Gabor J Tigyi

..However, successful targeting of the pathways associated with this pleiotropic lipid will depend on the future development of as yet undeveloped pharmacons...

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..In the present article, we review some of the key findings that make the ATX-LPA signalling axis an emerging target for cancer therapy...

..The objective of this grant application is to elucidate the an- tiapoptotic mechanism of action unique to the LPA2 receptor subtype ..

..Mills at MD Anderson Cancer Center, who will coordinate in vivo testing of anti-metastatic drug candidates, and Dr. Baker (junior faculty), who will assist with photoaffinity labels and mass spectrometry. ..

..The objective of this grant application is to elucidate the an- tiapoptotic mechanism of action unique to the LPA2 receptor subtype ..

..2. Identify residues conferring specificity for sphingolipids in the EDG3/5/6/8 receptor subfamily. 3. Identify residues involved in glycerolipid recognition in the EDG2/4/7 receptor subfamily. ..

..These studies will have a twofold impact: first, advance our understanding of the physiological function of PLGF; and, second, provide new information concerning the regulation of apoptosis by G protein-coupled receptors. ..

..abstract_text> ..

..The biotechnology industry has just begun to explore the utilization of LPA to prevent apoptosis associated with myocardial ischemia, chemotherapy, and AIDS. ..

..Mills at MD Anderson Cancer Center, who will coordinate in vivo testing of anti-metastatic drug candidates, and Dr. Baker (junior faculty), who will assist with photoaffinity labels and mass spectrometry. ..