Gabor J Tigyi

Summary

Publications

  1. pmc Aiming drug discovery at lysophosphatidic acid targets
    Gabor Tigyi
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA
    Br J Pharmacol 161:241-70. 2010
  2. pmc Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions
    Gyongyi N Kiss
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Pharmacol 82:1162-73. 2012
  3. pmc Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
    Mari Gotoh
    Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Biochem Soc Trans 40:31-6. 2012

Collaborators

  • Junming Yue
  • Jianxiong Liu
  • Gyongyi N Kiss
  • Duane D Miller
  • Renuka Gupte
  • Mari Gotoh
  • James Fells
  • Stephen Kennel
  • Ayako Uchiyama
  • Kimiko Murakami-Murofushi
  • Sue Chin Lee
  • Yuko Fujiwara
  • Ramesh M Ray
  • Renukadevi Patil
  • Keng G Lim
  • Suechin Lee
  • Balazs Sumegi
  • Jonathan Wall
  • Abby L Parrill
  • James I Fells
  • Nora Nusser
  • Louisa Balazs
  • Fang Tsyr Lin

Detail Information

Publications3

  1. pmc Aiming drug discovery at lysophosphatidic acid targets
    Gabor Tigyi
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA
    Br J Pharmacol 161:241-70. 2010
    ..However, successful targeting of the pathways associated with this pleiotropic lipid will depend on the future development of as yet undeveloped pharmacons...
  2. pmc Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions
    Gyongyi N Kiss
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Pharmacol 82:1162-73. 2012
    ....
  3. pmc Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
    Mari Gotoh
    Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Biochem Soc Trans 40:31-6. 2012
    ..In the present article, we review some of the key findings that make the ATX-LPA signalling axis an emerging target for cancer therapy...

Research Grants27

  1. Analysis of Radiomitigative Cell Signaling
    Gabor Tigyi; Fiscal Year: 2009
    ..The objective of this grant application is to elucidate the an- tiapoptotic mechanism of action unique to the LPA2 receptor subtype ..
  2. Ligand Recognition by Phospholipid Growth Factor Receptors
    Gabor J Tigyi; Fiscal Year: 2010
    ..Mills at MD Anderson Cancer Center, who will coordinate in vivo testing of anti-metastatic drug candidates, and Dr. Baker (junior faculty), who will assist with photoaffinity labels and mass spectrometry. ..
  3. Analysis of Radiomitigative Cell Signaling
    Gabor J Tigyi; Fiscal Year: 2010
    ..The objective of this grant application is to elucidate the an- tiapoptotic mechanism of action unique to the LPA2 receptor subtype ..
  4. THERAPEUTICALLY PROMISING PHOSPHOLIPID GROWTH FACTORS
    Gabor Tigyi; Fiscal Year: 2006
    ..These studies will have a twofold impact: first, advance our understanding of the physiological function of PLGF; and, second, provide new information concerning the regulation of apoptosis by G protein-coupled receptors. ..
  5. Ligand recognition by growth factor receptors
    Gabor Tigyi; Fiscal Year: 2005
    ..2. Identify residues conferring specificity for sphingolipids in the EDG3/5/6/8 receptor subfamily. 3. Identify residues involved in glycerolipid recognition in the EDG2/4/7 receptor subfamily. ..
  6. Analysis of LPA Signaling through the GPCR-PPARgamma Axis
    Gabor Tigyi; Fiscal Year: 2007
    ..abstract_text> ..
  7. Ligand Recognition by Phospholipid Growth Factor Receptors
    Gabor Tigyi; Fiscal Year: 2007
    ..Mills at MD Anderson Cancer Center, who will coordinate in vivo testing of anti-metastatic drug candidates, and Dr. Baker (junior faculty), who will assist with photoaffinity labels and mass spectrometry. ..
  8. THERAPEUTICALLY PROMISING PHOSPHOLIPID GROWTH FACTORS
    Gabor Tigyi; Fiscal Year: 2002
    ..The biotechnology industry has just begun to explore the utilization of LPA to prevent apoptosis associated with myocardial ischemia, chemotherapy, and AIDS. ..