Chen Hung Ting

Summary

Publications

  1. pmc Sodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy
    Huei Chun Liu
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    BMC Med 11:38. 2013
  2. pmc The spinal muscular atrophy disease protein SMN is linked to the Golgi network
    Chen Hung Ting
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    PLoS ONE 7:e51826. 2012
  3. doi request reprint Decreased stathmin expression ameliorates neuromuscular defects but fails to prolong survival in a mouse model of spinal muscular atrophy
    Hsin Lan Wen
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neurobiol Dis 52:94-103. 2013
  4. doi request reprint Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy
    Hsin Lan Wen
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Hum Mol Genet 19:1766-78. 2010
  5. doi request reprint Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy
    Li Kai Tsai
    Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Pediatr 154:303-5. 2009
  6. doi request reprint Multiple therapeutic effects of valproic acid in spinal muscular atrophy model mice
    Li Kai Tsai
    Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan
    J Mol Med (Berl) 86:1243-54. 2008

Collaborators

  • Li Kai Tsai
  • Hsin Lan Wen
  • Huei Chun Liu
  • Hung Li
  • Sue Lin-Chao
  • Hsiu Mei Hsieh-Li
  • Yuan Ta Lin

Detail Information

Publications6

  1. pmc Sodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy
    Huei Chun Liu
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    BMC Med 11:38. 2013
    ..We evaluated the therapeutic potential of sodium vanadate combined with a vanadium detoxification agent, L-ascorbic acid, in a SMA mouse model...
  2. pmc The spinal muscular atrophy disease protein SMN is linked to the Golgi network
    Chen Hung Ting
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    PLoS ONE 7:e51826. 2012
    ..In addition to the well-studied role of SMN in small nuclear ribonucleoprotein (SnRNP) assembly, this work links SMN granules with the Golgi network and thus sheds light on Golgi-mediated SMN granule transport...
  3. doi request reprint Decreased stathmin expression ameliorates neuromuscular defects but fails to prolong survival in a mouse model of spinal muscular atrophy
    Hsin Lan Wen
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neurobiol Dis 52:94-103. 2013
    ..This work demonstrates that limiting the amount of stathmin in SMA-like mice is effective in reducing their neuromuscular defects, whereas induced aberrant expression of stathmin in SMA-like animals is detrimental...
  4. doi request reprint Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy
    Hsin Lan Wen
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Hum Mol Genet 19:1766-78. 2010
    ..We conclude that aberrant stathmin levels may play a detrimental role in SMA; this finding suggests a novel approach to treating SMA by enhancing microtubule stability...
  5. doi request reprint Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy
    Li Kai Tsai
    Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Pediatr 154:303-5. 2009
    ..There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA...
  6. doi request reprint Multiple therapeutic effects of valproic acid in spinal muscular atrophy model mice
    Li Kai Tsai
    Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan
    J Mol Med (Berl) 86:1243-54. 2008
    ..Through these effects of elevation of SMN protein level, anti-apoptosis, and probable neuroprotection, VPA-treated SMA mice had less degeneration of spinal motor neurons and better motor function than untreated type III-like SMA mice...