Gian Paolo Tonini

Summary

Publications

  1. pmc Multiple endocrine neoplasias type 2B and RET proto-oncogene
    Giuseppe Martucciello
    University of Genova, DIPE, Via Gaslini, 5 Genova 16147, Italy
    Ital J Pediatr 38:9. 2012
  2. pmc Epigenetic Silencing of DKK3 in Medulloblastoma
    Francesca Valdora
    Department of Experimental Medicine DIMES, University of Genoa IRCCS A O U San Martino IST National Cancer Research Institute, Genoa 16132, Italy
    Int J Mol Sci 14:7492-505. 2013
  3. doi request reprint Towards a turning point of neuroblastoma therapy
    Gian Paolo Tonini
    Italian Neuroblastoma Foundation, IRCCS A O U San Martino IST, National Cancer Research Institute, Genoa, Italy
    Cancer Lett 326:128-34. 2012
  4. pmc High genomic instability predicts survival in metastatic high-risk neuroblastoma
    Sara Stigliani
    Center of Physiopathology of Human Reproduction, Department of Obstetrics and Gynecology, IRCCS San Martino Hospital, National Cancer Research Institute IST, Genoa, Italy
    Neoplasia 14:823-32. 2012
  5. doi request reprint Bone marrow of neuroblastoma patients shows downregulation of CXCL12 expression and presence of IFN signature
    Paola Scaruffi
    Translational Oncopathology, National Cancer Research Institute, Genoa, Italy
    Pediatr Blood Cancer 59:44-51. 2012
  6. pmc Transcribed-Ultra Conserved Region expression is associated with outcome in high-risk neuroblastoma
    Paola Scaruffi
    Translational Paediatric Oncology, National Cancer Research Institute IST, Genoa, Italy
    BMC Cancer 9:441. 2009
  7. doi request reprint Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory
    Domenico Albino
    Laboratory of Italian Neuroblastoma Foundation, National Cancer Research Institute, Genoa, Italy
    Cancer 113:1412-22. 2008
  8. doi request reprint Age-dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma
    Simona Coco
    Department of Advanced Diagnostic Technologies IRCCS AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Int J Cancer 131:1591-600. 2012
  9. ncbi request reprint Concomitant DDX1 and MYCN gain in neuroblastoma
    Raffaella Defferrari
    Laboratory of Neuroblastoma Research, Italian Neuroblastoma Foundation, National Institute for Cancer Research IST, Largo R Benzi 10, 16132 Genoa, Italy
    Cancer Lett 256:56-63. 2007
  10. ncbi request reprint Genetic predisposition to familial neuroblastoma: identification of two novel genomic regions at 2p and 12p
    Luca Longo
    Unit of Translational Pediatric Oncology, National Institute for Cancer Research IST, Genoa, Italy
    Hum Hered 63:205-11. 2007

Collaborators

Detail Information

Publications27

  1. pmc Multiple endocrine neoplasias type 2B and RET proto-oncogene
    Giuseppe Martucciello
    University of Genova, DIPE, Via Gaslini, 5 Genova 16147, Italy
    Ital J Pediatr 38:9. 2012
    ..Recent advances into the mechanisms of RET proto-oncogene signaling and pathways of RET signal transduction in the development of MEN 2 and MTC will allow new treatment possibilities...
  2. pmc Epigenetic Silencing of DKK3 in Medulloblastoma
    Francesca Valdora
    Department of Experimental Medicine DIMES, University of Genoa IRCCS A O U San Martino IST National Cancer Research Institute, Genoa 16132, Italy
    Int J Mol Sci 14:7492-505. 2013
    ..In conclusion, DKK3 downregulation across all MB subgroups may be due to epigenetic mechanisms, in particular, through chromatin condensation...
  3. doi request reprint Towards a turning point of neuroblastoma therapy
    Gian Paolo Tonini
    Italian Neuroblastoma Foundation, IRCCS A O U San Martino IST, National Cancer Research Institute, Genoa, Italy
    Cancer Lett 326:128-34. 2012
    ..The huge amount of clinical and biological information collected in the last 20 years suggests that it is time to turn on for new and more personalized therapies of neuroblastoma...
  4. pmc High genomic instability predicts survival in metastatic high-risk neuroblastoma
    Sara Stigliani
    Center of Physiopathology of Human Reproduction, Department of Obstetrics and Gynecology, IRCCS San Martino Hospital, National Cancer Research Institute IST, Genoa, Italy
    Neoplasia 14:823-32. 2012
    ..Further validation studies are warranted to establish this as a risk stratification for patients...
  5. doi request reprint Bone marrow of neuroblastoma patients shows downregulation of CXCL12 expression and presence of IFN signature
    Paola Scaruffi
    Translational Oncopathology, National Cancer Research Institute, Genoa, Italy
    Pediatr Blood Cancer 59:44-51. 2012
    ..Since the mechanisms responsible for BM invasion are not well known, we investigated the transcriptome of resident BM cells from NB patients as compared to healthy children...
  6. pmc Transcribed-Ultra Conserved Region expression is associated with outcome in high-risk neuroblastoma
    Paola Scaruffi
    Translational Paediatric Oncology, National Cancer Research Institute IST, Genoa, Italy
    BMC Cancer 9:441. 2009
    ..Hereby, we evaluated the potential of non-coding RNA expression to predict outcome in high-risk, stage 4 neuroblastoma...
  7. doi request reprint Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory
    Domenico Albino
    Laboratory of Italian Neuroblastoma Foundation, National Cancer Research Institute, Genoa, Italy
    Cancer 113:1412-22. 2008
    ..NT gene expression profiles reported so far have not taken into account the cellular components. The authors reported the genome-wide expression analysis of whole tumors and microdissected Nb and SS cells...
  8. doi request reprint Age-dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma
    Simona Coco
    Department of Advanced Diagnostic Technologies IRCCS AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Int J Cancer 131:1591-600. 2012
    ..The higher DNA instability observed in G3/MYCN- NBs than in MYCN-amplified G3 may also explain why patients ≥ 19 months have a poor outcome independently by MYCN status...
  9. ncbi request reprint Concomitant DDX1 and MYCN gain in neuroblastoma
    Raffaella Defferrari
    Laboratory of Neuroblastoma Research, Italian Neuroblastoma Foundation, National Institute for Cancer Research IST, Largo R Benzi 10, 16132 Genoa, Italy
    Cancer Lett 256:56-63. 2007
    ..Moreover, all patients with DDX1/MYCN gain show a good overall survival but a high frequency of adverse events...
  10. ncbi request reprint Genetic predisposition to familial neuroblastoma: identification of two novel genomic regions at 2p and 12p
    Luca Longo
    Unit of Translational Pediatric Oncology, National Institute for Cancer Research IST, Genoa, Italy
    Hum Hered 63:205-11. 2007
    ..We screened a highly informative family with recurrent NB by genome-wide linkage analysis aimed at identifying chromosomal regions for NB predisposing genes...
  11. pmc Bone marrow-infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins
    Fabio Morandi
    Laboratory of Oncology, Gaslini Institute, Genoa, Italy
    PLoS ONE 7:e29922. 2012
    ....
  12. doi request reprint Identification of ALK germline mutation (3605delG) in pediatric anaplastic medulloblastoma
    Simona Coco
    Translational Oncopathology, Department of Pathology, IRCCS A O U San Martino IST, National Cancer Research Institute, Genoa, Italy
    J Hum Genet 57:682-4. 2012
    ..Moreover, a deletion of ALK gene producing a stop codon has not been detected in human tumors up to now. Further investigations are now required to elucidate whether the truncated form of ALK may have a role in signal transduction...
  13. doi request reprint MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma
    Chiara Perfumo
    Molecular Mutagenesis and DNA Repair Unit, National Cancer Research Institute, Genoa, Italy
    Pediatr Blood Cancer 53:576-83. 2009
    ..We investigated its impact on NB development and survival in relation with major clinical and biological characteristics...
  14. doi request reprint Role of CXCL13-CXCR5 crosstalk between malignant neuroblastoma cells and Schwannian stromal cells in neuroblastic tumors
    Federica Del Grosso
    Translational Oncopathology, National Cancer Research Institute, L go R Benzi, 10 16132, Genoa, Italy
    Mol Cancer Res 9:815-23. 2011
    ....
  15. doi request reprint Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma
    Stefania Sorrentino
    Department of Haematology Oncology, Giannina Gaslini Children s Hospital, National Cancer Research Institute, Genova, Italy
    J Pediatr Hematol Oncol 34:154-8. 2012
    ..TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI...
  16. doi request reprint Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration
    Domenico Albino
    Laboratory of Italian Neuroblastoma Foundation, Genoa, Italy
    Int J Dev Biol 55:65-72. 2011
    ..Our model of enriched murine NCCs and neural crest-derived cells can be used to elucidate the key roles of genes during normal embryonic development and in cancer pathogenesis...
  17. pmc Transcribed-ultra conserved region expression profiling from low-input total RNA
    Paola Scaruffi
    Translational Paediatric Oncology, National Cancer Research Institute IST, Largo R Benzi 10, Genoa, 16132, Italy
    BMC Genomics 11:149. 2010
    ..The recent findings that they are significantly altered in adult chronic lymphocytic leukemias, carcinomas, and pediatric neuroblastomas lead to the hypothesis that UCRs may play a role in tumorigenesis...
  18. doi request reprint Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma
    Simona Coco
    Translational Oncopathology, National Cancer Research Institute IST, Genoa, Italy
    OMICS 15:273-80. 2011
    ..97; p < 0.006) or 16q loss (HR = 2.41; p = 0.038). Our results highlight the importance of genomic studies in different MB histological variants and indicate a genotype-phenotype correlation...
  19. doi request reprint Multiple target molecular monitoring of bone marrow and peripheral blood samples from patients with localized neuroblastoma and healthy donors
    Maria Valeria Corrias
    Laboratory of Oncology, Gaslini Institute, Genoa, Italy
    Pediatr Blood Cancer 58:43-9. 2012
    ..However, multiple target analysis is costly and time consuming, thus improvement with respect to single target monitoring needs to be achieved...
  20. ncbi request reprint Oligogenic inheritance in neuroblastoma
    Luca Longo
    Paediatric Translational Oncology, National Institute for Cancer Research IST, Genoa, Italy
    Cancer Lett 228:65-9. 2005
    ..Instead, an oligogenic mode of inheritance might explain the existence of different NB loci genetically interacting to cause and/or modify the disease-phenotype...
  21. doi request reprint Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma
    Annalisa Pezzolo
    Department of Experimental and Laboratory Medicine, IRCCS G Gaslini Hospital, Genoa, Italy
    Cancer Lett 308:215-24. 2011
    ..12cM at 10q26.1-q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1-q26.3 loss plus 17q24.3-q25.3 gain and/or 7q34-q36.3 gain associations...
  22. pmc Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines
    Federica Del Grosso
    Translational Oncopathology, IRCSS A O U San Martino IST, National Cancer Research Institute, L go R Benzi 10, 16132 Genoa, Italy
    BMC Cancer 11:525. 2011
    ..We hypothesized that ALK function may depend on N-linked glycosylation and that disruption of this post-translational modification would impair ALK activation, regardless the presence of either gene mutations or overexpression...
  23. ncbi request reprint Application of microarray-based technology to neuroblastoma
    Paola Scaruffi
    Unit of Translational Paediatric Oncology, National Institute for Cancer Research IST, Genoa, Italy
    Cancer Lett 228:13-20. 2005
    ..This review summarizes the current status of the application of microarray technology to neuroblastoma research...
  24. pmc Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue
    Patrizio Castagnola
    Department of Diagnostic Oncology, Translational Oncopathology, National Institute for Cancer Research, Genoa, Italy
    BMC Cancer 11:445. 2011
    ..Here, we report a pilot study that compared the occurrence of DNA aneuploidy and chromosomal copy number aberrations (CNAs) in the OPMLs from different oral anatomical subsites...
  25. ncbi request reprint Glutathione S-transferase polymorphisms and susceptibility to neuroblastoma
    Marina Lanciotti
    Department of Pediatric Hemato Oncology, National Institute Cancer Research IST, Genoa, Italy
    Pharmacogenet Genomics 15:423-6. 2005
    ..Our data do not support an important effect of GSTs genotype on neuroblastoma susceptibility...
  26. ncbi request reprint Detection of MYCN amplification and chromosome 1p36 loss in neuroblastoma by cDNA microarray comparative genomic hybridization
    Paola Scaruffi
    Laboratory of Neuroblastoma, National Cancer Research Institute IST, Genoa, Italy
    Mol Diagn 8:93-100. 2004
    ..We have developed a microarray-based comparative genomic hybridization (CGH) approach to identify MYCN gene amplification and 1p36 chromosome loss, two markers of tumor aggressiveness in neuroblastoma...
  27. ncbi request reprint Linkage analysis in families with recurrent neuroblastoma
    Patrizia Perri
    Laboratory of Neuroblastoma Research, Advanced Biotechnology Center, Genoa, Italy
    Ann N Y Acad Sci 963:74-84. 2002
    ..Our findings indicate that the candidate chromosomal regions and genes analyzed are not in linkage with neuroblastoma...