Martin R Tremblay

Summary

Publications

  1. doi request reprint Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Med Chem 52:4400-18. 2009
  2. doi request reprint Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 51:6646-9. 2008
  3. doi request reprint Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Expert Opin Ther Pat 19:1039-56. 2009
  4. doi request reprint New developments in the discovery of small molecule Hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 14:428-35. 2010
  5. doi request reprint Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors
    Tao Liu
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 55:8859-78. 2012

Collaborators

  • Julian Adams
  • Bonnie Tillotson
  • James R Porter
  • Tao Liu
  • Kip West
  • Sherri Smith
  • AndrĂ© Lescarbeau
  • Patrick O'Hearn
  • Andrew Wylie
  • Christian Fritz
  • Vito J Palombella
  • Mark Douglas
  • Adilah Bahadoor
  • James Conley
  • Somarajan J Nair
  • Alfredo C Castro
  • Karen McGovern
  • Kelly Slocum
  • Joseph Helble
  • JANID ALI
  • Stephane Peluso
  • Jitendra Belani

Detail Information

Publications5

  1. doi request reprint Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Med Chem 52:4400-18. 2009
    ..As a result, complete tumor regression was observed in a Hh-dependent medulloblastoma allograft model after daily oral administration of 40 mg/kg of compound 28...
  2. doi request reprint Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 51:6646-9. 2008
    ..Further modification of the A/B-ring homoallylic alcohol to the conjugated ketone led to the discovery of new cyclopamine analogues with improved pharmaceutical properties and in vitro potency (EC 50) ranging from 10 to 1000 nM...
  3. doi request reprint Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Expert Opin Ther Pat 19:1039-56. 2009
    ..During the past decade, efforts from academic and industrial groups have led to the discovery of a variety of Hh pathway inhibitors...
  4. doi request reprint New developments in the discovery of small molecule Hedgehog pathway antagonists
    Martin R Tremblay
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 14:428-35. 2010
    ..While most of the small molecule modulators of the Hh pathway were discovered through screening and subsequent medicinal chemistry, a number of them originated from rational design or natural products...
  5. doi request reprint Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors
    Tao Liu
    Infinity Pharmaceuticals, Inc, 780 Memorial Drive, Cambridge, Massachusetts 02139, USA
    J Med Chem 55:8859-78. 2012
    ..Simplified analogues of silvestrol such as compounds 74 and 76 were shown to have similar cytotoxic potency and better ADME characteristics relative to those of silvestrol...