    Biomol NMR Assign 4:167-9. 2010
  10. pmc Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification
    Morgan S Gadd
    School of Molecular Bioscience, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 286:42971-80. 2011

Collaborators

Detail Information

Publications17

  1. doi request reprint Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB
    Jill Trewhella
    School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia
    Structure 21:875-81. 2013
    ....
  2. pmc Reliable structural interpretation of small-angle scattering data from bio-molecules in solution--the importance of quality control and a standard reporting framework
    David A Jacques
    School of Molecular Bioscience Building, University of Sydney, G08 Butlin Avenue, Sydney, NSW 2006, Australia
    BMC Struct Biol 12:9. 2012
    ..Here we describe the rationale for these guidelines and the importance of standardising the way in which small-angle scattering data from bio-molecules and associated structural interpretations are reported...
  3. pmc The motif of human cardiac myosin-binding protein C is required for its Ca2+-dependent interaction with calmodulin
    Yanling Lu
    School of Molecular Bioscience, Building G08, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 287:31596-607. 2012
    ....
  4. pmc Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions
    Mugdha Bhati
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e40719. 2012
    ..Thus the mutation would affect the formation of Lhx3-containing transcription factor complexes, particularly in the pituitary gland where these complexes are required for the production of multiple pituitary cell types and hormones...
  5. doi request reprint Human cardiac myosin binding protein C: structural flexibility within an extended modular architecture
    Cy M Jeffries
    School of Molecular Bioscience, University of Sydney, New South Wales 2006, Australia
    J Mol Biol 414:735-48. 2011
    ..These structural features of cMyBP-C could facilitate its putative role as a molecular switch between actin and myosin and may contribute to modulating the transverse pliancy of the C-zone of the A-band across muscle sarcomeres...
  6. doi request reprint The C0C1 fragment of human cardiac myosin binding protein C has common binding determinants for both actin and myosin
    Yanling Lu
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    J Mol Biol 413:908-13. 2011
    ..Our results suggest that C0 and C1 interact with myosin and actin using a common set of binding determinants and therefore support a cMyBP-C switching mechanism between myosin and actin...
  7. doi request reprint The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase
    David A Jacques
    School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
    Acta Crystallogr D Biol Crystallogr 67:105-11. 2011
    ..However, no such activity could be identified and genetic analysis across species with known allophanate hydrolases indicates that a misannotation has occurred...
  8. pmc Solution structure studies of monomeric human TIP47/perilipin-3 reveal a highly extended conformation
    Robert M G Hynson
    School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia
    Proteins 80:2046-55. 2012
    ..Moreover, we show that full-length TIP47/perilipin-3 adopts an extended conformation in solution, with considerable spatial separation of the N- and C-termini that would likely translate into a separation of functional domains...
  9. doi request reprint 1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis
    Robert M G Hynson
    School of Molecular Biosciences, The University of Sydney, New South Wales, 2006, Australia
    Biomol NMR Assign 4:167-9. 2010
    ..The N-terminal domain has two conformers and resonance assignments have been made for both conformers...
  10. pmc Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification
    Morgan S Gadd
    School of Molecular Bioscience, The University of Sydney, New South Wales 2006, Australia
    J Biol Chem 286:42971-80. 2011
    ..The formation of weaker Lhx·Isl complexes would likely be masked by the availability of the other Lhx·Isl complexes in postmitotic motor neurons...
  11. pmc Calmodulin disrupts the structure of the HIV-1 MA protein
    John Y H Chow
    School of Molecular Bioscience, University of Sydney, New South Wales 2006, Australia
    J Mol Biol 400:702-14. 2010
    ..Thus, CaM binding is expected to impact upon the accessibility of interaction sites within MA that are involved in its various functions...
  12. doi request reprint Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution
    David A Jacques
    School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia
    Acta Crystallogr D Biol Crystallogr 68:620-6. 2012
    ..Here, these guidelines are outlined and the reasons for standardizing the way in which small-angle scattering data are presented...
  13. pmc The role of heme binding by DNA-protective protein from starved cells (Dps) in the Tolerance of Porphyromonas gingivalis to heme toxicity
    Jin Long Gao
    University of Sydney, New South Wales 2006, Australia
    J Biol Chem 287:42243-58. 2012
    ..gingivalis under excess heme as the only iron source. Conservation of the heme-coordinating cysteine among Dps isoforms from the Bacteroidales order suggests that this function may be a common feature within these anaerobic bacteria...
  14. doi request reprint Invited review: probing the structures of muscle regulatory proteins using small-angle solution scattering
    Yanling Lu
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Biopolymers 95:505-16. 2011
    ....
  15. doi request reprint A novel structure of an antikinase and its inhibitor
    David A Jacques
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    J Mol Biol 405:214-26. 2011
    ..We discuss the sequence conservation and possible roles across species of this near-ubiquitous protein family, which is poorly understood in terms of function...
  16. doi request reprint K7del is a common TPM2 gene mutation associated with nemaline myopathy and raised myofibre calcium sensitivity
    Nancy Mokbel
    Institute for Neuroscience and Muscle Research, Children s Hospital at Westmead, Sydney, NSW 2145, Australia
    Brain 136:494-507. 2013
    ..These results suggest that patients may benefit from therapies that reduce skeletal muscle calcium sensitivity, and we highlight late muscle decompensation as an important cause of morbidity...
  17. pmc Small-angle scattering for structural biology--expanding the frontier while avoiding the pitfalls
    David A Jacques
    School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, New South Wales 2006, Australia
    Protein Sci 19:642-57. 2010
    ..Examples of current best practice are given that also demonstrate the power of the technique to advance our understanding of protein structure and function...