James A Timmons

Summary

Publications

  1. ncbi request reprint Can we "switch" the emphasis please?
    James A Timmons
    J Appl Physiol 92:2221. 2002
  2. pmc Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
    Iain J Gallagher
    Translational Biomedicine, Heriot Watt University, Edinburgh, EH14 4AS, UK
    Genome Med 2:9. 2010
  3. pmc Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment
    Anna Karin Roos
    Department of Oncology and Pathology, Cancer Center Karolinska R8 01, Immune and Gene Therapy Laboratory, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e7226. 2009
  4. doi request reprint Using functional genomics to study PINK1 and metabolic physiology
    Camilla Scheele
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    Methods Enzymol 457:211-29. 2009
  5. pmc Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure
    Katarina Fredriksson
    Department of Anesthesiology and Intensive Care, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 3:e3686. 2008
  6. pmc Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
    Nathan A Stephens
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, EH16 4SB, UK
    Genome Med 2:1. 2010
  7. pmc Variability in training-induced skeletal muscle adaptation
    James A Timmons
    Royal Veterinary College, Univ of London, Camden NW1 0TU, United Kingdom
    J Appl Physiol 110:846-53. 2011
  8. pmc Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
    James A Timmons
    Panum Institutet and Center for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 108:1487-96. 2010
  9. pmc Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
    Pernille Keller
    Royal Veterinary College, University of London, UK
    BMC Endocr Disord 11:7. 2011
  10. doi request reprint High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression
    Peter K Davidsen
    The Royal Veterinary College, 4 Royal College St, Univ of London, London NW1 0TU, UK
    J Appl Physiol 110:309-17. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Can we "switch" the emphasis please?
    James A Timmons
    J Appl Physiol 92:2221. 2002
  2. pmc Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
    Iain J Gallagher
    Translational Biomedicine, Heriot Watt University, Edinburgh, EH14 4AS, UK
    Genome Med 2:9. 2010
    ..The relative importance and mode of action of miRNAs in human complex diseases remains to be fully elucidated. We produce a global map of coding and non-coding RNAs in human muscle IR with the aim of identifying novel disease biomarkers...
  3. pmc Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment
    Anna Karin Roos
    Department of Oncology and Pathology, Cancer Center Karolinska R8 01, Immune and Gene Therapy Laboratory, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e7226. 2009
    ..However, the mode of action at molecular level is not yet fully understood...
  4. doi request reprint Using functional genomics to study PINK1 and metabolic physiology
    Camilla Scheele
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    Methods Enzymol 457:211-29. 2009
    ..We apologize for not referring to all relevant publications and for any technical considerations we have also failed to factor into our discussion...
  5. pmc Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure
    Katarina Fredriksson
    Department of Anesthesiology and Intensive Care, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 3:e3686. 2008
    ..Here we use detailed phenotyping and genomics to elucidate mechanisms leading to these impairments and the molecular consequences...
  6. pmc Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
    Nathan A Stephens
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, EH16 4SB, UK
    Genome Med 2:1. 2010
    ..Our genomics analysis also supports the view that the available preclinical models do not accurately reflect the molecular characteristics of human muscle from cancer cachexia patients...
  7. pmc Variability in training-induced skeletal muscle adaptation
    James A Timmons
    Royal Veterinary College, Univ of London, Camden NW1 0TU, United Kingdom
    J Appl Physiol 110:846-53. 2011
    ..I will also comment on the idea that certain gene networks may be associated with muscle "adaptability" regardless the stimulus provided...
  8. pmc Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
    James A Timmons
    Panum Institutet and Center for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 108:1487-96. 2010
    ..The general approach taken could accelerate the discovery of genetic biomarkers, sufficiently discrete for diagnostic purposes, for a range of physiological and pharmacological phenotypes in humans...
  9. pmc Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
    Pernille Keller
    Royal Veterinary College, University of London, UK
    BMC Endocr Disord 11:7. 2011
    ..abstract:..
  10. doi request reprint High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression
    Peter K Davidsen
    The Royal Veterinary College, 4 Royal College St, Univ of London, London NW1 0TU, UK
    J Appl Physiol 110:309-17. 2011
    ..Our analysis indicates that miRNAs may play a role in the phenotypic change and pronounced intergroup variation in the RT response...
  11. ncbi request reprint Oligonucleotide microarray expression profiling: human skeletal muscle phenotype and aerobic exercise training
    James A Timmons
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    IUBMB Life 58:15-24. 2006
    ..Weaknesses in existing human studies are identified and future objectives are discussed...
  12. pmc Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans
    James A Timmons
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SE171 77, Sweden
    BMC Biol 3:19. 2005
    ....
  13. doi request reprint Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues
    Tomas B Walden
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 302:E19-31. 2012
    ..The significance of the gene expression patterns for classifying the depots and for understanding the developmental background of the depots is discussed, as are the possible regulatory functions of the genes...
  14. doi request reprint Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes
    Tomas B Walden
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    J Cell Physiol 218:444-9. 2009
    ....
  15. ncbi request reprint Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes
    James A Timmons
    Center for Genomics and Bioinformatics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Genomics 87:165-72. 2006
    ....
  16. pmc Considerations when using the significance analysis of microarrays (SAM) algorithm
    Ola Larsson
    Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius Väg, 35, 171 77 Stockholm, Sweden
    BMC Bioinformatics 6:129. 2005
    ..The impact of selection thresholds, on the output from SAM, may critically alter the conclusion of a study, yet this consideration has not been systematically evaluated in any publication...
  17. ncbi request reprint Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy
    James A Timmons
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    FASEB J 19:750-60. 2005
    ..Furthermore, our analysis demonstrates that numerous genes previously suggested as being important for the DMD disease phenotype may principally reflect compensatory integrin signaling...
  18. doi request reprint Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist
    Natasa Petrovic
    Wenner Gren Institute, Arrhenius Laboratories, Stockholm University, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 295:E287-96. 2008
    ..Thus the PPARgamma pathway represents an alternative, potent, and fully competent mechanism for BAT recruitment, which may be the cellular explanation for the enigmatic recruitment in prehibernation and prenatal states...
  19. pmc The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
    Camilla Scheele
    Department of Cellular and Molecular Biology, Program for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    BMC Genomics 8:74. 2007
    ..PINK1 is expressed abundantly in mitochondria rich tissues, such as skeletal muscle, where it plays a critical role determining mitochondrial structural integrity in Drosophila...
  20. ncbi request reprint Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?
    Camilla Scheele
    Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden
    FASEB J 21:3653-65. 2007
    ....
  21. pmc A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
    Pernille Keller
    Translational Biomedicine, Heriot Watt University, Edinburgh, UK
    J Appl Physiol 110:46-59. 2011
    ..This analysis provides a comprehensive map of the transcriptomic features important for aerobic exercise-induced improvements in maximal oxygen consumption...
  22. pmc Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal
    Valentina Gburcik
    Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK
    Am J Physiol Endocrinol Metab 304:E885-94. 2013
    ..In contrast, loss of neuronatin had no effect on insulin signaling. In conclusion, neuronatin appears to be a novel regulator of browning and metabolic substrate disposal in white adipocytes...
  23. doi request reprint Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
    Blandine Poulet
    Royal Veterinary College, University of London, London, UK
    Arthritis Rheum 64:3256-66. 2012
    ..Through global transcriptome profiling, we attempted to discover the molecular signature linked with both OA vulnerability and progression...
  24. ncbi request reprint Chasing the "ghost" of the acetyl group deficit
    James A Timmons
    Med Sci Sports Exerc 37:162; author reply 163. 2005
  25. pmc Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle
    Alan MacInnes
    Cardiovascular Research Department, Pfizer Global R and D, St Louis, MO 63017, USA
    BMC Physiol 5:11. 2005
    ..Muscle biopsies were obtained prior to and following the first and fourth contraction periods. Direct arterio-venous sampling allowed for the calculation of muscle metabolite efflux and oxygen consumption...
  26. ncbi request reprint Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle
    David J Baker
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Science, University of Nottingham, UK
    Diabetes 54:2453-9. 2005
    ..These data indicate that glycogen phosphorylase inhibition aimed at attenuating hyperglycaemia is unlikely to negatively impact muscle metabolic and functional capacity...
  27. ncbi request reprint The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction
    David J Baker
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Science, University of Nottingham, Nottingham, UK
    Diabetes 55:1855-61. 2006
    ..Alternatively, greater effort should be devoted toward the discovery of hepatic-selective GPi, hepatic-specific drug delivery strategies, and/or alternative strategies for controlling excess hepatic glucose production in type 2 diabetes...
  28. ncbi request reprint Chronic treatment with the beta(2)-adrenoceptor agonist prodrug BRL-47672 impairs rat skeletal muscle function by inducing a comprehensive shift to a faster muscle phenotype
    David J Baker
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Science, University of Nottingham, Nottingham, United Kingdom
    J Pharmacol Exp Ther 319:439-46. 2006
    ..05). We conclude that beta(2)-agonist induced muscle hypertrophy may be clinically limited as impaired energy metabolism and function occur, presumably as a consequence of the shift in muscle phenotype...
  29. pmc Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    James A Timmons
    Wenner Gren Institute, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:4401-6. 2007
    ....
  30. doi request reprint Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription
    James A Timmons
    J Appl Physiol 104:1250. 2008