Anna Maija Tolppanen

Summary

Publications

  1. doi request reprint Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia
    Anna Maija Tolppanen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland Electronic address
    Alzheimers Dement 11:434-443.e6. 2015
  2. pmc From prescriptions to drug use periods - things to notice
    Antti Tanskanen
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    BMC Res Notes 7:796. 2014
  3. doi request reprint Incident ischaemic heart disease in persons with Alzheimer's disease in a Finnish nationwide exposure-matched cohort
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland Electronic address
    Int J Cardiol 170:195-201. 2013
  4. doi request reprint Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 32:531-40. 2012
  5. pmc History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study
    Anna Maija Tolppanen
    Institute of Clinical Medicine, Neurology, University of Kuopio, Kuopio, Finland
    Diabetes Care 36:2015-9. 2013
  6. pmc Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e59124. 2013
  7. doi request reprint Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis
    Anna Maija Tolppanen
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Epidemiology 24:310-9. 2013
  8. doi request reprint Incidence of stroke in people with Alzheimer disease: a national register-based approach
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland
    Neurology 80:353-8. 2013
  9. pmc Association of serum 25-hydroxyvitamin D₃ and D₂ with academic performance in childhood: findings from a prospective birth cohort
    Anna Maija Tolppanen
    MRC Centre for Causal Analysis in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, 15 23 Oakfield Grove, Clifton, Bristol BS8 2BN, UK
    J Epidemiol Community Health 66:1137-42. 2012
  10. doi request reprint Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort
    Elisa Neuvonen
    From the Department of Neurology E N, M R, A s, H S, M K, A M T and Institute of Public Health and Clinical Nutrition T L, University of Eastern Finland, Kuopio Aging Research Center A S, M K, Karolinska Institutet and Stockholm University, Sweden Department of Chronic Disease Prevention T N, T L, National Institute for Health and Welfare, Helsinki, Finland Alzheimer Disease Research Center T N, Karolinska Institutet, Stockholm, Sweden Hospital District of North Karelia T L, Joensuu and Department of Neurology H S, Kuopio University Hospital, Finland
    Neurology 82:2205-12. 2014

Detail Information

Publications32

  1. doi request reprint Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia
    Anna Maija Tolppanen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland Electronic address
    Alzheimers Dement 11:434-443.e6. 2015
    ..Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics...
  2. pmc From prescriptions to drug use periods - things to notice
    Antti Tanskanen
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    BMC Res Notes 7:796. 2014
    ..g., studying concurrent use of different drugs or adverse drug events during current use. For those purposes, data on dispensed prescriptions needs to be transformed to periods of drug use...
  3. doi request reprint Incident ischaemic heart disease in persons with Alzheimer's disease in a Finnish nationwide exposure-matched cohort
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland Electronic address
    Int J Cardiol 170:195-201. 2013
    ..We assessed whether the incidence of ischaemic heart disease (IHD) and revascularisation procedures are different in persons with AD than in the matched population without AD...
  4. doi request reprint Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 32:531-40. 2012
    ..The vascular risk factors can directly increase the susceptibility to AD, or the effect can be mediated via cardio- and cerebrovascular diseases...
  5. pmc History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study
    Anna Maija Tolppanen
    Institute of Clinical Medicine, Neurology, University of Kuopio, Kuopio, Finland
    Diabetes Care 36:2015-9. 2013
    ..We investigated whether individuals with AD were more likely to have a history of diabetes than matched controls from the general aged population...
  6. pmc Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e59124. 2013
    ..Previous cohort studies have shown that persons with Alzheimer's disease (AD) have a higher risk of hip fractures but recent data from large representative cohorts is scarce...
  7. doi request reprint Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis
    Anna Maija Tolppanen
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Epidemiology 24:310-9. 2013
    ....
  8. doi request reprint Incidence of stroke in people with Alzheimer disease: a national register-based approach
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland
    Neurology 80:353-8. 2013
    ..We investigated whether noninstitutionalized persons with AD were more likely to experience incident stroke than persons without AD and whether there are differences in the incidence of ischemic or hemorrhagic strokes...
  9. pmc Association of serum 25-hydroxyvitamin D₃ and D₂ with academic performance in childhood: findings from a prospective birth cohort
    Anna Maija Tolppanen
    MRC Centre for Causal Analysis in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, 15 23 Oakfield Grove, Clifton, Bristol BS8 2BN, UK
    J Epidemiol Community Health 66:1137-42. 2012
    ..It is unknown if the associations of different forms of 25(OH)D (25(OH)D(3) and 25(OH)D(2)) are similar...
  10. doi request reprint Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort
    Elisa Neuvonen
    From the Department of Neurology E N, M R, A s, H S, M K, A M T and Institute of Public Health and Clinical Nutrition T L, University of Eastern Finland, Kuopio Aging Research Center A S, M K, Karolinska Institutet and Stockholm University, Sweden Department of Chronic Disease Prevention T N, T L, National Institute for Health and Welfare, Helsinki, Finland Alzheimer Disease Research Center T N, Karolinska Institutet, Stockholm, Sweden Hospital District of North Karelia T L, Joensuu and Department of Neurology H S, Kuopio University Hospital, Finland
    Neurology 82:2205-12. 2014
    ..We investigated the association between late-life cynical distrust and incident dementia and mortality (mean follow-up times of 8.4 and 10.4 years, respectively) in the Cardiovascular Risk Factors, Aging and Dementia Study...
  11. ncbi request reprint Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Obesity (Silver Spring) 15:1082-8. 2007
    ..191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men...
  12. doi request reprint The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Genet Med 10:536-44. 2008
    ..Our objective was to investigate the genetic associations of the single nucleotide polymorphisms of the TNMD gene with the serum levels of systemic immune mediators...
  13. pmc Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study
    Titta Salopuro
    University of Kuopio, Department of Clinical Nutrition and Food and Health Research Center, Kuopio, Finland
    BMC Med Genet 10:94. 2009
    ..2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group...
  14. doi request reprint Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurobiol Aging 32:546.e7-9. 2011
    ..47, p=0.019, false discovery rate 10.4%). According to these results the sequence variation of TNMD is not associated with AD, but might modify the effect of APOE ε4-allele in women...
  15. doi request reprint Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort
    Anna Maija Tolppanen
    Department of Neurology, University of Eastern Finland, P O Kuopio, Finland
    J Alzheimers Dis 38:201-9. 2014
    ..Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged...
  16. doi request reprint Risk factors for variation in 25-hydroxyvitamin D₃ and D₂ concentrations and vitamin D deficiency in children
    Anna Maija Tolppanen
    Medical Research Council, Centre for Causal Analysis in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, 15 23 Oakfield Grove, Clifton, Bristol BS8 2BN, United Kingdom
    J Clin Endocrinol Metab 97:1202-10. 2012
    ..Suboptimal vitamin D status is common and associated with adverse health outcomes...
  17. doi request reprint The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
    Tiina J Lappalainen
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 17:832-6. 2009
    ..Based on the results from the DPS, it is unlikely that the common variant of the FTO gene affects the success of lifestyle modification on weight loss...
  18. pmc The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood--a prospective cohort study
    Anna Maija Tolppanen
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, UK
    J Child Psychol Psychiatry 53:757-66. 2012
    ..Depression in adolescence is common and early onset predicts worse outcome in adulthood. Studies in adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations and lower risk of depression...
  19. doi request reprint Future directions in Alzheimer's disease from risk factors to prevention
    Bushra Imtiaz
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    Biochem Pharmacol 88:661-70. 2014
    ....
  20. doi request reprint Tenomodulin gene and obesity-related phenotypes
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Ann Med 42:265-75. 2010
    ..In this review, the potential mechanisms that could link TNMD with the pathogenesis of obesity and related disorders are discussed...
  21. doi request reprint The association of circulating 25-hydroxyvitamin D and calcium with cognitive performance in adolescents: cross-sectional study using data from the third National Health and Nutrition Examination Survey
    Anna Maija Tolppanen
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Paediatr Perinat Epidemiol 25:67-74. 2011
    ..A positive association of 25(OH)D with cognitive function was completely explained by confounding due to race/ethnicity...
  22. pmc The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood
    Anna Maija Tolppanen
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e40097. 2012
    ..Concentrations of 1,25-dihydroxyvitamin D(3) (the active vitamin D(3) metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans...
  23. pmc Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood
    Anna Maija Tolppanen
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e41575. 2012
    ....
  24. ncbi request reprint High prevalence of psychotropic drug use among persons with and without Alzheimer's disease in Finnish nationwide cohort
    Heidi Taipale
    Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland
    Eur Neuropsychopharmacol 24:1729-37. 2014
    ..Widespread utilization of psychotropic drugs was observed among persons with AD. Despite safety warnings of antipsychotic use for BPSD, antipsychotic use increased from 2005 to 2011 among newly diagnosed persons with AD in Finland...
  25. doi request reprint Antipsychotic polypharmacy among a nationwide sample of community-dwelling persons with Alzheimer's disease
    Heidi Taipale
    Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 41:1223-8. 2014
    ..Antipsychotic polypharmacy (APP) is not recommended in treatment of behavioral and psychological symptoms of dementia (BPSD). There is lack of studies concerning prevalence of APP among persons with dementia...
  26. pmc Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Mol Vis 15:762-70. 2009
    ..Associations of single nucleotide polymorphisms of TNMD with the prevalence of age-related macular degeneration (AMD) were examined...
  27. doi request reprint Oophorectomy, hysterectomy, and risk of Alzheimer's disease: a nationwide case-control study
    Bushra Imtiaz
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 42:575-81. 2014
    ..Association between oophorectomy and/or hysterectomy and dementia in context of hormone therapy (HT) use is ambiguous...
  28. pmc The association of serum ionized calcium and vitamin D with adult cognitive performance
    Anna Maija Tolppanen
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Epidemiology 22:113-7. 2011
    ..These associations have not been studied in younger adults. The possible association of vitamin D with cognitive function, independent of calcium, is unknown...
  29. doi request reprint Associations across spatial patterns of disease incidences, socio-demographics, and land use in Finland 1991-2010
    Ari Voutilainen
    Department of Nursing Science, University of Eastern Finland, Finland
    Scand J Public Health 43:356-63. 2015
    ..The methodological purpose was to compare and combine two statistical techniques to approach the data from different viewpoints...
  30. doi request reprint Antipsychotic doses among community-dwelling persons with Alzheimer disease in Finland
    Heidi Taipale
    From the Kuopio Research Centre of Geriatric Care and School of Pharmacy, University of Eastern Finland, Kuopio, Finland Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden and National Institute for Health and Welfare, Helsinki and Research Centre for Comparative Effectiveness and Patient Safety RECEPS and Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland
    J Clin Psychopharmacol 34:435-40. 2014
    ..Clinicians should regularly assess dosing levels especially among men and those with history of psychiatric disorder. ..
  31. pmc Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
    Ursula Mager
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2941. 2008
    ..Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR)...