Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cellsLydia W T Cheung
Department of Zoology, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
Endocrinology 147:4179-91. 2006
..This study is the first to demonstrate a role of PEDF in OSE biology and ovarian cancer and suggests that the loss of PEDF may e of relevance in carcinogenesis...
Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebratesXuming Xu
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
BMC Genomics 7:248. 2006
..Defining the molecular phylogeny of PEDF by bioinformatic analysis is one approach to understanding the link between its gene structure and its function in these biological processes...
- PEDF in angiogenic eye diseases
J Tombran-Tink
Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Curr Mol Med 10:267-78. 2010
..Its control of a neuroprotective and an antineovascular regulatory axis that determines cell fate, and its possible use in combination therapeutic strategies for ocular neovascular diseases are also reviewed...
- The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling
Joyce Tombran-Tink
Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
Front Biosci 10:2131-49. 2005
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- Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling
Joyce Tombran-Tink
University of Missouri-Kansas City, Pharmaceutical Sciences, Kansas City, MO 64110, USA
Adv Exp Med Biol 533:315-26. 2003
- Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells
J Tombran-Tink
Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO, USA
Exp Eye Res 78:945-55. 2004
..It will be an interesting therapeutic strategy to co-administer PEDF and retinoic acid in developing protocols for neovascular diseases in the eye and in cancer...
- Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone
J Tombran-Tink
Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
Biochem Biophys Res Commun 316:573-9. 2004
..The proangiogenic factors, VEGF and its receptors VEGF-R1 and VEGF-R2, are also expressed by both osteoblasts and osteoclasts. These findings suggest that bone angiogenesis and matrix remodeling may be mediated both by PEDF and by VEGF...
- PEDF: a multifaceted neurotrophic factor
Joyce Tombran-Tink
Division of Pharmaceutical Sciences, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110, USA
Nat Rev Neurosci 4:628-36. 2003
- Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor
Joyce Tombran-Tink
Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
Trends Mol Med 9:244-50. 2003
..The production of PEDF by many tissues suggests its therapeutic potential should be explored in a much wider range of diseases, including tumor proliferation and metastasis...
- PEDF and the serpins: phylogeny, sequence conservation, and functional domains
Joyce Tombran-Tink
Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
J Struct Biol 151:130-50. 2005
..Our results suggest that secretion is required for PEDF's activity, that PEDF can migrate to the nucleus, and that PEDF has structural and functional features more common with inhibitory serpins...
- Expression of angiogenesis factors in human umbilical vein endothelial cells and their regulation by PEDF
S Aparicio
Pharmaceutical Sciences, University of Missouri Kansas City, USA
Biochem Biophys Res Commun 326:387-94. 2005
..PEDF may also modulate vascular leakage by maintaining the transcriptional levels of the vascular homeostasis factors, VEGF-C and VEGF-R3 in hypoxic conditions...
- Regulation of factors controlling angiogenesis in liver development: a role for PEDF in the formation and maintenance of normal vasculature
S Sawant
Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO, USA
Biochem Biophys Res Commun 325:408-13. 2004
..The VEGF isoforms 121 and 189 may be key regulators of increased vascularity and progression of hepatocellular carcinoma, one of the most common malignant tumors, and may be of prognostic significance for this tumor...
- Space shuttle flight environment induces degeneration in the retina of rat neonates
J Tombran-Tink
Pharmaceutical Sciences, UMKC, Kansas City, MO, USA
Gravit Space Biol Bull 18:97-8. 2005
- Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential
Colin J Barnstable
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
Prog Retin Eye Res 23:561-77. 2004
..Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye...
Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cellsYuan He
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
Invest Ophthalmol Vis Sci 49:4912-22. 2008
..This study was conducted to examine intracellular Ca(2+) levels and mitochondrial vulnerability to Ca(2+) stress in trabecular meshwork (TM) of individuals with primary open-angle glaucoma (POAG)...
- Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors
Kar Wah Leung
Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Invest Ophthalmol Vis Sci 49:1221-31. 2008
..The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined...
- Expression of pigment-epithelium-derived factor during kidney development and aging
Ana Luisa Pina
Department of Neurosurgery, University Clinic of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
Cell Tissue Res 329:329-38. 2007
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- Molecular mechanisms of neuroprotection in the eye
Colin J Barnstable
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
Adv Exp Med Biol 572:291-5. 2006
- Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes
Helen Hutchings
GDR CNRS 1927-Angiogenese and Institut de Pharmacologie et Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, Toulouse cedex 31077, France
Biochem Biophys Res Commun 294:764-9. 2002
..However, in endothelial cells cultured with VEGF, PEDF has a synergistic action on cell proliferation with VEGF, and this corresponds to increased MAPK activation...
- PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases
Leiling Chen
Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA
Biochem Biophys Res Commun 348:1288-95. 2006
..Based on these findings, we propose that the antiangiogenic action of PEDF is dependent on activation of p38 MAPkinase which regulates cleavage of multiple caspases cascades...
- A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres
Hong Li
Department of Ophthalmology, Yale University School of Medicine, New Haven, CT, USA
Exp Eye Res 83:824-33. 2006
..PLGA-PEDF(82-121) offers greater protection to the retina suggesting that this peptide and the method of delivering therapeutically active drugs have potential clinical advantages for longer-term treatments of retinal diseases...
- Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles
Jignesh I Patel
Institute of Ophthalmology, London, UK
Exp Eye Res 82:798-806. 2006
..The structural and molecular differences between the two OCT macular profiles may explain the varying response to PPV in patients with diffuse CSMO...
- Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization
Nahoko Ogata
Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
Invest Ophthalmol Vis Sci 43:1168-75. 2002
..In this study, the expression of PEDF was investigated in normal rat eyes and in eyes with experimentally induced choroidal neovascularization and compared with the expression of vascular endothelial growth factor (VEGF)...
- Space flight environment induces degeneration in the retina of rat neonates
Joyce Tombran-Tink
Joyce Tombran-Tink, Division of Pharmaceutical Sciences, UMKC, Kansas City, MO 64110, USA
Adv Exp Med Biol 572:417-24. 2006
