J Tombran-Tink

Summary

Publications

  1. ncbi request reprint Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells
    Lydia W T Cheung
    Department of Zoology, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
    Endocrinology 147:4179-91. 2006
  2. pmc Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates
    Xuming Xu
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Genomics 7:248. 2006
  3. ncbi request reprint PEDF in angiogenic eye diseases
    J Tombran-Tink
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Curr Mol Med 10:267-78. 2010
  4. ncbi request reprint The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
    Front Biosci 10:2131-49. 2005
  5. ncbi request reprint Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling
    Joyce Tombran-Tink
    University of Missouri Kansas City, Pharmaceutical Sciences, Kansas City, MO 64110, USA
    Adv Exp Med Biol 533:315-26. 2003
  6. ncbi request reprint Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells
    J Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO, USA
    Exp Eye Res 78:945-55. 2004
  7. ncbi request reprint Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone
    J Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
    Biochem Biophys Res Commun 316:573-9. 2004
  8. ncbi request reprint PEDF: a multifaceted neurotrophic factor
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110, USA
    Nat Rev Neurosci 4:628-36. 2003
  9. ncbi request reprint Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
    Trends Mol Med 9:244-50. 2003
  10. ncbi request reprint PEDF and the serpins: phylogeny, sequence conservation, and functional domains
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    J Struct Biol 151:130-50. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells
    Lydia W T Cheung
    Department of Zoology, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
    Endocrinology 147:4179-91. 2006
    ..This study is the first to demonstrate a role of PEDF in OSE biology and ovarian cancer and suggests that the loss of PEDF may e of relevance in carcinogenesis...
  2. pmc Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates
    Xuming Xu
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Genomics 7:248. 2006
    ..Defining the molecular phylogeny of PEDF by bioinformatic analysis is one approach to understanding the link between its gene structure and its function in these biological processes...
  3. ncbi request reprint PEDF in angiogenic eye diseases
    J Tombran-Tink
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Curr Mol Med 10:267-78. 2010
    ..Its control of a neuroprotective and an antineovascular regulatory axis that determines cell fate, and its possible use in combination therapeutic strategies for ocular neovascular diseases are also reviewed...
  4. ncbi request reprint The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
    Front Biosci 10:2131-49. 2005
    ....
  5. ncbi request reprint Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling
    Joyce Tombran-Tink
    University of Missouri Kansas City, Pharmaceutical Sciences, Kansas City, MO 64110, USA
    Adv Exp Med Biol 533:315-26. 2003
  6. ncbi request reprint Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells
    J Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO, USA
    Exp Eye Res 78:945-55. 2004
    ..It will be an interesting therapeutic strategy to co-administer PEDF and retinoic acid in developing protocols for neovascular diseases in the eye and in cancer...
  7. ncbi request reprint Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone
    J Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
    Biochem Biophys Res Commun 316:573-9. 2004
    ..The proangiogenic factors, VEGF and its receptors VEGF-R1 and VEGF-R2, are also expressed by both osteoblasts and osteoclasts. These findings suggest that bone angiogenesis and matrix remodeling may be mediated both by PEDF and by VEGF...
  8. ncbi request reprint PEDF: a multifaceted neurotrophic factor
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110, USA
    Nat Rev Neurosci 4:628-36. 2003
  9. ncbi request reprint Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA
    Trends Mol Med 9:244-50. 2003
    ..The production of PEDF by many tissues suggests its therapeutic potential should be explored in a much wider range of diseases, including tumor proliferation and metastasis...
  10. ncbi request reprint PEDF and the serpins: phylogeny, sequence conservation, and functional domains
    Joyce Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    J Struct Biol 151:130-50. 2005
    ..Our results suggest that secretion is required for PEDF's activity, that PEDF can migrate to the nucleus, and that PEDF has structural and functional features more common with inhibitory serpins...
  11. ncbi request reprint Expression of angiogenesis factors in human umbilical vein endothelial cells and their regulation by PEDF
    S Aparicio
    Pharmaceutical Sciences, University of Missouri Kansas City, USA
    Biochem Biophys Res Commun 326:387-94. 2005
    ..PEDF may also modulate vascular leakage by maintaining the transcriptional levels of the vascular homeostasis factors, VEGF-C and VEGF-R3 in hypoxic conditions...
  12. ncbi request reprint Regulation of factors controlling angiogenesis in liver development: a role for PEDF in the formation and maintenance of normal vasculature
    S Sawant
    Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO, USA
    Biochem Biophys Res Commun 325:408-13. 2004
    ..The VEGF isoforms 121 and 189 may be key regulators of increased vascularity and progression of hepatocellular carcinoma, one of the most common malignant tumors, and may be of prognostic significance for this tumor...
  13. ncbi request reprint Space shuttle flight environment induces degeneration in the retina of rat neonates
    J Tombran-Tink
    Pharmaceutical Sciences, UMKC, Kansas City, MO, USA
    Gravit Space Biol Bull 18:97-8. 2005
  14. ncbi request reprint Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential
    Colin J Barnstable
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    Prog Retin Eye Res 23:561-77. 2004
    ..Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye...
  15. doi request reprint Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:4912-22. 2008
    ..This study was conducted to examine intracellular Ca(2+) levels and mitochondrial vulnerability to Ca(2+) stress in trabecular meshwork (TM) of individuals with primary open-angle glaucoma (POAG)...
  16. doi request reprint Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors
    Kar Wah Leung
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:1221-31. 2008
    ..The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined...
  17. ncbi request reprint Expression of pigment-epithelium-derived factor during kidney development and aging
    Ana Luisa Pina
    Department of Neurosurgery, University Clinic of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Cell Tissue Res 329:329-38. 2007
    ....
  18. ncbi request reprint Molecular mechanisms of neuroprotection in the eye
    Colin J Barnstable
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    Adv Exp Med Biol 572:291-5. 2006
  19. ncbi request reprint Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes
    Helen Hutchings
    GDR CNRS 1927 Angiogenese and Institut de Pharmacologie et Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, Toulouse cedex 31077, France
    Biochem Biophys Res Commun 294:764-9. 2002
    ..However, in endothelial cells cultured with VEGF, PEDF has a synergistic action on cell proliferation with VEGF, and this corresponds to increased MAPK activation...
  20. ncbi request reprint PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases
    Leiling Chen
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA
    Biochem Biophys Res Commun 348:1288-95. 2006
    ..Based on these findings, we propose that the antiangiogenic action of PEDF is dependent on activation of p38 MAPkinase which regulates cleavage of multiple caspases cascades...
  21. ncbi request reprint A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres
    Hong Li
    Department of Ophthalmology, Yale University School of Medicine, New Haven, CT, USA
    Exp Eye Res 83:824-33. 2006
    ..PLGA-PEDF(82-121) offers greater protection to the retina suggesting that this peptide and the method of delivering therapeutically active drugs have potential clinical advantages for longer-term treatments of retinal diseases...
  22. ncbi request reprint Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles
    Jignesh I Patel
    Institute of Ophthalmology, London, UK
    Exp Eye Res 82:798-806. 2006
    ..The structural and molecular differences between the two OCT macular profiles may explain the varying response to PPV in patients with diffuse CSMO...
  23. ncbi request reprint Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization
    Nahoko Ogata
    Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
    Invest Ophthalmol Vis Sci 43:1168-75. 2002
    ..In this study, the expression of PEDF was investigated in normal rat eyes and in eyes with experimentally induced choroidal neovascularization and compared with the expression of vascular endothelial growth factor (VEGF)...
  24. ncbi request reprint Space flight environment induces degeneration in the retina of rat neonates
    Joyce Tombran-Tink
    Joyce Tombran Tink, Division of Pharmaceutical Sciences, UMKC, Kansas City, MO 64110, USA
    Adv Exp Med Biol 572:417-24. 2006