D Tousoulis

Summary

Publications

  1. ncbi request reprint Diabetes mellitus and vascular endothelial dysfunction: current perspectives
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:19-32. 2012
  2. ncbi request reprint Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins
    Dimitris Tousoulis
    First Cardiology Department, Athens University Medical School, Athens, Greece Electronic address
    J Am Coll Cardiol 63:2491-502. 2014
  3. doi request reprint Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece Electronic address
    Atherosclerosis 232:10-6. 2014
  4. ncbi request reprint Statins in heart failure-With preserved and reduced ejection fraction. An update
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece Electronic address
    Pharmacol Ther 141:79-91. 2014
  5. ncbi request reprint Effects of direct infusion of bone marrow-derived progenitor cells and indirect mobilization of hematopoietic progenitor cells on atherosclerotic plaque and inflammatory process in atherosclerosis
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece Electronic address
    Int J Cardiol 168:4769-74. 2013
  6. doi request reprint Infusion of lin-/sca-1+ and endothelial progenitor cells improves proinflammatory and oxidative stress markers in atherosclerotic mice
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Int J Cardiol 167:1900-5. 2013
  7. doi request reprint Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 167:1924-8. 2013
  8. doi request reprint Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches
    Dimitris Tousoulis
    First Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    J Am Coll Cardiol 62:667-76. 2013
  9. ncbi request reprint Novel biomarkers assessing endothelial dysfunction: role of microRNAs
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 13:1518-26. 2013
  10. doi request reprint Genetic predisposition to left ventricular hypertrophy and the potential involvement of cystatin-C in untreated hypertension
    Dimitris Tousoulis
    First Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 26:683-90. 2013

Collaborators

Detail Information

Publications149 found, 100 shown here

  1. ncbi request reprint Diabetes mellitus and vascular endothelial dysfunction: current perspectives
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:19-32. 2012
    ....
  2. ncbi request reprint Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins
    Dimitris Tousoulis
    First Cardiology Department, Athens University Medical School, Athens, Greece Electronic address
    J Am Coll Cardiol 63:2491-502. 2014
    ..Finally, we review the most important clinical data for the role of statins in primary and secondary prevention of cardiovascular events. ..
  3. doi request reprint Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece Electronic address
    Atherosclerosis 232:10-6. 2014
    ..In this study we evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on vascular function, inflammatory and fibrinolytic process in subjects with MetS...
  4. ncbi request reprint Statins in heart failure-With preserved and reduced ejection fraction. An update
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece Electronic address
    Pharmacol Ther 141:79-91. 2014
    ....
  5. ncbi request reprint Effects of direct infusion of bone marrow-derived progenitor cells and indirect mobilization of hematopoietic progenitor cells on atherosclerotic plaque and inflammatory process in atherosclerosis
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece Electronic address
    Int J Cardiol 168:4769-74. 2013
    ..We sought to investigate the effects of lin-/sca+ cells, endothelial progenitor cells (EPCs) and granulocyte colony-stimulating factor (G-CSF) administration on atherosclerotic plaque progression...
  6. doi request reprint Infusion of lin-/sca-1+ and endothelial progenitor cells improves proinflammatory and oxidative stress markers in atherosclerotic mice
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Int J Cardiol 167:1900-5. 2013
    ....
  7. doi request reprint Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 167:1924-8. 2013
    ..Arterial stiffness has an independent predictive value for cardiovascular events. We evaluate the relationship between OPG, OPN serum levels and vascular function in coronary artery disease (CAD) patients...
  8. doi request reprint Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches
    Dimitris Tousoulis
    First Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    J Am Coll Cardiol 62:667-76. 2013
    ..The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients. ..
  9. ncbi request reprint Novel biomarkers assessing endothelial dysfunction: role of microRNAs
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 13:1518-26. 2013
    ..They have been shown to participate in cardiovascular disease pathogenesis including atherosclerosis and endothelial dysfunction and this may have important clinical implications. ..
  10. doi request reprint Genetic predisposition to left ventricular hypertrophy and the potential involvement of cystatin-C in untreated hypertension
    Dimitris Tousoulis
    First Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 26:683-90. 2013
    ..We examined whether these variants determined both echocardiography indices and the potential associated underlying mechanisms, including cystatin-C and vascular inflammation...
  11. doi request reprint Dose-dependent effects of short term atorvastatin treatment on arterial wall properties and on indices of left ventricular remodeling in ischemic heart failure
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Vasilissis Sofias 114, TK 115 28 Athens, Greece
    Atherosclerosis 227:367-72. 2013
    ....
  12. ncbi request reprint Heart rate as a therapeutic target in angina pectoris
    Emmanuel Androulakis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 19:1562-8. 2013
    ..However, additional data are now being sought to assess the impact of this approach on clinical practice...
  13. ncbi request reprint Insight to the pathophysiology of stable angina pectoris
    Dimitris Tousoulis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 19:1593-600. 2013
    ..However, several issues with respect to the comprehension of the pathophysiology of the chronic coronary syndrome have not been fully elucidated...
  14. ncbi request reprint Targeting myocardial metabolism for the treatment of stable angina
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Pharm Des 19:1587-92. 2013
    ..This review summarizes the main aspects of myocardial metabolism and focuses on the therapeutic approaches that could offer clinical benefit in patients with stable angina...
  15. ncbi request reprint Stable angina pectoris: current medical treatment
    Katerina Siama
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 19:1569-80. 2013
    ..These drugs, which are currently approved as second-line treatments, have dynamically entered the clinical practice and their long-term effects are still under investigation...
  16. doi request reprint Novel therapeutic strategies in the management of arterial hypertension
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Pharmacol Ther 135:168-75. 2012
    ..However, continued efforts must progress in these areas and the effects of therapeutic strategies in hypertensive patients need to be further explored in larger trials over a longer period of time...
  17. ncbi request reprint Matrix metallopropteinases in heart failure
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1181-91. 2012
    ....
  18. ncbi request reprint Assessment of acute coronary syndromes: focus on novel biomarkers
    D Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Med Chem 19:2572-87. 2012
    ..In the current review, we summarize recent evidence of the most promising biomarkers and discuss their potential role in clinical practice in patients suffering from ACSs...
  19. ncbi request reprint Novel biomarkers assessing the calcium deposition in coronary artery disease
    D Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Curr Med Chem 19:901-20. 2012
    ..Within this context, the present review sets out to discuss the role of new biomarkers assessing calcium deposition in coronary arteries and their role in the prognosis, progression, and treatment of cardiovascular disease...
  20. ncbi request reprint The role of nitric oxide on endothelial function
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:4-18. 2012
    ..In the present review we will discuss the important role of nitric oxide in physiological endothelium and we will pinpoint the significance of this molecule in pathological states altering the endothelial function...
  21. pmc Quantitative analysis of left atrial function in asymptomatic patients with b-thalassemia major using real-time three-dimensional echocardiography
    Constantina Aggeli
    Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Cardiovasc Ultrasound 9:38. 2011
    ..The aim of this study was to investigate the performance of the left atrium in beta-thalassemic patients with preserved left ventricular ejection fraction (EF) and no iron overload, using RT3DE...
  22. ncbi request reprint The failure of immunomodulation therapy in heart failure: does the statins "paradigm" prove the rule?
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:114-21. 2010
    ..Thus, more large scale clinical trials are required to evaluate the impact of statins on immune imbalance and its restoration in patients with CHF...
  23. ncbi request reprint Endothelial function and inflammation in coronary artery disease
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Postgrad Med J 84:368-71. 2008
    ..However, randomised controlled trials are required to explore further whether drugs targeting the inflammatory process and endothelial function will constitute a reasonable adjunctive treatment for patients with coronary artery disease...
  24. ncbi request reprint Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens, Medical School, Athens, Greece
    Int J Cardiol 136:258-62. 2009
    ..We searched for clinical determinants of oxidative stress status, endothelial function and inflammatory process in patients with chronic atrial fibrillation...
  25. doi request reprint Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases
    Dimitris Tousoulis
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 201:236-47. 2008
    ....
  26. ncbi request reprint New biochemical markers in acute coronary syndromes
    Dimitris Tousoulis
    Athens University Medical School, Cardiology Department, Hippokration Hospital, Athens, Greece
    Curr Med Chem 15:1288-96. 2008
    ..In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS...
  27. ncbi request reprint Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada, Athens, Greece
    Clin Nutr 27:594-600. 2008
    ..We compared the acute effects of several alcoholic beverages on endothelial function, inflammatory process and thrombosis/fibrinolysis system in young adults...
  28. doi request reprint Heart regeneration: what cells to use and how?
    Dimitris Tousoulis
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Curr Opin Pharmacol 8:211-8. 2008
    ..Although the results of the recent clinical trials in this area are rather conflicting, these therapeutic approaches seem to be promising for the treatment of ischemic heart disease...
  29. ncbi request reprint Effects of insulin resistance on endothelial function: possible mechanisms and clinical implications
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Diabetes Obes Metab 10:834-42. 2008
    ..Finally, improved endothelial function by such treatments is not in itself proof of reduced risk for atherosclerosis; this remains to be directly tested in clinical trials...
  30. pmc Assessing inflammatory status in cardiovascular disease
    Dimitris Tousoulis
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Heart 93:1001-7. 2007
  31. ncbi request reprint Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
    D Tousoulis
    Athens University Medical School, Athens, Greece
    Eur J Clin Invest 37:623-8. 2007
    ..Although sCD40L is part of immune response, the mechanisms regulating its release in different disease states remain unknown...
  32. ncbi request reprint Novel therapies targeting vascular endothelium
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Endothelium 13:411-21. 2006
    ..Although there are a variety of strategies to improve NO bioavailability in human endothelium, it is still unclear whether they have any direct benefit at a clinical level...
  33. ncbi request reprint Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective
    Dimitris Tousoulis
    Athens University Medical School, S Karagiorga 69, Glifada, 16675 Athens, Greece
    Nat Clin Pract Cardiovasc Med 4:274-83. 2007
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis...
  34. doi request reprint Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 145:438-43. 2010
    ..In the present study, we sought to compare the effects of statins and xanthine oxidase inhibitors on circulating levels of MMPs and TIMPs in patients with chronic HF...
  35. ncbi request reprint Statins in heart failure. Beyond the lipid lowering effect
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 115:144-50. 2007
    ..Finally the statin dose and the interaction with co-administered drugs need to be studied...
  36. doi request reprint Role of depression in heart failure--choosing the right antidepressive treatment
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 140:12-8. 2010
    ..Even though certain conclusions cannot be drawn yet, evidence suggests that the use of selective serotonin reuptake inhibitors may have a beneficial effect on clinical outcome of heart failure patients...
  37. ncbi request reprint The impact of diabetes mellitus on coronary artery disease: new therapeutic approaches
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Curr Pharm Des 15:2037-48. 2009
    ....
  38. doi request reprint Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers
    Dimitris Tousoulis
    Hippokration Hospital, Athens University Medical School, Athens, Greece
    Br J Nutr 103:43-9. 2010
    ..However, all types of oils did not affect inflammatory process and systemic oxidative stress, suggesting that their effect on endothelial function may not be mediated by free radicals bioavailability...
  39. doi request reprint From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 115 28 Athens, Greece
    Trends Cardiovasc Med 20:153-64. 2010
    ..Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future...
  40. doi request reprint Fibrinogen and cardiovascular disease: genetics and biomarkers
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Blood Rev 25:239-45. 2011
    ....
  41. ncbi request reprint Oxidative stress and endothelial function: therapeutic interventions
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias, Greece
    Recent Pat Cardiovasc Drug Discov 6:103-14. 2011
    ..However, the discussion of recent patents with the novel antioxidant strategies are required to clarify the role of antioxidant intervention in vascular diseases...
  42. doi request reprint Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: potential therapeutic strategies
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Athens, Greece
    Heart Fail Rev 17:65-79. 2012
    ..Approaches using more-effective antioxidants or targeting myocardial oxidant-producing enzymes and oxidative or nitrosative stress might be promising strategies in the future...
  43. doi request reprint Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Clin Ther 32:1720-8. 2010
    ..Endothelium-dependent dilation (EDD) measured by gauge-strain plethysmography in the forearm is considered to be a reliable marker of endothelial function in forearm resistance vessels...
  44. ncbi request reprint The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility
    D Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Curr Med Chem 18:427-38. 2011
    ....
  45. doi request reprint Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact of inflammatory process and oxidative stress
    Dimitris Tousoulis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 214:151-7. 2011
    ....
  46. ncbi request reprint Endothelial dysfunction: potential clinical implications
    D Tousoulis
    Hippokration Hospital, Athens University Medical School, Greece
    Minerva Med 101:271-84. 2010
    ..Despite of the fact that there are several strategies aiming to improve endothelial dysfunction by enhancing nitric oxide bioavailability, it is still unclear whether they could be beneficial at a clinical level...
  47. doi request reprint Novel therapeutic strategies targeting vascular endothelium in essential hypertension
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, First Cardiology Unit, Athens, Greece
    Expert Opin Investig Drugs 19:1395-412. 2010
    ....
  48. doi request reprint Recent therapeutic approaches to platelet activation in coronary artery disease
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Pharmacol Ther 127:108-20. 2010
    ..Presently, antiplatelet intervention remains an important therapeutic modality, with novel antiplatelet therapies, such as prasugrel and ticagrelor under clinical investigation...
  49. doi request reprint The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    Dimitris Tousoulis
    S Karagiorga 69, Glifada 166 75, Athens, Greece
    J Hypertens 28:925-30. 2010
    ..We examined the impact of acute homocysteinemia on endothelial function in hypertensive patients and healthy individuals, and the potential role of ET-1...
  50. ncbi request reprint The oxidative stress menace to coronary vasculature: any place for antioxidants?
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675, Glifada, Athens, Greece
    Curr Pharm Des 15:3078-90. 2009
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  51. ncbi request reprint Circulating biomarkers for the diagnosis and prognosis of heart failure
    D Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Greece
    Curr Med Chem 16:3828-40. 2009
    ....
  52. ncbi request reprint Pathophysiology of atherosclerosis: the role of inflammation
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4089-110. 2011
    ..The main drug categories that have been proved to ameliorate the inflammatory state in atherosclerosis are angiotensin converting enzyme inhibitors/angiotensin receptors blockers, statins, and antioxidants...
  53. ncbi request reprint L-arginine in cardiovascular disease: dream or reality?
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Vasc Med 7:203-11. 2002
    ..However, more data derived from large-scale prospective studies evaluating the effects of long-term treatment with L-arginine are needed...
  54. pmc Inflammatory and thrombotic mechanisms in coronary atherosclerosis
    D Tousoulis
    Cardiology Unit, Athens University Medical School, Athens, Greece
    Heart 89:993-7. 2003
    ..There may thus be therapeutic potential in modifying the atherosclerotic, vasomotor, and thrombotic components of ischaemic heart disease...
  55. pmc Effects of atorvastatin on reactive hyperaemia and the thrombosis-fibrinolysis system in patients with heart failure
    D Tousoulis
    Cardiology Unit, Athens University Medical School, 69 S Karagiorga, 16675, Athens, Greece
    Heart 91:27-31. 2005
    ....
  56. doi request reprint Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 24:936-42. 2011
    ..However, the mechanisms regulating ADMA synthesis in hypertension are unclear...
  57. ncbi request reprint Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 115:203-7. 2007
    ..However, the underlying mechanisms of the acute coronary syndromes are still obscure. We evaluated the differences of inflammatory and thrombotic markers, at the acute phase of unstable angina (UA) and acute myocardial infarction (AMI)...
  58. ncbi request reprint Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada Athens, Greece
    Int J Cardiol 100:347-53. 2005
    ..Treatments with beneficial effects on endothelial dysfunction may also improve prognosis in patients with heart failure...
  59. pmc Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina
    D Tousoulis
    Athens University Medical School, Athens, Greece
    Heart 91:1319-23. 2005
    ..To assess the effects of intravenous vitamin C administration on the vasomotor responses to intracoronary L-arginine infusion in epicardial coronary arteries...
  60. pmc Endothelial function and inflammation in coronary artery disease
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Heart 92:441-4. 2006
    ..However, randomised controlled trials are required to explore further whether drugs targeting the inflammatory process and endothelial function will constitute a reasonable adjunctive treatment for patients with coronary artery disease...
  61. ncbi request reprint Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C
    C Antoniades
    Cardiology Department, Athens University Medical School, Greece
    Diabet Med 21:552-8. 2004
    ....
  62. doi request reprint Impact of type 2 diabetes mellitus on diffuse inflammatory activation of de novo atheromatous lesions: implications for systemic inflammation
    K Toutouzas
    First Department of Cardiology, Athens Medical School, Hippokration Hospital, Holargos, Greece
    Diabetes Metab 35:299-304. 2009
    ..We investigated whether or not, in patients with DM, thermal heterogeneity of culprit lesions (CLs) correlates with that of non-culprit lesions (NCLs) and with systemic inflammation...
  63. doi request reprint Soluble receptor for advanced glycation end-product levels are related to albuminuria and arterial stiffness in essential hypertension
    K Dimitriadis
    First Cardiology Clinic, University of Athens, Hippokration Hospital, 3 Kolokotroni Street, 15236 P Panteli, Athens, Greece
    Nutr Metab Cardiovasc Dis 23:382-8. 2013
    ..We investigated the interrelationships of sRAGE with albumin to creatinine ratio (ACR) and arterial stiffness in essential hypertension...
  64. doi request reprint Impact of metabolic syndrome on clinical outcomes after new generation drug-eluting stent implantation: the 'obesity paradox' phenomenon is still apparent
    C Patsa
    First Department of Cardiology, Athens Medical School, Hippokration Hospital, 114 Vas Sophias Str, 11527 Athens, Greece
    Nutr Metab Cardiovasc Dis 23:307-13. 2013
    ..Therefore, we evaluated the impact of the new generation DES on patients with an isolated lesion in the proximal segment of the left anterior descending artery (pLAD) suffering from MS...
  65. ncbi request reprint Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes
    C Bakogiannis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Med Chem 19:2597-604. 2012
    ....
  66. ncbi request reprint Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006
    ..Homocystinemia is a metabolic abnormality associated with endothelial dysfunction and increased cardiovascular disease risk. The underlying mechanisms of these effects, however, are obscure...
  67. doi request reprint Prognostic clinical and angiographic characteristics for the development of a new significant lesion in remote segments after successful percutaneous coronary intervention
    E Tsiamis
    First Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece
    Int J Cardiol 143:29-34. 2010
    ..The purpose of the study was to investigate the clinical and angiographic factors related to the progression of non-culprit lesions (NCL) of patients undergoing percutaneous coronary interventions (PCI)...
  68. ncbi request reprint Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta
    S Brili
    Athens University Medical School, S Karagiorga 69, Glifada, Athens 16675, Greece
    Heart 98:325-9. 2012
    ..To investigate the effects of atorvastatin on endothelial function and low-grade systemic inflammation in subjects with successful surgery for aortic coarctation repair (SCR)...
  69. pmc Effects of L-arginine on flow mediated dilatation induced by atrial pacing in diseased epicardial coronary arteries
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Heart 89:531-4. 2003
    ..To examine the effects of L-arginine on basal coronary tone and flow mediated dilatation induced by atrial pacing in patients with coronary artery disease and stable angina...
  70. pmc Vasomotor effects of L- and D-arginine in stenotic atheromatous coronary plaque
    D Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Heart 86:296-301. 2001
    ..This finding is consistent with partial deficiency of the substrate for nitric oxide synthesis, L-arginine, at the site of complex stenoses...
  71. doi request reprint Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals
    N Papageorgiou
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Eur J Clin Nutr 65:514-9. 2011
    ..In this parallel study, we assessed the acute effects of extra virgin olive oil, soy oil, corn oil and cod liver oil on circulating soluble(s) forms of adhesion molecules and TNF-α...
  72. ncbi request reprint Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
    ..Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity and abnormal inflammatory response...
  73. ncbi request reprint Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response
    Charalambos Antoniades
    Department of Cardiology, Athens University Medical School, Athens, Greece
    Am J Cardiol 94:1181-4. 2004
    ..01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system...
  74. ncbi request reprint Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease
    Dimitris Tousoulis
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Diabetes Care 26:2749-53. 2003
    ....
  75. ncbi request reprint Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
    ..We also examined the role of endothelin-1 (ET-1) in the development of endothelial dysfunction in these two conditions...
  76. ncbi request reprint The role of microRNAs in cardiovascular disease
    N Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Med Chem 19:2605-10. 2012
    ..Understanding the underlying mechanisms, in which these major regulatory gene families are implicated, will provide novel opportunities for diagnosis and therapy of cardiovascular diseases...
  77. ncbi request reprint Biomarkers determining cardiovascular risk in patients with kidney disease
    G Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Curr Med Chem 19:2555-71. 2012
    ....
  78. ncbi request reprint Chemokines in patients with ischaemic heart disease and the effect of coronary angioplasty
    E Economou
    Cardiology Unit, Athens University Medical School, Hippokration Hospital, 114 Vasillisis Sofias, 11528, Athens, Greece
    Int J Cardiol 80:55-60. 2001
    ..MCP-1 levels remain significantly elevated for at least 6 months following elective PTCA, suggesting an inflammatory stimulation...
  79. ncbi request reprint Increased coronary sinus blood temperature: correlation with systemic inflammation
    K Toutouzas
    First Department of Cardiology, Athens Medical School, Hippokration Hospital, Greece
    Eur J Clin Invest 36:218-23. 2006
    ..Coronary sinus and RA blood temperature measurements were performed by a 7F thermography catheter. DeltaTau was calculated by subtracting the RA from the CS blood temperature...
  80. ncbi request reprint Clinical utility of biomarkers in premature atherosclerosis
    A M Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Med Chem 19:2521-33. 2012
    ....
  81. ncbi request reprint Predictive value of biomarkers in patients with heart failure
    D Tousoulis
    1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    Curr Med Chem 19:2534-47. 2012
    ..In the present review, we will discuss the usefulness and significance of potentials or established biomarkers in HF patients focusing on their ability to predict adverse events, morbidity and mortality...
  82. ncbi request reprint Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
    ....
  83. ncbi request reprint Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, A Cardiology Department, Greece
    Eur J Heart Fail 7:1126-32. 2005
    ..Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and/or advanced atherosclerosis...
  84. ncbi request reprint Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Herz 28:628-38. 2003
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  85. ncbi request reprint Monitoring calcific aortic valve disease: the role of biomarkers
    G Latsios
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Med Chem 19:2548-54. 2012
    ..Also, several studies have investigated the role of biomarkers regarding their utility in the screening of calcific aortic valve disease and their putative clinical value, though their role still remains undetermined...
  86. doi request reprint Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension
    K Dimitriadis
    First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece
    J Hum Hypertens 23:668-73. 2009
    ..Moreover, the independent association of resistin with eGFR suggests involvement of resistin in the progression of kidney damage in the early stages of hypertension...
  87. doi request reprint Adherence to the Mediterranean diet and albuminuria levels in Greek adolescents: data from the Leontio Lyceum ALbuminuria (3L study)
    A Mazaraki
    First Cardiology Clinic, University of Athens, Hippokration Hospital, 43 Agias Marinas Street, Melissia, Athens, Greece
    Eur J Clin Nutr 65:219-25. 2011
    ..The aim of the study was to assess the relationships of adherence rates to the Mediterranean diet with albumin to creatinine ratio (ACR), in a cohort of Greek adolescents who participated in the Leontio Lyceum ALbuminuria (3L) study...
  88. ncbi request reprint Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
    ..These findings indicate that atorvastatin may improve forearm vasodilatory response to reactive hyperemia and depress inflammatory process in patients with heart failure and normal baseline cholesterol levels...
  89. ncbi request reprint Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
    Constadina Aggeli
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, Greece
    Int J Cardiol 105:80-4. 2005
    ..We examined endothelial function and serum levels of inflammatory mediators in transfusion-dependent patients with beta-thalassemia major...
  90. ncbi request reprint Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Thromb Haemost 89:990-5. 2003
    ..In conclusion, combined administration of vitamin C and vitamin E at high dosages, improved endothelial function and decreased plasma levels of PAI-1, vWF and PAI-1/tPA ratio in chronic smokers...
  91. doi request reprint Gender variation of exercise-induced anti-arrhythmic protection: the Ikaria Study
    E Oikonomou
    First Cardiology Clinic, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    QJM 104:1035-43. 2011
    ....
  92. ncbi request reprint Statin treatment is associated with reduced thermal heterogeneity in human atherosclerotic plaques
    C Stefanadis
    Department of Cardiology, Athens Medical School, Athens, Greece
    Eur Heart J 23:1664-9. 2002
    ..Statins seem to have an antiinflammatory effect which results in plaque stabilization. The aim of this study was to investigate the effect of statins on plaque temperature...
  93. pmc Endogenous endothelin maintains coronary artery tone by endothelin type A receptor stimulation in patients undergoing coronary arteriography
    Z S Kyriakides
    2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    Heart 84:176-82. 2000
    ..To examine the contribution of endothelin type A (ET(A)) receptor stimulation by endogenously generated endothelin-1 (ET-1) to the maintenance of coronary vascular tone in humans...
  94. ncbi request reprint Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis
    P P Sfikakis
    First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
    Arthritis Rheum 56:1985-93. 2007
    ..Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular endothelial function in SSc patients...
  95. doi request reprint Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study
    Stella Brili
    First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 51:742-9. 2008
    ..The purpose of this study was to evaluate the effect of ramipril on endothelial function and inflammatory process in a group of normotensive subjects with successfully repaired coarctation of the aorta (SCR)...
  96. pmc Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques
    D Tousoulis
    Athens University Medical School, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Heart 91:553-8. 2005
  97. ncbi request reprint Microalbuminuria is associated with unfavourable cardiac geometric adaptations in essential hypertensive subjects
    C Tsioufis
    Department of Cardiology, University of Athens, Hippokration Hospital, Greece
    J Hum Hypertens 16:249-54. 2002
    ....
  98. ncbi request reprint Novel therapeutic strategies targeting vascular redox in human atherosclerosis
    Alexis S Antonopoulos
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Recent Pat Cardiovasc Drug Discov 4:76-87. 2009
    ....
  99. ncbi request reprint Inflammatory biomarkers predicting events in atherosclerosis
    E Stefanadi
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Curr Med Chem 17:1690-707. 2010
    ..Thus, further studies are required to evaluate the predictive role of such molecules, as well as others under investigation in states of atherosclerosis...
  100. ncbi request reprint The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 109:48-52. 2006
    ..In this study we assessed the effects of low-dose atorvastatin treatment, on inflammatory process in patients admitted for unstable angina with low cholesterol level...
  101. ncbi request reprint Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 46:1101-9. 2005
    ....