Maria Lina Tornesello

Summary

Publications

  1. doi request reprint Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit, Department of Experimental Oncology, National Cancer Institute, Fond Pascale, Naples, Italy
    Genomics 102:74-83. 2013
  2. pmc Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer
    Clorinda Annunziata
    Molecular Biology and Viral Oncology, National Cancer Institute Fond, Pascale, Cappella Cangiani, 80131, Naples, Italy
    Infect Agent Cancer 8:2. 2013
  3. pmc Effects of adjuvants on IgG subclasses elicited by virus-like particles
    Maria Luisa Visciano
    Lab, of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond, G, Pascale, Naples Italy
    J Transl Med 10:4. 2012
  4. ncbi request reprint Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Cappella Cangiani, 80131 Naples, Italy
    Cancer Lett 269:159-64. 2008
  5. doi request reprint TP53 codon 72 polymorphism in classic, endemic and epidemic Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Naples, Italy
    Oncology 77:328-34. 2009
  6. ncbi request reprint Human papillomavirus genotypes and HPV16 variants in penile carcinoma
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    Int J Cancer 122:132-7. 2008
  7. doi request reprint Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women
    Maria Lina Tornesello
    Ist Naz Tumori Fond G Pascale, Cappella Cangiani, I 80131 Naples, Italy
    J Gen Virol 89:1380-9. 2008
  8. ncbi request reprint Prevalence of alpha-papillomavirus genotypes in cervical squamous intraepithelial lesions and invasive cervical carcinoma in the Italian population
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 78:1663-72. 2006
  9. doi request reprint MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Biomarkers 16:42-50. 2011
  10. doi request reprint A pilot study on the distribution of human papillomavirus genotypes and HPV-16 variants in cervical neoplastic lesions from Ecuadorian women
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 80:1959-65. 2008

Detail Information

Publications39

  1. doi request reprint Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit, Department of Experimental Oncology, National Cancer Institute, Fond Pascale, Naples, Italy
    Genomics 102:74-83. 2013
    ..015). The extended analysis of genetic alterations will help to identify molecular markers for liver cancer prevention, diagnosis and treatment of HBV and HCV-associated liver cancer. ..
  2. pmc Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer
    Clorinda Annunziata
    Molecular Biology and Viral Oncology, National Cancer Institute Fond, Pascale, Cappella Cangiani, 80131, Naples, Italy
    Infect Agent Cancer 8:2. 2013
    ....
  3. pmc Effects of adjuvants on IgG subclasses elicited by virus-like particles
    Maria Luisa Visciano
    Lab, of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond, G, Pascale, Naples Italy
    J Transl Med 10:4. 2012
    ..In the present study, the elicitation of different patterns of IgG subclasses by VLPs, administered in CpG ODN1826 or poly(I:C) adjuvants, has been evaluated in an animal model...
  4. ncbi request reprint Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Cappella Cangiani, 80131 Naples, Italy
    Cancer Lett 269:159-64. 2008
    ..Therefore, no evidence of association between homozygosity for p53 arginine and HPV-related or HPV-unrelated penile squamous cell carcinoma was observed neither among Ugandan nor among Italian populations...
  5. doi request reprint TP53 codon 72 polymorphism in classic, endemic and epidemic Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Naples, Italy
    Oncology 77:328-34. 2009
    ..Several studies have examined the association of codon 72 polymorphism of the TP53 gene, encoding either arginine or proline, in several tumor types but none have investigated its role in Kaposi's sarcoma (KS) development...
  6. ncbi request reprint Human papillomavirus genotypes and HPV16 variants in penile carcinoma
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    Int J Cancer 122:132-7. 2008
    ....
  7. doi request reprint Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women
    Maria Lina Tornesello
    Ist Naz Tumori Fond G Pascale, Cappella Cangiani, I 80131 Naples, Italy
    J Gen Virol 89:1380-9. 2008
    ..The increased prevalence of uncommon viral genotypes and HPV16 variants in HIV-positive Italian women underscores the need to target a wide range of HPV types in cervical screening of high-risk women...
  8. ncbi request reprint Prevalence of alpha-papillomavirus genotypes in cervical squamous intraepithelial lesions and invasive cervical carcinoma in the Italian population
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 78:1663-72. 2006
    ....
  9. doi request reprint MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Biomarkers 16:42-50. 2011
    ..The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients...
  10. doi request reprint A pilot study on the distribution of human papillomavirus genotypes and HPV-16 variants in cervical neoplastic lesions from Ecuadorian women
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 80:1959-65. 2008
    ....
  11. doi request reprint High prevalence of human papillomavirus infection in Eastern European and West African women immigrants in South Italy
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    APMIS 119:701-9. 2011
    ..The implementation of vaccination strategies and cervical cancer surveillance are critical for women in this risk group...
  12. doi request reprint Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagus
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit and AIDS Reference Centre, National Cancer Institute Fond Pascale, Naples, Italy
    J Clin Virol 45:28-33. 2009
    ..Still controversial is the association of HPV infection with oesophageal neoplasia...
  13. pmc Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example
    Luigi Buonaguro
    Lab of Viral Oncogenesis and Immunotherapy and AIDS Refer Center, Ist Naz Tumori Fond G Pascale, Naples, Italy
    Retrovirology 4:34. 2007
    ..The study and monitoring of the genetic evolution of the HIV-1 represent, therefore, an essential strategy for controlling the local as well as global HIV-1 epidemic and for developing efficient preventive and therapeutic strategies...
  14. ncbi request reprint Challenges in cancer vaccine development for hepatocellular carcinoma
    Luigi Buonaguro
    Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Pascale IRCCS, Naples, Italy Electronic address
    J Hepatol 59:897-903. 2013
    ..The state of the art in immunotherapy strategies for HCC and future perspectives are reported in the present review. ..
  15. ncbi request reprint TP53 codon 72 polymorphism and risk of conjunctival squamous cell carcinoma in Uganda
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Cappella Cangiani, I 80131 Naples, Italy
    Cancer Detect Prev 29:501-8. 2005
    ..Several studies have associated this polymorphism with different types of cancer. We have analyzed the distribution and the role of TP53 Arg72 and Pro72 alleles in conjunctival neoplasia...
  16. ncbi request reprint Developments in virus-like particle-based vaccines for HIV
    Luigi Buonaguro
    Department of Experimental Oncology, Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Expert Rev Vaccines 12:119-27. 2013
    ..This review describes an update on the development and use of VLPs as vaccine approaches for HIV...
  17. ncbi request reprint Human papillomavirus infection in urine samples from male renal transplant patients
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Naples, Italy
    J Med Virol 82:1179-85. 2010
    ....
  18. doi request reprint Human herpesvirus type 8 variants circulating in Europe, Africa and North America in classic, endemic and epidemic Kaposi's sarcoma lesions during pre-AIDS and AIDS era
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Cappella Cangiani, 80131 Naples, Italy
    Virology 398:280-9. 2010
    ..In conclusion, comparison of the HHV-8 sequences from classic or endemic versus AIDS-associated KS showed a strong linkage of the HHV-8 variants with specific populations, which has not changed during AIDS epidemic...
  19. ncbi request reprint VLPs and particle strategies for cancer vaccines
    Francesca Ungaro
    Department of Pharmacy, University of Napoli Federico II, Via Domenico Montesano 49, 80131, Napoli, Italy
    Expert Rev Vaccines 12:1173-93. 2013
    ..In the present review, we report some leading technologies for developing particulate vaccines employed in cancer immunotherapy, highlighting the key parameters for a rational design to elicit both humoral and cellular responses. ..
  20. pmc HIV p24 as scaffold for presenting conformational HIV Env antigens
    Maria Tagliamonte
    Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy
    PLoS ONE 7:e43318. 2012
    ..This strongly support the feasibility of developing a scaffolding strategy based on p24 CA proteins displaying conformational minimal structural, antigenic HIV Env epitopes...
  21. pmc Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology, National Cancer Institute Fondazione Pascale, Cappella Cangiani, 80131 Naples, Italy
    Biomed Res Int 2013:519619. 2013
    ....
  22. ncbi request reprint Characterization of the human papillomavirus (HPV) integration sites into genital cancers
    Clorinda Annunziata
    Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute Fondazione Pascale, Cappella Cangiani, 80131, Naples, Italy
    Pathol Oncol Res 18:803-8. 2012
    ..3, within the intronic region of TRAP1 gene. These results confirm previous observations, summarized in a systematic review of the literature, on the HPV integration events in gene loci relevant to cancer pathogenesis...
  23. pmc Multiparametric analyses of human PBMCs loaded ex vivo with a candidate idiotype vaccine for HCV-related lymphoproliferative disorders
    Annacarmen Petrizzo
    Laboratory of Molecular Biology and Viral Oncogenesis, National Cancer Institute Fond G Pascale, Naples, Italy
    PLoS ONE 7:e44870. 2012
    ....
  24. pmc TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients
    Valeria Di Vuolo
    Molecular Biology and Viral Oncology and AIDS Ref, Centre, National Cancer Institute Fond, Pascale, Naples, Italy
    Infect Agent Cancer 6:13. 2011
    ..abstract:..
  25. doi request reprint Virus-like particle vaccines and adjuvants: the HPV paradigm
    Franco Maria Buonaguro
    Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Expert Rev Vaccines 8:1379-98. 2009
    ....
  26. pmc Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration
    Luigi Buonaguro
    Laboratory of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond G Pascale, Naples, Italy
    Clin Vaccine Immunol 19:970-3. 2012
    ..The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level...
  27. ncbi request reprint Screening of HIV-1 isolates by reverse heteroduplex mobility assay and identification of non-B subtypes in Italy
    Luigi Buonaguro
    Viral Oncology and AIDS Refer Center, Ist Naz Tumori Fond G Pascale, Naples, Italy
    J Acquir Immune Defic Syndr 37:1295-306. 2004
    ....
  28. pmc Prediction of individual immune responsiveness to a candidate vaccine by a systems vaccinology approach
    Annacarmen Petrizzo
    Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione Pascale IRCCS, Naples, Italy
    J Transl Med 12:11. 2014
    ....
  29. pmc Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate
    Maria Luisa Visciano
    Molecular Biology and Viral Oncogenesis Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Pascale IRCCS, Naples, Italy
    J Transl Med 11:165. 2013
    ..Our results provide a rationale for the design and evaluation of immunogens and the clade A gp14094UG018 shows promising characteristics for potential involvement in an effective HIV vaccine with broad activity. ..
  30. doi request reprint Mutations of the TP53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit, and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Naples, Italy
    Gynecol Oncol 128:442-8. 2013
    ..This study provides a detailed analysis of TP53 mutation spectra in cervical squamous cell carcinoma and adenocarcinoma from different geographical regions...
  31. doi request reprint Developments in virus-like particle-based vaccines for infectious diseases and cancer
    Luigi Buonaguro
    Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    Expert Rev Vaccines 10:1569-83. 2011
    ..This article provides an update on the development and use of virus-like particles as vaccine approaches for infectious diseases and cancer...
  32. doi request reprint Advances in viral oncology research: summary of the 3rd International Meeting
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology and AIDS Reference Centre, Istituto Nazionale Tumori Fond Pascale, Naples, Italy
    Expert Rev Vaccines 11:411-4. 2012
    ..More than 100 scientists attended the meeting. A summary of the invited lectures and oral selected presentations is reported...
  33. doi request reprint Plant-based anti-HIV-1 strategies: vaccine molecules and antiviral approaches
    Nunzia Scotti
    CNR IGV, Institute of Plant Genetics, Portici, Naples, Italy
    Expert Rev Vaccines 9:925-36. 2010
    ..Furthermore, plant-based anti-HIV strategies can be administered not only parenterally but also by the more convenient and safer oral route, which is a more suitable approach for possible mass vaccination...
  34. pmc Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies
    Maria Tagliamonte
    Lab, of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Istituto Nazionale Tumori Fond, G, Pascale, Naples, Italy
    J Transl Med 9:S1. 2011
    ..The relevance of conformational HIV-1 Envelope proteins presented on Virus-like Particles for appropriate assessment of this molecular interaction, is also discussed...
  35. doi request reprint New adjuvants in evolving vaccine strategies
    Franco M Buonaguro
    Molecular Biology and Viral Oncology, Dpt of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Napoli, Italy
    Expert Opin Biol Ther 11:827-32. 2011
    ..In the May issue of this journal, Garcon and colleagues describe the highly enhanced humoral and memory B cellular immunity of the AS04-adjuvanted HPV vaccine, which results in a long-lasting and broad spectrum immunity...
  36. pmc Systems biology applied to vaccine and immunotherapy development
    Luigi Buonaguro
    Molecular Biology and Viral Oncology, Dept of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy
    BMC Syst Biol 5:146. 2011
    ..Thus, the paradigm switch from "empirical" to "knowledge-based" conduct of medicine and immunotherapy in particular, leading to patient-tailored treatment...
  37. pmc Innate immunity and hepatitis C virus infection: a microarray's view
    Luigi Buonaguro
    Molecular Biology and Viral Oncogenesis Unit, Istituto Nazionale Tumori Fond, G, Pascale, 80131, Naples, Italy
    Infect Agent Cancer 7:7. 2012
    ....
  38. ncbi request reprint Analysis of human papillomavirus type-16 variants in Italian women with cervical intraepithelial neoplasia and cervical cancer
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 74:117-26. 2004
    ..The increased frequency of non-European variants in invasive lesions suggests that they are more oncogenic than European variants. This could have implications for future diagnostic and therapeutic strategies...
  39. pmc Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation
    Luigi Buonaguro
    Lab, Viral Oncogenesis and Immunotherapies and AIDS Reference Center, Department of Experimental Oncology, Istituto Nazionale Tumori Fond, G, Pascale, 80131 Napoli, Italy
    BMC Bioinformatics 9:S5. 2008
    ..Baculovirus-expressed HIV-1 Pr55gag Virus-Like Particles (HIV-VLPs) induce maturation and activation of monocyte-derived dendritic cells (MDDCs) with a production of Th1- and Th2-specific cytokines...