Prognostic significance of blood markers of inflammation in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty and effects of pexelizumab, a C5 inhibitor: a substudy of the COMMA trialPierre Theroux
Montreal Heart Institute, Montreal, 5000 Belanger E, Montreal, Quebec, Canada H1T 1C8
Eur Heart J 26:1964-70. 2005
..Inflammation is a critical component of ST-elevation myocardial infarction (STEMI); this substudy examines prognostic values of selected markers and treatment effects...
Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute MyocardiaCatherine Martel
Department of Medicine, Montreal Heart Institute, Quebec, Canada
Am Heart J 164:43-51. 2012
..In a substudy of the APEX-AMI trial, we explored the hypothesis that early complement activation preceding drug administration explained the failure...
- Meta-analysis of randomized trials comparing enoxaparin versus unfractionated heparin as adjunctive therapy to fibrinolysis in ST-elevation acute myocardial infarction
Pierre Theroux
Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
Am J Cardiol 91:860-4. 2003
- Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug
Benoit Labarthe
Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
J Am Coll Cardiol 46:638-45. 2005
..This study aimed to explore platelet function tests relevant to the biological effects of clopidogrel that could help the clinical monitoring of drug efficacy...
- Comparison of primary percutaneous coronary intervention and fibrinolytic therapy in ST-segment-elevation myocardial infarction: bayesian hierarchical meta-analyses of randomized controlled trials and observational studies
Thao Huynh
1650 Ave Cedar, Room E 5200, Montreal, Quebec, H3G 1A4, Canada
Circulation 119:3101-9. 2009
..We aim to obviate the limited applicability of RCTs to real-world settings by undertaking meta-analyses of both RCTs and observational studies...
Coping with new challenges in acute coronary syndromesPierre Theroux
Montreal Heart Institute and University of Montreal, Montreal, Quebec
Can J Cardiol 22:13C-20C. 2006
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- The pre-hospital fibrinolysis experience in Europe and North America and implications for wider dissemination
Thao Huynh
Division of Cardiology, Department of Medicine, McGill Health University Center, Montreal, Quebec, Canada
JACC Cardiovasc Interv 4:877-83. 2011
..A secondary objective is to report the outcome data of the PHL programs surveyed...
- Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets
Catherine Martel
Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
PLoS ONE 6:e18812. 2011
..The activation of complement during platelet activation is incompletely understood. Objectives: We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets...
- Perspectives on acute coronary syndromes
Pierre Theroux
Montreal Heart Institute, University of Montreal, Quebec
Can J Cardiol 21:1053-60. 2005
..New therapeutic frontiers are thus being suggested to control the most fundamental mechanisms involved in ACSs and related to inflammation and autoimmunity...
- Classification and risk stratification of patients with acute chest pain using a low discriminatory level of cardiac troponin T
B Charles Solymoss
Department of Laboratory Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
Clin Cardiol 27:130-6. 2004
..20 or 0.10 microg/l cardiac troponin T (cTnT) levels. With the highly sensitive and specific second- and third-generation assays, cTnT is undetectable in most healthy individuals...
- Complement activity and pharmacological inhibition in cardiovascular disease
Pierre Theroux
University of Montreal, Montreal, Quebec
Can J Cardiol 22:18B-24B. 2006
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- Analysis of bleeding complications associated with glycoprotein IIb/IIIa receptors blockade in patients with high-risk acute coronary syndromes: insights from the PRISM-PLUS study
Thao Huynh
Montreal General Hospital, McGill University Health Center, 1650 Cedar Avenue, Room E 5200, Montreal, Quebec, Canada H3G 1A4
Int J Cardiol 100:73-8. 2005
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- Endothelial progenitor cells bind and inhibit platelet function and thrombus formation
Haissam Abou-Saleh
Research Center, Montreal Heart Institute and Universite de Montreal, Faculty of Medicine, Montreal, Quebec, Canada, H1T 1C8
Circulation 120:2230-9. 2009
..Herein, we addressed the interactions between EPCs and platelets and their impact on platelet function and thrombus formation...
- Effect of inhibition of the Na+/H+ exchanger with cariporide on left ventricular function in acute coronary syndromes: results from the echocardiographic substudy of the GUARDIAN trial
Jean Claude Tardif
Department of Medicine, Montreal Heart Institute, Montreal, Quebec
Can J Cardiol 20:317-22. 2004
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- A score predicts failure of reperfusion after fibrinolytic therapy for acute myocardial infarction
John K French
Cardiology Department, Green Lane Hospital, Auckland, New Zealand, Montreal Heart Institute, Montreal, Quebec, Canada
Am Heart J 145:508-14. 2003
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