Biological approaches to the development of novel periodontal therapies--consensus of the Seventh European Workshop on PeriodontologyMaurizio S Tonetti
European Research Group on Periodontology, Genova, Italy
J Clin Periodontol 38:114-8. 2011
..The objective of this session was to assess if and how, current understanding of periodontitis provides the opportunity to develop new preventive and therapeutic strategies...
- Clinical research in implant dentistry: study design, reporting and outcome measurements: consensus report of Working Group 2 of the VIII European Workshop on Periodontology
Maurizio Tonetti
European Research Group on Periodontology, Genova, Italy
J Clin Periodontol 39:73-80. 2012
..The objective of this working group was to assess and make specific recommendations to improve the quality of reporting of clinical research in implant dentistry and discuss ways to reach a consensus on choice of outcomes...
- Effects of a single topical doxycycline administration adjunctive to mechanical debridement in patients with persistent/recurrent periodontitis but acceptable oral hygiene during supportive periodontal therapy
Maurizio S Tonetti
European Research Group on Periodontology, Genova, Italy
J Clin Periodontol 39:475-82. 2012
..To evaluate the efficacy of a slow release doxycycline gel (SRD) adjunctively administered to non-surgical therapy in subjects with recurrent or persistent periodontitis but acceptable oral hygiene during supportive periodontal care...
Treatment of periodontitis and endothelial functionMaurizio S Tonetti
Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, USA
N Engl J Med 356:911-20. 2007
..Systemic inflammation may impair vascular function, and epidemiologic data suggest a possible link between periodontitis and cardiovascular disease...
- Advances in bone augmentation to enable dental implant placement: Consensus Report of the Sixth European Workshop on Periodontology
Maurizio S Tonetti
European Research Group on Periodontology, Berne, Switzerland
J Clin Periodontol 35:168-72. 2008
..Bone augmentation procedures to enable dental implant placement are frequently performed in practice...
- Periodontitis and risk for atherosclerosis: an update on intervention trials
Maurizio S Tonetti
European Research Group on Periodontology ERGOPERIO, Berne, Switzerland
J Clin Periodontol 36:15-9. 2009
..Intervention trials are critical to explore the relationship. If the association were causal, successful periodontal therapy will lead to an attenuation of the effect - CVD...
- Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT)
Niklaus P Lang
Department of Periodontology and Fixed Prosthodontics, University of Berne, School of Dental Medicine, Berne, Switzerland
Oral Health Prev Dent 1:7-16. 2003
..A functional diagram may help the clinician in determining the risk for disease progression on the subject level. This may be useful in customizing the frequency and content of SPT visits...
- Periodontal regeneration versus extraction and prosthetic replacement of teeth severely compromised by attachment loss to the apex: 5-year results of an ongoing randomized clinical trial
Pierpaolo Cortellini
Accademia Toscana di Ricerca Odontostomatologia ATRO, Florence, Italy European Research Group on Periodontology ERGOPerio, Genova, Italy
J Clin Periodontol 38:915-24. 2011
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- Microbial colonization patterns predict the outcomes of surgical treatment of intrabony defects
Lisa Heitz-Mayfield
Department of Periodontology and Fixed Prosthodontics, University of Berne, Berne, Switzerland
J Clin Periodontol 33:62-8. 2006
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- Seventh European workshop on periodontology of the European academy of periodontology at the parador at la granja, segovia, Spain
Mariano Sanz
Faculty of Odontology, Universidad Complutense of Madrid, Madrid, Spain Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR China The School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA Faculty of Odontology, The Sahsgrenska Academy at Goteborg University, Goteborg, Sweden School of Dentistry, University of Birmingham, Birmingham, UK European Research Group on Periodontology ERGOPerio, Berne, Switzerland
J Clin Periodontol 38:1-2. 2011
..Seventh European Workshop on Periodontology of the European Academy of Periodontology at the Parador at La Granja, Segovia, Spain. J Clin Periodontol 2011; 38 (Suppl. 11): 1-2. doi: 10.1111/j.1600-051X.2010.01692.x...
- Periodontal disease and C-reactive protein-associated cardiovascular risk
Derren Ready
Department of Periodontology, Eastman Dental Institute and Hospital, 256 Gray's Inn Road, University College London, London WC1X 8LD, UK
J Periodontal Res 39:236-41. 2004
..Given the high prevalence of periodontitis in the population, these data would caution physicians to be aware of the possible oral source of an increased inflammatory burden...
- Acute effects of periodontal therapy on bio-markers of vascular health
M Parkar
Periodontology Unit, UCL Eastman Dental Institute, London, UK
J Clin Periodontol 34:124-9. 2007
..We aimed to study the impact of periodontal therapy on several bio-markers related to vascular health...
- Interleukin-6 polymorphisms are associated with pathogenic bacteria in subjects with periodontitis
Luigi Nibali
Eastman Dental Hospital, University College London, London, UK
J Periodontol 79:677-83. 2008
..The aim of this study was to investigate the association between IL-6 polymorphisms and periodontopathogenic bacteria in a larger, ethnically mixed population of subjects with periodontitis...
- Effects of two different methods of non-surgical periodontal therapy on patient perception of pain and quality of life: a randomized controlled clinical trial
Madeleine Aslund
Periodontology Unit, Division of Restorative Dentistry, Eastman Dental Institute and Hospital, University College London, 256 Gray s Inn Road, London, U K
J Periodontol 79:1031-40. 2008
..The purpose of this study was to investigate the effect of two modes of delivery of non-surgical periodontal therapy on patient experience of pain and oral health-related quality of life (OHQoL)...
- Relative contribution of patient-, tooth-, and site-associated variability on the clinical outcomes of subgingival debridement. I. Probing depths
Derren Ready
Department of Periodontology and Eastman Clinical Investigation Center, Eastman Dental Institute and Hospital, University College London, UK
J Periodontol 76:398-405. 2005
..CONCLUSION: These data provided an estimation of the relative contribution of site-, tooth-, and patient-associated variables in terms of PD reductions following a standard course of machine-driven subgingival debridement...
- Periodontitis and atherogenesis: causal association or simple coincidence?
Francesco D'Aiuto
Department of Periodontology, Eastman Dental Institute and Hospital, University College London, UK
J Clin Periodontol 31:402-11. 2004
..The potential impact of specific polymorphisms in cytokine genes known to influence both periodontitis and cardiovascular diseases was also examined...
- Systematic review of implant outcomes in treated periodontitis subjects
Constantine T T Ong
Unit of Periodontology and International Centre for Evidence Based Oral Health, UCL Eastman Dental Institute, London, UK
J Clin Periodontol 35:438-62. 2008
..To determine implant outcomes in partially dentate patients who have been treated for periodontitis compared with periodontally healthy patients...
- Vitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis
Luigi Nibali
Department of Periodontology, Eastman Dental Institute and Hospital, University College London UCL, London, UK
J Clin Periodontol 35:561-7. 2008
..The aim of this analysis was to investigate the relationship between a vitamin D receptor (VDR) polymorphism and the diagnosis and progression of periodontitis...
- Association between interleukin-6 promoter haplotypes and aggressive periodontitis
Luigi Nibali
Periodontology Unit, University College London, London, UK
J Clin Periodontol 35:193-8. 2008
..Interleukin-6 (IL-6) polymorphisms have been shown to affect IL-6 promoter activity. This study investigated the possible role of IL-6 genetic polymorphisms and haplotypes in the predisposition to aggressive periodontitis (AgP)...
- Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control study
Luigi Nibali
Periodontology Unit, Eastman Dental Institute and Hospital, University College London, London, UK
J Clin Periodontol 34:931-7. 2007
..The aim of this study was to investigate the association between severe periodontitis and increase in inflammatory and metabolic risk factors for cardiovascular disease...
- Chlorhexidine with an anti discoloration system after periodontal flap surgery: a cross-over, randomized, triple-blind clinical trial
Pierpaolo Cortellini
Accademia Toscana di Ricerca Odontostomatologica ATRO, Florence, Italy
J Clin Periodontol 35:614-20. 2008
..2% CHX mouthwash containing an anti discoloration system (ADS) compared with a 0.2% CHX alone, after periodontal flap surgery...
- Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study
Adrian Guerrero
Graduate Comprehensive Dentistry, University of Barcelona, Spain
J Clin Periodontol 34:897-902. 2007
..The objective of this study was to explore the effect of incomplete adherence to the prescribed antibiotic regimen, amoxicillin and metronidazole, in the non-surgical treatment of generalized aggressive periodontitis (GAP)...
- Long-term effects of supportive therapy in periodontal patients treated with fibre retention osseous resective surgery. I: recurrence of pockets, bleeding on probing and tooth loss
Gianfranco Carnevale
J Clin Periodontol 34:334-41. 2007
..The aim of this study was to evaluate the long-term effect of supportive therapy in periodontal patients treated with fibre retention osseous resective surgery...
- Severe periodontitis in Marfan's syndrome: a case report
Antje M Straub
Department of Periodontology, Eastman Dental Institute, University College, London, UK
J Periodontol 73:823-6. 2002
..It supports the hypothesis that a variety of connective tissue disorders may confer increased susceptibility to periodontal tissue breakdown...
- IL-1 gene polymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population
Andreas Feloutzis
Department of Periodontology, University of Berne, Switzerland
Clin Oral Implants Res 14:10-7. 2003
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- The future of periodontology: new treatments for a new era
Maurizio S Tonetti
Department of Periodontology, Eastman Dental Institute, University College London, UK
J Int Acad Periodontol 4:110-4. 2002
..Novel treatment strategies and therapeutics. Choice between multiple therapeutic modalities. The purpose of this manuscript is to critically discuss changes in understanding and to provide a rationale to change daily practice...
- Treatment of intrabony defects with enamel matrix proteins or barrier membranes: results from a multicenter practice-based clinical trial
Mariano Sanz
Department of Periodontology, University Complutense, Madrid, Spain
J Periodontol 75:726-33. 2004
..This prospective multicenter, randomized, controlled clinical trial compared the clinical outcomes of enamel matrix proteins (EMD) versus placement of a bioabsorbable membrane in conjunction with guided tissue regeneration (GTR)...
- Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial
Maurizio S Tonetti
Department of Periodontology, Eastman Dental Institute, University College London, London, UK
J Clin Periodontol 31:770-6. 2004
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- Influence of interleukin-1 gene polymorphism on the outcome of supportive periodontal therapy explored by a multi-factorial periodontal risk assessment model (PRA)
G Rutger Persson
School of Dental Medicine, University of Berne, Switzerland
Oral Health Prev Dent 1:17-27. 2003
..CONCLUSION: The PRA allowed the assessment of the outcomes of SPT therapy. Subjects with positive IP did not respond to individualized SPT as favorably as did IP negative subjects...
- C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus
Francesco D'Aiuto
Department of Periodontology and Eastman Clinical Investigation Center, Eastman Dental Institute and Hospital, 256 Gray s Inn Road, University College London UCL, London WC1X 8LD, UK
Atherosclerosis 179:413-7. 2005
..00 mg/L). This effect was independent of conventional cardiovascular risk factors and inflammatory factors known to affect CRP concentrations. CRP genotype may need to be considered when CRP values are used in coronary risk prediction...
- Contribution of periodontal therapy on individual cardiovascular risk assessment
Maurizio S Tonetti
Arch Intern Med 165:1920-1. 2005
- Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial
Adrian Guerrero
Department of Periodontology and Eastman Clinical Investigation Centre, Eastman Dental Institute and Hospital, University College London, London, UK
J Clin Periodontol 32:1096-107. 2005
..CONCLUSIONS: These data indicate that a 7-day adjunctive course of systemic metronidazole and amoxicillin significantly improved the short-term clinical outcomes of full-mouth non-surgical periodontal debridement in subjects with GAP...
- Guided tissue regeneration/deproteinized bovine bone mineral or papilla preservation flaps alone for treatment of intrabony defects. II: radiographic predictors and outcomes
Antonio Linares
Periodontology Unit, School of Dentistry, University of Santiago de Compostela, Santiago, Spain
J Clin Periodontol 33:351-8. 2006
..The specific aims of this report are (1) to analyse the radiographic bone changes 1 year after therapy and (2) to assess the association between radiographic defect angle and treatment outcomes...
- Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial
Mohamed Parkar
Department of Periodontology, Eastman Clinical Investigation Centre, University College London, London, United Kingdom
Am Heart J 151:977-84. 2006
..CONCLUSIONS: Our findings suggest that intensive periodontal treatment reduces systemic inflammatory markers and systolic BP, and improves lipid profiles with subsequent changes in cardiovascular risk when compared to standard therapy...
- Long-term effects of supportive therapy in periodontal patients treated with fibre retention osseous resective surgery. II: tooth extractions during active and supportive therapy
Gianfranco Carnevale
J Clin Periodontol 34:342-8. 2007
..The aim of this retrospective study was to describe the prevalence and reasons of tooth extraction during active periodontal therapy (APT) and supportive periodontal care (SPC) in periodontal patients...
- Enamel matrix proteins in the regenerative therapy of deep intrabony defects
Maurizio S Tonetti
Department of Periodontology, Eastman Dental Institute, University College London, UK
J Clin Periodontol 29:317-25. 2002
..This prospective multicentre randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of enamel matrix proteins (EMD)...
