Kulbhushan Tikoo

Summary

Publications

  1. doi request reprint Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160062, Punjab, India
    Toxicol Lett 177:90-6. 2008
  2. doi request reprint Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: potential role of tannins in cancer chemotherapy
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Mohali 160062, Punjab, India
    Toxicol Appl Pharmacol 251:191-200. 2011
  3. doi request reprint Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Free Radic Res 42:397-404. 2008
  4. pmc Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy
    K Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Br J Pharmacol 153:1225-31. 2008
  5. ncbi request reprint Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab 160 062, India
    FEBS Lett 581:2027-35. 2007
  6. doi request reprint 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
    Toxicol Lett 191:158-66. 2009
  7. ncbi request reprint Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    FEBS Lett 581:1071-8. 2007
  8. pmc Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab, India
    BMC Cancer 9:107. 2009
  9. doi request reprint Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells
    Jeena Gupta
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
    Biochimie 94:2656-64. 2012
  10. doi request reprint Involvement of insulin-induced reversible chromatin remodeling in altering the expression of oxidative stress-responsive genes under hyperglycemia in 3T3-L1 preadipocytes
    Jeena Gupta
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Punjab, India
    Gene 504:181-91. 2012

Collaborators

  • Terrence J Monks
  • Gopabandhu Jena
  • Sandeep Kumar
  • Jeena Gupta
  • Jasmine Kaur
  • Kiritkumar K Vekariya
  • Pinakin Arun Karpe
  • Gopal L Khatik
  • Chanchal Gupta
  • Anil Bhanudas Gaikwad
  • K Sonaje
  • G Sharma
  • Dhaval Sharad Bendale
  • Sonam Jain
  • Mahesh Rachamalla
  • Ronak S Patel
  • Vipin A Nair
  • Varun Kumar
  • Ujwal Mukund Mahajan
  • Vivek Madhukar Surse
  • Shrikant Ramesh Mulay
  • Anil B Gaikwad
  • Dhiraj G Kabra
  • Prakash Gopaldas Chandak
  • M N V Ravi Kumar
  • J L Italia
  • Jing Dong
  • Apoorva Kulkarni
  • Richa Chhabra
  • Sachin Prabhakarrao Shete
  • Heta Shah
  • R Krishna Murthy Karuturi
  • Namoju R Chary
  • Rickey F Marthong
  • Poduri Ramarao
  • Firdos Y Shera
  • Juntao Li
  • P Venugopalan
  • Preshit Ravindra Wagh
  • V Bhardwaj
  • Zhe Jia
  • Sampath Ramachandiran
  • Serrine S Lau

Detail Information

Publications33

  1. doi request reprint Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160062, Punjab, India
    Toxicol Lett 177:90-6. 2008
    ..Moreover, treatment of tannic acid also decreases MN count in peripheral blood, suggesting its anti-mutagenic effect. In light of these findings we suggest the potential role of tannic acid treatment in preventing AZT induced toxicity...
  2. doi request reprint Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: potential role of tannins in cancer chemotherapy
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Mohali 160062, Punjab, India
    Toxicol Appl Pharmacol 251:191-200. 2011
    ....
  3. doi request reprint Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Free Radic Res 42:397-404. 2008
    ..This is the first report which suggests that protection against development of diabetic nephropathy by resveratrol treatment involves change in phosphorylation of histone H3, expression of Sir-2, p53 and p38 in diabetic kidney...
  4. pmc Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy
    K Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Br J Pharmacol 153:1225-31. 2008
    ..The present study was undertaken to examine changes in histone modification by curcumin treatment which prevents development of type I diabetic nephropathy...
  5. ncbi request reprint Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab 160 062, India
    FEBS Lett 581:2027-35. 2007
    ..5mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin...
  6. doi request reprint 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
    Toxicol Lett 191:158-66. 2009
    ..Thus, combination of 5-azactydine with cisplatin attenuates the cisplatin induced nephrotoxicity and potentiates the anti-cancer activity which can have profound clinical implications...
  7. ncbi request reprint Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    FEBS Lett 581:1071-8. 2007
    ..These findings suggest that IF significantly improves biochemical parameters associated with development of DN and changes the expression of Sir2 and p53...
  8. pmc Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab, India
    BMC Cancer 9:107. 2009
    ..The present study was undertaken to assess the effect of rosiglitazone, a PPARgamma agonist and an anti-inflammatory agent, on cisplatin induced nephrotoxicity, and its anticancer activity in DMBA induced breast cancer rats...
  9. doi request reprint Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells
    Jeena Gupta
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
    Biochimie 94:2656-64. 2012
    ..To best of our knowledge this is the first report that shows regulation of chromatin remodelling genes by alteration in the occupancy of histone H3Ac/H3K4/K9me on both promoter and transcribed regions...
  10. doi request reprint Involvement of insulin-induced reversible chromatin remodeling in altering the expression of oxidative stress-responsive genes under hyperglycemia in 3T3-L1 preadipocytes
    Jeena Gupta
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Punjab, India
    Gene 504:181-91. 2012
    ..To the best of our knowledge this is the first report that shows the role of reversible histone modifications in regulating oxidative stress-responsive genes under hyperglycemic condition in 3T3-L1 preadipocytes...
  11. doi request reprint Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats
    Jeena Gupta
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Punjab, India
    J Cell Biochem 111:944-54. 2010
    ..To the best of our knowledge, this is the first report which shows the involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in the liver of type 2 diabetic rats and its association with diabetic nephropathy...
  12. doi request reprint High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells
    Chanchal Gupta
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali, Punjab 160062, India
    J Mol Endocrinol 51:119-29. 2013
    ....
  13. doi request reprint Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy
    Shrikant Ramesh Mulay
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, India
    Chem Biol Interact 185:137-42. 2010
    ....
  14. doi request reprint Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats
    Vivek Madhukar Surse
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali, Punjab 160 062, India
    J Mol Endocrinol 46:245-54. 2011
    ....
  15. doi request reprint 1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents
    Gopal L Khatik
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab 160 062, India
    Bioorg Med Chem Lett 22:1912-6. 2012
    ..Also a very low cytotoxicity was observed on non-cancerous cells MCF-10A...
  16. doi request reprint Alleviating anastrozole induced bone toxicity by selenium nanoparticles in SD rats
    Kiritkumar K Vekariya
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Toxicol Appl Pharmacol 268:212-20. 2013
    ..Interestingly, SeNPs (1mg/kg/day) also exhibited protective effect in ovariectomized rat model, by preventing osteoporosis, which signifies that bone loss due to estrogen deficiency can be effectively overcome by using SeNPs...
  17. doi request reprint Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations
    Ronak S Patel
    Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160062, India
    Toxicology 293:41-52. 2012
    ..Present results indicated that Ara-C, by inducing oxidative stress mediated DNA damage, executes neuronal apoptosis which is accompanied by an increase in the p53 and caspase-3, but decrease in the calbindin expression...
  18. doi request reprint Insulin induced alteration in post-translational modifications of histone H3 under a hyperglycemic condition in L6 skeletal muscle myoblasts
    Dhiraj G Kabra
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062 Punjab, India
    Biochim Biophys Acta 1792:574-83. 2009
    ..These changes in epigenetic modifications can provide new insights into pathogenesis of diabetes...
  19. doi request reprint Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions
    Anil B Gaikwad
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160 062, India
    Biochem J 432:333-41. 2010
    ..We provide the first evidence regarding the role of hyperglycaemia/hyperinsulinaemia in altering histone H3 modifications, which may result in the alteration of extracellular matrix gene expression...
  20. doi request reprint Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP
    Prakash Gopaldas Chandak
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali 160 062, Punjab, India
    Phytother Res 23:72-7. 2009
    ..As a PARG inhibitor gallotannin treatment also showed protection in PARP cleavage which is a hallmark for apoptotic cell death signifying the protective role of gallotannin in cell death signaling...
  21. doi request reprint p300/CBP dependent hyperacetylation of histone potentiates anticancer activity of gefitinib nanoparticles
    Jasmine Kaur
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India
    Biochim Biophys Acta 1833:1028-40. 2013
    ..To best of our knowledge, we provide first evidence that GNPs potentiate cell death by activating p300/CBP histone acetyltransferases...
  22. doi request reprint Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice
    Ujwal Mukund Mahajan
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
    Apoptosis 16:1138-49. 2011
    ....
  23. doi request reprint Evaluating cell specific cytotoxicity of differentially charged silver nanoparticles
    Jasmine Kaur
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali 160 062, Punjab, India
    Food Chem Toxicol 51:1-14. 2013
    ..TSNPs induced a dose dependent increase in the expression of stress markers pp38, TNF-α and HSP-70. Our report proposes that cytotoxicity of AgNPs changes with surface potential of nanoparticles and cells type...
  24. doi request reprint ERα signaling imparts chemotherapeutic selectivity to selenium nanoparticles in breast cancer
    Kiritkumar K Vekariya
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Nagar, Punjab, India
    Nanomedicine 8:1125-32. 2012
    ..This is the first report in our knowledge suggesting that the anticancer activity of SeNPs correlates with the level of ERα in breast cancer cells both in vivo and in vitro...
  25. doi request reprint Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors
    Pinakin Arun Karpe
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar, Mohali, Punjab, India
    J Hypertens 30:132-46. 2012
    ..The study was pursued to understand and compare the vascular reactivity to angiotensin II (Ang II) and its receptor expression in thoracic and abdominal aorta under insulin resistance...
  26. doi request reprint Aldol derivatives of Thioxoimidazolidinones as potential anti-prostate cancer agents
    Gopal L Khatik
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab 160 062, India
    Eur J Med Chem 46:3291-301. 2011
    ..The compounds were screened in vitro against prostate cancer cell lines, PC-3 and LNCaP and the most potent derivatives were identified...
  27. doi request reprint Pulmonary fibrotic response to inhalation of ZnO nanoparticles and toluene co-exposure through directed flow nose only exposure chamber
    Sonam Jain
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
    Inhal Toxicol 25:703-13. 2013
    ..To best of our knowledge this is the first study which highlights the toxicity of co-exposed ZnO NPs and toluene...
  28. pmc 17-β Oestradiol prevents cardiovascular dysfunction in post-menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation
    Dhaval Sharad Bendale
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
    Br J Pharmacol 170:779-95. 2013
    ..Hence, we investigated the effect of 17-β oestradiol (E2) on functional responses to angiotensin II and cardiovascular dysfunction in a rat model of PMS...
  29. doi request reprint Retracted: Modulation of p53 /Akt / phosphatase and tensin homolog expression by esculetin potentiates the anticancer activity of cisplatin and prevents its nephrotoxicity
    Kulbhushan Tikoo
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India
    Cancer Sci 103:154. 2012
    ..1111/j.1349-7006.2011.02091.x), by Kulbhushan Tikoo, Abhijit Babaji Shinde, Chanchal Gupta and Gopabandhu Jena, published online on 18 October 2011 in Wiley ..
  30. ncbi request reprint Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats
    K Sonaje
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, SAS Nagar, Mohali, Punjab, 160062, India
    Pharm Res 24:899-908. 2007
    ..Ellagic acid (EA), a dietary antioxidant associated with poor biopharmaceutical properties, was encapsulated into poly(lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) nanoparticles to improve oral bioavailability...
  31. ncbi request reprint Biodegradable in situ gelling system for subcutaneous administration of ellagic acid and ellagic acid loaded nanoparticles: evaluation of their antioxidant potential against cyclosporine induced nephrotoxicity in rats
    G Sharma
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Mohali, Punjab, 1600 62, India
    J Control Release 118:27-37. 2007
    ..Together, these results indicate that the bioavailability of ellagic acid can be improved by subcutaneous formulations administered as simple EA or EA nps...
  32. ncbi request reprint EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death
    Jing Dong
    Dept of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ 85721, USA
    Am J Physiol Renal Physiol 287:F1049-58. 2004
    ..e., histone H3 and Hsp27 phosphorylation, which have in common the potential ability to remodel chromatin...
  33. ncbi request reprint Ros-induced histone modifications and their role in cell survival and cell death
    Terrence J Monks
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721 0207, USA
    Drug Metab Rev 38:755-67. 2006
    ..Attempts to determine the precise site of histone H3 phosphorylation, putative histone H3 kinases, and histone H3 interacting proteins are underway...