Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylationKulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160062, Punjab, India
Toxicol Lett 177:90-6. 2008
..Moreover, treatment of tannic acid also decreases MN count in peripheral blood, suggesting its anti-mutagenic effect. In light of these findings we suggest the potential role of tannic acid treatment in preventing AZT induced toxicity...
- 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats
Kulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
Toxicol Lett 191:158-66. 2009
..Thus, combination of 5-azactydine with cisplatin attenuates the cisplatin induced nephrotoxicity and potentiates the anti-cancer activity which can have profound clinical implications...
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53Kulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
FEBS Lett 581:1071-8. 2007
..These findings suggest that IF significantly improves biochemical parameters associated with development of DN and changes the expression of Sir2 and p53...
Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer ratsKulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab, India
BMC Cancer 9:107. 2009
..The present study was undertaken to assess the effect of rosiglitazone, a PPARgamma agonist and an anti-inflammatory agent, on cisplatin induced nephrotoxicity, and its anticancer activity in DMBA induced breast cancer rats...
- Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
Kulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab 160 062, India
FEBS Lett 581:2027-35. 2007
..5mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin...
- Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy
K Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
Br J Pharmacol 153:1225-31. 2008
..The present study was undertaken to examine changes in histone modification by curcumin treatment which prevents development of type I diabetic nephropathy...
- Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: potential role of tannins in cancer chemotherapy
Kulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Mohali 160062, Punjab, India
Toxicol Appl Pharmacol 251:191-200. 2011
....
- Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy
Kulbhushan Tikoo
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
Free Radic Res 42:397-404. 2008
..This is the first report which suggests that protection against development of diabetic nephropathy by resveratrol treatment involves change in phosphorylation of histone H3, expression of Sir-2, p53 and p38 in diabetic kidney...
- Involvement of insulin-induced reversible chromatin remodeling in altering the expression of oxidative stress-responsive genes under hyperglycemia in 3T3-L1 preadipocytes
Jeena Gupta
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Punjab, India
Gene 504:181-91. 2012
..To the best of our knowledge this is the first report that shows the role of reversible histone modifications in regulating oxidative stress-responsive genes under hyperglycemic condition in 3T3-L1 preadipocytes...
- Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats
Jeena Gupta
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Punjab, India
J Cell Biochem 111:944-54. 2010
..To the best of our knowledge, this is the first report which shows the involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in the liver of type 2 diabetic rats and its association with diabetic nephropathy...
- Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats
Vivek Madhukar Surse
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali, Punjab 160 062, India
J Mol Endocrinol 46:245-54. 2011
....
- Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy
Shrikant Ramesh Mulay
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, India
Chem Biol Interact 185:137-42. 2010
....
- 1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents
Gopal L Khatik
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab 160 062, India
Bioorg Med Chem Lett 22:1912-6. 2012
..Also a very low cytotoxicity was observed on non-cancerous cells MCF-10A...
- Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations
Ronak S Patel
Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160062, India
Toxicology 293:41-52. 2012
..Present results indicated that Ara-C, by inducing oxidative stress mediated DNA damage, executes neuronal apoptosis which is accompanied by an increase in the p53 and caspase-3, but decrease in the calbindin expression...
- Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions
Anil B Gaikwad
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160 062, India
Biochem J 432:333-41. 2010
..We provide the first evidence regarding the role of hyperglycaemia/hyperinsulinaemia in altering histone H3 modifications, which may result in the alteration of extracellular matrix gene expression...
- Insulin induced alteration in post-translational modifications of histone H3 under a hyperglycemic condition in L6 skeletal muscle myoblasts
Dhiraj G Kabra
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062 Punjab, India
Biochim Biophys Acta 1792:574-83. 2009
..These changes in epigenetic modifications can provide new insights into pathogenesis of diabetes...
- Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP
Prakash Gopaldas Chandak
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali 160 062, Punjab, India
Phytother Res 23:72-7. 2009
..As a PARG inhibitor gallotannin treatment also showed protection in PARP cleavage which is a hallmark for apoptotic cell death signifying the protective role of gallotannin in cell death signaling...
- Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice
Ujwal Mukund Mahajan
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
Apoptosis 16:1138-49. 2011
....
- Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors
Pinakin Arun Karpe
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar, Mohali, Punjab, India
J Hypertens 30:132-46. 2012
..The study was pursued to understand and compare the vascular reactivity to angiotensin II (Ang II) and its receptor expression in thoracic and abdominal aorta under insulin resistance...
- Aldol derivatives of Thioxoimidazolidinones as potential anti-prostate cancer agents
Gopal L Khatik
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab 160 062, India
Eur J Med Chem 46:3291-301. 2011
..The compounds were screened in vitro against prostate cancer cell lines, PC-3 and LNCaP and the most potent derivatives were identified...
- Evaluating cell specific cytotoxicity of differentially charged silver nanoparticles
Jasmine Kaur
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali 160 062, Punjab, India
Food Chem Toxicol 51:1-14. 2013
..TSNPs induced a dose dependent increase in the expression of stress markers pp38, TNF-α and HSP-70. Our report proposes that cytotoxicity of AgNPs changes with surface potential of nanoparticles and cells type...
- Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells
Jeena Gupta
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
Biochimie 94:2656-64. 2012
..To best of our knowledge this is the first report that shows regulation of chromatin remodelling genes by alteration in the occupancy of histone H3Ac/H3K4/K9me on both promoter and transcribed regions...
- ERα signaling imparts chemotherapeutic selectivity to selenium nanoparticles in breast cancer
Kiritkumar K Vekariya
Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Nagar, Punjab, India
Nanomedicine 8:1125-32. 2012
....
- Retracted: Modulation of p53 /Akt / phosphatase and tensin homolog expression by esculetin potentiates the anticancer activity of cisplatin and prevents its nephrotoxicity
Kulbhushan Tikoo
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India
Cancer Sci 103:154. 2012
..1111/j.1349-7006.2011.02091.x), by Kulbhushan Tikoo, Abhijit Babaji Shinde, Chanchal Gupta and Gopabandhu Jena, published online on 18 October 2011 in Wiley ..
- Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats
K Sonaje
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, SAS Nagar, Mohali, Punjab, 160062, India
Pharm Res 24:899-908. 2007
..Ellagic acid (EA), a dietary antioxidant associated with poor biopharmaceutical properties, was encapsulated into poly(lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) nanoparticles to improve oral bioavailability...
- Biodegradable in situ gelling system for subcutaneous administration of ellagic acid and ellagic acid loaded nanoparticles: evaluation of their antioxidant potential against cyclosporine induced nephrotoxicity in rats
G Sharma
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Mohali, Punjab, 1600 62, India
J Control Release 118:27-37. 2007
..Together, these results indicate that the bioavailability of ellagic acid can be improved by subcutaneous formulations administered as simple EA or EA nps...
- EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death
Jing Dong
Dept. of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ 85721, USA
Am J Physiol Renal Physiol 287:F1049-58. 2004
..e., histone H3 and Hsp27 phosphorylation, which have in common the potential ability to remodel chromatin...
- Ros-induced histone modifications and their role in cell survival and cell death
Terrence J Monks
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721 0207, USA
Drug Metab Rev 38:755-67. 2006
..Attempts to determine the precise site of histone H3 phosphorylation, putative histone H3 kinases, and histone H3 interacting proteins are underway...
