Eef L Theunissen

Summary

Publications

  1. doi request reprint A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition
    E L Theunissen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Clin Pharmacol Ther 93:493-501. 2013
  2. pmc Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P O Box 616, 6200MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 220:341-50. 2012
  3. doi request reprint Comparing the stimulant effects of the H1-antagonist fexofenadine with 2 psychostimulants, modafinil and methylphenidate
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Facultyof Psychology and Neuroscience, Maastricht University, The Netherlands
    J Clin Psychopharmacol 29:439-43. 2009
  4. pmc Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
    Johannes G Ramaekers
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 214:391-401. 2011
  5. doi request reprint Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Clin Psychopharmacol 31:294-301. 2011
  6. pmc Psychomotor function in chronic daily Cannabis smokers during sustained abstinence
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e53127. 2013
  7. pmc Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 215:321-32. 2011
  8. ncbi request reprint Medicinal Δ(9) -tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Faculty Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Addiction 107:1837-44. 2012
  9. doi request reprint The role of P-glycoprotein in CNS antihistamine effects
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 229:9-19. 2013
  10. pmc Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Br J Clin Pharmacol 61:79-86. 2006

Detail Information

Publications16

  1. doi request reprint A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition
    E L Theunissen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Clin Pharmacol Ther 93:493-501. 2013
    ..Most of these effects disappeared after multiple doses of mirtazapine. To conclude, vortioxetine did not impair driving, cognitive, or psychomotor performance after single or multiple doses...
  2. pmc Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P O Box 616, 6200MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 220:341-50. 2012
    ..Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis...
  3. doi request reprint Comparing the stimulant effects of the H1-antagonist fexofenadine with 2 psychostimulants, modafinil and methylphenidate
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Facultyof Psychology and Neuroscience, Maastricht University, The Netherlands
    J Clin Psychopharmacol 29:439-43. 2009
    ..These stimulant effects were rather mild in magnitude and were only demonstrated in tasks with a high workload...
  4. pmc Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
    Johannes G Ramaekers
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 214:391-401. 2011
    ..Animal studies suggest that chronic cannabis consumption may also produce cross-tolerance for the impairing effects of alcohol, but supportive data in humans is scarce...
  5. doi request reprint Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Clin Psychopharmacol 31:294-301. 2011
    ....
  6. pmc Psychomotor function in chronic daily Cannabis smokers during sustained abstinence
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e53127. 2013
    ..We hypothesized that psychomotor performance would improve during abstinence of chronic, daily cannabis smokers...
  7. pmc Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 215:321-32. 2011
    ..Esmirtazapine is evaluated as a novel drug for treatment of insomnia...
  8. ncbi request reprint Medicinal Δ(9) -tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Faculty Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Addiction 107:1837-44. 2012
    ..It was hypothesized that occasional users would be impaired on these tests and that heavy users would show less impairment due to tolerance...
  9. doi request reprint The role of P-glycoprotein in CNS antihistamine effects
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 229:9-19. 2013
    ..Studies in rodents have demonstrated that antihistamines that are substrates of the P-gp transporter display no or minor central nervous system (CNS) effects as compared to antihistamines that are not P-gp transporter substrates...
  10. pmc Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Br J Clin Pharmacol 61:79-86. 2006
    ..It is unknown, however, whether acute sedation persists after repeated dosing. Therefore, this study assessed the effects of repeated dosing of these antihistamines on driving and psychomotor performance...
  11. ncbi request reprint A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 20:496-505. 2006
    ....
  12. ncbi request reprint High-potency marijuana impairs executive function and inhibitory motor control
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2296-303. 2006
    ..Use of higher doses of THC in controlled studies may offer a reliable indication of THC induced impairment as compared to lower doses of THC that have traditionally been used in performance studies...
  13. ncbi request reprint Stimulating effects of the antihistamine fexofenadine: testing the dopamine transporter hypothesis
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 187:95-102. 2006
    ..One hypothesis suggests that this is due to fexofenadine producing an increase in dopamine levels by blocking the dopamine transporter...
  14. doi request reprint Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 25:1517-23. 2011
    ..Bilastine did not produce any driving impairment after single and repeated doses and can be safely used in traffic in doses up to 40 mg...
  15. ncbi request reprint Stimulating effects of H1-antagonists
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Curr Pharm Des 12:2501-9. 2006
    ..In addition, it would be useful to determine whether terfenadine, ebastine, fexofenadine and desloratadine can return allergic patient's performance back to their preclinical level...
  16. pmc Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT2 and 5-HT1 receptors
    Janelle H P van Wel
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 7:e40187. 2012
    ..In conclusion, 5-HT(2) receptors mediate positive moods induced by MDMA but not negative moods or impulsivity. 5-HT(1) receptors do not appear to be involved in MDMA effects on mood and impulse control...