Luba Trakhtenbrot

Summary

Publications

  1. ncbi request reprint Interphase fluorescence in situ hybridization detection of chromosome 17 and 17q region gains in neuroblastoma: are they secondary events?
    Luba Trakhtenbrot
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
    Cancer Genet Cytogenet 137:95-101. 2002
  2. ncbi request reprint Karyotypic evolution pathways in medulloblastoma/primitive neuroectodermal tumor determined with a combination of spectral karyotyping, G-banding, and fluorescence in situ hybridization
    Ninette Cohen
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Cancer Genet Cytogenet 149:44-52. 2004
  3. doi request reprint Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma
    Luba Trakhtenbrot
    Division of Hematology and the Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Genes Chromosomes Cancer 49:17-27. 2010
  4. ncbi request reprint Clonal expansion and not cell interconversion is the basis for the neuroblast and nonneuronal types of the SK-N-SH neuroblastoma cell line
    Ninette Cohen
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Genet Cytogenet 143:80-4. 2003
  5. ncbi request reprint Chromosome 13q deletion and IgH abnormalities may be both masked by near-tetraploidy in a high proportion of multiple myeloma patients: a combined morphology and I-FISH analysis
    Maya Koren-Michowitz
    Division of Hematology, The Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Lett 255:307-14. 2007
  6. ncbi request reprint SKY detection of chromosome rearrangements in two cases of tMDS with a complex karyotype
    Ninette Cohen
    Institute of Hematology and Pediatric Hemato Oncology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Genet Cytogenet 138:128-32. 2002
  7. ncbi request reprint Determination of chromosome 13 status in bone marrow cells of patients with multiple myeloma using combined morphologic and fluorescence in situ hybridization analysis
    Izhar Hardan
    Department of Bone Marrow Transplantation, Hematology and the Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Exp Hematol 32:254-60. 2004
  8. ncbi request reprint The multiparametric scanning system for evaluation of minimal residual disease in hematological malignancies
    Luba Trakhtenbrot
    Department of Pediatric Hematology Oncology, Safra Children s Hospital and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Haematol 112:24-9. 2004
  9. ncbi request reprint Assessment of the response to imatinib in chronic myeloid leukemia patients--comparison between the FISH, multiplex and RT-PCR methods
    Pia Raanani
    The Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Eur J Haematol 73:243-50. 2004
  10. ncbi request reprint Combined analysis of morphology and fluorescence in situ hybridization in follow-up of minimal residual disease in a child with Philadelphia-positive acute lymphoblastic leukemia
    Bella Bielorai
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, 5262, Tel Aviv, Israel
    Cancer Genet Cytogenet 138:64-8. 2002

Collaborators

  • Arnon Nagler
  • Maya Koren-Michowitz
  • Michael A Grotzer
  • Isaac Ben-Bassat
  • Pia Raanani
  • D R Betts
  • A Amiel
  • Abraham Hirshberg
  • A Shimoni
  • Gideon Rechavi
  • Ninette Amariglio
  • Ninette Cohen
  • Jutta Schwarz-Finsterle
  • Rachel Rothman
  • Malka Reichart
  • Izhar Hardan
  • Amos Toren
  • Bella Bielorai
  • Racheli Stanchescu
  • Michael Hausmann
  • Stefan Stein
  • Christoph Cremer
  • Constance Grossmann
  • Eberhard Schmitt
  • Abraham Kneller
  • Galina Ishoev
  • Paulina Patchenko
  • Asaf Hellman
  • Peter Ambros
  • Daniel Yekutieli
  • Shai Izraeli
  • Miriam Berkowicz
  • Esther Rosner
  • Helmut Schneider
  • Maya Sokolovski
  • Abraham Klepfish
  • Uri Tavori
  • Tzvi Ram
  • Shlomi Constantini
  • Eliezer A Rachmilewitz
  • Alain Gelibter
  • Maya Sokolovsky
  • Eitan Zlotorynski
  • Stephen W Scherer
  • Michal Daniely
  • Yosef Manor
  • Joseph Cheung
  • Batsheva Kerem
  • Elena Gaber
  • Mona Yukla
  • Chaim Kaplinsky
  • Yulia Zilberstein
  • Hana Golan
  • David I Smith
  • John B Vincent
  • Gabi Yosef

Detail Information

Publications21

  1. ncbi request reprint Interphase fluorescence in situ hybridization detection of chromosome 17 and 17q region gains in neuroblastoma: are they secondary events?
    Luba Trakhtenbrot
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
    Cancer Genet Cytogenet 137:95-101. 2002
    ..We suggest that chromosome 17 and 17q gains are not a primary event in the development of neuroblastoma...
  2. ncbi request reprint Karyotypic evolution pathways in medulloblastoma/primitive neuroectodermal tumor determined with a combination of spectral karyotyping, G-banding, and fluorescence in situ hybridization
    Ninette Cohen
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Cancer Genet Cytogenet 149:44-52. 2004
    ....
  3. doi request reprint Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma
    Luba Trakhtenbrot
    Division of Hematology and the Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Genes Chromosomes Cancer 49:17-27. 2010
    ..In contrast, we did not find any association between Delta13 and deletions of the IGH gene or its segments in the MM patients with t(4;14)(p16;q32)...
  4. ncbi request reprint Clonal expansion and not cell interconversion is the basis for the neuroblast and nonneuronal types of the SK-N-SH neuroblastoma cell line
    Ninette Cohen
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Genet Cytogenet 143:80-4. 2003
    ..Under certain conditions, the less-aggressive S cells can dominate over the highly aggressive N cells, which eventually lead to the formation of the SH-EP and vice-versa...
  5. ncbi request reprint Chromosome 13q deletion and IgH abnormalities may be both masked by near-tetraploidy in a high proportion of multiple myeloma patients: a combined morphology and I-FISH analysis
    Maya Koren-Michowitz
    Division of Hematology, The Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Lett 255:307-14. 2007
    ..Therefore, we suggest that a search for NT should be added to the routine BM assessment in MM patients...
  6. ncbi request reprint SKY detection of chromosome rearrangements in two cases of tMDS with a complex karyotype
    Ninette Cohen
    Institute of Hematology and Pediatric Hemato Oncology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Genet Cytogenet 138:128-32. 2002
    ..We clearly present that the use of SKY combined with conventional G-banding analysis and FISH has assisted in the identification of important chromosomal events that may play a key role in the development of t-MDS...
  7. ncbi request reprint Determination of chromosome 13 status in bone marrow cells of patients with multiple myeloma using combined morphologic and fluorescence in situ hybridization analysis
    Izhar Hardan
    Department of Bone Marrow Transplantation, Hematology and the Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Exp Hematol 32:254-60. 2004
    ..We suggest this technique as a novel sensitive and specific method for detection of del13q in a minor PC population of MM patients...
  8. ncbi request reprint The multiparametric scanning system for evaluation of minimal residual disease in hematological malignancies
    Luba Trakhtenbrot
    Department of Pediatric Hematology Oncology, Safra Children s Hospital and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Haematol 112:24-9. 2004
    ..Morphological analysis of small populations of cells related either to malignancy or recipient-associated markers may improve the accuracy of chimerism and MRD testing and delineate their clinical significance...
  9. ncbi request reprint Assessment of the response to imatinib in chronic myeloid leukemia patients--comparison between the FISH, multiplex and RT-PCR methods
    Pia Raanani
    The Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Eur J Haematol 73:243-50. 2004
    ....
  10. ncbi request reprint Combined analysis of morphology and fluorescence in situ hybridization in follow-up of minimal residual disease in a child with Philadelphia-positive acute lymphoblastic leukemia
    Bella Bielorai
    Department of Pediatric Hemato Oncology and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, 5262, Tel Aviv, Israel
    Cancer Genet Cytogenet 138:64-8. 2002
    ..Moreover, since mature differentiated cells have a low proliferative capacity, there is a low risk for relapse...
  11. ncbi request reprint SKY analysis of childhood neural tumors and cell lines demonstrates a susceptibility of aberrant chromosomes to further rearrangements
    Racheli Stanchescu
    Department of Pediatric Hemato Oncology and Cancer Research Center, The Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer Lett 250:47-52. 2007
    ..9%, 54 of 1099 chromosomes). These results are highly suggestive that aberrant chromosomes in solid tumors have a higher susceptibility to accumulate further rearrangements than "normal" chromosomes...
  12. ncbi request reprint Acquisition of a Ph chromosome with minor BCR/ABL fusion in treatment-related myelodysplastic syndrome with chromosome 7 abnormalities in a patient treated for Hodgkin disease
    Abraham Kneller
    Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Cancer Genet Cytogenet 159:58-62. 2005
    ..We propose two possible models that may explain the appearance of the BCR/ABL fusion in the pre-existing treatment-related MDS clones characterized by chromosome 7 rearrangements...
  13. ncbi request reprint A role for common fragile site induction in amplification of human oncogenes
    Asaf Hellman
    Department of Genetics, The Life Sciences Institute, The Hebrew University, Jerusalem 91904, Israel
    Cancer Cell 1:89-97. 2002
    ..Upon replication stress, this region showed perturbed chromatin organization, predisposing it to breakage. Thus, in vivo induction of CFSs can play an important role in human oncogenesis...
  14. ncbi request reprint Philadelphia-chromosome-positive T-lymphoblastic leukemia: acute leukemia or chronic myelogenous leukemia blastic crisis
    Pia Raanani
    Institute of Hematology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Haematol 113:181-9. 2005
    ..Although both entities carry a severe prognosis, differentiating between them might have clinical relevance, especially in the imatinib era...
  15. ncbi request reprint Co-existence of multiple subclones in TEL-AML1 at diagnosis of acute lymphoblastic leukaemia in association with submicroscopic deletion of AML1
    Rachel Rothman
    Department of Paediatric Haemato Oncology and Institute of Haematology, The Edmond and Lily Safra Children Hospital, The Chaim Sheba Medical Centre, Tel Hashomer, Israel
    Br J Haematol 129:491-8. 2005
    ..The presence of numerous subclones in about 25% of patients with TEL/AML1+ ALL suggests extensive clonal evolution by the time of diagnosis...
  16. ncbi request reprint COMBO-FISH for focussed fluorescence labelling of gene domains: 3D-analysis of the genome architecture of abl and bcr in human blood cells
    Jutta Schwarz-Finsterle
    Kirchhoff Institute of Physics, University of Heidelberg, Im Neuenheimer Feld 227, D 69120 Heidelberg, Germany
    Cell Biol Int 29:1038-46. 2005
    ..These results indicate that COMBO-FISH may be more sensitive than standard FISH in case of slight modifications in the genome architecture...
  17. ncbi request reprint Comparison of triple helical COMBO-FISH and standard FISH by means of quantitative microscopic image analysis of abl/bcr positions in cell nuclei
    Jutta Schwarz-Finsterle
    Kirchhoff Institute of Physics, University of Heidelberg, Im Neuenheimer Feld 227, D 69120 Heidelberg, Germany
    J Biochem Biophys Methods 70:397-406. 2007
    ..For precise quantitative microscopic analysis of genomic loci, fluorescence labelling procedures are recommended that well maintain the native chromatin topology. Triple helical COMBO-FISH may offer such an approach...
  18. ncbi request reprint Detection of non-diploid cells in premalignant and malignant oral lesions using combined morphological and FISH analysis - a new method for early detection of suspicious oral lesions
    Abraham Hirshberg
    Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer Lett 253:282-90. 2007
    ..We suggest that the combined morphological and cytogenetic analysis of cells collected by a non-invasive brush sampling can enhance early detection of potentially malignant cells...
  19. ncbi request reprint SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia
    David R Betts
    Department of Oncology, University Children s Hospital, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Leuk Res 32:39-43. 2008
    ..The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL...
  20. ncbi request reprint Simultaneous detection of deletions of 9q and 22q in a subgroup of chronic myelocytic leukemia Philadelphia-positive patients by a novel probe
    Ninette Cohen
    Cancer Genet Cytogenet 141:89-90. 2003
  21. ncbi request reprint Reciprocal relationship between a Ph-negative clone with trisomy 8 associated with severe myelodysplasia and a Ph-positive clone following imatinib treatment in a patient with accelerated-phase chronic myelogenous leukemia (CML)
    Paulina Patchenko
    Am J Hematol 77:420. 2004