Dimitrios T P Trafalis

Summary

Publications

  1. ncbi request reprint Preclinical studies on NSC290205 aza-steroid alkylator activity in combination with adriamycin against lymphoid leukaemia
    Dimitrios T P Trafalis
    Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, Patras, Greece
    Br J Haematol 128:343-50. 2005
  2. ncbi request reprint Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma
    Dimitrios T P Trafalis
    Laboratory of Pharmaceutical Chemistry, School of Pharmacy, University of Patras, Greece
    Melanoma Res 15:273-81. 2005
  3. ncbi request reprint Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer
    Dimitrios T P Trafalis
    Laboratory of Medicinal Chemistry, Faculty of Pharmacy, University of Patras, Patras, Greece
    Breast Cancer Res Treat 97:17-31. 2006
  4. ncbi request reprint Hybrid aza-steroid alkylators in the treatment of colon cancer
    Dimitrios T P Trafalis
    1st Department of Medical Oncology, Metaxa Cancer Hospital, Piraeus, Greece
    Cancer Lett 243:202-10. 2006
  5. ncbi request reprint An overview on the antileukemic potential of D-homo-aza- and respective 17beta-acetamido-steroidal alkylating esters
    Charalambos Camoutsis
    Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, Faculty of Pharmacy, School of Health Science, University of Patras, Greece
    Invest New Drugs 21:47-54. 2003
  6. ncbi request reprint The effect of an estrone D-lactam steroid ester derivative on breast cancer cells and its predicted binding interactions with the ligand binding domain of estrogen receptor-alpha
    Michael Kontos
    1st Department of Surgery, University of Athens, Laiko General Hospital, Greece
    Oncol Res 16:129-42. 2005

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Preclinical studies on NSC290205 aza-steroid alkylator activity in combination with adriamycin against lymphoid leukaemia
    Dimitrios T P Trafalis
    Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, Patras, Greece
    Br J Haematol 128:343-50. 2005
    ..NSC290205 showed superior antineoplastic potential against lymphoid leukaemia and significant synergy with ADR, producing an excellent therapeutic outcome...
  2. ncbi request reprint Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma
    Dimitrios T P Trafalis
    Laboratory of Pharmaceutical Chemistry, School of Pharmacy, University of Patras, Greece
    Melanoma Res 15:273-81. 2005
    ..HASE exhibited a toxicity similar to that of DTIC, BCNU and MeCCNU, but significantly lower than that of CPDD. It can be concluded that HASE displays significant in-vitro and in-vivo activity in the treatment of melanoma...
  3. ncbi request reprint Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer
    Dimitrios T P Trafalis
    Laboratory of Medicinal Chemistry, Faculty of Pharmacy, University of Patras, Patras, Greece
    Breast Cancer Res Treat 97:17-31. 2006
    ..Some correlation between ER and lactandrate effect was demonstrated. Docking studies provide the basis for the structure-based design of improved steroidal alkylating esters for the treatment of estrogen-related cancers...
  4. ncbi request reprint Hybrid aza-steroid alkylators in the treatment of colon cancer
    Dimitrios T P Trafalis
    1st Department of Medical Oncology, Metaxa Cancer Hospital, Piraeus, Greece
    Cancer Lett 243:202-10. 2006
    ..Both of the tested compounds displayed a very satisfactory anti-cancer activity in vitro and in vivo. Lactestoxate produced a significantly higher overall activity than lactandrate...
  5. ncbi request reprint An overview on the antileukemic potential of D-homo-aza- and respective 17beta-acetamido-steroidal alkylating esters
    Charalambos Camoutsis
    Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, Faculty of Pharmacy, School of Health Science, University of Patras, Greece
    Invest New Drugs 21:47-54. 2003
    ..Conclusively, HASE presented low acute toxicity but significant high antileukemic activity. These results point out that HASE may be of important therapeutic efficacy in the treatment of leukemia in humans...
  6. ncbi request reprint The effect of an estrone D-lactam steroid ester derivative on breast cancer cells and its predicted binding interactions with the ligand binding domain of estrogen receptor-alpha
    Michael Kontos
    1st Department of Surgery, University of Athens, Laiko General Hospital, Greece
    Oncol Res 16:129-42. 2005
    ..ESBL was found to be positioned inside the binding cavity with its steroidal moiety, whereas the alkylating moiety protruded out of receptor's pocket...