Ethnic variations of IL-10 polymorphisms in a Sami and Norwegian populationO Torkildsen
The Multiple Sclerosis National Competence Centre, Department of Clinical Medicine, Section for Neurology, University of Bergen, Haukeland University Hospital, Bergen, Norway
Scand J Immunol 62:71-4. 2005
..There was a significant difference in haplotypes in the two populations with a P=0.0024. These findings may be important for the distribution and clinical outcome of various infectious and immune-related disorders in the two populations...
The cuprizone model for demyelinationO Torkildsen
Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway
Acta Neurol Scand Suppl 188:72-6. 2008
..In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone...
- ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial
Oivind Torkildsen
Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway
Arch Neurol 69:1044-51. 2012
..To investigate whether ω-3 fatty acids reduce magnetic resonance imaging (MRI) and clinical disease activity in patients with multiple sclerosis, both as monotherapy and in combination with interferon beta-1a treatment...
- High dose methylprednisolone induces FcgammaRI on granulocytes in MS-patients
O Torkildsen
The Multiple Sclerosis National Competence Centre, Department of Clinical Medicine, Section for Neurology, Haukeland University Hospital, University of Bergen, N 5021 Bergen, Norway
J Neuroimmunol 167:138-42. 2005
..There was no change in FcgammaRII and FcgammaRIII expression. The effect of IVMP on FcgammaRI expression could be important for the clearance of immune complexes in MS...
- Upregulation of immunoglobulin-related genes in cortical sections from multiple sclerosis patients
Øivind Torkildsen
Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
Brain Pathol 20:720-9. 2010
..The findings indicate that the Ig-producing B-cells found in the cerebrospinal fluid (CSF) of MS patients could have meningeal origin...
- A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination
Øivind Torkildsen
Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
Clin Nutr 28:83-7. 2009
..Cuprizone induced demyelination is a commonly used animal model for demyelination in the central nervous system...
- Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination
Øivind Torkildsen
Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
Exp Neurol 215:160-6. 2009
..This may be of importance related to the discrepant results in dietary intervention studies for demyelinating diseases...
- Vitamin D-dependent rickets as a possible risk factor for multiple sclerosis
Øivind Torkildsen
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Arch Neurol 65:809-11. 2008
..Vitamin D is emerging as an important risk factor for susceptibility to multiple sclerosis (MS), but there have been no studies on the possible association between hereditary rickets and this disease...
- Immunomodulatory treatment of multiple sclerosis in Norway
Ø Torkildsen
The Multiple Sclerosis National Competence Center, Haukeland University Hospital, Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
Acta Neurol Scand Suppl 187:46-50. 2007
..To further calculate the treatment frequency, a nation-wide prevalence of MS in Norway was estimated, based on available prevalence studies...
- FcgammaR and multiple sclerosis: an overview
O Torkildsen
The Multiple Sclerosis National Competence Centre, Department of Neurology, Haukeland University Hospital and Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
Acta Neurol Scand Suppl 183:61-3. 2006
..Studies indicate however, that polymorphisms in some FcgammaR genes and treatment that induces FcgammaR on immune-competent cells could influence disease progression and treatment response...
- [Lars Hertervig and Carl Fredrik Hill--creativeness and mental illness]
Øivind Torkildsen
Senter for klinisk nevroforskning, Stavanger universitetssjukehus, 4068 Stavanger
Tidsskr Nor Laegeforen 125:3450-3. 2005
..This paper describes the artistic development of the two painters and discusses this in relation to how brain diseases may influence creativity and artistic expression...
- The cuprizone model: regional heterogeneity of pathology
Stig Wergeland
Department of Neurology, Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
APMIS 120:648-57. 2012
..Cuprizone-induced demyelination is a relevant model for the study of regional heterogeneity of demyelination and lesion pathology in multiple sclerosis...
Dietary vitamin D3 supplements reduce demyelination in the cuprizone modelStig Wergeland
Department of Neurology, Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
PLoS ONE 6:e26262. 2011
..In conclusion, high dietary doses of vitamin D3 reduce the extent of demyelination, and attenuate microglia activation and macrophage infiltration in a toxic model of demyelination, independent of lymphocyte infiltration...
- Alpha-tocopherol and MRI outcomes in multiple sclerosis--association and prediction
Kristin I Løken-Amsrud
Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway
PLoS ONE 8:e54417. 2013
..The aim of this study was to study alpha-tocopherol concentrations and their relationship to disease activity in Norwegian multiple sclerosis (MS) patients...
